Gentadueto yog ib qho ntawm cov tshuaj uas tau siv hauv kev kho mob ntshav qab zib. Nws muaj cov nyhuv hypoglycemic pheej ua haujlwm thiab tso cai rau koj los tswj cov ntshav qabzib nyob rau lub sijhawm ntev txaus.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
INN: Linagliptin + Metformil
Gentadueto yog ib qho ntawm cov tshuaj uas tau siv hauv kev kho mob ntshav qab zib.
ATX
A10BD11
Tso cov ntawv thiab cov nyob ua ke
Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov zaj duab xis-ntsiav tshuaj. Cov tshuaj tseem ceeb: linagliptin 2.5 mg thiab metformin hydrochloride hauv ntau npaum li 500, 850 lossis 1000 mg. Cov khoom siv ntxiv yog nthuav tawm: arginine, pob kws hmoov txhuv nplej siab, copovidone, silicon dioxide, magnesium stearate. Cov qog ua yeeb yaj kiab yog tsim los ntawm titanium dioxide, daj thiab xim liab ntawm cov hlau, propylene glycol, hypromellose, talc.
Cov ntsiav tshuaj 2.5 + 500 mg: biconvex, oval, coated nrog zaj duab xis ntawm cov xim daj. Ntawm ib sab nws muaj kev nkag tau ntawm cov chaw tsim khoom, thiab ntawm ib sab muaj cov ntawv sau "D2 / 500".
Lub 2.5 + 850 mg ntsiav tshuaj zoo ib yam, tsuas yog cov zaj duab xis txheej xim xim lub teeb yog xim txiv kab ntxwv, thiab cov ntsiav tshuaj 2.5 + 1000 mg muaj lub teeb liab plhaub xim.
Pharmacological kev txiav txim
Linagliptin yog ib qho inhibitor ntawm qhov enzyme DPP-4. Nws inactivates incretins thiab qabzib-insulinotropic polypeptide qabzib-qabzib-qabzib. Tus incretins koom tes txhawm rau tswj hwm cov ntshav khov nyob hauv qab. Cov nquag tivthaiv khi rau cov enzymes thiab tsub kom cov ntsiab ntawm nce zuj zus. Cov piam thaj hauv cov piam thaj hauv cov roj ntsha insulin ntau dua, thiab lub ntsej muag glucagon zais cia tsawg, uas ua rau cov piam thaj tsis muaj txiaj ntsig.
Metformin yog qhov loj. Nws muaj cov nyhuv hypoglycemic pheej. Plasma glucose concentration txo qis. Hauv qhov no, kev tsim cov tshuaj insulin tsis yog ua kom loj hlob, yog li ntawd cov ntshav qog ntshav qab zib tsuas yog tsim muaj hauv qee qhov xwm txheej tsawg. Daim siab ua haujlwm ntshav qab zib yog txo qis vim kev tiv thaiv cov glycogenesis thiab gluconeogenesis. Vim tias muaj cov tshuaj insulin ntau dua ntawm cov chaw txais tau, kev siv cov kua nplaum zoo dua qub los ntawm cov hlwb tshwm sim.
Metformin stimulates glycogen synthesis hauv hlwb.
Metformin stimulates glycogen synthesis hauv hlwb. Nws muaj cov nyhuv zoo ntawm lipid metabolism. Txo cov concentration ntawm cov roj cholesterol thiab triglycerides hauv cov ntshav. Kev siv ntawm linagliptin ua ke nrog sulfonylurea derivatives thiab metformin txo HbA1c (los ntawm 0.62% piv nrog cov placebo; HbA1c thaum pib yog 8.14%).
Cov Tshuaj Pharmacokinetics
Cov tshuaj yeeb dej caw yog nqus sai sai ntawm lub plab zom mov. Cov kabmob tau muab faib tsis ncaj. Bioavailability thiab lub peev xwm los khi rau cov qauv protein muaj tsawg heev. Kev tshem tawm yog tshwm sim tom qab lub raum lim feem ntau tsis hloov.
Kev ntsuas rau siv
Qhov taw qhia ncaj qha rau kev siv cov tshuaj no yog:
- kev kho mob ntawm hom 2 mob ntshav qab zib mellitus hauv cov neeg mob uas tsis txaus glycemic tswj nrog qhov ntau tshaj plaws ntawm metformin;
- ua ke nrog lwm cov tshuaj thiab cov tshuaj insulin rau hauv cov neeg laus uas muaj kab mob ntshav qab zib, yog tias kev siv cov metformin thiab cov tshuaj no tsis muaj kev tiv thaiv glycemic txaus;
- kev kho mob ntawm cov neeg yav tas los noj tshuaj metformin thiab linagliptin cais.
Qhov qhia tau ncaj qha rau kev siv cov tshuaj no yog kev kho mob hom 2 mob ntshav qab zib mellitus hauv cov neeg mob uas tsis txaus glycemic tswj nrog ntau kawg ntawm cov tshuaj metformin.
Nws yog siv los ntxiv rau kev noj haus thiab tawm dag zog lub cev los txhim kho glycemic tswj hauv cov neeg uas muaj hom 2 pathology.
Cov Yuav Tsum Muaj
Nws yog txwv tsis pub siv cov yeeb tshuaj hauv cov xwm txheej zoo li no:
- yam 1 mob ntshav qab zib mellitus;
- lub cev tsis haum rau ib qho ntawm tus kheej;
- mob ketoacidosis;
- lactic acidosis;
- kev mob ntshav qab zib tsis xeev;
- mob raum tsis ua haujlwm;
- cov kab mob uas ua rau cov nqaij ntshiv hypoxia: decompensation ntawm lub plawv tsis ua haujlwm, ua tsis taus pa, tsis ntev los no lub plawv nres;
- daim siab ua haujlwm;
- cawv intoxication.
Nrog saib xyuas
Qhov tshwj xeeb yuav tsum tau saib xyuas hauv cov neeg mob laus dua 80 xyoo.
Yuav ua li cas noj Gentadueto?
Cov tshuaj yog npaj rau hauv lub qhov ncauj. Txhawm rau txo cov tsos mob uas tsis xav pom qhov tshwm sim, cov ntsiav tshuaj raug pom zoo kom noj nrog zaub mov noj.
Kho ntshav qab zib
Qhov koob tshuaj rau txhua hnub yog 2.5 mg + 500 mg, 2.5 mg + 850 mg lossis 2.5 mg + 1000 mg. Haus cov ntsiav tshuaj ob zaug ib hnub. Cov koob tshuaj yog xaiv rau hauv tus account qhov hnyav ntawm cov tsos mob tshawb nrhiav ntawm tus kab mob thiab cov tib neeg raug ntxim nyiam ntawm cov tshuaj yeeb dej caw rau lub cev. Qhov ntau kawg noj txhua hnub yuav tsum tsis txhob siab dua 5 mg + 2000 mg.
Sab Sij Huam Gentadueto
Feem ntau, nrog kev siv ua ke ntawm metformin nrog linagliptin, zawv plab tshwm sim. Thaum noj cov tshuaj linagliptin nrog metformin hauv kev sib xyaw nrog sulfonylurea derivatives, hypoglycemia feem ntau tshwm sim. Nws kuj tshwm sim thaum noj cov tshuaj linagliptin, metformin nrog cov tshuaj insulin.
Cov tsos mob tshwm sim ntawm cov tsos mob hnyav:
- nasopharyngitis;
- kev hnoos;
- tsis qab los noj mov;
- zawv plab
- xeev siab
- tawv nqaij ua pob sawv nrog nws khaus;
- nce ntshav lipase theem;
- ntshav tshuaj qis;
- cem quav
- lub siab ua tsis taus haujlwm;
- lactic acidosis;
- saj kev ua txhaum;
- mob plab.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Tsis cuam tshuam dab tsi.
Cov lus qhia tshwj xeeb
Raws li kev tshawb nrhiav, yog tias koj sib xyaw nrog cov tshuaj sulfonylurea derivatives, cov nyhuv hauv lub ntsej muag tshwm sim sai dua li cov tshuaj placebo. Cov tshuaj nws tus kheej yuav luag ib txwm tsis ua rau kom ntshav qab zib hauv lub siab. Yog tias siv tsis raug, lactic acidosis tuaj yeem tshwm sim, uas tsim kev hem thawj rau tib neeg lub neej.
Cov kev siv ntau zaus ntawm cov tshuaj metformin hauv kev kho mob cawv cawv tuaj yeem ua rau kev loj hlob ntawm cov kab mob lactic acid, tshwj xeeb tshaj yog nrog kev tshaib plab ntev, noj zaub mov tsis zoo, lossis lub siab ua haujlwm tsis ua haujlwm.
Siv rau lub sijhawm qub
Cov tshuaj no tuaj yeem siv rau kev sau ntawv rau tib neeg txij thaum muaj hnub nyoog 65 xyoos. Tab sis tib lub sijhawm, koj yuav tsum tau saib xyuas lub raum tsis tu ncua, vim tias thaum lub hnub nyoog laus dua, cov kev pheej hmoo ntawm kev tsim cov kab mob hauv lub raum yog qhov siab, uas siv cov tshuaj metformin yog contraindicated.
Txiag tej menyuam
Cov tshuaj tsis yog siv hauv kev kho mob hauv cov laus.
Siv thaum cev xeeb tub thiab lactation
Koj tsis tuaj yeem noj cov tshuaj noj thaum lub caij cev xeeb tub. Txhawm rau kom tsis txhob muaj kev pheej hmoo ntawm cov teeb meem me nyuam hauv plab, koj yuav tsum hloov mus rau cov tshuaj insulin sai li sai tau.
Muaj kev tshawb fawb tsis txaus ntseeg hais tias cov khoom ua kom nquag plias mus rau hauv niam mis, tab sis yuav muaj kev pheej hmoo rau tus menyuam yug tshiab. Yog li ntawd, rau lub sijhawm ntawm cov tshuaj kho mob zoo li no, nws zoo dua rau kev tso tseg kev pub niam mis.
Daim ntawv thov rau lub raum khiav tsis zoo
Nrog siab creatinine tshem tawm, cov tshuaj yog contraindicated. Qhov no kuj tseem siv tau rau lub raum tsis ua haujlwm nrog ib chav kawm ntev.
Siv rau lub siab ua haujlwm tsis zoo
Hauv qhov tsis muaj txhij txhua, cov tshuaj tsis raug tso cai, vim tias thaum noj tshuaj los ntawm kab mob hepatobiliary, kab mob siab thiab kab mob siab ua haujlwm tau.
Gentadueto Noj Ntau Tshaj
Tsis muaj ntaub ntawv hais txog kev noj ntau dhau. Hauv kev sim tshuaj, kev pom kev noj tshuaj ntau dhau ntawm linagliptin tsis tau pom. Nrog rau ib koob tshuaj metformin, tsis pom kev mob ntshav qab zib tsawg, tab sis muaj cov neeg mob ntawm cov kab mob lactic acidosis. Lactic acidosis yog ib tus mob uas yuav tsum tau mus pw hauv tsev kho mob. Metformin raug ntuav tawm los ntawm hemodialysis.
Kev cuam tshuam nrog lwm yam tshuaj
Rov ua dua txoj kev saib xyuas ntawm cov tshuaj lossis nws cov dej num sib cais tsis hloov pauv pharmacokinetics ntawm cov tshuaj. Koj tuaj yeem siv cov tshuaj hauv kev sib xyaw nrog Glibenclamide, Warfarin, Digoxin thiab qee cov tshuaj tiv thaiv tshuaj hormonal.
Contraindicated kev sib txuas ua ke
Koj tuaj yeem siv tsis tau cov tshuaj ua ke nrog ritonavir, rifampicin thiab qee qhov kev tiv thaiv qhov ncauj.
Koj tuaj yeem tsis siv cov tshuaj ua ke nrog ritonavir.
Tsis pom zoo kev sib txuas ua ke
Nws tsis pom zoo kom sib xyaw ua ke noj cov tshuaj nrog thiazolidinediones thiab qee qhov sulfonylurea derivatives, vim tias lawv pab ua rau kom muaj suab thaj txo qis thiab ua rau glycemia.
Tej kev sib txuam uas xav tau ceev faj
Siv nrog cov tshuaj cationic nquag, piv txwv li, cimetidine. Nyob rau hauv cov xwm txheej zoo li no, nws yog ib qhov tsim nyog los saib xyuas kev ua haujlwm ntawm cov hlab ntsws txoj kev thauj khoom thiab ua tib zoo saib xyuas cov piam thaj hauv cov ntshav ntshav.
Cawv tau zoo
Koj tsis tuaj yeem sib xyaw nrog kev noj tshuaj nrog cawv, vim tias txoj kev kho mob txo qis, thiab cov nyhuv ntawm cov tshuaj rau ntawm cov leeg poob siab thiab plab zom mov nce ntxiv.
Koj tsis tuaj yeem sib xyaw nrog kev noj tshuaj nrog cawv, vim tias kho cov nyhuv yog txo qis.
Analogs
Cov tshuaj no muaj ntau cov analogues uas zoo ib yam li nws nyob hauv ib lossis ntau cov tshuaj yeeb dej cawv thiab cov txiaj ntsig kho:
- Avandamet;
- Amaryl;
- Douglimax;
- Velmetia;
- Janumet;
- Vokanamet;
- Galvusmet;
- Glibomet;
- Glybophor;
- Glucovans;
- Duotrol;
- Dianorm-M;
- Dibizid-M;
- Casano;
- Comboglize;
- Sinjardi;
- Choj.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Tus kws kho mob yuav tsum tau yuav khoom.
Kuv puas yuav tau yam tsis muaj daim ntawv yuav tshuaj?
Tsis suav.
Gentadueto Nqe
Nqe ntaub ntawv tsis muaj, raws li Tam sim no cov tshuaj tau rov ua ntawv pov thawj.
Cia rau cov neeg mob rau cov tshuaj
Nws yog qhov tsim nyog kom pom qhov chaw qhuav thiab tsaus, qhov kub ntawm qhov tsis muaj siab tshaj + 25 ° C.
Nws yog qhov tsim nyog kom pom qhov chaw qhuav thiab tsaus, qhov kub ntawm qhov tsis muaj siab tshaj + 25 ° C.
Hnub tas sij hawm
Tsis pub ntau tshaj 3 xyoos txij li hnub muab cov khoom ntim rau thawj lub ntim. Tsis txhob siv tom qab lub sijhawm no.
Chaw tsim tshuaj paus
Lub tuam txhab raug tsim: Beringer Ingelheim Pharma GmbH & Co. KG, Lub Tebchaws Yelemees.
Gentadueto Xyuas
Irina, 37 xyoo, Ivanovo
Cov tshuaj zoo uas pab tswj cov ntshav qab zib kom siab li 12 teev. Nws yog qhov xav paub tias tam sim no nws tsis yooj yim sua kom pom nws hauv cov chaw muag tshuaj, nws yog qhov yuav tsum tau xaiv lwm cov tshuaj nrog cov nyhuv zoo ib yam.
Vladimir, 64 xyoo, Murmansk
Kuv tau haus cov tshuaj no tau ob peb xyoos kom txog thaum nws tawm ntawm kev muag khoom. Qab zib cia rau nws, tsis muaj kev mob tshwm sim, nws yooj yim los qhia. Tam sim no kuv yuav tsum tau nrhiav tus los hloov chaw.
Yaroslav, 57 xyoo, Chelyabinsk
Siv cov tshuaj no ua ke nrog cov tshuaj insulin. Zawv plab tau mob hnyav. Kuv yuav tsum tau hloov nws nrog lwm cov tshuaj.
