Saroten Retard belongs rau cov pawg ntawm tricyclic antidepressants. Cov tshuaj yog siv hauv kev kho mob kom tshem tawm kev ntxhov siab thiab kev ntxhov siab uas tshwm sim los ntawm lub xeev nyuaj siab. Cov kws kho mob tshwj xeeb tuaj yeem sau tshuaj rau cov mob ua rau mob ntev ntev thiab ua kom muaj kev nyuaj siab nrog kev mob schizophrenia. Capsules tsis yog npaj rau siv thaum yau thiab tsis yog rau cov poj niam cev xeeb tub.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Amitriptyline.
ATX
N06AA09.
Saroten Retard belongs rau cov pawg ntawm tricyclic antidepressants.
Tso cov ntawv thiab cov nyob ua ke
Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm tsiav tshuaj nrog lub sij hawm ntev. Amitriptyline hydrochloride 50 mg yog siv los ua cov tshuaj nquag hauv cov tshuaj tiv thaiv kab mob. Cov ntsiab lus ntawm cov tsiav tshuaj ntxiv los ntawm cov sib txuas pabcuam:
- qab zib spheres;
- povidone;
- stearic acid;
- shellac.
Lub plhaub sab nraud muaj gelatin thiab titanium dioxide. Lub txiv kab ntxwv liab-daj zas rau cov tsiav tshuaj muab qhov muaj zas xim raws li hlau oxide.
Pharmacological kev txiav txim
Cov tshuaj rau cov tshuaj tiv thaiv kev ntxhov siab uas muaj lub zog ntev sedative zoo nyob rau hauv nruab nrab lub paj hlwb. Cov tshuaj yeeb tshuaj amitriptyline ib txhij inhibits kev coj ntawm norepinephrine thiab serotonin ua ntej nkag mus rau hauv synapse. Cov khoom tseem ceeb ntawm amitriptyline metabolism (nortriptyline) muaj cov kev kho mob ntau dua. Raws li qhov txiaj ntsig ntawm qhov yeeb tshuaj, qhov kev ua ntawm H1-histamine receptors thiab M-cholinergic receptors poob qis. Tus neeg mob tawm los ntawm kev nyuaj siab, ntxhov siab thiab ntxhov siab ploj.
Vim tias cov nyhuv sedative, cov tshuaj inhibits REM pw tsaug zog theem, yog li ua rau lub sijhawm ntawm nws qeeb qeeb theem.
Cov Tshuaj Pharmacokinetics
Tom qab kev tswj hwm ntawm qhov ncauj, lub plhaub gelatin yaj hauv txoj hnyuv, amitriptyline raug tso tawm thiab raug nqus los ntawm 60% ntawm cov hnyuv microvilli. Los ntawm phab ntsa ntawm cov khoom nruab nrog, cov tshuaj nquag nkag mus rau hauv cov ntshav, qhov twg ntshav plasma nce mus txog nws tus nqi siab tshaj plaws hauv 4-10 teev. Amitriptyline khi rau cov ntshav muaj protein li 95%.
Kev zom zaub mov ntawm cov nquag nquag kis hauv lub siab los ntawm hydroxylation nrog kev tsim ntawm nortriptyline. Ib nrab-lub neej ntawm cov tshuaj yog 25-27 teev. Cov tshuaj muaj yees tawm hauv lub cev mus nrog quav thiab hla ntawm lub tso zis.
Kev ntsuas rau siv
Cov tshuaj tau sau tseg nyob rau hauv qhov chaw muaj kev ntxhov siab lub xeev thiab neurosis, tshwj xeeb tshaj yog nyob rau hauv rooj plaub uas qhov kev ua txhaum ntawm kev xav hauv lub siab nrog rau qhov kev ntxhov siab, pw tsaug zog, ntxhov siab. Cov tshuaj tiv thaiv kev ntxhov siab tuaj yeem suav nrog kev kho mob sib xyaw rau tus mob schizophrenia.
Cov Yuav Tsum Muaj
Cov tshuaj tiv thaiv kev ntxhov siab yog txwv tsis pub siv rau ntawm qhov muaj kev fab tshuaj rau cov tshuaj uas ua rau hauv daim ntawv tshuaj. Cov tshuaj tsis tawm rau cov neeg uas muaj keeb kwm ntawm kev tsis haum tshuaj fructose, malabsorption ntawm qabzib thiab galactose, nrog isomaltase tsis muaj peev xwm.
Nrog saib xyuas
Kev saib xyuas yuav tsum tau saib xyuas thaum noj Saroten hauv cov xwm txheej hauv qab no:
- pom kev ntshaus siab
- kev puas tsuaj hnyav rau lub siab thiab cov hlab plawv;
- nce hormonal secretion ntawm lub qog gland;
- bronchial hawb pob;
- mob hlwb pob txha hematopoiesis tsis zoo;
- nce siab intraocular;
- ntsoos ntsoos cawv cawv;
Vim tias qhov tshwm sim tuaj yeem ua rau tuag tes tuag taw ntawm cov leeg nqaij ntawm txoj hnyuv zom zaub mov, cov tshuaj tsis pom zoo rau qhov ua tsis taus pa.
Yuav ua li cas noj Saroten Retard?
Cov tshuaj ntsiav lossis cov ncauj lus (pellets) raug nquahu kom haus dej kom ntau tsis tas yuav zom. Txog kev nyuaj siab, suav nrog kev ua tsis zoo rau lub keeb kwm yav dhau los ntawm tus mob schizophrenia, nws yuav tsum noj 1 lub tshuaj ntsiav ib hnub rau 3-4 teev ua ntej yuav mus pw, nrog kev nce ntxiv ntawm cov tshuaj txhua lub lis piam txog 100-150 mg. Thaum kev ua kom zoo ntawm lub dag zog kom ua tiav, qhov tshuaj txhua hnub raug txo kom tsawg li 50-100 mg.
Cov nyhuv tshuaj tiv thaiv kev ntxhov siab ua tus hais tawm tom qab 2-4 lub lis piam. Kev siv tshuaj kho mob yuav tsum txuas ntxiv, vim hais tias txoj kev kho yog mob tshwm sim thaum lub sijhawm uas tus kws kho mob koom nrog. Txhawm rau tiv thaiv kom rov huam mob, nws pom zoo kom txuas ntxiv kev kho mob rau 6 lub hlis. Hauv kev nyuaj siab monopolar, cov tshuaj tiv thaiv kev ntxhov siab raug coj mus rau ntau xyoo raws li kev saib xyuas kev kho mob kom tiv thaiv kom rov huam dua.
Nrog ntshav qab zib
Cov neeg mob ntshav qab zib yuav tsum noj cov tshuaj ntsiav nrog ceev faj, vim tias amitriptyline tuaj yeem hloov pauv kev ua haujlwm ntawm insulin mus rau ntshav plasma concentration ntawm cov piam thaj hauv cov ntshav. Nrog rau kev hloov pauv hauv cov piam thaj, nws yog ib qho tsim nyog yuav tau kho cov tshuaj ntawm cov kab mob ntshav insulin thiab hypoglycemic.
Kev phiv los ntawm Saroten Retard
Muaj qee kis, cov kev mob tshwm sim tsis xws luag (kiv taub hau, tsis pom kev erection, tshee tshee, ua kom cov metabolism hauv kev ua kom tsis muaj zog, mob taub hau) tuaj yeem yog cov cim kev nyuaj siab.
Kev kho mob txoj hnyuv
Qab los txo qis lossis nce ntxiv, zoo nkaus li xeev siab thiab dryness ntawm lub qhov ncauj pom tshwm, qhov loj ntawm cov qaub ncaug qaub ncaug nce, qhov kev ua haujlwm ntawm hepatocytic transaminases nce.
Nruab nrab hauv lub paj hlwb
Cov kev mob tsis zoo ntawm cov kev nyuaj siab CNS tau qhia tias:
- tsaug zog
- tshee hnyo ntawm nqua;
- kev cuam tshuam ntawm saj, tactile thiab olfactory receptors;
- insomnia
- tsis meej pem, ntxhov siab vim thiab npau suav phem;
- kiv tob hau thiab disorientation;
- mloog tsis txaus siab;
- kev xav tua tus kheej;
- kev coj cwj pwm;
- cov lus qhia tawm tsam tom qab ntawm kev mob siab ntsws schizophrenic.
Kev hloov pauv ntawm cov saj yog ib qho kev phiv tshuaj.
Hauv cov neeg mob qaug dab peg, qaug dab peg yuav ua ntau dua.
Los ntawm cov kab mob zis
Tso zis cia yog tau.
Ntawm ib sab ntawm daim tawv nqaij
Nrog kev ua txhaum ntawm cov dej-electrolyte tshuav vim tias noj Saroten, kev txhim kho puffiness ntawm daim tawv nqaij, alopecia yog tau.
Los ntawm genitourinary system
Kev cuam tshuam ntawm kev yug me nyuam raug pom tsuas yog hauv cov txiv neej, ua qauv hauv kev ua haujlwm ntawm erectile kawg thiab mob ntawm cov qog mammary.
Los ntawm cov hlab plawv system
Nrog rau kev txhim kho ntawm qhov tshwm sim tsis zoo, tus neeg mob yuav hnov lub plawv dhia, siab poob qis, tachycardia tshwm. Txoj kev pheej hmoo ntawm atrioventricular blockade, conduction cuam tshuam hauv cov pob ntawm Nws nce. Nrog kev tsis pom kev ntawm cov kab mob hematopoietic, agranulocytosis thiab leukopenia tsim.
Kev ua xua
Hauv cov neeg mob uas tsis tau npaj ua ntej, cov tawv nqaij ua xua, urticaria, khaus, erythema yuav tshwm sim. Tsis tshua muaj xwm txheej, Quincke edema thiab rhiab heev rau lub teeb pom kev zoo.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Yog tias siv qhov tsis zoo, cov tshuaj muaj peev xwm ua rau nkees nkees thiab kev nyuaj siab ntawm cov hlab ntsha tsis zoo, yog li thaum kho cov tshuaj tiv thaiv kev ntxhov siab nws pom zoo kom tsis txhob tsav tsheb, ua haujlwm nrog cov cuab yeej nyuaj thiab koom nrog lwm cov dej num uas xav kom muaj kev kub ceev ntawm psychomotor tshua thiab siab.
Cov lus qhia tshwj xeeb
Tus neeg mob yuav tsum tau txais kev ceeb toom hais tias muaj qhov ntxim nyiam ntawm kev cuam tshuam los ntawm cov hlab plawv.
Kev ntxhov siab tau koom nrog txoj kev nyiam ua leeg nyiam. Cov kev xav ntawm kev tua tus kheej tuaj yeem ua kom txog thaum tag nrho txoj kev noj qab haus huv zoo dua, yog li ua tib zoo saib xyuas tus neeg mob noj tshuaj yog qhov tsim nyog thaum kho. Qhov no yog qhov tsim nyog ntawm thawj theem ntawm txoj kev kho, thaum txoj kev mob siab sai ntawm qhov mob muaj peev xwm ua tau, thiab kev txhim kho txoj kev ua haujlwm tua tus kheej tawm tsam nws. Hauv cov xwm txheej zoo li no, nws yog qhov tsim nyog kom txwv txoj kev siv tshuaj.
Thaum manic tus cwj pwm zoo nkaus li tshwm sim, kev kho tsis tu ncua.
Cov tshuaj raug muab tshem tawm ua ntej npaj yuav phais mob. Yog tias yuav tsum tau phais sai, tus kws tshuaj loog yuav tsum ceeb toom txog kev siv tshuaj tiv thaiv kab mob. Kev ua kom loog yuav ua rau hypotension.
Nrog kev txiav tawm zoo ntawm kev noj Saroten tawm tsam keeb kwm ntawm kev kho mob ntev, qee kis, kev tshem tawm mob huam tuaj. Txo qhov kev pheej hmoo ntawm qhov tshuaj tiv thaiv, nws yog ib qho tsim nyog yuav tsum maj mam txo cov tshuaj ntau dua li 4-5 lub lis piam.
Cov tshuaj yuav txwv tsis pub siv rau cov menyuam yaus hnub nyoog qis dua 18 xyoo.
Siv rau lub sijhawm qub
Cov neeg laus dua 65 yuav tsum noj 1 lub tshuaj 50 mg rau yav tsaus ntuj.
Teem sijhawm Sarotin Retard rau menyuam yaus
Cov tshuaj yuav txwv tsis pub siv rau cov menyuam yaus hnub nyoog qis dua 18 xyoo.
Siv thaum cev xeeb tub thiab lactation
Cov tshuaj tiv thaiv kab mob yog txwv tsis pub rau cov poj niam thaum cev xeeb tub, vim tias amitriptyline tuaj yeem cuam tshuam kev tso ntawm lub plab hnyuv siab raum thiab cov kab ke thaum lub sij hawm muaj kev loj hlob, tshwj xeeb tshaj yog nyob rau lub hlis thib peb.
Thaum noj tshuaj tiv thaiv kab mob, lactation tsis tso tseg yog tias yuav tsum tau txhaj tshuaj. Hauv lub sijhawm kho, saib xyuas tus mob ntawm tus menyuam mos hauv thawj lub hlis ntawm nws lub neej.
Siv rau lub siab ua haujlwm tsis zoo
Cov neeg mob uas muaj lub siab ua haujlwm tsis zoo yuav tsum ua tib zoo saib xyuas thiab, yog tias ua tau, tswj kev xav ntawm amitriptyline hauv cov ntshav dej.
Thaum noj tshuaj tiv thaiv kab mob, lactation tsis tso tseg yog tias yuav tsum tau txhaj tshuaj.
Noj ntau dhau ntawm Saroten Retard
Nrog rau ib qho koob tshuaj ntau npaum li cas ntawm cov tshuaj rau ib teev, koj yuav ntsib kev:
- tsaug zog
- ua kom pom tseeb;
- arousal
- cov menyuam kawm ntawv dilation;
- qhov ncauj qhuav
- convulsions thiab kev nyuaj siab ntawm lub hauv nruab nrab lub paj hlwb;
- precomatous xeev, tsis meej pem, coma;
- metabolic acidosis, qis poov tshuaj concentration;
- plawv dhia;
- cov tsos mob ntawm tus mob cardiotoxicity: poob hauv ntshav siab, mob plawv poob siab, lub plawv tsis ua haujlwm.
Tus neeg raug mob yuav tsum tau mus pw hauv tsev kho mob sai. Nyob rau hauv chaw nyob ruaj ruaj, nws yog ib qho tsim nyog los ntxuav lub plab thiab muab ib qho adsorbent tiv thaiv kom tsis txhob nqus ntxiv ntawm cov tshuaj.
Txoj kev kho yog tsom rau rov ua pa thiab kev mob plawv ntawm kev tshem tawm cov tsos mob ntawm kev haus ntau dhau. Kev saib xyuas cov kev ua haujlwm hauv lub plawv yog xav tau nyob rau hauv 3-5 hnub.
Kev cuam tshuam nrog lwm yam tshuaj
Kev siv cov tshuaj amitriptyline nrog rau lwm cov tshuaj muab rau kev sib tham hauv qab no:
- Ua ke nrog monoamine oxidase inhibitors, ib qho kev mob serotonin tshwm sim, tus yam ntxwv tsis meej pem, myoclonus, kub taub hau, tshee tshee ntawm qhov kawg. Txhawm rau kom txo qis kev pheej hmoo ntawm cov tshuaj intoxication, Saroten tsuas yog kho tom qab 2 lub lis piam los ntawm qhov kawg ntawm kev kho nrog kev tsis tuaj yeem MAO inhibitors lossis 24 teev tom qab siv tshuaj thim rov qab monoamine oxidase blockers.
- Kev kho tshuaj nyhuv ntawm barbiturates yog kho kom zoo.
- Ua rau muaj kev cuam tshuam ntawm cov hnyuv ntau ntxiv vim yog inhibition ntawm peristalsis ntawm cov leeg du ntawm cov hnyuv thaum noj cov tshuaj tiv thaiv kab mob los yog anticholinergics. Nrog hyperthermia, mob plab hnyuv plab nyhuv yog nrog hyperpyrexia. Thaum noj tshuaj tiv thaiv kab mob, qhov pib ntawm rau qhov muaj peev xwm nyeem tau tsawg.
- Amitriptyline ua rau kev kho mob kom zoo ntxiv rau kev mob siab, ua kom mob plab, ephedrine thiab phenylpropanolamine. Vim tias muaj kev puas tsuaj rau cov hlab plawv cov ntshav, cov tshuaj tsis tau hais kom ua kev kho mob ua ke.
- Cov tshuaj nquag ntawm Saroten txo cov nyhuv hypotensive ntawm Methyldopa, Guanethidine, Reserpine thiab lwm yam tshuaj tiv thaiv kab mob siab. Nrog rau kev tswj hwm tib lub sijhawm ntawm amitriptyline, koj yuav tsum hloov cov tshuaj ntawm cov tshuaj uas txo cov ntshav siab.
- Tshuaj txwv tsis pub muaj me nyuam thiab tshuaj muaj poj niam cov txiv neej pw ua ke yuav ua rau kom ntau dua ntawm amitriptyline, uas yuav tsum tau txo qis ntau npaum li cas ntawm ob yam tshuaj. Yog tias tsim nyog, yuav tsum tshem tawm Saroten ntxiv.
Ua ke nrog cov tshuaj acetaldehydrogenase inhibitors, qhov ntxim nyiam ntawm kev txhim kho psychotic, tsis meej pem thiab tsis nco qab nce.
Nyob rau lub sijhawm ntawm cov tshuaj kho, nws yog ib qho tsim nyog yuav tsum tsis txhob haus cawv.
Cawv tau zoo
Nyob rau lub sijhawm ntawm cov tshuaj kho, nws yog ib qho tsim nyog yuav tsum tsis txhob haus cawv. Kev haus dej cawv ethyl tuaj yeem txo cov nyhuv tshuaj tiv thaiv kev ua kom zoo ntxiv, txhim kho lossis nce ntxiv ntawm qhov tshwm sim ntawm kev phiv tshuaj. Tshwj xeeb tshaj yog nyob rau hauv kev sib txuas nrog cov leeg hlwb, vim tias ethanol muaj qhov cuam tshuam ntawm lub hauv nruab nrab lub paj hlwb.
Analogs
Cov kev hloov pauv Saroten suav nrog cov neeg sawv cev uas rov ua cov tshuaj ntxiv ntawm cov tshuaj tiv thaiv kab mob thiab tshuaj:
- Amitriptyline;
- Clofranil;
- Doxepin;
- Lyudiomil.
Kev hloov pauv ntawm cov tshuaj yog nqa tawm tsuas yog thaum tsis muaj cov txiaj ntsig zoo, tom qab kev sab laj kho mob.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Ntsiav tshuaj muag los ntawm cov tshuaj noj.
Clofranil yog ib qho qauv ntawm Saroten.
Kuv puas yuav tau yam tsis muaj daim ntawv yuav tshuaj?
Cov tshuaj tiv thaiv kev ntxhov siab yog koom nrog chav kawm ntawm cov tshuaj psychotropic, yog li yog siv tsis raug, lawv tuaj yeem ua rau poob siab ntawm lub hauv nruab nrab cov hlab hlwb. Vim tias qhov no, muag dawb yog txwv.
Sarotin Retard Nqe
Tus nqi nruab nrab ntawm cov tshuaj ntsiav yog 590 rubles. Hauv Belarus - 18 rubles.
Cia rau cov neeg mob rau cov tshuaj
Cov tshuaj ntsiav yuav tsum tau muab cia rau hauv qhov chaw uas tsis muaj av noo, tiv thaiv los ntawm tshav ntuj, ntawm qhov kub tsis tshaj + 25 ° C.
Hnub tas sij hawm
3 xyoos
Chaw tsim tshuaj paus
H. Lundbeck AO, Denmark.
Kev Tshawb Xyuas ntawm Saroten Retard
Taras Evdokimov, 39 xyoo, Saransk.
Raug kev nyuaj siab ntev. Kuv tsis tuaj yeem tawm ntawm lub xeev no ntawm kuv tus kheej, yog li kuv tig mus rau kws kho mob hlwb kom pab. Tus kws kho mob sau Saroten. Kuv xav txog cov tshuaj kom zoo, nws tiv thaiv tau zoo nrog txoj kev xav ntawm kev ntxhov siab thiab pab tshem tawm insomnia. Cov tshuaj ntsiav yuav tsum tau noj thaum tav su nrog thaj tshuaj ntawm 50 mg thiab thaum mus pw, 100 mg. Tom qab ib lub lim tiam, tsuas siv ib hmo ntuj noj tshuaj. Kuv tsis pom tias muaj kev mob tshwm sim, yog tias tsis tsaug zog. Tab sis nws tsim nyog los cuam tshuam nrog insomnia.
Angelica Nikiforova, 41 xyoo, St.
Tus kws kho mob hlwb tau sau tshuaj Saroten tsiav tshuaj nrog kev ntxhov siab. Thaum siv kom raug, nruj me ntsis raws li cov lus qhia, muaj qhov cuam tshuam zoo. Kuv pom zoo kom noj cov ntsiav tshuaj kawg kom txog thaum 20:00. Yog tias qhov no tsis ua tiav, hauv kuv li, kev txaus siab ntawm cov leeg poob siab thiab insomnia tau pib. Yog hais tias tachycardia tshwm sim, tsav tsheb mus pw tsaug zog, tom qab ntawd txo qhov tsuas tshuaj, thiab cov tsos mob ploj.Tau txais cov txiaj ntsig zoo thaum noj 50 mg 2 zaug hauv ib hnub thiab ib qho ntxiv 50 mg thaum tsaus ntuj. Nws yog ib qho tseem ceeb kom xaiv txoj kev siv tshuaj ntau hauv kev sib tham nrog koj tus kws kho mob.
