Cov neeg mob ntshav qab zib tau paub txog qhov tseem ceeb ntawm kev tswj xyuas ib txwm muaj cov ntshav qab zib. Qhov no yuav zam rau kev mob tshwm sim hnyav. Feem ntau, cov kws kho mob endocrinologist tau muab tshuaj rau kev tswj hwm qhov ncauj, suav nrog Diabinax.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Gliclazide
Cov tshuaj muaj cov npe nrov thoob ntiaj teb - Gliclazide.
ATX
A10VB09
Tso cov ntawv thiab cov nyob ua ke
Cov tshuaj muaj nyob rau hauv daim ntawv qhia ua ntsiav tshuaj nkaus xwb: puag ncig, tiaj tus nrog ib ntug ntawm ntug thiab ib qho nqis siab ntawm ib sab, dawb. Ib pawg ntawm cov tshuaj muaj 0.02, 0.04 lossis 0.08 g ntawm cov tshuaj nquag. Cov khoom siv hauv qab no suav nrog nrog rau lwm cov cim rau cov ntsiav tshuaj:
- MCC;
- aerosil;
- hmoov txhuv nplej siab thiab sodium starch glycolate;
- talc;
- povidone;
- sodium methylparaben;
- magnesium stearate;
- dej.
Ib pob ntawv thawv muaj 1, 2, 3, 4, 5, lossis 6 hlwv nrog 10 lossis 20 ntsiav tshuaj hauv ib.
Pharmacological kev txiav txim
Cov piam thaj ua rau txo qis ntawm cov tshuaj yog ua raws li lub peev xwm ntawm cov tshuaj nquag los thaiv ATP-dependent potassium cov yeeb yaj kiab ntawm cov kab mob pancreatic incretory. Raws li qhov tshwm sim, cov calcium calcium qhib thiab qhov nkag ntawm calcium ions rau hauv cytoplasm nce, qhov no ua rau thauj ntawm vesicles nrog insulin rau daim nyias nyias thiab qhov nqus ntawm cov tshuaj hormones rau hauv cov ntshav.
Cov tshuaj tuaj yeem pom zoo rau cov neeg mob uas muaj qhov hnyav dua, vim yog nws tsis ua rau koj hnyav nce.
Qhov tshuaj yeeb dej caw cuam tshuam feem ntau pib tso tawm cov tshuaj insulin hauv kev teb rau hyperglycemia tom qab noj mov. Qhov no txawv nws los ntawm lwm yam kev coj ua ntawm sulfonylurea 2 tiam. Hauv qhov no, cov tshuaj tuaj yeem pom zoo rau cov neeg mob uas muaj qhov hnyav dua, vim tias nws tsis ua rau koj hnyav nce.
Ntxiv rau kev ua kom cov kua dej tso rau hauv cov ntshav, cov tshuaj muaj peev xwm txhawb kev siv cov kua nplaum los ntawm kev ua haujlwm ntawm cov leeg nqaij glycogen synthetase, thiab tseem muaj peev xwm cuam tshuam cov txheej txheem hauv qab no:
- poob qis rhiab heev ntawm vascular adrenergic receptors;
- maj mam ua cov platelet adhesion thiab kev sib sau ua ke, ib txwm muaj ntawm fibrin lysis cov txheej txheem;
- txo cov roj (cholesterol);
- kev kho kom rov qab vascular permeability.
Vim tias cov khoom no, cov tshuaj tuaj yeem ua kom rov qab tso ntshav ntshav microcirculation, yog li, nws tuaj yeem txo cov protein poob ntawm lub raum thiab tiv thaiv kev puas tsuaj ntxiv rau cov hlab ntsha hauv ntshav qab zib mellitus.
Cov Tshuaj Pharmacokinetics
Tus neeg sawv cev qhov ncauj rau qhov ncauj ntshav mus rau lub plab zom mov tag nrho, uas yog ywj siab ntawm kev noj zaub mov. Hauv cov roj ntsha, ntau dua 90% khi rau hemoproteins, ncav cov ntsiab lus siab tshaj plaws tom qab kwv yees li 4 teev tom qab kev tswj hwm.
Ib nrab-lub neej yog nyob ntev txog 12 teev, yog li ntawd cov tshuaj tawm tau ntev yuav luag ib hnub. Ib zaug hauv cov kab ke hepatobiliary, nws yauv hloov pauv. Ib qho ntawm cov yeeb tshuaj tsim muaj cov nyhuv ntawm lub vascular system. Kwv yees li 70% ntawm kev lees txais nyob rau hauv daim ntawv ntawm metabolites pom nyob hauv cov zis, txog 12% hauv cov quav.
Cov tshuaj siv yog siv los ua kom muaj kev tiv thaiv glycemic profile hauv cov neeg mob uas muaj ntshav qab zib hom 2.
Kev ntsuas rau siv
Cov tshuaj siv yog siv los ua kom muaj kev tiv thaiv glycemic profile hauv cov neeg mob uas muaj ntshav qab zib hom 2. Qhov no pab tiv thaiv lub txim thiab mob tshwm sim los ntawm hyperglycemia.
Cov Yuav Tsum Muaj
Hauv kev kho mob ntawm hom 1 mob ntshav qab zib mellitus, kev siv tshuaj kho mob yog impractical vim kev puas tsuaj rau pancreatic beta hlwb. Nws tsis pom zoo rau siv rau hauv menyuam yaus, cev xeeb tub thiab lactating tus poj niam, nrog rau kev ua hauv qab no:
- decompensation ntawm tus kab mob: mob ntshav qab zib ketoacidosis, coma lossis mob ntshav qab zib precoma;
- mob raum lossis daim siab tsis txaus;
- cov kab mob uas kev xav tau cov tshuaj insulin nce ntau ntxiv: kev kis mob, kev raug mob, kub hnyiab, kev phais mob;
- cov thyroid kawg;
- gliclazide intolerance;
- kev tswj hwm tib txhij ntawm imidazole derivatives (fluconazole, miconazole, thiab lwm yam).
Yuav siv li cas Diabinax
Cov tshuaj yog pom zoo kom noj ntawm qhov ncauj ob zaug hauv ib hnub rau 0.5-1 teev ua ntej noj tshais thiab ua ntej noj hmo, ntxuav nrog dej. Kev noj tshuaj txhua hnub tau teeb tsa raws li daim ntawv glycemic, muaj cov kab mob concomitant, qhov hnyav ntawm cov kev kuaj mob.
Nws tuaj yeem ua ke nrog cov tshuaj hypoglycemic los ntawm lwm pab pawg (tsis yog sulfonylurea derivatives), zoo li nrog cov tshuaj insulin.
Nrog ntshav qab zib
Nws raug nquahu kom pib nrog cov koob tshuaj kom tsawg kawg - 20-40 mg rau ib koob. Qhov tshuaj nruab nrab txhua hnub yog 160 mg hauv 2 koob tshuaj 2 faib. Qhov tshuaj tso cai ntau tshaj plaws txhua hnub yog 320 mg.
Phiv Phom Sij Diabinax
Toxin-txo qis kev siv tshuaj kho mob, kev tsis haum tshuaj yog muaj peev xwm ua tau:
- cov tawv nqaij ua pob: pob khaus, khaus, urticaria;
- thim rov qab cuam tshuam ntawm cov ntshav hematopoietic system: thrombocytopenia, leukopenia, ua rau muaj ntshav tsis txaus;
- mob taub hau, kiv taub hau;
- dajntoo.
Cov tshuaj nquag yuav ua rau nce rhiab rau qhov cuam tshuam ntawm insolation. Ntawm lwm cov kev tsis txaus siab, dyspeptic ces, xws li:
- xeev siab
- ntuav
- tsis qab los noj mov;
- zawv plab
- mob ncauj plab.
Tej zaum yuav muaj qee ntu kev poob qis hauv cov ntshav qab zib nrog cov tsos mob li nram no:
- tsis muaj zog
- palpitations
- kev xav ntawm kev tshaib plab;
- mob taub hau;
- trembling hauv lub cev, thiab lwm yam.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Hauv kev sib txuas nrog cov kev phiv uas yuav tshwm sim, tus neeg mob yuav tsum tau ceev faj thaum tswj cov cuab yeej ua cov nyom.
Cov lus qhia tshwj xeeb
Kev kho nrog cov tshuaj yog kwv nrog kev noj zaub mov nrog cov ntsiab lus qis ntawm qab zib thiab lwm yam carbohydrates hauv qhov khoom. Tab sis nws raug nquahu tias kev noj haus tsis tu ncua ua tiav raws li cov khoom noj muaj txiaj ntsig thiab cov ntsiab lus ntawm cov vitamins nrog kab kawm. Yuav tsum qhia rau tus neeg mob tias nrog kev hloov pauv ntawm kev noj zaub mov noj, yuag poob, mob hnyav, kev kho mob phais, kev hloov kho tshuaj lossis hloov tshuaj yuav tsim nyog.
Siv rau lub sijhawm qub
Hauv cov neeg laus, kev siv cov tshuaj muaj qhov zoo dua hauv kev sib piv nrog cov yeeb tshuaj ntev dua ntawm cov pab pawg no. Cov tshuaj yog ua rau kev tso ntxov ntawm cov tshuaj hormones los ntawm tus txiav, yog li ntawd, qhov kev pheej hmoo ntawm hypoglycemia thaum muaj hnub nyoog no yuav txo qis. Nrog rau kev kho mob ntev, kev txo qis ntawm cov tshuaj thiab qhov xav tau ntawm kev noj tshuaj rau niaj hnub yog ua tau.
Txiag tej menyuam
Cov tshuaj yog contraindicated nyob rau hauv lub hnub nyoog ntawm 18 xyoo, vim hais tias Tsis muaj cov ntaub ntawv qhia txog kev nyab xeeb ntawm kev siv.
Siv thaum cev xeeb tub thiab lactation
Thaum lub sijhawm cev xeeb tub, kev siv tiam 2 sulfonylurea derivatives tsis tsim nyog, raws li FDA kev faib tawm lawv raug tso rau chav kawm C. Tau muab qhov tsis muaj kev tshawb fawb lees paub qhov tsis muaj teratogenic thiab embryotoxic cuam tshuam rau tus menyuam thaum noj cov tshuaj no, nws siv yog contraindicated rau cov poj niam cev xeeb tub.
Tsis muaj ntaub ntawv hais txog kev nkag mus ntawm cov khoom nquag mus rau niam mis. Yog tias tsim nyog, nws txoj kev teem caij rau kev pub mis rau menyuam tshem tawm kom pub niam mis.
Daim ntawv thov rau lub raum khiav tsis zoo
Nrog lub raum ua rau mob tsis zoo, uas yog tus yam ntxwv GFR txo qis dua 15 ml / min, cov tshuaj yog contraindicated. Txoj kev kho yog nqa nrog ceev faj nrog tsawg dua raum tsis ua haujlwm, tab sis tib cov tshuaj yog siv raws li tau qhia hauv cov lus qhia.
Siv rau lub siab ua haujlwm tsis zoo
Nrog kev cuam tshuam ntawm cov kab mob hepatobiliary, ib qho kev nce ntxiv hauv cov tshuaj ntawm cov tshuaj hauv cov ntshav yog tau. Qhov no yuav ua rau muaj kev pheej hmoo ntawm lub qog ntshav qab zib. Yog li, cov tshuaj tsis tuaj yeem raug kho rau cov neeg mob uas muaj lub siab tsis ua haujlwm ntxiv.
Thaum noj cov tshuaj hauv cov tshuaj ntau dua kom zoo rau ib tus neeg, cov tsos mob ntawm qis qis glycemia tshwm sim.
Noj ntau tshaj ntawm Diabinax
Thaum noj cov tshuaj hauv cov tshuaj ntau dua kom zoo rau ib tus neeg, cov tsos mob ntawm qis qis glycemia tshwm sim. Tus mob no yog tus cwj pwm los ntawm qhov tsis zoo nyob hauv qhov muaj txiaj ntsig zoo sib xws: los ntawm kev ua kom tsis muaj zog rau txoj kev ntxhov siab ntawm kev nco qab. Nrog rau qhov tshaj tawm tshaj tawm, yuav tsum tsis meej pem yuav pib.
Kev Kho Mob: rov qab ua kom ntshav qab zib ntxiv. Cov neeg mob uas lub cev tsis zoo ntawm kev noj qab haus huv yog muab cov khoom qab zib uas muaj nyob sab hauv, thiab yog tias tsis nco qab, cov piam thaj yuav tsum tau txhaj tshuaj rau hauv lub cev.
Kev cuam tshuam nrog lwm yam tshuaj
Cov neeg kawm ntawv ntawm kev txo qis hauv glycemia nce nrog rau tib lub sijhawm tau teem caij nrog cov tshuaj hauv qab no:
- tetracyclines;
- sulfonamides;
- salicylates (suav nrog acetylsalicylic acid);
- anticoagulants tsis ncaj ncees;
- anabolic tshuaj steroids;
- beta-blockers;
- fibrates;
- chloramphenicol;
- fenfluramine;
- fluoxetine;
- guanethidine;
- MAO inhibitors;
- pentoxifylline;
- theophylline;
- tshuaj muaj roj
- phenylbutazone;
- cimetidine.
Thaum sau ntawv ntawm Gliclazide nrog acarbose, ib qho lus xaus ntawm cov teebmeem hypoglycemic tau pom.
Thaum muab nrog acarbose, ib qho lus xaus ntawm cov teebmeem hypoglycemic tau pom. Thiab qhov tsis tuaj lossis txo qhov tshwm sim ntawm kev siv tshuaj tau pom nrog kev tswj hwm thooj txhij nrog cov tshuaj hauv qab no:
- barbiturates;
- chlorpromazine;
- glucocorticosteroids;
- sympathomimetics;
- glucagon;
- nicotinic acid;
- estrogens;
- progestins;
- tshuaj noj tswj kev xeeb tub;
- tshuaj kho mob;
- rifampicin;
- cov thyroid hormones;
- lithium ntsev.
Cov tshuaj tsub kom qhov tshwm sim ntawm ventricular extarsystole thaum kho mob nrog plawv glycosides.
Cawv tau zoo
Hauv cov tib neeg tib lub sijhawm uas siv cov tshuaj ethanol thiab glycazide, cov neeg kawm tiav ntawm hypoglycemia nce ntxiv, thiab ib qho zoo li disulfiram zoo li tau tsim. Nrog kev ceev faj, txoj kev kho yog kho rau cov neeg mob uas cuam tshuam los ntawm kev quav cawv.
Analogs
Txog cov tshuaj Indian hauv tebchaws Russia, cov lus piv txwv nram qab no rau cov tshuaj yeeb dej caw muaj:
- Glidiab;
- Ntshav Qab Zib;
- Gliclazide;
- Diabefarm MV;
- Gliclazide MV, thiab lwm yam.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Cov tshuaj yog ntawv sau los ntawm kws kho mob ncaj qha thiab tau muab tshuaj.
Kuv tuaj yeem yuav yam tsis tas yuav tshuaj
Cov koob tshuaj tsim nyog rau kev pom zoo thiab kev nyab xeeb glycemic yuav tsum tau xaiv rau tus neeg mob, yog li ntawd cov tshuaj no tsis raug muag yam tsis muaj daim ntawv yuav tshuaj.
Diabinax nqi
Cov tshuaj tau teev nyob hauv Tseem Ceeb thiab Cov Tshuaj Tseem Ceeb. Nws cov nqi yog tswj tau. Tus nqi ntawm 1 ntsiav tshuaj hauv 20 mg rau tus nqi nruab nrab 1.4 rubles, 40 mg - los ntawm 2.4 txog 3.07 rubles, thiab 80 mg - 1.54 rubles.
Cia rau cov neeg mob rau cov tshuaj
Cov tshuaj ntim tau khaws cia rau qhov kub hauv qab +25 ° C hauv qhov chaw tiv thaiv los ntawm tshav ntuj ncaj qha thiab noo noo. Khaws tsis ncav cuag ntawm cov menyuam yaus.
Hnub tas sij hawm
3 xyoos
Chaw tsim tshuaj paus
Cov tshuaj no yog tsim los ntawm lub tuam txhab Indian Shreya Lub Neej Kev Tshawb Fawb, muaj tus sawv cev chaw sawv cev hauv tebchaws Russia txij xyoo 2002.
Cov tshuaj yog ntawv sau los ntawm kws kho mob ncaj qha thiab tau muab tshuaj.
Kev txheeb xyuas txog Diabinax
Elizabeth, 30 xyoo, Nizhny Novgorod
Tus pog raug kuaj mob ntshav qab zib 5 xyoo dhau los. Txij li thaum ntawd nws ib txwm haus cov tshuaj 2 zaug hauv ib hnub. Peb ib txwm soj ntsuam saib nws cov ntshav muaj piam thaj qhov siab - nws nyob qis qis li qub. Grandma kam rau kev kho mob kom zoo. Tus kws endocrinologist pom zoo kom noj nws tsis tu ncua.
Stanislav, 65 xyoo, Chelyabinsk
Cov tshuaj noj rau lub cev thaum sawv ntxov ua ntej noj tshais. Kuv tau siv tshuaj rau ib nrab xyoo tam sim no. Kuv mloog zoo dua: Kuv tuaj yeem ua haujlwm dua, nkees tsawg dua, nqhis dej tsawg dua. Nws tau dhau los ua qhov tsis tshua tau noj tshuaj rau cov kev kub siab.
Regina, 53 xyoo, Voronezh
Vim tias rau siab ua haujlwm, teeb meem kev noj qab haus huv tau pib: raws li kev ntsuas, lawv pom muaj ntshav qab zib siab. Tom qab tshuaj xyuas, 0.5 ntsiav tshuaj ntawm cov tshuaj tau sau tseg ua ntej noj tshais thiab noj hmo. Kuv lees txais tsis tu ncua, tab sis nco ntsoov ua raws kev noj haus. Txhua qhov ntshav rov qab los ua qub.
