Cov lus qhia ntxaws ntxiv rau cov tshuaj Glucofage - yuav ua li cas noj rau qhov poob phaus thiab hom 2 ntshav qab zib?

Glucophage yog ib hom tshuaj hypoglycemic, uas suav nrog metformin, ib qho kev sib xyaw ua haujlwm uas muaj lub npe antidiabetic zoo.

Cov tshuaj nquag ntawm cov tshuaj tshem tawm hyperglycemia yam tsis muaj kab mob txo qis ntshav qab zib. Tsis ua kom puas cov insulin ntau lawm thiab hypoglycemic lub xeev hauv cov neeg noj qab haus huv.

Nws txhim kho lub zog ntawm receptor kom peptide cov tshuaj hormones thiab ua kom nrawm nrawm ntawm cov carbohydrates yooj yim. Txo cov piam thaj ntau ntau los ntawm kev ua kom cov metabolism hauv qis thiab ua rau glycogen tawg. Nws inhibits qhov nqus ntawm carbohydrates yooj yim los ntawm kev mob plab.

Metformin ua rau glycogenesis, ua rau muaj peev xwm thauj cov piam thaj hauv cov protein, qhov zoo tshaj ntawm lipid metabolism. Raws li kev noj cov tshuaj Glucofage, tus neeg mob lub cev hnyav zuj zus. Cov kev tshawb fawb tau lees paub txog prophylactic antidiabetic yam ntxwv ntawm Glucophage hauv cov tib neeg muaj kev pheej ntxiv hauv cov piam thaj hauv ntshav thiab cuam tshuam txog kev pheej hmoo.

Cov tshuaj tau qhia rau cov neeg mob uas, tau hloov pauv txoj kev ib txwm ntawm lub neej ntawm lawv tus kheej, tseem tsis tau mus txog lawv lub xeev glycemic. Yuav ua li cas noj Glucofage kom tsis txhob noj tshuaj ntau dhau thiab cov phiv tuaj yeem pom nyob hauv cov ntaub ntawv muab hauv qab no.

Cov lus sib xyaw thiab ntau npaum cov ntawv

Qhov nquag ua haujlwm ntawm cov tshuaj muaj metformin hydrochloride, tsis tshua muaj molecular hnyav polyvinylpyrrolidone, magnesium stearate.

Glucophage ntsiav tshuaj

Hloov, biconvex dawb ntsiav tshuaj ntawm 500 thiab 850 mg yog coated nrog zaj duab xis ntawm hypromellose. Ib homogeneous dawb pawg yog nyob rau hauv ntu ntoo khaub lig.

Oval, 1000 mg dawb ntsiav tshuaj convex ntawm ob sab muaj ib zaj duab xis ntawm opadra, ib txoj kab sib faib thiab cov ntawv sau "1000".

Kev ntsuas rau siv

Cov tshuaj nquag ua haujlwm ntawm cov tshuaj txhim kho cov metabolism hauv cov rog, pab tshem tawm atherogenic lipoproteins thiab cov roj cholesterol.

Cov cim tseem ceeb rau kev siv cov tshuaj yog li hauv qab no:

• non-insulin-mob ntshav qab zib nyob rau hauv kev rog thiab nyob rau hauv qhov tsis muaj tshwm sim ntawm kev siv ntawm kev noj haus kev noj haus lossis kev ua si lub cev muaj zog
• hauv cov neeg mob cov laus thiab cov menyuam yaus hnub nyoog tshaj 10 xyoo raws li kev kho tus mob ntshav qab zib hom 2 lossis zoo ib yam nrog lwm cov tshuaj ntshav qab zib;
• kev tiv thaiv ntawm tus mob ntshav qab zib hom 2 nyob rau hauv ciam chaw mob.

Cov Yuav Tsum Muaj

Zoo li txhua yam tshuaj ntawm cov tshuaj keeb kwm, glucophage muaj ntau qhov kev txwv.

Noj tshuaj yog txwv tsis pub ua tej yam hauv qab no:

• ua kom lub cev tsis haum rau cov tshuaj metformin, cov tshuaj ntxiv ntawm cov tshuaj;
• lub xeev ntawm hyperglycemia, ketoanemia, precoma, coma;
• tej lub raum pathology syndrome;
• hloov hauv dej-ntsev sib npaug;
• cov mob txhab hom mob hnyav;
• lub ntsej muag tsis ua haujlwm ntawm cov txheej txheem ntawm cov kev cai ntawm lub neej txheej txheem;
• ua txhaum cov roj pauv hauv lub ntsws;
• decompensated myocardial kawg nrog cov ntshav tsis khov;
• mob ischemic necrosis;
• kev ua haujlwm ntau thiab kev raug mob uas xav tau kev kho mob insulin;
• kev ua haujlwm ntawm lub siab;
• muaj yees mus ntev mus rau cawv, ethanol lom;
• cev xeeb tub
• ntxiv ntshav lactate;
• kev tso tawm ntawm scintigraphy lossis radiography nrog kev qhia ntawm kev sib piv yeeb tshuaj uas muaj iodine;
• kev ua raws nrog kev noj zaub mov kom tsis muaj calorie ntau.

Cov kua nplaum tau ua tib zoo siv rau cov xwm txheej hauv qab no:

• kev siv dag zog hnyav ntawm lub hnub nyoog laus dua, uas tuaj yeem ua rau kev tsim cov kab mob lactic acidosis;
• lub raum tsis ua haujlwm;
• lactation lub sijhawm.

Muab thiab muab tshuaj rau cov ntshav qab zib

Ib zaug hauv sab hauv cov hnyuv, metformin yog nqus tag.

Kev tsis raug cai ntawm cov neeg nruab nrog cev txog 60%. Qhov siab tshaj plaws ntshav plasma yog pom 2.5 teev tom qab daim ntawv thov.

Kev siv khoom noj ib txhij ua rau ncua kev nqus ntawm cov khoom nquag. Metformin ceev nrawm cov ntaub so ntswg yam tsis muaj kev cuam tshuam ntawm protein.

Cov khoom hypoglycemic dhau los ua kom cov metabolism hauv lub cev tsis muaj zog. Nws yog tawm vim txhaws txhaws txhaws rau lub raum thiab tso zis tso pa tawm. Qhov kev tshem tawm ib nrab-lub neej yog 6,5 teev. Pathologies ntawm lub raum nce lub sijhawm sib nrug, ua rau kev pheej hmoo ntawm kev txuam nrog tshuaj lom neeg.

Cov tshuaj yaj yeeb siv tshuaj txhua hnub, tsis muaj hnub so.Rau cov neeg laus, qhov pib txhua hnub ntawm cov tshuaj - 500 lossis 850 mg tau faib ua 2 lossis 3 kev siv. Nws tau noj nrog zaub mov lossis tom qab nws. Txhua 2 asthiv, cov ntshav qab zib cov ntshav yuav tsom kwm. Raws li cov ntsuas tau, ib qho kev kho mob yog ua tiav.

Kev nce mentsis hauv koob tshuaj tiv thaiv qhov tsis zoo ntawm lub plab zom mov. Kev muab cov txheej txheem tshuaj ib hnub ib zaug yog 1500-2000 mg. Kev pom zoo tso cai yog 3000 mg. Nws tau muab faib ua peb txoj hauv kev.

Rau cov neeg mob siv metformin hauv ib qho npaum li 2000-3000 mg rau ib hnub, nws raug nquahu kom hloov mus rau 1000 mg ntsiav tshuaj. Lub qhov ntim txhua hnub tau faib ua 3 qhov kev siv.

Kev sib xyaw ua ke ntawm kev noj tshuaj nrog insulin pab tswj ntshav qab zib. Tus nqi tshuaj txhua hnub yog 850 mg. Nws tau faib ua 2-3 daim siv. Cov koob tshuaj ntawm peptide hormone yog xaiv tau raws li cov piam thaj hauv ntshav.

Glucophage yog xaj rau cov menyuam yaus hnub nyoog tshaj 10 xyoo. Kev pub siv cov tshuaj insulin sib xyaw. Thawj qhov ntim txhua hnub yog 500 lossis 850 mg. Siv 1 zaug nyob rau ib hnub nrog lossis tom qab khoom noj. Tom qab 2 lub lis piam, kho kho ntawm kev kho yog nqa tawm. Qhov ntau npaum li cas txhua hnub - 2000 mg tau muab faib ua 2-3 koob.

Sab sij huam

Qee zaum glucophage ua rau qhov tsis haum ntawm lub cev. Cov xwm txheej hauv qab no yog qhov ua tau:

• lactic acidosis;
• kev nqus tsis tau txaus cov vitamin B 12;
• tsis muaj qhov ntuj tso tau hnov;
• hnyav nyob rau hauv lub plab, ntuav, tso quav ntau zaus, mob plab;
• hloov pauv ntawm lub luag haujlwm ua haujlwm ntawm daim siab, kab mob siab.

Cov kev tshawb fawb hauv cov pab pawg hnub nyoog ntawm cov menyuam yaus ntawm 10 txog 16 xyoo tau lees tias muaj cov kev phiv zoo sib xws rau cov kev tsis zoo hauv cov neeg laus.

Noj ntau dhau

Qhov tseem ceeb tshaj ntawm cov koob tshuaj ntau tshaj los yog cov xwm txheej ntsig txog ua rau muaj qhov nce ntawm lactate. Cov tsos mob ntawm cov tsos mob ntawm kev nce ntxiv ntawm cov kab mob lactic xav tau kev kho mob sai sai, mus pw hauv tsev kho mob sai rau cov txheej txheem ua kom huv thiab kho cov tsos mob.

Cawv kev sib tham

Tsis tas siv cov tshuaj tiv thaiv kab mob vwm thiab tshuaj pleev kom tsis haum nrog ethanol.

Cawv ua rau mob plab ua cov lactic acidosis nyob hauv cov teeb meem hauv qab no:

• Noj tsis txaus
• cov khoom noj khoom haus muaj tsawg-tsawg;
• kev ua haujlwm ntawm lub siab.

Cev xeeb tub thiab lactation

Qhov tsis muaj txiaj ntsig ntawm kev siv tshuaj tua kab mob thaum lub sijhawm yug menyuam yuav dhau los ua qhov ua tsis taus ntawm lub plab thiab kev tuag hauv lub sijhawm perinatal.

Cov ntaub ntawv qhia txog kev nce ntxiv ntawm qhov ntxim nyiam ua rau ntawm cov menyuam mos thaum cov poj niam cev xeeb tub noj Glucofage tseem tsis tau muaj.

Yog hais tias qhov tseeb ntawm kev xeeb tub pom los yog tus txheej txheem cev xeeb tub, cov tshuaj yuav raug muab tso tseg. Metformin hla mus rau hauv niam cov kua mis.

Cov txiaj ntsig tsis zoo ntawm cov tshuaj nyob rau hauv cov menyuam tshiab tsis tau txheeb xyuas, tab sis qee yam ntawm cov ntaub ntawv qhia tias qhov tsis xav tau ntawm cov khoom hypoglycemic nyob rau lub sijhawm no.

Yeeb Tshuaj Sib Raug

Qhov sib xyaw ua ke txaus ntshai yog kev siv cov metformin nrog radiopaque cov khoom xyaw uas muaj iodine. Tawm tsam keeb kwm yav dhau los ntawm lub raum pathology, xws li kev tshawb fawb pab txhawb kev txhim kho ntawm cov kab mob lactic acidosis.

Kev siv ntawm cov tshuaj tau raug muab tso tseg ob hnub ua ntej kev kawm. Rov qab txiav txim siab tom qab 48 teev raws li lub raum kev ua.

Kev sib xyaw ntawm Glucophage nrog cov tshuaj teev hauv qab no yog ua kom pom raws li hauv qab no:

• Danazole provokes cov nyhuv hyperglycemic ntawm metformin;
• Chlorpromazine hauv qhov loj ntau ua rau kom muaj ntau qhov sib xyaw ntawm cov carbohydrates yooj yim, txo qhov kev tso tawm peptide hormone;
• analogues ntawm cov tshuaj hormones endogenous nce nce ntxiv cov piam thaj, ua rau kev cuam tshuam ntawm cov rog khaws cia;
• diuretics provoke lactic acidosis nyob rau hauv lub xub ntiag ntawm kev ua haujlwm lub raum tsis ua haujlwm;
• kev txhaj tshuaj ntawm cov tshuaj beta2-adrenergic agonists ua rau kom cov ntshav qabzib ntau ntxiv;
• cov tshuaj tiv thaiv kab mob siab, nrog rau kev zam ntawm ACE blockers, txo cov ntau ntawm cov suab thaj hauv qab zib;
• tib lub sij hawm siv cov tshuaj nrog sulfonylurea derivatives, peptide cov tshuaj hormones, alpha-glucosidase inhibitors, salicylates provokes hypoglycemia;
• Nifedipine txhim kho cov txheej txheem tshuaj lom neeg ntawm kev nqus ntawm nqus ntawm cov khoom nquag;
• cationic cov kab mob tiv thaiv kab mob sib tw nrog metformin rau cov kab kev thauj khoom ntawm tes, nce nws cov txiaj ntsig ntau tshaj plaws.

Cov nqe lus ntawm kev muag khoom thiab chaw cia khoom

Cov tshuaj yuav muab faib tawm los ntawm cov tshuaj noj. Cia kub - txog 25 ° C. Khaws tsis ncav cuag ntawm cov menyuam yaus.

Nws puas tuaj yeem ua kom poob ceeb thawj los ntawm cov tshuaj

Muaj cov lus pom zoo ua kom poob phaus tseem ceeb yam tsis muaj kev phom sij rau kev noj qab haus huv. Tus nqi kho mob rau ib tug neeg yog xaiv los ntawm tus kws kho mob.

Pib nrog qhov kev ntsuas me me, txav mus ntawm cov neeg nce zuj zus. Siv tus neeg sawv cev hypoglycemic los tiv thaiv keeb kwm ntawm cov zaub mov zoo.

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