Txhawm rau cov theem ntawm cov piam thaj hauv cov ntshav, ntau yam tshuaj siv, uas suav nrog Minidiab. Lub cuab yeej muaj contraindications thiab phiv, yog li ua ntej siv nws yog tsim nyog los kawm cov lus qhia.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
INN ntawm cov tshuaj yog Glipizide (Glipizide).
Txhawm rau cov theem ntawm cov piam thaj hauv cov ntshav, ntau yam tshuaj siv, uas suav nrog Minidiab.
ATX
Cov khoom lag luam muaj cov cai ATX hauv qab no: A10BB07.
Tso cov ntawv thiab cov nyob ua ke
Kev tso tawm ntawm cov tshuaj yog nqa tawm hauv daim ntawv ntawm 5 mg ntsiav tshuaj, muab tso rau hauv 15 daim. nyob rau hauv sawv hlwv sawb ntim. Ib cardboard pob muaj 2 lub hlwv. Glipizide ua raws li kev ua kom muaj txiaj ntsig.
Pharmacological kev txiav txim
Cov tshuaj yog ib tus neeg sawv cev hypoglycemic. Nws pab tso tawm cov tshuaj insulin nyob hauv kev ua haujlwm ntawm pancreatic beta hlwb. Vim tias nws siv rau ntawm lub plab khoob, hauv cov neeg mob uas muaj mob loj thiab tsis hnyav ntawm cov ntshav qab zib uas tsis muaj cov tshuaj insulin, muaj qhov txo qis hauv glycosylated hemoglobin thiab cov concentration ntawm cov piam thaj hauv cov ntshav.
Thaum lub sij hawm kho, muaj ib qho kev nce ntxiv nyob rau hauv cov qabzib ua kom tsis txaus siab, qhov tsis muaj kev cuam tshuam ntawm cov kua ua kom dawb thiab txo qis hauv cov zaub mov tom qab hyperglycemia. Kev txhim kho ntawm cov tshuaj insulinotropic tshwm sim 30 feeb tom qab noj cov tshuaj. Cov nyhuv ntawm ib zaug ntawm cov ntsiav tshuaj kav 24 teev. Cov tshuaj ua si tsis cuam tshuam rau lipid profile ntawm cov ntshav ntshav.
Cov Tshuaj Pharmacokinetics
Cov tshuaj ntawm cov tshuaj yog nqus tau sai thiab sai hauv lub plab zom mov. Thaum noj mov, tag nrho cov kev nqus poob qis los ntawm 40 feeb. Cov ntsiab lus siab tshaj plaws ntawm cov tshuaj hauv cov ntshav tau tiav tom qab 1-3 teev. Cov tshuaj tau tawm hauv cov zis hauv daim ntawv ntawm tsis muaj zog metabolites.
Kev ntsuas rau siv
Cov tshuaj yog sau rau ntawm cov tsis muaj tshuaj insulin-tiv thaiv hom 2 mob ntshav qab zib mellitus, thaum tsis muaj kev cuam tshuam los ntawm kev ua si lub cev thiab noj zaub mov kom tsis muaj mob, nrog rau ntshav qab zib microangiopathy.
Cov Yuav Tsum Muaj
Cov neeg mob uas lub cev tsis haum lub cev rau kev siv tshuaj, cev xeeb tub thiab lactating cov poj niam, thiab cov neeg mob uas muaj cov tshuaj tiv thaiv uas cov tshuaj insulin yuav tsum tsis kam lees kho nrog Minidiab:
- kev phais mob loj;
- hyperosmolar coma;
- ntshav qab zib hom 1;
- kev raug mob hnyav;
- cov kab mob sib kis;
- dav hlawv;
- kuaj mob ntshav qab zib;
- mob ketoacidosis.
Nyob rau hauv kev saib xyuas ntawm tus kws tshaj lij, cov tshuaj no tau noj los ntawm cov neeg mob kev haus cawv, mob siab lossis lub raum tsis ua haujlwm, febrile syndrome, mob leukopenia thiab kab mob ntawm lub plab zom mov, uas hloov lub sijhawm siv tshuaj hauv lub cev.
Yuav ua li cas kom noj minidiab?
Cov tshuaj yog npaj rau hauv lub qhov ncauj. Nws raug nquahu kom pib nrog kev noj tshuaj txhua hnub tsis pub tshaj 2.5-5 mg. Tom qab ntawd, qhov khoom ntxiv tau nce mus rau 20 mg. Cov ntsiav tshuaj tau noj 2-4 zaug ib hnub ua ntej noj mov loj.
Nyob rau ntawm qhov muaj mob ntshav qab zib mellitus, nws yog ib qho tsim nyog siv cov tshuaj raws li cov qauv uas kws kho mob tau hais tseg tom qab kuaj tag nrho.
Nrog ntshav qab zib
Nyob rau ntawm qhov muaj mob ntshav qab zib mellitus, nws yog ib qho tsim nyog siv cov tshuaj raws li cov txheej txheem sau los ntawm tus kws kho mob tom qab kev tshuaj xyuas tag nrho thiab raws li cov txiaj ntsig ntawm kev kuaj ntsuas, nyob rau theem uas glycemia thiab glucosuria tau txiav txim siab.
Phiv los ntawm Minidiab
Qee qhov xwm txheej, qhov tshwm sim tsis zoo ntawm lub cev mus rau qhov ua yeeb yam sai thiab maj mam ua ntawm glipizide los ntawm cov kab mob genitourinary thiab lwm yam kabmob tuaj yeem tshwm sim. Yog tias muaj ib qho tshwm sim tshwm sim, tsis txuas kev kho mob thiab tham nrog tus kws kho mob tshwj xeeb.
Los ntawm cov kabmob hauv nruab nrog
Cov lus teb rau kev noj tshuaj los ntawm qhov tsis nkag siab yog pom nyob rau hauv daim ntawv ntawm kiv taub hau, tsaug zog thiab mob taub hau.
Kev kho mob txoj hnyuv
Cov tshuaj yuav ua rau xeev ntuav, ntuav, tsis nco qab, mob plab, quav tawv, tsam nyob hauv plab, zoo nkaus li cov ntshav tsis ua haujlwm hauv cov quav thiab cholestatic mob siab.
Minidiab tuaj yeem ua rau hnyav hauv lub plab.
Hematopoietic plab hnyuv siab raum
Cov kev mob tshwm sim los ntawm hemopoietic plab hnyuv siab raum thiab hemostatic system tshwm sim nyob rau hauv daim ntawv ntawm arrhythmia, syncope, kub flashes, mob ntshav txhaws, mob leukopenia, thrombocytopenia, agranulocytosis, hemolytic lossis aplastic anemia thiab pancytopenia.
Nruab nrab hauv lub paj hlwb
Nrog rau qhov tshwm sim tsis zoo ntawm cov leeg hlwb, muaj cov tsos ntawm daim ntaub thaiv nyob rau hauv pem hauv ntej ntawm lub qhov muag, kev nyuaj siab, tsis meej pem, gait cuam tshuam, fiber ntau hemorrhage, paresthesia, hypersthesia, mob rau lub qhov muag thiab pom.
Ntawm ib sab ntawm daim tawv nqaij
Cov tsos mob tsis zoo ntawm daim tawv nqaij tau tshwm sim los ntawm daim tawv nqaij ua pob, urticaria, khaus, erythema, photosensitivity thiab maculopapular pob.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Tsis muaj cov ntaub ntawv hais txog qhov tsis zoo ntawm Minidiab ntawm kev tswj hwm ntawm cov twj. Cov neeg mob uas feem ntau tsav tsheb lossis ua cov haujlwm muaj kev phom sij yuav tsum tau ua tib zoo saib xyuas vim tias qhov tshwm sim tuaj yeem ua rau kiv taub hau thiab mob ntshav qab zib.
Cov lus qhia tshwj xeeb
Yuav tsum tau muaj kev tswj hauv kev kho mob rau cov neeg mob uas siv cov tshuaj thaum lub sij hawm siv tshuaj Insulin lossis ua ntej lawv siv lwm yam tshuaj txo suab thaj. Qhov ntau npaum ntawm cov tshuaj rau cov pab pawg neeg no yog txiav txim siab los ntawm theem ntawm cov piam thaj hauv cov ntshav
Siv rau lub sijhawm qub
Cov neeg mob laus yuav tsum noj cov ntsiav tshuaj nrog kev ceev faj, vim tias nws muaj kev pheej hmoo ntawm lub qog ntshav qab zib.
Txiag tej menyuam
Nws tsis pom zoo kom siv cov tshuaj los kho cov menyuam yaus, vim tias tsis muaj ntaub ntawv hais txog nws txoj kev nyab xeeb rau pawg neeg mob no.
Thaum ua kev ntsuas kev kho mob siv Minidiab, kev pub mis niam yuav tsum tsis tsum.
Siv thaum cev xeeb tub thiab lactation
Yog tias cov tshuaj siv thaum lub sijhawm menyuam yaus, tom qab ntawd cov ntsiav tshuaj nres 30 hnub ua ntej hnub xav tias yuav yug menyuam thiab, yog tias tsim nyog, hloov mus rau kev kho tshuaj insulin. Thaum ua qhov kev ntsuas kho mob, nws yog ib qho tsim nyog kom tsum tsis pub niam mis.
Daim ntawv thov rau lub raum khiav tsis zoo
Lub xeev hypoglycemic tuaj yeem tshwm sim nrog kev ua haujlwm raum thiab lub raum tsis ua haujlwm thaum noj Minidiab.
Siv rau lub siab ua haujlwm tsis zoo
Cov neeg mob uas muaj lub siab ua haujlwm thiab lub siab ua haujlwm tsis zoo yog kho nyob rau hauv kev saib xyuas ntawm tus kws kho mob.
Overdose ntawm Minidiab
Yog tias koj tsim txom cov tshuaj pom zoo, kev noj ntau dhau yuav tshwm sim, raws li muaj pov thawj los ntawm hypoglycemia.
Txhawm rau kom tshem tawm cov kev mob tsis zoo, nws yog qhov yuav tsum tau tsum tsis txhob noj tshuaj, hloov kev noj haus thiab qabzib.
Yog tias pom tias muaj ntshav qab zib tsawg, nws yuav tsum tau mus pw hauv tsev kho mob thiab ua kom cov kua qab zib 50% nyob rau hauv cov kua nplaum thiab tso kua dej kom tsawg li 10%. Thaum tus neeg mob tsis nco qab, nws yuav tsum kuaj nws cov ntshav qab zib kom tsis tu ncua. Kev siv ntshav lim hauv qhov no yuav ua tsis tau dab tsi.
Kev siv lim ntshav thaum kev siv tshuaj ntau dhau nrog Minidiab yuav ua tsis tau zoo.
Kev cuam tshuam nrog lwm yam tshuaj
Kev txo qis ntawm qhov ua tau ntawm cov tshuaj nquag yog pom thaum sib cuam tshuam nrog anticonvulsants, Baclofen, carbonic anhydrase inhibitors, amphetamines, glucocorticoids, calcium antagonists, thyroid hormones, tshuaj tiv thaiv lub qhov ncauj, Epinephrine, Furosemide, ethacrine acid thiab lwm yam tshuaj uas tuaj yeem ua rau tawg.
Kev ua haujlwm hypoglycemic yog kho kom zoo dua thaum noj androgens thiab anabolic steroids. Kev ua kom nrawm ntawm biotransformation thiab ib qho kev nce ntxiv ntawm kev ua kom muaj feem ntawm cov roj ntsha dawb hauv cov ntshav tshwm sim thaum ua ke nrog cov tshuaj tua kabmob tsis ncaj, NSAIDs, clofibrate, MAO inhibitors, sulfonamides, chloramphenicol, guanethidine, probenecid thiab rifampicin.
Kev nce hauv lub xeev hypoglycemic thiab kev tiv thaiv ntawm kev tsis muaj zog yog pom thaum noj Miconazole, Ketoconazole thiab Sulfinpyrazone. Txoj kev pheej hmoo ntawm agranulocytosis nce nrog kev sib xyaw ntawm Minidiab nrog cov tshuaj myelotoxic thiab antithyroid.
Cawv tau zoo
Kev haus dej haus cawv thaum kho mob tuaj yeem ua rau disulfiram-zoo li tus mob syndrome, uas ua rau mob plab, xeev siab, ntuav, thiab mob taub hau.
Analogs
Yog tias tsim nyog, cov tshuaj hloov nrog cov tshuaj zoo sib xws:
- Antidiab;
- Glibenesis;
- Glenezom;
- Glucotrol ChL.
Tus kws kho mob xaiv cov tshuaj analogue coj los ua kom zoo rau qee tus yam ntxwv ntawm tus neeg mob thiab mob hnyav ntawm tus kab mob.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Cov cuab yeej siv tau yuav tau ntawm txhua lub tsev muag tshuaj yog tias muaj ntawv sau los ntawm kws kho mob.
Kuv puas yuav tau yam tsis muaj daim ntawv yuav tshuaj?
Cov tshuaj yuav muab faib tawm los ntawm cov tshuaj noj.
Minidiab nqi
Tus nqi ntawm cov tshuaj yog nyob ntawm txoj cai nqe ntawm lub tsev muag tshuaj thiab qhov nruab nrab 2750 cov quav.
Cia rau cov neeg mob rau cov tshuaj
Lub pob nrog cov ntsiav tshuaj muab tso rau hauv qhov chaw tsaus, qhuav thiab nkag tsis tau rau cov menyuam uas muaj qhov kub tsis dhau + 25 ° C.
Hnub tas sij hawm
Cov tshuaj kho nws cov khoom nyob rau 5 xyoo txij li hnub ntawm kev tsim khoom, yog tias txoj cai khaws cia ua raws. Tom qab hnub tas sijhawm, cov tshuaj no pov tseg.
Minidiab, uas muaj lub npe txawv tebchaws tsis muaj npe hu ua Glipizide, yog khaws cia hauv qhov tsaus ntuj, qhuav thiab tawm ntawm qhov chaw ncav cuag ntawm cov menyuam yaus.
Chaw tsim tshuaj paus
Cov chaw tsim khoom ntawm cov tshuaj yog nqa tawm los ntawm Pharmacia & Upjohn (Ltalis).
Kev txheeb xyuas txog Minidiab
Inna, lub hnub nyoog 33 xyoo, Stavropol: "Kuv tau raug mob ntshav qab zib tau 6 xyoo. Cov tshuaj pab thiab tsis ua rau muaj kev mob tshwm sim, txawm hais tias lwm cov tshuaj cuam tshuam rau kuv kev noj qab haus huv. Tus nqi ntau heev, tab sis cov txiaj ntsig tuaj yeem xav tom qab thawj hnub kho mob."
Angelina, 46 xyoo, Moscow: "Cov tshuaj yog kws kho los ntawm tus kws kho mob. Kuv tau noj tshuaj raws li cov txheej txheem, tab sis tom qab ob peb hnub kuv tau xeev siab thiab ntuav. Txoj kev kho tau nres thiab tam sim no kuv tab tom soj ntsuam kom pom txoj kev kho mob zoo."
