Baeta (Byetta) yog ib tus neeg sawv cev hypoglycemic uas tuaj yeem siv los kho hom ntshav qab zib hom 2 yog ib yam tshuaj los yog ua ke nrog lwm cov tshuaj nrog cov nyhuv zoo sib xws. Qhov ua tau zoo tshaj plaws hauv kev tsim tshuaj tshiab no tso cai rau koj los tswj cov qib ntawm cov piam thaj hauv cov ntshav, thiab tswj cov neeg mob lub siab thiab lub cev qhov hnyav.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
INN Bayeta - Exenatide.
Baeta yog ib tus neeg sawv cev hypoglycemic tsim los kho tus mob ntshav qab zib hom II, muaj cov tshuaj lag luam zoo heev.
ATX
Cov tshuaj yog zwm rau pharmacological pawg ntawm hluavtaws hypoglycemic cov neeg sawv cev npaj rau kev kho mob ntawm insulin-dependant ntshav qab zib mellitus, thiab muaj ATX code ntawm A10X.
Tso cov ntawv thiab cov nyob ua ke
Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov tshuaj tov siv rau kev tswj hwm subcutaneous. Nws yog cov kua ntshiab, tsis muaj xim thiab tsw. Nws cov tshuaj tshaj tawm exenatide muaj qhov kub siab ntawm 250 μg rau 1 ml ntawm kev daws. Lub luag haujlwm ntawm cov kuab tshuaj yog ua si los ntawm kev txhaj tshuaj, thiab cov pabcuam pabcuam yog sawv cev los ntawm metacresol, sodium acetate trihydrate, acetic acid, thiab mannitol (ntxiv rau E421).
Ib qho kev daws teeb meem ntawm 1.2 lossis 2.4 ml yog nchuav rau hauv daim iav iav, txhua tus tau muab tso rau hauv cov ntawv xuav pov tseg - qhov sib piv ntawm cov tshuaj insulin. Cov thawv ntim khoom. Tsuas muaj 1 rab koob tshuaj muaj tshuaj nyob hauv lub thawv.
Daim ntawv tso tawm ntev ntev uas muaj npaj muaj nyob hauv cov hmoov uas yog npaj rau kev sib xyaw cov kev ncua ntawv. Cov kua dej hauv lub cev tseem siv rau kev txhaj tshuaj subcutaneous. Cov tshuaj yeeb tshuaj (2 mg) yog nchuav rau hauv lub thawv ntawv uas tau muab tso rau hauv rab koob xaum qhuav. Cov khoom siv nrog cov tshuaj tiv thaiv thiab cov lus qhia.
Bayeta yog lub khob ntim tshuaj txhuam nrog cov tshuaj tiv thaiv rau cov txheej txheem subcutaneous, muab tso rau hauv cov khoom xaum pov tseg.
Pharmacological kev txiav txim
Cov nyhuv ntawm cov tshuaj yog muab los ntawm kev ua ntawm exenatide (exendin-4).
Cov khoom sib txuas ua ke no yog cov amino peptide saw nrog 39 amino acid ntsiab.
Cov tshuaj no yog cov qauv ua qauv ntawm enteroglucagon, peptide hormone ntawm cov chav kawm ntau zuj zus hauv tib neeg lub cev, uas tseem hu ua glucagon-zoo li peptide-1, lossis GLP-1.
Tus incretins yog tsim los ntawm cov hlwb ntawm lub txiav thiab hnyuv tom qab noj mov. Lawv qhov ua haujlwm yog pib cov tshuaj insulin zais cia. Vim tias nws zoo sib xws nrog cov tshuaj hormonal, exenatide muaj tib lub cev. Ua raws li GLP-1 lub ntsej muag, nws ua kom pom cov yam ntxwv hauv qab no:
- txhim kho kev tso tawm ntawm cov tshuaj insulin los ntawm pancreatic β-hlwb nrog kev nce ntxiv ntawm cov ntshav ntshav siab;
- txo cov pa glucagon tso zis ntau dhau, tsis muaj kev cuam tshuam dab tsi rau cov ntshav qab zib;
- inhibits lub cev muaj zog ntawm lub plab, ua kom qeeb;
- tswj kev qab los noj mov;
- txo tus nqi ntawm cov khoom noj noj;
- txhawb nqa poob.
Hauv hom 2 Ntshav Qab Zib, pancreatic β-cell muaj qhov ua haujlwm tsis zoo, uas ua rau muaj insulin secretion. Exenatide cuam tshuam rau ob theem ntawm insulin secretion. Tab sis tib lub sijhawm, qhov kev siv ntau ntawm kev ua haujlwm of-hlwb pib los ntawm nws txo nrog kev txo qis hauv cov piam thaj. Qhov kev nqus ntawm cov tshuaj insulin nres rau lub sijhawm thaum glycemic Performance index rov qab zoo li qub. Yog li, kev qhia txog cov tshuaj nyob rau hauv nqe lus nug txo qhov zoo li ntawm kev txhim kho hypoglycemia.
Cov kev tshawb fawb pom tau hais tias kev kho mob ua rau tswj tau cov ntshav qab zib kom zoo rau cov neeg mob ntshav qab zib hom 2.
Cov Tshuaj Pharmacokinetics
Tom qab tswj hwm ntawm Baeta nyob rau hauv txoj kev txhaj tshuaj subcutaneous, cov tshuaj pib yuav nqus mus rau hauv cov ntshav, nce mus txog qib siab ntawm kev saturation hauv kwv yees li 2 teev.
Tag nrho qhov kev xav ntawm exenatide nce rau hauv kev faib ua feem rau cov koob tshuaj uas tau txais nyob hauv thaj tsam ntawm 5-10 μg.
Cov tshuaj Baeta ncav cuag nws qhov siab tshaj plaws nyob rau hauv cov ntshav 2 teev tom qab kev coj ua subcutaneous thiab raug tshem tawm ntawm lub cev tsis pub dhau 10 teev.
Qhov pom ntawm cov tshuaj yog nqa tawm los ntawm cov hlab ntsha hauv lub raum, cov proteolytic enzymes tau koom nrog nws cov metabolism hauv. Nws yuav siv sijhawm li 5 teev los txhawm rau tshem tawm qhov tseem ceeb ntawm cov tshuaj tawm hauv lub cev, tsis hais txog kev siv lub koob tshuaj. Kev ua kom tiav ntawm lub cev ua tiav yuav siv 10 teev.
Kev ntsuas rau siv
Cov tshuaj tau qhia rau kev kho glycemic txaus hauv kev tsim tshuaj insulin-mob ntshav qab zib. Byetu tuaj yeem raug siv los ua tshuaj hypoglycemic rau kev kho mob monotherapy. Xws li kev txhaj tshuaj muaj txiaj ntsig zoo yog tias kev noj zaub mov zoo tsim nyog tau ua thiab kev tawm dag zog kom ib ce muaj zog.
Cov tshuaj no tuaj yeem suav nrog hauv kev kawm ua ke nrog kev ua haujlwm tsis txaus ntawm kev kho mob nrog lwm tus neeg sawv cev antiglycemic. Ntau hom tshuaj sib xyaw ua ke nrog Bayeta raug tso cai:
- Sulfonylurea derivative (PSM) thiab Metformin.
- Metformin thiab Thiazolidinedione.
- PSM nrog Thiazolidinedione thiab Metformin.
Cov tswv yim zoo li no ua rau txo qis rau cov ntshav qab zib thiab tom qab noj mov, nrog rau glycemic hemoglobin, uas txhim kho glycemic tswj cov neeg mob.
Bayeta yog qhov tsim nyog kho kho glycemic txaus, thiab nws kuj tseem siv tau rau kev kho mob monotherapy.
Cov Yuav Tsum Muaj
Cov tshuaj tsis tuaj yeem siv rau hom ntshav qab zib hom 1. Lwm yam contraindications:
- muaj kev cuam tshuam ntau ntxiv rau exenatide;
- intolerance mus rau pab additives;
- ketoacidosis;
- kev puas tsuaj rau cov zom plab, nrog los txo qis ntawm txoj kev sib cog lus ntawm lub plab zom mov;
- pub niam mis lossis cev xeeb tub;
- mob raum tsis ua haujlwm;
- hnub nyoog txog 18 xyoo.
Kev pub niam mis yog ib qho ntawm kev tsis pom zoo rau kev siv tshuaj Bayet.
Yuav ua li cas noj bayetu?
Tus kws kho mob muaj lub luag haujlwm sau tshuaj, txiav txim siab pom tias pom zoo tshaj plaws thiab saib xyuas tus neeg mob ntshav qab zib. Nws raug nquahu tias koj yuav tsum tsis txhob tus kheej-kev noj tshuaj.
Qhov hno tau muab tso rau hauv qab daim tawv nqaij hauv thaj chaw mos, nqaij mos lossis plab. Qhov chaw txhaj tshuaj ntawm cov tshuaj tsis cuam tshuam rau nws qhov kev ua tau zoo.
Thaum xub thawj, ib zaug tshuaj tsuas yog 0.005 mg (5 μg). Kev txhaj tshuaj yog muab ua ntej noj tshais thiab noj hmo. Qhov sib txawv ib ntus nruab nrab ntawm kev qhia ntawm cov tshuaj thiab pib noj mov yuav tsum tsis txhob ntau dua 1 teev.
Nruab nrab ntawm cov zaub mov tseem ceeb, uas cuam tshuam nrog kev siv tshuaj, tsawg kawg 6 teev yuav tsum hla.
Tom qab ib hlis kho, ib koob tshuaj ib zaug tuaj yeem ua ob npaug. Txoj kev ncua tsis mus txhaj tsis tau txais txiaj ntsig ntxiv nrog kev siv tshuaj txuas ntxiv. Tom qab noj Bayetu yuav tsum tsis txhob pricked.
Nrog rau thaum uas tig mus siv cov tshuaj hauv cov nqe lus nug nrog kev npaj sulfonylurea, tus kws kho mob tuaj yeem txo qhov ntau npaum ntawm qhov tom kawg vim tias muaj qhov tshwm sim rau kev txhim kho ntawm cov tshuaj tiv thaiv hypoglycemic. Kev kho ua ke nrog Thiazolidinedione thiab / lossis Metformin tsis tas yuav muaj kev hloov pauv ntawm cov tshuaj thawj zaug ntawm cov tshuaj no.
Sab sij huam
Cov kev phiv tshuaj uas tshwm sim los ntawm exenatide muaj qhov mob nyhav ib nrab thiab tsis tas yuav tsum tsis txiav tawm cov tshuaj (muaj qhov tsis tshua pom). Feem ntau feem ntau, thaum pib ntawm kev kho mob nrog Bayeta nrog ib koob tshuaj 5 mg lossis 10 mg, xeev siab tshwm sim, uas dhau ntawm nws tus kheej lossis tom qab kho qhov ntau ntawm cov tshuaj.
Xeev siab yog qhov tshwm sim tsis zoo rau kev nqis tes ua ntawm Bayeta, feem ntau tshwm sim thaum pib theem ntawm kev kho mob.
Kev kho mob txoj hnyuv
Feem ntau, cov neeg mob ua kom lub plab zom mov. Cov neeg mob yws yws, tsis hnov qab, ua kom poob plab, ntuav, ua tsis tau dab tsi, mob plab. Qhov tsim nyog tsis kam rov qab, qhov tshwm sim ntawm txoj kev sib, pom pob zom, quav tawv, ua txhaum cai ntawm kev saj. Ntau qhov tshwm sim ntawm tus mob pancreatitis tau sau tseg.
Hematopoietic plab hnyuv siab raum
Thaum muab sib xyaw nrog warfarin, ntshav coagulation tej zaum yuav tsis taus. Cov neeg mob ntshav tau qhia tawm.
Nruab nrab hauv lub paj hlwb
Feem ntau cov neeg mob muaj mob yastaw. Lawv yuav zoo li kiv taub hau lossis hnov zoo li tsaug zog thaum nruab hnub.
Los ntawm cov kab mob zis
Muaj peev xwm ua rau lub raum khiav tsis zoo, ua rau cov neeg mob uas tau muaj mob raum tsis ua haujlwm, dhia hauv cov ntshav creatinine.
Ntawm ib sab ntawm daim tawv nqaij
Ntawm qhov chaw txhaj tshuaj, cov cim focal tuaj yeem pom.
Kev ua xua
Kev ua xua muaj peev xwm ua tau rau hauv daim ntawv ntawm daim tawv nqaij ua pob, khaus, liab liab, o. Kev tsis pom qhov tsis zoo yog tsis tshua pom muaj.
Cov tawv nqaij khaus yog qhov tshwm sim tsis haum rau kev siv tshuaj Bayet.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Cov kev kawm tshwj xeeb hauv cov kev taw qhia no tseem tsis tau ua. Nws yuav tsum coj mus rau hauv tus lej muaj peev xwm ntawm kev txhim kho hypoglycemia thaum muab cov tshuaj hauv cov lus nug nrog cov tshuaj insulin lossis PSM thiab kev coj ua tiv thaiv kev ntsuas.
Cov lus qhia tshwj xeeb
Yog tias cov xim, pob tshab lossis kev sib thooj ntawm qhov txhaj tshuaj tau hloov pauv, nws siv tsis tau. Koj yuav tsum ua raws li txoj kev pom zoo ntawm kev tswj hwm tshuaj. Kev txhaj tshuaj tsis yog muab rau cov tshuaj los yog ua kom cev txau.
Kev ntsuas tsis zoo los ntawm kev qab los lossis qhov poob ntawm tus neeg mob tsis yog qhov qhia txog kev txiav tshuaj, ib qho kev hloov pauv hauv nws cov ntau npaum li cas thiab kev siv ntau npaum li cas.
Hauv kev teb rau kev qhia tawm ntawm exenatide, cov tshuaj tiv thaiv tuaj yeem tsim nyob rau hauv lub cev. Qhov no tsis cuam tshuam qhov tshwm sim ntawm cov tsos mob tshwm sim.
Siv rau lub sijhawm qub
Lub chaw muag tshuaj ntawm cov tshuaj tsis yog nyob ntawm lub hnub nyoog ntawm cov neeg mob. Yog li, tsis tas yuav siv tshuaj ntau rau cov neeg laus.
Cov hnub nyoog laus tsis yog contraindication rau kev siv tshuaj Bayet, tsis tas nws yuav tsum tau hloov kho ntau npaum li cas ntawm cov tshuaj.
Txiag tej menyuam
Cov txiaj ntsig ntawm exenatide rau cov menyuam lub cev tseem tsis tau kawm txog, qhov theem ntawm nws cov txiaj ntsig thiab theem ntawm kev nyab xeeb rau menyuam yaus thiab tub ntxhais hluas tsis paub. Yog li, lub hnub nyoog txwv rau kev siv cov tshuaj yog 18 xyoo.
Siv thaum cev xeeb tub thiab lactation
Nyob rau theem ntawm kev coj tus menyuam thiab thaum lub sijhawm pub mis, cov tshuaj tsis raug qhia rau cov niam.
Daim ntawv thov rau lub raum khiav tsis zoo
Yog tias lub raum tsis ua haujlwm yog mob me lossis mob pes tsawg, yog li qhov ntau ntawm cov tshuaj tsis tas yuav hloov pauv (cov koob tshuaj ib txwm siv).
Nrog cov kab mob loj, kev tshem tawm tuaj yeem txo txog 10 zaug, yog li ntawd, Bayete tsis tau teev tseg rau cov neeg mob zoo li no.
Siv rau lub siab ua haujlwm tsis zoo
Vim tias qhov tseeb uas tau ua rau lub luag haujlwm tseem ceeb rau kev tshem tawm exenatide ntog rau ob lub raum, ua haujlwm ntawm lub siab lossis lub zais plab ua haujlwm tsis yog qhov sib txuam rau kev siv tshuaj thiab tsis ua rau muaj kev txwv.
Ua tsis tiav rau hauv daim siab lossis lub zais zis hauv plab tsis yog qhov sib tshooj rau kev siv tshuaj.
Noj ntau dua ntawm Byeta
Muaj zog dhau ntawm cov tshuaj pom zoo ntawm exenatide ua rau cov ntshav qab zib tsawg. Hauv qhov no, txhaj tshuaj los yog kua dej ntawm qabzib yog yuav tsum muaj. Cov tsos mob ntawm kev overdose:
- bouts ntawm xeev siab;
- ntuav
- ntshav qab zib tsawg tsawg;
- pallor ntawm integument;
- ua daus no;
- mob taub hau
- hws
- arrhythmia;
- kev tshee
- nce nyob rau hauv cov ntshav siab:
- tshee hnyo.
Arrhythmia yog ib qho ntawm cov tsos mob ntawm kev overdose ntawm Bayet.
Kev cuam tshuam nrog lwm yam tshuaj
Sib tov cov tshuaj nrog lwm cov tshuaj txhaj rau hauv 1 koob txhaj tshuaj yog txwv.
Koj yuav tsum coj mus rau hauv kev qeeb ntawm lub plab hauv qab qhov kev ua ntawm exenatide thaum noj tshuaj sab hauv, vim hais tias cov neeg kawm ntawv qib siab thiab nqus tau tuaj yeem txo qis heev. Cov nyiaj no yuav tsum tau siv sijhawm ntev ua ntej kev qhia ntawm Byeta, lub sijhawm tsawg kawg yog 1 teev. Yog tias cov tshuaj xav noj nrog zaub mov, ces nws yuav tsum yog cov pluas noj tsis cuam tshuam nrog kev txhaj tshuaj ntawm tus neeg sawv cev hypoglycemic no.
Proton twj tso kua mis inhibitors yuav tsum noj 4 teev tom qab txhaj tshuaj lossis 1 teev ua ntej nws.
Nrog rau kev siv cov tshuaj warfarin los yog lwm yam kev npaj noj haus marmarin, qhov nce sij hawm ntawm prothrombin yog ua tau. Yog li, ntshav coagulation yuav tsum tau tswj.
Txawm hais tias kev sib xyaw ua ke ntawm Bajeta nrog rau cov tshuaj uas tiv thaiv HMG-CoA reductase tsis ua rau muaj kev hloov pauv tseem ceeb hauv cov ntshav lipid, nws pom zoo kom soj ntsuam cov roj cholesterol.
Kev sib xyaw ntawm cov tshuaj nyob rau hauv nqe lus nug nrog Lisinopril tsis ua rau muaj kev hloov pauv hauv cov ntshav nruab nrab hauv tus neeg mob.
Kev sib xyaw nrog kev txhaj tshuaj nrog kev tswj hwm ntawm qhov ncauj ntawm qhov ncauj tsis tas yuav hloov pauv tshuaj.
Nws tsis yog yuav tsum tau soj ntsuam ib qho tshwj xeeb sib xyaw ntawm Bayeta kev txhaj tshuaj thiab kev noj tshuaj - tshuaj ntsuab ntawm sulfanylurea.
Nrog kev sib txuas / ua ke tswj hwm ntawm Bayeta nrog Warfarin, nws yog qhov tsim nyog los tswj ntshav coagulation.
Cawv tau zoo
Nws yog qhov tsis tsim nyog txog kev haus cawv los yog tshuaj rau cawv thaum kho.
Analogs
Tsuas muaj 2 qho tiav ntawm cov tshuaj - Exenatide thiab Baeta Ntev. Cov kab mob hypoglycemic hauv qab no muaj cov nyhuv zoo sib xws:
- Victoza;
- Invokana;
- Guarem;
- Novonorm;
- Jardins li al.
Generic Baeta - Bydureon (Bydureon).
Victoza yog ib tus neeg sawv cev hypoglycemic uas muaj cov duab zoo sib xws nrog Bayeta.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Tsis muaj kev pub dawb rau cov tshuaj.
Kuv puas yuav tau yam tsis muaj daim ntawv yuav tshuaj?
Koj tuaj yeem yuav Baeta hauv khw muag tshuaj tsuas yog los ntawm daim ntawv sau tshuaj.
Nqi
Tus nqi ntawm cov tshuaj yog 1.2 ml - los ntawm 5339 rubles.
Cia rau cov neeg mob rau cov tshuaj
Cov tshuaj yuav tsum tau muab cia rau hauv qhov chaw tsaus kom tsis txhob tuaj yeem ncav cuag me nyuam, ntawm qhov kub ntawm + 2 ... + 8 ° C, zam tsis pub kom txias.
Hnub tas sij hawm
Hauv nws daim ntawv qub, cov tshuaj muab cia rau 2 xyoos. Tom qab qhib lub pob, nws yuav tsum siv hauv 30 hnub.
Lub txee lub neej ntawm cov tshuaj Bayeta yog 2 xyoos nyob rau hauv nws thawj daim ntawv thiab 30 hnub tom qab qhib lub pob.
Chaw tsim tshuaj paus
Tshaj tawm lub teb chaws ntawm keeb kwm yog Great Britain. Txawm li cas los xij, kev tsim cov tshuaj yog nqa tawm los ntawm Indian chaw lag luam kws tshuaj Macleods Pharmaceuticals Ltd.
Xyuas
Alla, 29 xyoos, Stavropol.
Yuav Baitu niam. Kim kim, tab sis yooj yim siv. Thaum xub thawj, leej niam yws yws tias nws tsis xeev siab, tab sis tsis ntev nws cia li tsum. Qab zib yog qhov ruaj khov, yog li peb yuav siv cov tshuaj txuas ntxiv mus.
Veronika, 34 xyoo, Danilov.
Thaum kuv rov nyeem cov lus qhia, Kuv xav tias tsis yooj yim los ntawm daim ntawv teev cov kev mob tshwm sim. Tom qab kev txhaj tshuaj Kuv tau mob. Kuv kuj tau ntshai los saib xyuas cov tshuaj tom ntej. Tab sis kuv tus txiv hais tias kuv tau khib kuv tus kheej. Nws hais yog lawm. Thaum txhaj ntxiv lawm tsis muaj kev mob siab ntxiv lawm. Tus kws kho mob tau hais tias ntau npaum li cas yuav tsum tsis txhob faib, thiab tom qab ntawd txawm nce ntxiv. Tam sim no nws tsis hnov mob ntxiv lawm, tsuas yog qee zaum muaj kev tsis xis nyob hauv plab.
Olga, 51 xyoo, lub nroog Azov.
Kuv pib siv tshuaj kom pab Metformin. Nws noj dhau thawj hnub dhau ntawm qhov muaj zog - nws qhov qab los noj mov yuav luag ploj mus.Tom qab ntawd lub cev yoog. Cov ntu tau ua me me, tab sis qab los noj mov tau rov qab. Tam sim no nws meej meej vim li cas hauv Asmeskas Bayetu tau raug tshaj tawm rau cov neeg uas xav poob phaus.
