Cov kev npaj ua ke uas muaj 2 yam tshuaj, ntxiv tshuaj muaj txiaj ntsig zoo, thiab tau siv los kho kev mob ntshav siab.
Npe
Noliprel (Bi) Forte yog ib qho tshuaj nrog muab ob npaug tshuaj ntawm cov tshuaj muaj zog (Perindopril 4 mg + Indapamide 1.25 mg). Yog tias nws yuav tsum tau siv ntau tshaj plaws hauv cov neeg mob uas muaj kev phom sij (ntshav qab zib, haus luam yeeb, hypercholesterolemia), Bi-Forte (Perindopril 10 mg + Indapamide 2.5 mg) yog cov tshuaj.
Kev npaj ua ke muaj 2 yam tshuaj uas cuam tshuam txog cov teeb meem ntawm tus kws tshuaj.
ATX
C09BA04 Perindopril ua ke nrog nrog diuretics.
Tso cov ntawv thiab cov nyob ua ke
Zaj duab xis-coated ntsiav tshuaj.
Cov khoom siv nquag: Perindopril 2 mg + Indapamide 0.625 mg.
Pharmacological kev txiav txim
Pab ua kom ob leeg systolic thiab diastolic ntshav siab (BP) hauv 24 teev. Tag nrho cov txiaj ntsig tau paub tom qab ib hlis dhau los ntawm kev noj kom tsawg. Kev ua tiav ntawm kev tswj hwm tsis ua rau muaj kev txhim kho ntawm kev tshem tawm cov tsos mob
Cov tshuaj txo cov kev khiav ceev ntawm myocardial kev kho dua tshiab, txo qhov tsis kam ntawm cov hlab ntsha peripheral ntawm cov leeg tsis muaj kev cuam tshuam txog qib ntawm lipids thiab ntshav qabzib.
Perindopril inhibits cov kev ua ntawm enzyme, uas txhais cov angiotensin Kuv mus rau hauv lub enzyme angiotensin II, uas yog vasoconstrictor muaj zog. ACE kuj rhuav tshem cov bradykinin, yog ib lub vasodilator dhia ua haujlwm. Raws li cov txiaj ntsig ntawm vasodilation, tiv thaiv vascular txo qis thiab ntshav siab poob qis.
Zaj duab xis-coated ntsiav tshuaj.
Indapamide yog cov diuretic los ntawm pab pawg thiazide. Cov nyhuv diuretic thiab hypotensive yog pom tau los ntawm kev txo qhov thim rov qab nqus ntawm sodium ions hauv ob lub raum. Muaj qhov nce ntawm excretion nrog zis ntawm sodium, vim qhov kev cuam tshuam ntawm cov hlab ntsha tsawg dua thiab cov ntshav tawm los ntawm lub siab nce.
Kev sib xyaw ua ke ntawm kev siv perindopril thiab indapamide ua rau kom muaj txiaj ntsig ntawm kev kho rau kev kub siab, txo qhov kev pheej hmoo ntawm hypokalemia (muaj kev cuam tshuam ntawm kev noj tshuaj diuretics).
Cov Tshuaj Pharmacokinetics
Cov chaw muag tshuaj ntawm cov tshuaj nquag tsis txawv nrog lawv cov kev sib koom ua ke lossis siv cais.
Thaum noj ntawm qhov ncauj, kwv yees li 20% ntawm tag nrho cov koob tshuaj perindopril yog metabolized rau daim ntawv nquag. Tus nqi no yuav qis dua thaum siv ua ke nrog khoom noj. Cov ntsiab lus siab tshaj plaws hauv cov ntshav tau sau tseg 3-4 teev tom qab kev coj noj coj ua. Ib feem me me ntawm perindopril khi rau cov qe ntshav. Nws tawm hauv cov zis.
Kev nqhis dej ntawm perindopril yuav ua rau lub raum tsis ua haujlwm, tshwj xeeb tshaj yog rau cov neeg laus.
Indapamide yog nqus los ntawm lub plab zom mov, tom qab 60 feeb cov ntsiab lus siab kawg ntawm cov nquag metabolite yog tsau hauv cov ntshav ntshav. 80% ntawm cov tshuaj yog thauj nrog ntshav albumin. Nws yog tawm los ntawm kev lim los ntawm lub raum nrog cov zis, 22% yog tawm hauv cov quav.
Kev ntsuas rau siv
Tawg (arterial hypertension).
Cov tshuaj yog tawm rau cov hlab ntsha liab.
Cov Yuav Tsum Muaj
- ib leeg tsis kam rau thiazide diuretics, ACE inhibitors;
- ntshav poov tshuaj theem tsawg dua 3.5 mmol / l;
- mob raum tsis zoo nrog kev txo qis ntawm glomerular pom tus nqi qis dua 30 ml / min;
- atherosclerotic stenosis ntawm cov hlab ntsha ntawm ob lub raum lossis stenosis ntawm cov leeg ntawm ib lub raum ua haujlwm;
- kev mob siab rau daim siab hnyav;
- kev sib txig sib xyaw ua ke cov tshuaj nrog cov txiaj ntsig proarrhythmogenic;
- cev xeeb tub
- lub sijhawm pub niam mis.
Yuav noj li cas
Ua ntej pib txoj kev kho mob, nws yog ib qho tsim nyog yuav tsum nyeem cov lus qhia rau kev siv thiab sab laj tus kws tshaj lij.
Cov tshuaj no yuav tau noj 1 ntsiav tshuaj noj 1 zaug hauv ib hnub, zoo dua thaum sawv ntxov ntawm lub plab khoob.
Kuv puas tuaj yeem sib faib tshuaj noj
Koj tuaj yeem sib faib, hauv ncoo muaj qhov phom sij rau ntawm ob sab.
Cov ntawv ntawm cov tshuaj nrog cov lus ua ntej "forte" tsis muaj kev pheej hmoo thiab raug them nrog txheej txheej zaj duab xis. Lawv faib tsis tau.
Yuav kho li cas thiaj mob ntshav qab zib hom 2
Tsis cuam tshuam rau cov metabolism hauv qabzib, lub cev ntawm lub cev. Rau cov neeg mob ntshav qab zib, kev siv yog ua tau raws li tus qauv.
Sab sij huam
Kev kho mob txoj hnyuv
Mob plab, nrog mob xeev siab thiab ntuav; cov quav tsis taus; qhov ncauj qhuav cov tsos ntawm yellowness ntawm daim tawv nqaij; kev nce hauv chav sim ntawm daim siab thiab tus txiav ua ntshav; nrog concomitant daim siab mob siab, kev txhim kho ntawm encephalopathy yog ua tau.
Hematopoietic plab hnyuv siab raum
Mob Plab (rau cov neeg mob uas muaj lub raum ua mob hnyav lub raum); txo qis cov hemoglobin, platelets, leukocytes, granulocytes; txo qis hematocrit; hemolytic anemia; aplastic anemia; mob hlwb pob txha hypofunction.
Rau cov neeg mob ntshav qab zib, kev siv yog ua tau raws li tus qauv.
Nruab nrab hauv lub paj hlwb
Mob taub hau, kiv taub hau, tsis muaj zog, nkees, txob taus, tsim kua muag, lub siab tsis txaus ntseeg, kev puas ntsoog ntawm lub qhov hnov thiab lub qhov muag ntsia pom, pw tsis tsaug zog, ua rau lub siab tawv dhau.
Los ntawm lub tshuab ua pa
Kev hnoos uas pom nrog kev pib siv, tawm tsam thoob plaws lub sijhawm tshuaj thiab ploj mus tom qab tshem tawm; ua pa nyuaj airway spasm; tsis tshua muaj - hnoos qeev tau los ntawm lub qhov ntswg.
Los ntawm cov kab mob zis
Tsawg dua lub raum; cov tsos ntawm cov protein nyob hauv cov zis; qee qhov xwm txheej, mob raum tsis zoo; kev hloov pauv hauv cov qib roj ntsha: muaj tsawg ntxiv hauv potassium nyob hauv cov ntshav ntshav, nrog ntshav siab.
Kev ua xua
Cov tawv nqaij khaus khaus, tawm pob ntawm hom urticaria; Quincke's edema; hemorrhagic vasculitis; tsis tshua muaj - erythema multiforme.
Cov lus qhia tshwj xeeb
Cawv tau zoo
Kev sib koom tes siv nrog ethanol derivatives tuaj yeem pab txhawb rau kev mob ntshav siab ntawm cov ntshav siab, ntshav vau. Concomitant siv tsis pom zoo.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Thaum pib noj cov tshuaj, koj yuav tsum ceev faj thaum tsav tsheb thiab ua haujlwm uas yuav tsum tau saib xyuas thiab muaj kev cuam tshuam sai.
Nrog lub siab ua haujlwm tsis zoo
Nws tuaj yeem ua rau kev txhim kho cholestatic jaundice nrog kev nce siab hauv cov kev ua ntawm daim siab enzymes. Thaum muaj tus mob no tshwm sim, nws yog qhov yuav tsum tso tseg cov tshuaj thiab sab laj nrog kws kho mob.
Hauv cov neeg mob uas muaj mob ntsws, tsis tas yuav mus txhaj tshuaj.
Nrog lub raum tsis ua haujlwm
Nyob rau hauv lub xub ntiag ntawm cov kab mob ntawm cov kab mob tso zis nrog rau cov cim ua kom tsis zoo hauv kev lim dej muaj nuj nqi, qhov nce ntawm cov ntsiab lus ntawm creatinine, uric acid thiab urea hauv cov ntshav, qhov nce ntawm cov ntsiab lus poov tshuaj yog qhov ua tau.
Hauv cov neeg mob uas muaj mob ntsws, tsis tas yuav mus txhaj tshuaj.
Nrog ib qho kev txo qis hauv creatinine tshem tawm ntawm tsawg dua 30 ml / min. cov tshuaj yuav tsum raug cais tawm ntawm kev kho kev mob siab.
Thaum cev xeeb tub thiab lactation
Kev siv yog contraindicated nyob rau hauv qhov tsis muaj kev tshawb fawb ntawm cov nyhuv ntawm cov tshuaj rau ntawm tus me nyuam hauv plab. Cov poj niam nyob hauv lub hlis thib ob thiab peb yuav tsum ua tib zoo saib xyuas.
Hnub nyoog laus
Ua ntej pib nkag, nws yog ib qho tsim nyog yuav tau soj ntsuam cov ntsuas ntawm lub raum muaj nuj nqi (creatinine, urea), daim siab ua kom ntshav siab (AST, ALT), electrolytes. Kev kho yuav pib nrog kev noj tshuaj tsawg thiab raug xaiv ntawm tus kheej coj mus rau hauv tus account txo qis ntshav siab.
Lub Sijhawm Noliprel rau menyuam yaus
Nws yog qhov pom tseeb rau cov menyuam yaus thiab cov hluas hnub nyoog qis dua 18 xyoo vim tias tsis muaj cov ntaub ntawv ntawm nws txoj kev nyab xeeb hauv pawg neeg mob no.
Noj ntau dhau
Cov tsos mob ntawm kev noj haus ntau dhau: mob ntshav siab ntau, xeev siab, ntuav, ua tsis taus pa, mob hlwb, lub plawv dhia qis.
Kev saib xyuas thaum muaj xwm ceev: pais plab lav, kev tswj hwm ntawm cov pa roj carbon activated, kho cov ntshav electrolytes. Nrog hypotension, tus neeg mob yuav tsum muab txoj cai supine nrog tsa ceg tsa ceg.
Cov poj niam nyob hauv lub hlis thib ob thiab peb yuav tsum ua tib zoo saib xyuas.
Kev cuam tshuam nrog lwm yam tshuaj
Nrog saib xyuas
Thaum ua ke nrog cov tshuaj tiv thaiv kev ntxhov siab lossis tshuaj tiv thaiv kabmob, qhov tshwm sim ntawm cov ntshav nce siab nrog kev txhim kho ntawm hypotension yuav tshwm sim.
Glucocorticosteroids txo cov nyhuv antihypertensive.
Tawm tsam keeb kwm yav dhau los ntawm kev noj, nws muaj peev xwm txhim kho qhov qab zib-txo cov nyhuv ntawm insulin thiab sulfonylurea derivatives.
Kev sib xyaw ua ke nrog cov kab mob glycosides xav tau kev saib xyuas cov poov tshuaj thiab qib qib ECG, thiab kev txhim kho ntawm hypovolemia.
Nrog lub tswv yim npaj xoo hluav taws xob xaim, kev tiv thaiv lub cev qhuav dej yog qhov tsim nyog.
Nrog rau kev siv cov tshuaj ib txhij (Erythromycin, Amiodarone, Sotalol, Quinidine), txoj kev pheej hmoo ntawm ventricular arrhythmias nce ntxiv.
Kev sib xyaw tsis pom zoo
Sib faib nrog lithium npaj tsis tau vim tias muaj qhov pheej hmoo ntawm lithium overdose.
Nrog kev txo qis raum muaj nuj nqi, kev sib xyaw nrog tshuaj diuretics, uas pab cuam qeeb electrolytes, thiab infusions ntawm potassium chloride yuav tsum zam.
Nrog rau lub qhov ncauj ib txhij nrog NSAIDs tiv thaiv keeb kwm ntawm lub cev qhuav dej, nws tuaj yeem ua rau mob kab mob ntawm lub raum lim ntshav.
Analogs
Ko-Perineva, Ko-Parnawel, Perindapam, Perindid.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Tso tawm los ntawm kev kho mob.
Nqe Noliprel
Tus nqi ntawm ib pob ntawm cov tshuaj (30 ntsiav tshuaj), xam ib hlis ntawm kev kho mob, pib los ntawm 470 rubles.
Cia rau cov neeg mob ntawm cov tshuaj Noliprel
Txhob nyob ze cov me nyuam. Tsis muaj qhov tshwj xeeb cia cov khoom siv.
Hnub tas sij hawm
3 xyoos
Kev txheeb xyuas ntawm Noliprel
Kev kho plawv
Zafiraki V.K., Krasnodar: "Kev sib xyaw ua ke zoo, uas tau qhia nws tus kheej tsis yog hais txog kev txo qis ntshav siab xwb, tabsis tseem hais txog kev txo cov hlab plawv, nrog rau lub plawv tsis ua haujlwm."
Nekrasova GS, Krasnodar: "Qhov kev xaiv zoo tshaj plaws rau cov neeg mob ntshav siab."
Cov neeg mob
Hlub, Moscow: "Cov tshuaj zoo, nws pab."
Alexander, Oryol: "Lub siab tsis zoo."
