ACE inhibitors siv rau kev kub siab, lub plawv tsis ua hauj lwm thiab rau kev tiv thaiv kab mob ntawm cov hlab plawv. Cov tshuaj xws li enalapril lossis captopril inhibit ib yam tshuaj uas txhawb vasoconstriction thiab nce siab. Lawv tau siv los ua cov cuab yeej ywj pheej hauv lub zog txhawm rau ua kom cov ntshav siab, thiab ntxiv rau hauv kev sib xyaw nrog lwm yam tshuaj.
Tus Kheej Enalapril Cov Yam Ntxwv
Enalapril txo cov ntshav siab, lub nra rau lub myocardium, normalizes ua pa thiab cov ntshav ncig hauv lub voj voog me, txhawb kev ua kom muaj ntshav txaus hauv cov hlab ntsha ntawm lub raum.
Enalapril lossis Captopril inhibit ib yam tshuaj uas txhawb vasoconstriction thiab ua kom muaj zog nce
Cov khoom siv tseem ceeb yog enalapril, uas tom qab kev nqus tau yog hydrolyzed rau enalaprilat, ACE inhibitor, peptide dipeptidase uas txhawb nqa kev hloov pauv ntawm angiotensin. Ua tsaug rau qhov thaiv ntawm ACE, kev tsim cov vasoconstrictor yam raug txo qis thiab kev tsim cov kinins thiab prostacyclin, uas muaj cov vasodilating cov cuab yeej, ua haujlwm. Enalapril muaj cov nyhuv diuretic cuam tshuam nrog kev tsub ntawm aldosterone synthesis.
Kev ceeb toom txo qis hauv ACE kev ua haujlwm tshwm sim 3 teev tom qab noj tshuaj, qhov siab tshaj plaws hauv kev poob hauv cov ntshav siab tau pom tom qab 5 teev. Lub sijhawm sijhawm ntawm cov nyhuv yog cuam tshuam nrog kev muab tshuaj, feem ntau cov nyhuv ntawm cov tshuaj nyob ib hnub. Qee tus neeg mob yuav tsum tau kho mob ntau lub lim tiam kom ua tiav cov ntshav siab.
Thaum nkag mus rau hauv lub cev, cov tshuaj tau nrawm rau hauv lub plab zom mov, tom qab ntawd cov tshuaj tau hydrolyzed los ua enalaprilat, uas yog ntau dua tawm los ntawm lub raum, nrog rau los ntawm cov hnyuv.
Kev taw qhia rau kev siv:
- arterial kub siab;
- clinically lub plawv khiav tsis zoo;
- kev mob plawv hauv lub plawv;
- tej yam mob bronchospastic;
- kev tiv thaiv ntawm kev txhim kho cov kab mob hauv lub plawv tsis ua haujlwm loj.
Enalapril ua rau cov ntshav qis thiab txhawb kev noj qab nyob zoo hauv cov hlab ntsha ntawm lub raum.
Cov Tshuaj Tiv Thaiv:
- kev tsis qaug rau cov tshuaj ntawm cov tshuaj;
- cev xeeb tub, lub caij nyoog ntawm kev pub niam mis;
- stenosis ntawm aortic orifice;
- raum leeg ntshav hlab ntsha;
- tom qab hloov raum;
- hyperkalemia
- sib koom tes siv nrog Aliskiren hauv cov neeg mob ntshav qab zib mellitus, lub raum tsis ua haujlwm.
Cov tshuaj tsis tau sau tseg rau cov menyuam yaus hnub nyoog qis dua 18 xyoo.
Nrog rau kev kho mob enalapril, mob nqaij ntshiv, xeev siab, mob taub hau, raws plab, tawv nqaij ua xua, orthostatic hypotension ua tau.
Cov tshuaj yog noj ntawm qhov ncauj, tsis hais txog ntawm cov zaub mov noj.
Nrog rau kev kub siab, cov koob tshuaj ib zaug rau cov neeg laus yog 0.01-0.02 g hauv s
cov os. Qhov kev tso cai tau siv nyob rau txhua hnub yog 0.04 g. Cov koob tshuaj noj zoo tshaj plaws tsuas yog xaiv tau los ntawm tus kws kho mob koom nrog ib tus zuj zus rau txhua tus neeg mob. Lub sijhawm ntawm kev kho kom haum raws li cov txiaj ntsig ntawm kev kho mob.
Captopril Cov Cwj Pwm
ACE inhibitor txo qis ntshav siab thiab yog siv rau kev kub siab, mob taub hau, mob ntshav qab zib, lub plawv tsis ua haujlwm. Nws muaj cov nyhuv vasodilating, nce rau lub plawv tawm los thiab tawm tsam kev ntxhov siab, tsis muaj kev cuam tshuam cov lipid metabolism.
Lub hauv paus tseem ceeb tshaj plaws yog captopril, uas yog thawj hluavtaws ACE inhibitor hauv kev kho mob. Nws txwv tsis pub hloov pauv ntawm angiotensin I mus rau angiotensin II, pab txo qis ntshav siab, txo qis qhov tsis txaus ntawm sab laug ventricular myocardial hypertrophy, tiv thaiv kev txhim kho lub plawv tsis ua haujlwm, txhim kho hemodynamics hauv lub raum, thiab tiv thaiv kev txhim kho ntshav qab zib nephropathy.
Captopril yog qhov nqus tau sai sai, muab cov roj ntsha hauv lub siab, nthuav tawm mus rau ntau qhov los ntawm lub raum. Ib nrab-lub neej muaj nyob ntev txog 120 feeb.
Qhov siab tshaj plaws tau sau tseg tom qab 1-1.5 teev. Lub sijhawm ua haujlwm nyob ntawm qhov muab ntawm cov tshuaj.
Captopril paub zoo rau cov kabmob no:
- arterial kub siab;
- lub plawv tsis ua hauj lwm;
- myocardial infarction;
- uas mob ntshav qab zib nephropathy.
Lub hauv paus tseem ceeb tshaj plaws yog captopril, uas yog thawj hluavtaws ACE inhibitor hauv kev kho mob.
Cov tshuaj yog siv los tiv thaiv cov tsos mob lub plawv tsis ua hauj lwm hauv cov neeg mob nrog asymptomatic sab laug ventricular kawg ntawm lub chaw kho mob ruaj khov.
Cov Tshuaj Tiv Thaiv:
- ua kom lub cev tsis haum rau cov tshuaj;
- mob raum mob hnyav;
- hyperkalemia
- raum leeg ntshav hlab ntsha;
- stenosis ntawm aortic orifice thiab lwm yam kev hloov pauv uas ua txhaum lub cev tawm ntawm cov ntshav tawm ntawm sab laug ventricle;
- mob tom qab lub raum hloov;
- 2 thiab 3 trimesters kev xeeb tub;
- lub sijhawm pub niam mis.
Tsis tau tshuaj rau cov menyuam hnub nyoog qis dua 14 xyoos.
Kev ua xua rau khaub thuas, hloov pauv hloov, tsis muaj zog, mob leukopenia, proteinuria, agranulocytosis, ua kom mob, ua kom muaj kev cuam tshuam ntawm kev txav mus los yog muaj kev phiv thaum noj cov tshuaj.
Cov koob tshuaj zoo ntawm Captopril yog tsim los ntawm tus kws tshwj xeeb ib tus zuj zus thiab nws txawv ntawm 0.025 g txog 0.15 g ib hnub. Txheeb kom ntshav nce siab thiab ceev, nws pom zoo kom noj qhov tsawg kawg nkaus, nqus cov ntsiav tshuaj hauv qab tus nplaig. Hauv kev kho cov menyuam yaus, cov tshuaj noj kom zoo dua yog xam rau hauv qhov hnyav ntawm lub cev, qhov pom zoo yog 0.001-0.002 g ib 1 kg.
Cov Tshuaj Sib Piv
Qhov zoo sib xws
Cov tshuaj yog ib feem ntawm ACE inhibitor pawg, muaj qhov zoo sib xws ntawm kev ua thiab siv los kho ntshav siab, kab mob ntawm cov hlab plawv. Lawv muaj yuav luag yuav luag zoo tib yam contraindications. Kho nyhuv yog koob tshuaj vam khom.
Dab tsi yog qhov txawv
Qhov sib txawv tseem ceeb nyob hauv muaj pes tsawg leeg. Ob qho tshuaj yeeb tshuaj yog raws cov proline amino acid derivative. Tab sis enalapril txawv ntawm cov tshuaj analogue nyob rau hauv nws cov txheej txheem tshuaj lom neeg: thaum nws nkag rau hauv lub cev, cov tshuaj tseem ceeb yog hydrolyzed rau enalaprilat, uas inhibits ACE.
Cov tshuaj sib txawv ntawm qhov pom zoo ntau zaus ntawm kev tswj hwm. Nrog cov mob ntshav qis, enalapril noj 1 zaug nyob rau ib hnub. Captopril muaj lub dag lub zog ntev dua, rau kev saib xyuas ntawm nws yog qhov tsim nyog yuav tsum tau noj cov tshuaj ob peb zaug hauv ib hnub.
Captopril tau zoo dua nrog diuretics. Thaum kho nrog nws cov tshuaj analogue, nws raug nquahu kom txo qis cov tshuaj diuretic lossis tso tseg ib ntus.
Uas yog pheej yig dua
Cov tshuaj muaj nqi thiab ua tau zoo rau cov neeg siv khoom. Tus nqi nruab nrab yog 60-130 rubles.
Dab tsi yog qhov zoo dua enalapril lossis captopril
Enalapril zoo rau kev siv ntev yog tias tsim nyog los tswj kev ntsuas ntshav siab hauv qhov xav tau ntau, tab sis tsis siv los ua tsheb thauj neeg mob. Captopril ua hauj lwm tau zoo rau kev kho kom haum raws li qhov nce siab. Cov tshuaj kuj tseem muaj txiaj ntsig zoo rau kev ua haujlwm ntawm lub siab, nce siab ntev nrog kev ua haujlwm tsis tu ncua, uas ua rau nws siv tsim nyog nyob rau hauv muaj cov kab mob ntawm cov hlab plawv.
Yuav ua li cas hloov ntawm captopril rau enalapril
Cov tshuaj muaj rau tib pab pawg neeg pharmacological thiab tau cim los ntawm kev cuam tshuam nrog kev cuam tshuam, uas yog qhov txaus ntshai rau kev noj qab haus huv thiab tuaj yeem ua rau muaj ntshav nce siab. Hauv kev kho mob ntshav siab, tshuaj yog dosed ntawm tus kheej. Txhawm rau hloov los ntawm ib cov tshuaj mus rau lwm qhov, koj yuav tsum tau sab laj rau tus kws tshaj lij uas yuav xaiv cov koob tshuaj zoo tshaj plaws, daim ntawv tso tawm thiab kev kho mob noj tshuaj rau hauv keeb kwm kev kho mob, hnub nyoog thiab lwm yam ntawm tus kheej ntawm tus neeg mob.
Kev Ntsuam Xyuas Rau Neeg Mob
Marianna P.: "Ib zaug dhau ib ntus dhau los, kev nyuaj siab nce siab, tab sis kuv sim kom tsis txhob noj tshuaj kom txo tau cov tshuaj. Ib xyoos dhau los kuv tau nyob hauv tsev kho mob vim nquag mus ncig thiab huab cua hloov. Ib qho kev kho mob ntsuas tsis tuaj yeem txo lub siab, txawm tias kev txhaj tshuaj tsis tuaj yeem txhim kho mob ntau "Kuv nco qab tias thaum ib tus phooj ywg pom zoo Captopril. Kuv muab 2 ntsiav tshuaj tso rau hauv kuv tus nplaig, thiab tom qab 30 feeb lub siab pib poob qis. Hnub tom qab nws ua kom rov zoo li qub. Tam sim no kuv ib txwm khaws cov tshuaj no hauv kuv lub hnab."
Vika A .: "Kuv tsis xav tias Captopril yog lub tsheb tos neeg mob. Tus niam tsev ntshav siab dhia ceev heev, nws tso 2 hauv nws tus nplaig, 3 ntau dua ob peb teev tom qab, ze rau yav sawv ntxov dua 2. Thiab thaum sawv ntxov tau hloov pauv kom zoo dua. Maj mam. Yog tias cov tshuaj no tso rau hauv lub tsheb thauj neeg mob, ces cov tshuaj yuav tsum nrawm. Qhov siab ntawm niam tais tshwj xeeb rov qab rau qhov qub tsuas yog tom qab tus kws kho mob tau txhaj qee cov tshuaj nrog cov diuretic nyhuv. "
Elena R.: "Thaum tso tawm los ntawm tsev kho mob, niam tau hais kom Enalapril. Tam sim ntawd nws pom tus neeg mob hnoos uas tsis muaj. Ua ntej kuv nyeem cov lus qhia rau cov tshuaj, nws hloov tawm tias nws tsis ua haujlwm rau txhua tus. Nws yuav tsum tau ua nrog ceev faj, tab sis nws zoo dua los nrhiav qhov hloov tshiab."
Cov tshuaj sib txawv ntawm qhov pom zoo ntau zaus ntawm kev tswj hwm.
Cov kws kho mob tshuaj xyuas txog enalapril thiab captopril
Tsukanova A. A., kws kho mob nrog paub txog 5 xyoo: “Qhov zoo tshaj plaws ntawm Enalapril yog nws tus nqi pheej yig. Nws yog qhov tsis muaj txiaj ntsig hauv kev txhaj tshuaj me me, ntau yam haus nws nyob ntawm qhov tau txais ntau npaum li cas. Kuv pom zoo cov tshuaj no rau cov neeg mob, nws muaj tshuaj kho tau zoo dua thiab niaj hnub. "
Zafiraki V.K., kws kho plawv nrog kev paub 17 xyoo, Ph.D. ib qho yeeb tshuaj, tab sis thawj cov tshuaj yog tsim los ntawm lub tuam txhab uas tsim nws, thiab lub thib ob yog luam tawm ntawm daim qauv qub thiab yog tsim los ntawm cov tuam txhab sib txawv. Kuv pom zoo kom yuav ob qho tshuaj thiab piv qhov twg yog qhov muaj zog dua. "
