Hom 2 mob ntshav qab zib mellitus yog ib hom kev ua rau ntau tus mob, uas pom los ntawm kev ua txhaum ntawm cov metabolism hauv cov metabolism. Cov qauv tseem ceeb ntawm kev kho mob yog kev siv dag zog, kev noj zaub mov zoo, kev siv tshuaj yaj yeeb. Ib qho tshuaj uas tau muab tshuaj rau ntshav qab zib hom 2 yog glibenclamide.
Cov ntaub ntawv dav dav txog cov tshuaj
Glibenclamide yog cov tshuaj muaj suab thaj uas paub zoo uas tau siv hauv ntau lub tebchaws, tshwj xeeb hauv tebchaws Russia, txij thaum pib xyoo 70s. Nws yog tus sawv cev ntawm sulfonylurea derivatives (tiam 2). Cov tshuaj nquag siv kho mob ntshav qab zib hom 2.
Cov tshuaj tau nthuav tawm qhia cov txiaj ntsig ntxiv rau lub cev. Hauv 45 lub xyoos dhau los, txhim kho cov tshuaj tiv thaiv kab mob thiab tshuaj yeeb tshuaj nrog cov txheej txheem sib txawv ntawm cov yeeb yam tau tshwm sim hauv khw muag tshuaj. Tab sis Glibenclamide tseem tau sau tseg los ntawm kws kho mob thiab tsis plam nws qhov tseeb.
Tsis zoo li nws cov neeg ua ntej, cov tshuaj muaj kev tiv thaiv ntau dua thiab nquag. Nws tau raug xaj nyob rau hauv qhov tsis muaj ntawm cov nyhuv ntawm kev siv tshuaj tsis raug thiab tsis kam nrog lwm cov tshuaj.
Cov chaw muaj tshuaj thiab muaj pes tsawg leeg
Cov nyhuv ntawm cov tshuaj yog hypocholesterolemic, hypoglycemic. Nws tsub kom yuav tsum muaj cov tshuaj insulin ntau ntxiv los ntawm tus txiav, nquag ua hauj lwm hauv beta hlwb ntawm islet apparatus. Cov tshuaj thaiv cov poov tshuaj calcium uas tso rau (ATP channels).
Cov kev txhawb ntawm secretory granules nrog cov tshuaj insulin tshwm sim thiab, vim li ntawd, cov khoom siv roj ntsha tau nkag mus rau cov ntshav thiab cov kua dej ua pa.
Ntxiv nrog rau qhov kev txiav txim tseem ceeb, cov tshuaj muaj cov txiaj ntsig thrombogenic thiab txo cov roj cholesterol. Muab kev tshem tawm sai thiab kev nqus ntawm txoj hnyuv. Kev khi rau cov ntshav plasma protein tshwm sim yuav luag tiav (98%). Cov tshuaj yaj yeeb nyob rau hauv lub siab. Qhov siab tshaj plaws hauv cov ntshav tau mus txog hauv 2 teev.
Cov khoom siv tau siv tau rau 12 teev. Ib nrab-lub neej tom qab kev tswj hwm ntawm qhov ncauj yog 7 teev, xaus rau hauv 2-3 hnub. Muaj feem ntau yog tshem tawm nrog cov kua tsib thiab tso zis Nrog kev txo qis ntawm kev ua haujlwm ntawm lub siab, kev nthuav dav pom qis dua, thiab nrog lub raum tsis ua haujlwm, ntawm qhov tsis sib xws, nws nce.
Lub npe ntawm cov tshuaj nquag hauv Latin yog glibenclamide. Daim foos tso tawm: thawm kab hauv tsev. Txhua tus muaj 5 mg ntawm cov tshuaj nquag.
Kev taw qhia thiab contraindications
Qhov qhia rau kev siv: kev mob ntshav qab zib tsis yog-insulin, qhia tias tsis muaj tshwm sim cov ntshav qabzib los ntawm kev siv tshuaj kho mob tsis zoo.
Contraindications rau siv muaj:
- intolerance rau cov tshuaj nquag;
- lub siab ua tsis taus haujlwm;
- metabolism nrog ib tug nyiam rau acidification ntawm lub cev;
- precoma los yog mob ntshav qab zib coma;
- cev xeeb tub
- lub raum tsis ua haujlwm;
- lactation lub sijhawm;
- ua kom tiav txoj kev kho tsis ua haujlwm;
- mob ntshav qab zib insulin-ywj pheej (DM 1);
- cov hnub nyoog qis dua 18 xyoo.
Cov lus qhia rau kev siv
Qhov kev hloov mus rau glibenclamide yog ua tiav ntseeg nkaws, cov tshuaj yog kho nrog 0.5 ntsiav tshuaj ib hnub. Cov neeg laus uas lub cev ua rau cov plab hnyuv siab tsis pom zoo kom nce cov tshuaj noj tshuaj kom qeeb.
Qhov no muaj tseeb tshwj xeeb rau cov tib neeg hnyav txog 50 kg. Ib hnub, qhov ntau npaum li cas yog 2.5-5 mg ntawm qhov tshuaj (nce txog 1 ntsiav tshuaj). Yog tias tsim nyog, nce qhov koob tshuaj kom tsawg. Cov txheej txheem txhua hnub yog nce mus txog 3 ntsiav tshuaj.
Cov tshuaj yog noj ua ntej noj mov. Ntawm koob tshuaj ntau dua 1 ntsiav tshuaj, nws raug pom zoo kom ua raws li qhov sib piv ntawm 2: 1 (thaum sawv ntxov: yav tsaus ntuj). Kev txais tos yog nqa tawm ntawm ib lub sijhawm yam tsis muaj kev tawg ntse. Thaum kho, lub xeev cov metabolism yog saib xyuas.
Nrog faj seeb, cov tshuaj yuav tsum tau siv raws li cov hauv qab no ntawm cov neeg mob:
- laus laus;
- cov neeg uas muaj lub siab ua haujlwm tsis zoo;
- cov neeg mob uas ua kom cov thyroid tsawg dua;
- nrog cov cim ntawm cerebral sclerosis.
Cawv thaum kho nyob rau hauv txoj kev tswj hwm tau cuam tshuam rau qhov tsis meej - txhim kho lossis txo cov nyhuv ntawm cov tshuaj. Dye E124 ua rau ua xua rau cov neeg mob yooj yim. Yog tias muaj mob (lossis cov uas twb muaj lawm) tshwm sim, nws yog qhov tsim nyog yuav tau qhia rau tus kws kho mob. Cov neeg mob yuav tsum tsis txhob cia li tsis noj tshuaj los sis hloov qhov tshuaj yam tsis tau sab laj nrog lawv tus kws kho mob.
Phiv thiab haus tshaj
Ntawm cov kev phiv pom:
- hnyav;
- ntuav, xeev siab, hnyav hauv lub plab zom mov, mob plab zom mov;
- mob caj dab, ua pob liab vog, anemia;
- lub siab ua tsis taus haujlwm;
- nce hauv cov kab ke biochemical;
- pom kev tsis zoo;
- ntshav tshuaj qis;
- kev tsis haum tshuaj;
- thrombocytopenia, leukocytopenia, erythrocytopenia, granulocytopenia;
- tsis muaj zog diuretic nyhuv.
Kev noj tshuaj ntau dhau (ncua sijhawm ntev lossis ib zaug nce ntxiv hauv koob) feem ntau ua rau cov ntshav qog ntshav qab zib.
Nws cov tsos mob yog:
- hws
- pallor ntawm daim tawv nqaij;
- hnov lus tsis zoo thiab rhiab;
- palpitations, ntawj txias;
- nrog lub xeev muaj txiaj ntsig - hypoglycemic coma.
Hauv cov xwm txheej hnyav, nws yog ib qhov tsim nyog yuav tsum tau yaug lub plab thiab txhaj ib qho kua nplaum ntawm qabzib. Yog tias tsim nyog, glucagon raug tswj hwm. Cov ntshav qab zib me me tuaj yeem raug tshem tawm ntawm nws tus kheej los ntawm kev noj cov piam thaj.
Kev cuam tshuam nrog lwm cov tshuaj thiab cov tshuaj analogues
Cov tshuaj uas ua rau cov nyhuv ntawm Glibenclamide ntau ntxiv suav nrog: Miconazole, tetracycline tshuaj tua kab mob, anabolic steroids, tshuaj tua kab mob, tshuaj insulin thiab ntau cov tshuaj mob ntshav qab zib, txiv neej poj niam.
Cov tshuaj noj uas pab txo cov txiaj ntsig muaj xws li: cov thyroid hormones, corticosteroids, nicotinates, glucagon, beta-andrenoblockers, poj niam txiv neej pw ua ke, diuretics, barbiturates.
Cov tshuaj tuaj yeem cuam tshuam rau glibenclamide (txhim kho lossis, hloov pauv, qis dua) suav nrog: Clonidine, Reserpine, H2 receptor blockers, pentamidine.
Cov tshuaj ntawm kev ua zoo sib xws:
- cov analogue tsis yog Maninil (cov tshuaj muaj zog yog tib yam);
- ib pawg tshuaj uas muaj glimepiride - Amapirid, Amaril, Glibetic, Glimax, Diapride;
- npaj nrog Gliclazide - Glidia, Glicada, Gliclazide, Diagnizid, Panmicron-MV;
- cov nyiaj nrog Glipizidom - Glynez, Minidiab.
Cov khoom siv vis dis aus los ntawm Dr. Malysheva txog cov khoom uas txo cov suab thaj hauv ntshav qab zib thiab tuaj yeem siv ua tshuaj ntxiv rau cov tshuaj:
Tus neeg mob lub tswv yim
Los ntawm kev tshuaj xyuas ntawm cov neeg mob noj Glibenclamide, peb tuaj yeem xaus tias tus nqi ntawm cov tshuaj yog pheej yig heev thiab nws txo qis qab zib zoo, tab sis tom qab nws siv, cov kev mob tshwm sim feem ntau tshwm sim rau hauv daim ntawv ntawm xeev siab thiab tsis qab los noj mov.
Kuv tau mob ntshav qab zib tau 12 xyoos. Cov tshuaj sib txawv tau raug txiav txim, tab sis Glibenclamide tau ua pov thawj rau qhov tsim nyog tshaj plaws. Thaum xub thawj lawv raug kho nrog Metformin - tsis muaj ib qho tshwj xeeb ntawm qhov ib txwm ua ntawm qab zib txawm tias tom qab nce qhov ntau npaum. Tom qab pom zoo Glibenclamide. Cov kev mob tshwm sim hauv daim ntawv uas yuav ua kom tsis qab los thiab xeev siab nyob hauv thawj lub hlis, tom qab ntawd txhua yam rov qab zoo li qub. Qhov piam thaj nrog kev siv cov tshuaj txo thiab khaws cia tsis pub dhau 6. Thaum nruab hnub Kuv xav zoo li qub, thiab nws thov tau.
Irina, 42 xyoo, Samara
Kuv niam nyuam qhuav nrhiav tau tus mob ntshav qab zib hom 2 no. Tus kws kho mob tuaj koom tam sim ntawd tau muab tshuaj Glibenclamide thiab muab tshuaj rau nws. Kwv yees li ib lub lim tiam tom qab nws siv, Kuv tau pib mob siab thiab tsis qab los noj mov. Tab sis, zoo li nws tau hais, qhov no tsis tseem ceeb piv rau qhov tseeb tias cov piam thaj nyob hauv 6-7. Thaum kho, nws yog ib qho tsim nyog los tswj cov siab ua haujlwm ntxiv rau ntawm cov piam thaj. Tab sis niam, nrog rau Glibenklemin, hnov zoo.
Sergey, 34 xyoo, Yekaterinburg
Kuv tus mob ntshav qab zib muaj hnub nyoog 6 xyoo. Lawm, kua nplaum tsis tuaj yeem hloov kho. Kuv yuav tsum khaws ib cov tshuaj. Kuv xav tias cov nyhuv tsuas yog los ntawm Glibenklemin - piam thaj txo mus rau 6.5. (Kuv ib txwm siv lub 'meter'). Ua ntej ntawd, Kuv tsis tuaj yeem ua tiav qhov ntsuas ntawd ntev ntev, hauv qab 7 piam thaj tsis poob. Thaum kawg kuv khaws kuv cov tshuaj. Thaum xub thawj kuv tau nce phaus me ntsis, tab sis tom qab ntawd kuv kho kuv kev noj haus. Ntawm cov kev mob tshwm sim: tsis tseg, qee zaus - raws plab thiab tsis qab los noj mov.
Oksana, 51 xyoo, Nizhny Novgorod
Tus nqi ntawm cov tshuaj xub yog li ntawm 90 txog 120 rubles. Cov tshuaj yuav muab faib tawm los ntawm cov tshuaj noj.
Glibenclamide yog cov tshuaj zoo rau kev txo qis ntshav qabzib. Nws nquag ua haujlwm los ntawm cov kws kho mob thiab tsis plam nws qhov tseeb, txawm tias muaj cov tshuaj ntawm cov qauv tshiab.
