Diapiride yog ib qho tshuaj uas muaj qhov ua kom ntshav qab zib tsawg dua. Cov tshuaj yog rau tus lej ntawm sulfonylurea derivatives.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
INN nyiaj - Glimepiride.
Diapiride yog ib qho tshuaj uas muaj qhov ua kom ntshav qab zib tsawg dua.
ATX
ATX code: A10VB12.
Tso cov ntawv thiab cov nyob ua ke
Cov tshuaj yog tsim hauv daim ntawv ntawm cov ntsiav tshuaj nrog ntau qhov sib txawv ntawm cov tshuaj nquag. Hauv pob ntawv cardboard yog 30 ntsiav tshuaj hauv hlwv. 1 ntsiav tshuaj muaj 2, 3 lossis 4 mg ntawm glimepiride (cov tshuaj ua haujlwm tau zoo). Cov ntsiav tshuaj nrog qhov ntau npaum ntawm 2 mg yog lub teeb ntsuab, 3 mg yog lub teeb daj, 4 mg yog lub teeb xiav.
Cov muaj pes tsawg leeg ntawm cov ntsiav tshuaj suav nrog rau cov neeg:
- lactose monohydrate;
- microcrystalline cellulose;
- sodium starch glycolate;
- povidone;
- oxide daj daj;
- magnesium stearate;
- indigo carmine.
Glimepiride muaj cov nyhuv hypoglycemic los ntawm kev txhawb cov kev tso tawm ntawm cov kua dej.
Pharmacological kev txiav txim
Glimepiride muaj cov nyhuv hypoglycemic los ntawm kev txhawb cov kev tso tawm ntawm cov kua dej. Cov tshuaj ua rau ntawm daim nyias nyias ntawm β-hlwb ntawm cov txiav, kaw cov poov tshuaj raws. Yog li ntawd, cov kab mob no ua rau cov ntshav qab zib hauv lub cev nkag siab ntau dua, thiab cov kua dej tawm mus tau yooj yim dua thiab sai dua.
Kuj tseem muaj qhov nce ntawm qhov rhiab heev ntawm cov hlwb rau cov tshuaj insulin, thiab nws siv los ntawm daim siab yog txo. Tib lub sijhawm, gluconeogenesis yog inhibited. Lipid thiab cov leeg nqaij ua kom ntes cov kua nplaum nyeem sai sai vim qhov nce ntawm cov nyiaj thauj cov protein.
Cov tshuaj yeeb tshuaj lom neeg ua rau lub zog txo qis ntawm oxidative kev nyuaj siab los ntawm kev ua kom cov tsim tawm ntawm α-tocopherol thiab txhim kho kev ua ntawm antioxidant enzymes.
Cov Tshuaj Pharmacokinetics
Tom qab kev tswj hwm ntawm qhov ncauj, glimepiride nrawm rau hauv cov hnyuv thiab nkag mus rau hauv cov hlab ntshav. Kev noj zaub mov tsis txo qis kev quav tshuaj. Qhov khoom no nce mus rau nws cov kev xav ntau tshaj plaws hauv cov ntshav ntshav hauv 2-2.5 teev.
Tom qab kev tswj hwm ntawm qhov ncauj, glimepiride nrawm rau hauv cov hnyuv thiab nkag mus rau hauv cov hlab ntshav.
Glimepiride yog tus cwj pwm los ntawm zoo khi rau cov ntshav protein (99%). Cov metabolism ntawm cov tshuaj yog nqa tawm hauv lub siab. Qhov ua tau rau cov metabolites tau tawm ntawm lub raum thiab txoj hnyuv. Cov tshuaj kis tawm ntawm lub cev hauv 10-16 teev. Thaum noj Diapiride, kev txuam nrog cov tshuaj hauv lub cev tsis pom (txawm tias siv ntev heev).
Kev ntsuas rau siv
Cov tshuaj yog siv los kho cov neeg mob hom II mob ntshav qab zib mellitus. Cov ntsiav tshuaj tau sau tseg thaum nws tsis tuaj yeem kho cov ntshav qab zib kom siv cov khoom noj kom zoo thiab kev tawm dag zog.
Cov Yuav Tsum Muaj
Nws yog txwv tsis pub noj tshuaj yog tias muaj cov kabmob hauv qab no:
- Tus neeg tsis qaug rau sulfonamides.
- Hypersensitivity rau lub Cheebtsam.
- Coma
- Ketoacidosis.
- Cov foos hnyav ntawm lub siab lossis raum pathologies.
- Yam 1 ntshav qab zib.
- Lub sijhawm ntawm cev xeeb tub thiab lactation.
- Cov me nyuam lub hnub nyoog.
Nrog saib xyuas
Nyob hauv kev saib xyuas nruj ntawm tus kws kho mob, cov tshuaj yog siv rau kev ua haujlwm nrawm, haus dej cawv, kub cev, tsis muaj peev xwm ua haujlwm ntawm lub qog, ua tsis txaus adrenal thiab mob hnyav.
Tom qab kev phais mob hnyav, raug mob, kub hnyiab, cov neeg mob tau qhia kom hloov mus rau kev kho tshuaj insulin.
Yuav ua li cas noj diapiride?
Cov tshuaj tau noj ntawm qhov ncauj nrog me ntsis dej. Nws raug nquahu kom sib xyaw ua ke noj cov ntsiav tshuaj nrog zaub mov rau kev tiv thaiv ntawm txoj hnyuv pathologies.
Nrog ntshav qab zib
Rau kev kho mob ntawm tsis muaj tshuaj lom-tiv thaiv hom II mob ntshav qab zib mellitus, cov tshuaj no yog siv 1-2 zaug hauv ib hnub. Thaum pib ntawm lub koob tshuaj, qhov tshuaj yog 1 mg nyob rau hauv cov nqe lus ntawm glimepiride. Yog tias nws yog qhov txaus rau kev haus dej qab zib hauv cov ntshav, tom qab ntawd cov koob tshuaj tsis nce ntxiv.
Nrog cov nyhuv tsis txaus, qhov koob tshuaj tau maj mam nce mus rau 2, 3 lossis 4 mg. Lub sijhawm nruab nrab ntawm kev hloov cov tshuaj yuav tsum yog tsawg kawg 7 hnub. Qee zaum cov neeg mob tau kho 6 mg ntawm glimepiride ib hnub (qhov tso cai ntau tshaj plaws hauv ib hnub).
Cov kws kho mob tuaj yeem sau tshuaj rau kev sib koom tes ntawm cov tshuaj nrog metformin lossis insulin kom ua tiav cov txiaj ntsig siab tshaj plaws. Noj cov tshuaj no tuaj yeem ua rau muaj kev cuam tshuam ntau ntxiv hauv cov tshuaj insulin. Hauv qhov no, lub koob tshuaj yog txo lossis tshem tawm tag nrho.
Qhov tshwm sim ntawm Diapyrid
Ntawm ib feem ntawm cov khoom hauv nruab nrog kev pom
Thaum kho, kev cuam tshuam pom qhov muag mus ib ntus (cuam tshuam ib ntus) yuav tshwm sim. Qhov ua rau muaj qhov tshwm sim no yog qhov hloov pauv ntawm cov ntshav qab zib.
Rau kev kho mob ntawm tsis muaj tshuaj lom-tiv thaiv hom II mob ntshav qab zib mellitus, cov tshuaj no yog siv 1-2 zaug hauv ib hnub.
Kev kho mob txoj hnyuv
Ua rau lub plab zom mov:
- xeev siab thiab ntuav
- zawv plab
- mob plab;
- mob rau daim siab (kab mob siab, mob siab, thiab lwm yam).
Hematopoietic plab hnyuv siab raum
Phiv los ntawm hematopoietic system:
- thrombocytopenia;
- leukopenia;
- anemia
- granulocytopenia;
- erythrocytopenia;
- agranulocytosis;
- pancytopenia.
Nruab nrab hauv lub paj hlwb
Los ntawm sab ntawm lub hauv nruab nrab cov hlab hlwb tau pom:
- mob taub hau
- Kiv taub hau
- tsis meej pem txog txoj kev nco qab;
- insomnia
- kev nkees;
- kev nyuaj siab hauv xeev;
- txo qis hauv kev xav txog psychomotor;
- hais lus tsis meej;
- tshee hnyo ntawm nqua;
- cramps.
Los ntawm ib sab ntawm cov metabolism
Qhov tshwm sim tsis zoo rau cov metabolism yog tshwm sim los ntawm cov qog ntshav qab zib.
Kev ua xua
Lub sijhawm tswjhwm, kev ua xua muaj peev xwm ua tau:
- khaus tawv nqaij;
- urticaria;
- ua pob
- ua xua vasculitis.
Rau lub sijhawm ntawm kev kho mob nrog cov tshuaj los ntawm lub hauv nruab nrab cov hlab hlwb, mob taub hau yuav tshwm sim.
Rau lub sijhawm ntawm kev kho mob nrog cov tshuaj los ntawm lub hauv nruab nrab hauv lub paj hlwb, kiv taub hau yuav tshwm sim.
Rau lub sijhawm ntawm kev kho mob nrog rau cov tshuaj los ntawm ib sab ntawm lub hauv nruab nrab ntawm cov hlab ntsha hauv lub hlwb, yuav tsis meej pem.
Rau lub sijhawm ntawm kev kho mob nrog cov tshuaj los ntawm lub hauv nruab nrab hauv lub paj hlwb, insomnia yuav tshwm sim.
Rau lub sijhawm ntawm kev kho mob nrog cov tshuaj los ntawm lub hauv nruab nrab cov leeg hlwb, cov rog yuav ua haujlwm zoo tuaj yeem tshwm sim.
Thaum lub sijhawm kev kho mob nrog rau cov tshuaj los ntawm cov hlab ntsha hauv nruab nrab, cov mob depressive yuav tshwm sim.
Rau lub sij hawm ntawm kev kho mob nrog cov tshuaj los ntawm lub hauv nruab nrab cov hlab hlwb, cov leeg mob tuaj yeem tshwm sim.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Cov tshuaj tuaj yeem txo qhov ceev ntawm cov kev xav psychomotor thiab ua rau kiv taub hau. Thaum pib kho, nrog rau thaum kho cov koob tshuaj, nws tsis pom zoo kom tsav tsheb thiab ua lwm yam haujlwm uas yuav tsum muaj kev mloog ntxiv.
Cov lus qhia tshwj xeeb
Yog hais tias theem ntawm cov piam thaj hauv cov ntshav txo qis los ntawm qhov qis tshaj txhua hnub (1 mg ntawm glimepiride), nws raug nquahu kom maj mam tsum tsis siv cov tshuaj. Kev siv tshuaj hypoglycemic nyob rau hauv qhov no tuaj yeem ua tiav siv kev siv tshuaj kho mob (tsis tas siv tshuaj noj).
Thaum lub sijhawm kho, koj yuav tsum saib xyuas cov ntshav qabzib, glycosylated hemoglobin, ntxiv rau lub siab, cov qe ntshav dawb thiab cov plasmaets hauv cov ntshav.
Siv rau lub sijhawm qub
Cov twj yog pub siv rau cov neeg mob ntawm cov hnub nyoog sib txawv, tshwj tsis yog cov menyuam. Tab sis cov neeg laus uas siv cov tshuaj pab ncua ntev yuav ua rau lub qog ua rau ntshav qab zib. Txhawm rau zam txoj kab mob no, cov kws kho mob tau sau ntawv rau cov neeg laus noj zaub mov tshwj xeeb thiab noj tshuaj tsawg (yog tias ua tau).
Txiag tej menyuam
Cov tshuaj raug tso cai siv tom qab 18 xyoo.
Siv thaum cev xeeb tub thiab lactation
Thaum cev xeeb tub thiab lactation, noj cov tshuaj no yog contraindicated.
Yog hais tias theem ntawm cov piam thaj hauv cov ntshav txo qis los ntawm qhov qis tshaj txhua hnub (1 mg ntawm glimepiride), nws raug nquahu kom maj mam tsum tsis siv cov tshuaj.
Daim ntawv thov rau lub raum khiav tsis zoo
Hauv cov mob raum hnyav, tsis muaj tshuaj kho mob. Cov neeg mob zoo li no hloov mus rau kev kho mob insulin. Thaum pib theem ntawm lub raum tsis ua haujlwm, kev siv cov ntsiav tshuaj yog ua tau nyob rau hauv kev saib xyuas nruj ntawm tus kws kho mob.
Siv rau lub siab ua haujlwm tsis zoo
Kev mob siab rau daim siab yog contraindications rau kev siv ntawm cov tshuaj. Hauv cov kab mob ntawm cov mob sib khuav lossis mob hnyav, nws txoj kev tswj hwm hauv koob tshuaj tsawg kawg yog ua tau. Txoj kev kho yuav tsum nrog soj ntsuam daim siab.
Noj tshuaj Diapiride ntau tshaj
Kev noj tshuaj ntau dhau ntawm cov tshuaj ua rau cov tsos mob ntawm hypoglycemic kev ua haujlwm (muaj zog poob ntshav qab zib). Hauv qhov no, tus neeg mob xav tias qaug zog, tsaug zog, kiv taub hau. Muaj peev xwm tsis nco qab. Txhawm rau tshem tawm cov tsos mob ntawm kev siv ntau dhau, lawv yuav mus rau qhov kev kho mob cov tsos mob.
Kev noj tshuaj ntau dhau ntawm cov tshuaj ua rau cov tsos mob ntawm hypoglycemic kev ua haujlwm (muaj zog poob ntshav qab zib).
Kev cuam tshuam nrog lwm yam tshuaj
Cov tshuaj yuav tsum tau noj nrog ceev faj nyob rau hauv nrog rau cov tshuaj xws li:
- Fluconazole
- Phenylbutazone
- Azapropazone.
- Sulfinpyrazone.
- Oxyphenbutazone.
- Pentoxifylline.
- Tritokvalin.
- Disopyramides.
- Fenfluramine.
- Probenecid.
- Anticoagulants los ntawm cov pab pawg coumarin.
- Cov ntsev.
- Qee yam tshuaj tiv thaiv kab mob (MAO inhibitors).
- Fibrates.
- Fluoxetine.
- Cyclophosphamide.
- Feniramidol.
- Ifosfamide.
- Miconazole
- Cov tshuaj tua kab mob Tetracycline thiab quinolone.
- Lwm yam tshuaj hypoglycemic.
- Cov tshuaj steroid anabolic.
- ACE inhibitors.
- PASK (para-aminosalicylic acid).
Kev txo qis hauv cov nyhuv ntawm cov tshuaj yog pom thaum noj ua ke nrog Phenothiazine thiab nws cov derivatives.
Nrog rau kev siv ua ke nrog cov nyiaj no, cov nyhuv hypoglycemic ntawm Diapiride zoo tuaj. Kev txo qis ntawm cov tshuaj yog pom thaum noj ua ke nrog Phenothiazine thiab nws lub zog, estrogens thiab progestogens, glucagon, nicotinic acid, corticosteroids, barbiturates, Phenytoin, Acetazolamide, diuretics thiab tshuaj rau kev kho mob ntawm lub qog thyroid.
Cawv tau zoo
Cov tshuaj muaj tshuaj tsis haum nrog ethanol. Cov dej cawv muaj peev xwm ua kom ob leeg nce siab ntxiv thiab txo qis kho nyhuv ntawm Diapiride.
Analogs
Muaj cov piv txwv ntawm cov tshuaj:
- Gliclazide.
- Maninil.
- Lawj xeeb.
- Glidiab.
- Vaj Pov.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Kuv puas yuav tau yam tsis muaj daim ntawv yuav tshuaj?
Cov tshuaj yog raug faib tawm los ntawm cov tshuaj noj.
Nqi
Tus nqi ntawm Diapiride hauv cov chaw muag tshuaj muaj li ntawm 110 txog 270 rubles, nyob ntawm seb ntau npaum li cas ntawm cov tshuaj nquag.
Cia rau cov neeg mob rau cov tshuaj
Khaws cov ntsiav tshuaj hauv qhov chaw qhuav thiab tsaus kom tsis txhob ncav cuag ntawm cov menyuam, ntawm qhov kub txog + 25 ° C.
Hnub tas sij hawm
Txee lub neej yog 2 xyoos.
Chaw tsim tshuaj paus
Chaw Tsim Tshuaj PJSC "Farmak" (Ukraine).
Xyuas
Lyudmila, 44 xyoo, Izhevsk.
Kuv pib siv cov tshuaj no raws li kws kho mob tau hais kom txo cov ntshav qab zib. Cov tshuaj yog pheej yig thiab zoo heev. Nws pab tswj cov qib qab zib.
Alexey, 56 xyoo, Moscow.
Kuv tau raug tus mob ntshav qab zib hom 2 tau ntau tshaj 5 xyoos. Kuv noj cov tshuaj no hauv pes tsawg kawg. Nrog kev siv tsis tu ncua, cov ntshav qabzib cov ntshav yuav ruaj khov. Cov kev mob tshwm sim tsis tshwm sim. Tab sis kuv sim muab tshuaj ua ke nrog cov zaub mov kom tsis txhob muaj cov piam thaj kom tsawg.
Anna, 39 xyoo, Voronezh.
Tus kws kho mob endocrinologist pom zoo kom noj cov tshuaj tiv thaiv kabmob ntshav no. Kuv ua siab ntev cov tshuaj yooj yim, Kuv tsis xav tias muaj kev phiv tshuaj. Nws tus nqi kiag li haum kuv. Ntshav qab zib yog nyob rau hauv ib qho kev txwv. Kuv pom zoo nws!
