Insulin Humulin, nws cov ntawv tso tawm thiab cov qauv sib txig sib xyaw: mechanism ntawm kev txiav txim thiab kev pom zoo rau kev siv

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Humulin yog txoj hauv kev txo cov ntshav qab zib - cov ntshav nruab nrab. Nws yog cov tshuaj tua kabmob tua kabmob hlwb pancreatic hormone DNA.

Nws cov cuab yeej tseem ceeb yog txoj cai ntawm kev ua haujlwm ntawm cov khoom noj hauv lub cev.

Ntawm lwm yam, cov tshuaj no tus cwj pwm los ntawm anabolic thiab anti-catabolic cuam tshuam rau qee cov ntaub so ntswg cov qauv ntawm tib neeg lub cev. Hauv cov leeg nqaij, muaj qhov nce ntawm glycogen, fatty acids, glycerol, nrog rau cov protein ua ke ntau zog thiab muaj ntau ntawm cov amino acids.

Txawm li cas los xij, txo qis ntawm glycogenolysis, gluconeogenesis, lipolysis, protein catabolism thiab kev tso tawm ntawm cov amino acids tuaj yeem raug taug. Tsab ntawv xov xwm no piav qhia txhua yam txog cov tshuaj uas hloov rau cov tshuaj tua kabmob pancreatic hu ua Humulin, cov tshuaj tiv thaiv kab mob los kuj tuaj yeem nrhiav tau ntawm no.

Analogs

Humulin yog insulin npaj zoo ib yam li tib neeg, uas yog pom los ntawm nruab nrab lub sijhawm ua haujlwm ntev.

Raws li txoj cai, qhov pib ntawm nws cov nyhuv tau sau tseg 60 feeb tom qab kev tswj hwm ncaj qha. Qhov siab tshaj plaws tau tiav kwv yees li peb teev tom qab txhaj tshuaj. Lub sijhawm tiv thaiv yog los ntawm 17 txog 19 teev.

NPH

Cov tshuaj tseem ceeb ntawm cov tshuaj Humulin NPH yog isophan protamininsulin, uas yog kiag li tib neeg. Nws muaj lub sijhawm ua haujlwm nruab nrab. Nws yog tsim tawm rau cov ntshav qab zib insulin.

Feem ntau, cov kws tshaj lij pom zoo nws thaum npaj tus neeg mob kev txom nyem los ntawm cov kab mob endocrine no rau kev phais mob. Nws kuj tseem siv tau rau cov raug mob hnyav lossis mob kis hnyav.

Humulin NPH

Raws li rau qhov ntau npaum ntawm cov tshuaj no, hauv txhua kis nws tau xaiv los ntawm tus kws kho mob tus kheej. Ntxiv mus, raws li txoj cai, qhov ntau npaum li cas ntawm Humulin NPH nyob ntawm lub xeev dav ntawm kev noj qab haus huv ntawm tus neeg mob.

Thaum siv Humulin NPH rau hauv nws daim ntawv ntshiab, nws yuav tsum raug tswj hwm kwv yees li ob zaug ib hnub. Qhov no tsuas yog ua los ntawm kev txhaj tshuaj subcutaneous.

Feem ntau, qhov xav tau ntawm Humulin NPH tuaj yeem nce ntxiv thaum lub sij hawm mob hnyav thiab ntxhov siab. Nws kuj tseem kis tau thaum noj qee yam tshuaj nrog glycemic kev ua si (uas ua rau kom muaj suab thaj ntau ntau).

Nws kuj yuav tsum tau muab tshuaj rau hauv qhov ntau thaum siv cov tshuaj tiv thaiv qhov ncauj, corticosteroids, thiab cov thyroid hormones txaus.

Tab sis kev xav txog kev txo qhov ntau npaum li cas ntawm cov insulin analogue, qhov no yuav tsum tau ua nyob rau hauv rooj plaub uas tus neeg mob lub siab mob raum lossis mob siab tsis txaus.

Tsis tas li, qhov kev xav tau rau kev ua kom zoo li qub lawm pancreatic hormone tsawg dua thaum noj nrog MAO inhibitors, thiab beta-blockers.

Humulin NPH raug txwv tsis pub siv nrog qhov txo qis hauv cov ntshav qab zib cov ntshav.

Ntawm cov kev mob tshwm sim, feem ntau cov cim qhia yog qhov tseem ceeb txo qis hauv cov roj hauv cov nqaij mos. Qhov tshwm sim no hu ua lipodystrophy. Tsis tas li, feem ntau, cov neeg mob pom cov tshuaj insulin tiv thaiv (qhov ua tiav tsis muaj kev cuam tshuam rau kev tswj hwm insulin) thaum siv cov tshuaj no.

Tab sis kev siv tshuaj tiv thaiv tsis haum rau qhov muaj tshuaj ntawm kev ua haujlwm tsis xyaum. Qee zaum cov neeg mob tshaj tawm qhia txog muaj kev fab phiv ntau dhau los ntawm daim tawv nqaij khaus.

Ntxawg

Humulin Tsis tu ncua muaj cov cim suab hypoglycemic. Tus nquag ua hauj lwm yog insulin. Nws yuav tsum nkag mus rau hauv lub xub pwg, ncej puab, pob tw los sis plab. Ob leeg ua intramuscular thiab leeg coj yog ua tau.

Humulin Tsis tu ncua

Raws li rau qhov tsim nyog koob tshuaj ntawm cov tshuaj, nws yog txiav txim siab tsuas yog tus kheej los ntawm tus kheej mus koom kws kho mob. Qhov ntau ntawm Humulin yog xaiv nyob ntawm cov piam thaj hauv cov ntshav hauv cov ntshav.

Nws yog ib qho tseem ceeb kom nco ntsoov tias qhov ntsuas kub ntawm tus neeg saib xyuas yuav tsum yog xis nyob. Qhov chaw txhaj tshuaj yuav tsum tau hloov chaw kom tib thaj chaw siv tsis ntau tshaj ib zaug txhua 30 hnub.

Raws li koj paub, cov tshuaj hauv nqe lus nug raug tso cai muab tshuaj ua ke nrog Humulin NPH. Tab sis ua ntej ntawd, koj yuav tsum tau kawm hauv cov lus qhia kom ntxaws rau ob lub insulins no.
Cov tshuaj no tau qhia rau kev siv nrog insulin-tiv thaiv kev mob ntshav qab zib, hyperglycemic coma (poob ntawm kev nco qab, uas yog tus cwj pwm los ntawm lub cev tsis muaj qhov cuam tshuam rau qee yam kev xav tshwm sim vim qhov nce siab tshaj plaws nyob rau hauv qabzib hauv lub cev), zoo li hauv kev npaj ntawm tus neeg mob kev txom nyem los ntawm qhov kev cuam tshuam ntawm endocrine, kom phais kev cuam tshuam.

Nws kuj tseem raug kho rau kev raug mob thiab kis kab mob kis tau zoo hauv cov neeg mob ntshav qab zib.

Raws li rau qhov kev txiav txim pharmacological, cov tshuaj yog cov tshuaj insulin, uas yog zoo tib yam rau tib neeg. Nws yog tsim ntawm qhov siv tau cov ntawv tso tseg DNA.

Nws muaj qhov tseeb amino acid series ntawm tib neeg pancreatic hormone. Raws li txoj cai, cov tshuaj yog tus yam ntxwv luv luv. Thaum pib ntawm nws cov txiaj ntsig zoo raug pom tau kwv yees li ib nrab ib teev tom qab kev tswj hwm ncaj qha.

M3

Humulin M3 yog ib qho muaj zog thiab muaj txiaj ntsig hypoglycemic tus neeg sawv cev, uas yog kev sib txuas ntawm cov insulins luv thiab nruab nrab.

Lub hauv paus tseem ceeb ntawm cov tshuaj yog kev sib xyaw ntawm tib neeg cov tshuaj insulin thiab kev ncua ntawm isofan insulin. Humulin M3 yog DNA tso tawm tib neeg cov kua dej ntawm cov tshuaj nruab nrab ntev. Nws yog qhov kev tshem tawm biphasic.

Humulin M3

Qhov tseem ceeb ntawm cov tshuaj uas suav hais tias yog kev cai tswj ntawm cov roj zaub mov metabolism. Ntawm lwm yam, cov tshuaj no muaj cov nyhuv anabolic muaj zog. Hauv cov leeg nqaij thiab lwm cov ntaub so ntswg (tshwj tsis yog lub hlwb), cov tshuaj insulin provokes thauj cov ntshav qabzib thiab amino acids nrawm nrawm, khiav ceev protein anabolism.

Pancreatic hormone pab hloov cov piam thaj rau daim siab glycogen, inhibits gluconeogenesis thiab stimulates hloov dua siab tshiab ntawm cov piam thaj rau hauv lipids.

Humulin M3 yog qhia rau kev siv kab mob thiab kev mob ntawm lub cev, xws li:

  • ntshav qab zib mellitus nyob rau hauv muaj cov yam qhia rau kev kho mob insulin tam sim;
  • thawj kuaj mob ntshav qab zib mellitus;
  • nqa menyuam nrog tus kabmob endocrine ntawm hom ob (tsis yog-insulin-tiv thaiv tsis tau).
Humulin M3 yog nruj me ntsis txwv tsis pub noj nrog hypoglycemia, insulinoma, thiab ntxiv rau qhov tsis haum rau qhov kev noj qab haus huv pancreatic.

Cov yam ntxwv sib txawv

Cov yam ntxwv sib txawv ntawm cov ntawv sib txawv ntawm cov tshuaj:

  • Humulin NPHCov. Nws yog rau qeb ntawm nruab nrab-ua yeeb yam insulins. Ntawm cov tshuaj ntev heev uas ua los hloov chaw rau tib neeg tus kabmob pancreatic, cov tshuaj hauv nqe lus nug yog tshuaj rau cov neeg mob ntshav qab zib. Raws li txoj cai, nws qhov kev txiav txim pib 60 feeb tom qab kev tswj hwm ncaj qha. Thiab cov txiaj ntsig siab tshaj plaws yog pom tom qab 6 teev. Ntxiv rau, nws kav ntev txog 20 teev nyob rau hauv kab. Feem ntau, cov neeg mob siv ntau qhov kev txhaj tshuaj ib zaug vim yog kev ncua ntev hauv kev ua ntawm cov tshuaj no;
  • Humulin M3Cov. Nws yog tshwj xeeb sib xyaw ntawm cov yeeb yaj kiab luv luv ua haujlwm. Cov peev nyiaj no muaj cov txheej txheem ntawm lub sijhawm ntev NPH-insulin thiab pancreatic hormone ntawm ultrashort thiab kev ua haujlwm luv luv;
  • Humulin Tsis tu ncuaCov. Nws tau siv thaum nyuam qhuav pib paub qhov mob. Raws li koj paub, nws tuaj yeem siv txawm tias los ntawm poj niam cev xeeb tub. Cov tshuaj no zwm rau qeb ntawm cov tshuaj hormones ultrashort. Nws yog cov pab pawg no uas ua kom muaj kev cuam tshuam sai thiab txo cov ntshav qab zib kom sai. Siv cov khoom lag luam ua ntej noj mov. Qhov no ua tiav kom cov txheej txheem kev zom zaub mov pab kom nrawm nrawm nrawm ntawm cov tshuaj hauv lub sijhawm luv. Cov tshuaj hormones ntawm kev ua sai npaum li cas tuaj yeem coj ntawm qhov ncauj. Ntawm chav kawm, lawv yuav tsum xub raug coj mus rau lub xeev ua kua.

Nws yog ib qho tseem ceeb kom nco ntsoov tias lub ntsej muag luv luv-ua yeeb yam insulin muaj qhov txawv txav hauv qab no:

  • nws yuav tsum tau noj sijhawm li 35 feeb ua ntej noj mov;
  • rau qhov pib ntawm cov nyhuv, koj yuav tsum nkag mus rau cov tshuaj los ntawm kev txhaj tshuaj;
  • nws yog feem ntau muab tshuaj subcutaneously hauv plab;
  • Kev siv tshuaj yaj yeeb yuav tsum ua raws tom qab noj mov tom qab txhawm rau txhawm rau kom txo tau qhov muaj feem ntawm hypoglycemia.

Dab tsi yog qhov txawv ntawm Humulin NPH insulin thiab Rinsulin NPH sib txawv?

Humulin NPH yog ib qho piv txwv ntawm tib neeg cov tshuaj insulin. Rinsulin NPH kuj zoo ib yam rau tib neeg pancreatic hormone. Dab tsi yog qhov txawv ntawm ob?

Tshuaj yaug NPH

Nws yog tsim nyog sau cia tias lawv kuj ob leeg koom nrog cov tshuaj ntawm nruab nrab lub sijhawm ua haujlwm. Qhov sib txawv ntawm ob hom tshuaj no yog tias Humulin NPH yog cov tshuaj txawv teb chaws, thiab Rinsulin NPH yog tsim nyob rau hauv Russia, yog li nws tus nqi yog qis dua.

Chaw tsim tshuaj paus

Humulin NPHs raug tsim tawm hauv tebchaws Czech, Fab Kis, thiab UK. Humulin Tau Los Nyob Hauv Tebchaws Asmeskas. Humulin M3 tsim tawm hauv Fabkis.

Nkaus

Raws li tau sau tseg ua ntej, Humulin NPH yog hais txog cov tshuaj ntawm lub sijhawm nruab nrab. Humulin Tsis tu ncua yog txwv kom muab khaws cia rau cov tshuaj tiv thaiv luv-luv-yeeb-tshuaj. Tab sis Humulin M3 tau faib ua cov tshuaj insulin nrog cov nyhuv luv luv.

Txhawm rau xaiv cov duab xoo tsim nyog ntawm pancreatic hormone yuav tsum tsuas yog tus kheej endocrinologist. Tsis txhob muab tshuaj rau tus kheej.

Related videos

Txog hom insulin siv los kho ntshav qab zib hauv kev yees duab:

Los ntawm tag nrho cov lus qhia hauv tsab xov xwm no, peb tuaj yeem xaus tias kev xaiv ntawm kev hloov chaw uas tsim nyog tshaj rau cov tshuaj insulin, nws ntau npaum li cas thiab txoj kev noj haus yog nyob ntawm ib qho muaj txiaj ntsig zoo. Txhawm rau txiav txim siab qhov zoo tshaj plaws thiab nyab xeeb txoj kev kho mob, koj yuav tsum tau hu rau tus kws paub tshwj xeeb endocrinologist.

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