Qhov tshuaj tiv thaiv kab mob ntshav Humulin NPH yog tsim los ua kom cov ntshav qabzib hauv cov ntshav hauv ib qib, muaj lub sijhawm ua haujlwm nruab nrab.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Humulin NPH, ua ib qho yeeb tshuaj nrog cov tshuaj lom neeg tsis muaj txiaj ntsig, tau muab cov npe International International Nonproprietary - Insulin-Isophan (Human Genetic Engineering).
Tsis tas li, cov tshuaj no raug rau cov npe ua lag luam Humulin® NPH thiab lub npe Latin Insulinum isophanum (humanum biosyntheticum).
Humulin NPH tsim los tswj ntshav cov ntshav kom zoo ntawm lub cev ib txwm muaj thiab muaj lub sij hawm ua haujlwm nruab nrab.
ATX
Cov tshuaj sib raug rau tus lej A10AC01, uas txhais tau hais tias nws raug rau chav kawm ntawm tib neeg cov insulins.
Tso cov ntawv thiab cov nyob ua ke
Cov tshuaj sib xyaw ua ke ntawm cov tshuaj yog cov tshuaj tseem ceeb muaj xws li tib neeg insulin ntawm kev noj tshuaj ntawm 100 IU / ml. Txhawm rau kom muaj cov khoom tsim nyog, daim ntawv ntau dua yog ntxiv nrog cov tshuaj pab: metacresol, phenol, glycerol, protamine sulfate, sodium hydrogen phosphate heptahydrate, zinc oxide, hydrochloric acid tov, sodium hydroxide tov thiab dej rau kev txhaj tshuaj.
Cov tshuaj yog ntim rau hauv vials (10 ml) thiab cartridges (3 ml) ntawm cov iav nruab nrab. Vials ntawm 1 pc. muab tso rau hauv cov thawv ntawv thawv, thiab daim cartridges ntawm 5 pcs. muab tso rau hauv blisters. Ib qho kev hloov pauv tau muaj nyob rau hauv uas cov cartridges raug muag ua ntej tsim rau hauv cov phwj hauv syringe (hauv cartons 5 pcs.).
Kev Raug Ncua
Rau kev tswj hwm subcutaneous. Qhov kev tshem tawm dawb no tuaj yeem ua kom cov dej nag dawb thiab ntshiab, tsis muaj kob lossis yuav luag tsis muaj kob nyob rau hauv txheej txheej sab saud. Ua ntej siv, maj mam co cov tshuaj kom txog thaum tau txais ib homogeneous kua.
Cov tshuaj yog ntim hauv hwj (10 ml) thiab daim cartridges (3 ml) ntawm cov iav nruab nrab, qhov muaj pes tsawg leeg suav nrog tib neeg insulin ntawm kev noj ntau npaum li 100 IU / ml.
Pharmacological kev txiav txim
Cov tshuaj no yog DNA tawm rau tib neeg cov kua dej, nws siv los ua kev tswj hwm ntawm cov metabolism hauv qabzib. Cov yam ntxwv anabolic tau muab sau ua ntxiv hauv Humulin NPH. Cov tshuaj Insulin pab rau kev thauj cov ntshav qabzib thiab amino acids nyob rau hauv lub cev nqaij daim tawv (tsis suav nrog lub hlwb), nrog rau kev nrawm ntawm protein anabolism. Ua tsaug rau insulin, piam thaj yog hloov pauv hauv nplooj siab mus rau glycogen. Cov tshuaj ua raws li inhibitor ntawm gluconeogenesis thiab pab hloov cov piam thaj ntxiv rau hauv cov rog.
Cov Tshuaj Pharmacokinetics
Cov tshuaj pib ua 50-60 feeb tom qab kev tswj hwm, zoo tshaj nyob rau lub sijhawm txij li ob teev tom qab kev tswj hwm, tag nrho lub sijhawm ua haujlwm yog 18-20 teev.
Qhov ua tau zoo thiab ua kom tiav ntawm kev nqus ntawm cov tshuaj yog cuam tshuam los ntawm qhov chaw txhaj tshuaj, kev noj tshuaj thiab kev cia siab. Nws yog tus cwj pwm los ntawm kev faib tawm tsis ncaj tshaj lub cev cov ntaub so ntswg. Cov kev tshawb fawb tau lees paub qhov tsis muaj ntawm Humulin NPH hauv lub mis niam thiab nws qhov tsis tuaj yeem nkag mus rau qhov tsis pub thaiv qhov chaw. 30-80% yog tawm los ntawm lub raum.
Kev ntsuas rau siv
Cov tshuaj yog tshuaj rau hom 1 thiab hom 2 ntshav qab zib mellitus, zoo li thaum cev xeeb tub, uas tshwm sim nrog hom 2 mob ntshav qab zib mellitus.
Cov tshuaj Humulin NPH raug tshuaj rau yam 1 thiab ntshav qab zib hom 2.
Cov Yuav Tsum Muaj
Kev siv cov tshuaj Humulin NPH yog sib kis yog tias qhov ua rau lub qog ntshav nce siab thiab muaj qhov tsis txaus siab ntau ntxiv rau cov tshuaj insulin thiab ib qho ntawm cov tsis pom kev hauv cov tshuaj sib xyaw.
Nrog saib xyuas
Thaum cev xeeb tub thiab pub niam mis, kev xav tau ntawm cov tshuaj insulin tuaj yeem hloov pauv, yog li, kev siv tshuaj yuav tsum kho nrog ceev faj, saib xyuas qhov xwm txheej thiab kho qhov tshuaj yog tsim nyog.
Yuav noj Humulin NPH li cas
Qhov ntau thiab tsawg ntawm cov tshuaj yog muab tshuaj los ntawm tus kws kho mob thiab nyob ntawm cov ntsiab lus ntawm cov piam thaj hauv cov ntshav. Kev tso tshuaj Intramuscular ntawm kev tso cai raug cai, txawm li cas los xij, txoj kev tseem ceeb yog txhaj hauv qab daim tawv nqaij hauv lub pob tw, xub pwg, ncej puab, lossis hauv plab. Nws yog txwv tsis pub nkag rau hauv qhov quav.
Ua ntej kev tswj hwm, qhov ntsuas kub ntawm qhov raug muab tshem tawm yog coj mus rau chav kub, qhov chaw txhaj tshuaj yog hloov pauv tsis tas siv nyob rau tib qho chaw ntau tshaj 1 zaug hauv ib hlis. Nrog kev tswj hwm subcutaneous, nws yog qhov tsim nyog los xyuas kom meej tias cov hlab ntsha tsis cuam tshuam. Qhov chaw txhaj tshuaj tom qab kev txhaj tshuaj tsis muaj massaged.
Nrog ntshav qab zib
Ua ntej kev tswj hwm, cov tshuaj insulin yuav tsum rov siv dua, rau qhov lub hwj tau dov ntau zaus hauv txhais tes, thiab daim laub ntawv yob 10 zaug hauv xib teg ntawm lawv txhais tes, thiab tom qab ntawd tig dua lwm 10 zaug los ntawm 180 °. Qhov muaj pes tsawg leeg yuav tsum tshwm sim los ua cov kua turbid kua. Koj tsis tuaj yeem tshee cov khoom kom ruaj khov kom cov npuas dej tsis pom kev, uas cuam tshuam nrog lub teeb tsa kom raug. Ua ntej kev txhaj tshuaj, tus neeg mob yuav tsum kawm cov lus qhia los tswj cov tshuaj insulin los ntawm tus xaum xaum hluav taws xob.
Kev Qhia Siv Kev Ntaus Tshuaj
Cwj mem sai yog qhov yooj yim thiab yooj yim siv. Kev qhia ntawm cov kua dej yog ua tiav hauv ntau theem.
- Tom qab ntxuav koj txhais tes kom zoo, xaiv qhov chaw txhaj tshuaj thiab txhuam nws.
- Tshem lub hau ntawm cov tes muag phwj los ntawm nws rub, tab sis tsis tig. Tsis txhob tshem daim ntawv lo. Nco ntsoov tias insulin ua tau raws li txhua yam tseem ceeb (hom, hnub tim, tsos). Resuspend qhov tshuaj.
- Npaj ib rab koob tshiab los ntawm kev muab daim ntawv lo ntawm lub hau sab nraud pov tseg. So cov roj hmab disk ntawm qhov ntxeev ntawm daim cartridge nrog cawv, tom qab ntawd muab tso rau ntawm rab koob, uas yog nyob rau hauv lub hau, raws nraim ntawm txoj kab ntawm lub koob txhaj tshuaj. Ntsia ntawm rab koob kom txog thaum nws siab koom.
- Tshem tawm lub hau sab nraud ntawm qhov kawg ntawm rab koob, tab sis tsis pov tseg, thiab tshem lub hau sab hauv thiab pov tseg.
- Txheeb xyuas qhov nqus ntawm cov insulin los ntawm Quick Pen syringe.
- Ntxig rab koob rau hauv qab daim tawv nqaij, ua raws li cov txheej txheem pom zoo los ntawm tus kws kho mob saib xyuas. Khov siab nias lub pob tshuaj txhaj tshuaj kom nruj nrog koj tus ntiv tes xoo. Txhawm rau nkag mus rau lub koob tshuaj kiag li, lub khawm yog tuav kom qeeb ntawm 5.
- Tom qab tshem tawm rab koob, ua tib zoo nias qhov chaw txhaj tshuaj nrog pob khauj khauj khaum ntsej muag, tsis txhob txhuam.
- Tshem rab koob nrog lub hau tiv thaiv thiab pov tseg.
Humulin NPH raug txhaj rau hauv qab daim tawv nqaij, ua raws li cov txheej txheem pom zoo los ntawm tus kws kho mob uas tuaj koom, maj mam nias lub pob txhaj tshuaj nrog tus ntiv tes xoo.
Cov kev mob tshwm sim ntawm Humulin NPH
Endocrine system
Ib qho kev mob tshwm sim uas tuaj yeem tshwm sim vim muaj txiaj ntsig tseem ceeb ntawm cov tshuaj yog hypoglycemia. Hauv cov xwm txheej loj, tus mob no tuaj yeem ua rau lub siab tsis nco qab thiab ua rau tsis nco qab, thiab nyob rau hauv rooj plaub tshwj xeeb, kom tuag.
Kev ua xua
Qhov tshwm sim ntawm kev tsis haum tshuaj hauv zos, qhia los ntawm liab, o thiab khaus ntawm qhov chaw txhaj tshuaj, yog ua tau. Hauv qhov no, koj yuav tsum paub tseeb tias qhov tshuaj tiv thaiv yog los ntawm cov tshuaj, thiab tsis yog los ntawm kev ua xua rau ib qho tshuaj ntxuav los yog lwm yam.
Muaj qee zaus, kev tshwm sim los ntawm kev tsis haum siab ntau dua nyob rau hauv daim ntawv ua kom khaus, ua tsis taus pa, ua tsis taus pa, txo ntshav siab, nce ntshav siab thiab nce hws ntau yog ua tau. Cov xwm txheej zoo li no tuaj yeem ua rau tuag taus thiab xav tau kev kho mob sai. Tej zaum koj yuav tsum tau hloov cov tshuaj lossis ua tiav kev cia siab.
Tsis tshua muaj neeg mob (nrog qhov tshwm sim ntawm 0.001-0.01%) lipodystrophy muaj kev txhim kho.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Kev noj tshuaj tsis cuam tshuam rau kev tswj hwm thauj thiab lwm yam txheej txheem. Txawm li cas los xij, txoj kev tsis zoo tshwm sim muaj ib qho tshwm sim - hypoglycemia, uas yog tus cwj pwm los ntawm lub siab mloog, txawm tias tsis nco qab yog qhov ua tau.
Cov lus qhia tshwj xeeb
Hloov kho cov koob tshuaj nyob rau hauv cov kev taw qhia ntawm kev nce ntxiv yuav tsum muaj thaum hloov khoom noj khoom haus, nce lossis txo qis lub cev ua si, kev ntxhov siab. Noj kom haum nyob rau hauv cov kev coj yuav txo tau tej zaum yuav tsum tau nyob rau hauv cov ntaub ntawv ntawm malfunction ntawm lub qog gland, pituitary caj pas thiab qog adrenal.
Siv thaum cev xeeb tub thiab lactation
Feem ntau qhov xav tau rau insulin yog txo thaum thawj peb lub hlis thiab nce ntxiv nyob rau zaum ob thiab thib peb, yog li nws yog qhov tseem ceeb los soj ntsuam cov ntsuas. Nrog koj tus kws kho mob tham txog txhua yam hloov ntawm kev kho. Cev xeeb tub thiab nws txoj kev npaj yuav tsum tham nrog tus kws kho mob tshwj xeeb sai li sai tau.
Thaum lub sijhawm lactation, hloov tshuaj ntxiv yuav tsim nyog.
Daim ntawv thov rau lub raum khiav tsis zoo
Txoj kev xav tau cov tshuaj insulin tuaj yeem txo qis; kev hloov tshuaj rau yuav tsum ua.
Siv rau lub siab ua haujlwm tsis zoo
Txoj kev xav tau cov tshuaj insulin tuaj yeem txo qis; kev hloov tshuaj rau yuav tsum ua.
Kev Siv Ntau Tshaj ntawm Humulin NPH
Yog tias cov tshuaj insulin hauv cov ntshav tsis sib haum nrog kev noj haus uas tau txais thiab kev siv dag zog, kev mob ntshav qab zib yuav tshwm sim, uas yog qhia los ntawm nkees, tawm hws, tachycardia, pallor ntawm daim tawv nqaij, mob taub hau, tshee tshee, ntuav thiab tsis meej pem. Qhov mob hnyav thiab cov tsos mob ua ntej ntawm hypoglycemia yuav sib txawv raws li cov xwm txheej.
Kev cuam tshuam nrog lwm yam tshuaj
Cov nyhuv hypoglycemic ntawm insulin yog txhim kho los ntawm qhov ncauj hypoglycemic, MAO inhibitors, ACE inhibitors, carbonic anhydrase inhibitors, tsis-xaiv beta-adrenergic thaiv cov kab mob, bromocriptine, okreotide, sulfanilamides, anabolic steroids, tetracyclinum, clofofilofromide, clofofilofofide, clof, clofofilofromide, clof, clofofilofomide tshuaj ethanol-muaj cov tshuaj.
Cov nyhuv tshuaj lom cov ntshav hauv insulin tsis muaj zog los ntawm kev tiv thaiv qhov ncauj, glucocorticoids, cov thyroid hormones, thiazide diuretics, heparin, tricyclic antidepressants, sympathomimetics, danazole, clonidine, BKK, diazoxide, morphine, phenytoin thiab nicotine.
Reserpine thiab salicylates tuaj yeem ua rau ob leeg qaug zog thiab txhim kho kev ua ntawm Humulin NPH.
Cawv tau zoo
Kev haus dej haus cawv yog qhov tseem ceeb uas yuav ua rau txo tus mob ntshav qab zib kom tsawg, yog li, kev saib xyuas zoo, cov lus qhia tshwj xeeb thiab, tejzaum nws yuav tau hloov kho cov tshuaj uas tau txais.
Hauv qee kis, kev haus dej haus cawv nrog tshuaj insulin npaj tuaj yeem ua rau lactic acidosis, ketoacidosis, thiab ua rau muaj kev cuam tshuam zoo li lub cev tsis haum.
Kev haus dej cawv nrog cov tshuaj insulin tuaj yeem ua rau lactic acidosis thiab ua rau muaj kev cuam tshuam zoo li lub cev.
Analogs
Cov tshuaj yuav hloov tau tsuas yog tom qab sab laj nrog kws kho mob tshwj xeeb. Raws li cov analogues tuaj yeem muab cov cuab yeej hauv qab no:
- Insuman Bazal GT;
- Biosulin N;
- Protafan HM;
- Protafan HM Penfill.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Kuv tuaj yeem yuav yam tsis tas yuav tshuaj
Cov tshuaj los ntawm Daim Ntawv B uas tsis tuaj yeem yuav yuav yam tsis muaj kws kho mob sau ntawv.
Nqe rau Humulin NPH
Tus nqi nyob ntawm daim ntawv tso tawm, tus naj npawb ntawm lub hwj los yog daim qwj hauv lub hnab. Tus nqi kwv yees ntawm Humulin NPH 100 IU / ml:
- 3 ml cartridge, 5 pcs. nyob rau hauv pob ntawv txhaws (nrog QuickPen) - los ntawm 1107 rubles .;
- fwj ntawm 10 ml, 1 pc. nyob rau hauv ib lub thawv cardboard - los ntawm 555 rubles.
Cia rau cov neeg mob rau cov tshuaj
Txhawm rau khaws cov khoom koj xav tau kub ntawm + 2 ... + 8 ° C thiab ib qho chaw tiv thaiv los ntawm tshav ntuj ncaj qha. Yuav tsum tsis txhob muaj cov cuab yeej ua cua sov nyob ze. Nws yog txwv tsis pub khov.
Ib qho tshuaj noj tuaj yeem yog cov tshuaj Insuman Bazal GT.
Txhob nyob ze cov me nyuam.
Hnub tas sij hawm
Lub txim nyob rau hauv daim ntawv tsis qhib tau khaws nws cov khoom rau 3 xyoos. Tom qab pib siv - 28 hnub (ntawm + 15 ... + 25 ° C).
Chaw tsim tshuaj paus
Tus tuav daim ntawv pov thawj rau npe tshuaj yog Swiss tuam txhab "Eli Lilly Vostok S.A."
Fwj yog tsim hauv Tebchaws Asmeskas (Indianopolis), Eli Lilly thiab Tuam Txhab, thiab cov khoom lag luam nrog cov phwj ntim koob-nyob rau Fabkis, Lilly Fabkis.
Kev tshuaj xyuas txog Humulin NPH
Cov kws kho mob
Anna, 45 xyoos, Saratov
Kuv tau ua haujlwm hauv endocrinology rau ntau dua 20 xyoo. Kuv xav txog Humulin zoo nyob rau ntau lub sijhawm, tsis tshua muaj muab kev tsis haum tshuaj.
Andrey, 38, Kaliningrad
Cov tshuaj muaj ntau cov analogues muaj zog. Kuv taw nws yog tias lawv muaj intolerance ib tug neeg.
Cov neeg mob
Alexandra, 32, Moscow
Ib tug menyuam yaus ntawm Humulin muaj mob rau ntawm qhov chaw txhaj tshuaj, txawm hais tias kuv sim txhaj tshuaj qeeb. Txhua tus zoo tib yam, ntsaws ruaj ruaj tshwm, uas tom qab ntawd daws tsuas yog li ntawm ob peb hnub. Peb yuav tsum sim hloov mus rau ib qho piv txwv, txawm hais tias tsis muaj lwm yam kev tsis txaus siab.
Mikhail, 42, Kazan
Kuv sim tso tseg Humulin NPH nyob rau hauv kev txaus siab ntawm Biosulin, tab sis kuv pom tias nws tsis muaj nqis, vim tias cov teeb meem ntau npaum li tau pib tshwm sim, koj tau ua nws txoj cai, thiab cov piam thaj tsis tau muab qhov txiaj ntsig xav tau. Qhov no yeej tsis tau muaj nrog NPH.
Alexander, 52, Khanty-Mansiysk
Kuv tau raug tus mob ntshav qab zib ntau dua 10 xyoo. Kuv tau siv Humulin NPH thaum pib mob. Cov suab thaj theem tau zoo, Kuv xav txog qhov siab tshaj ntawm qhov nws nqis tes ua qhov tsis zoo, Kuv pom lwm txoj kev xaiv rau kuv tus kheej.
