Glidiab hauv kev sib ntaus cov tiv thaiv ntshav qab zib

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Glidiab yog ib qho tshuaj tiv thaiv kab mob ntshav siab uas nws muaj peev xwm tswj hwm kev mob ntshav qab zib mellitus hom 2: rov ua haujlwm glycemic tswj, tshem tawm cov glucosuria (nce ntxiv ntawm cov piam thaj hauv kev kuaj zis).

Cov tshuaj muaj pes tsawg leeg

Hauv cov khw muag tshuaj network Glidiab (hauv daim ntawv thoob ntiaj teb - Glidiab) tuaj yeem muas tau hauv cov qauv ntsiav tshuaj rau kev siv hauv qhov ncauj. Ib qho kev sib xyaw tshwj xeeb thiab cov thev naus laus zis tshiab rau kev tswj hwm tus nqi ntawm qhov hloov kho tawm ntawm cov tshuaj yeeb dej caw. Cov xim tsho xim yog multivariate: dawb, daj, qab zib.

Ntawm ib lub blister hauv lub contour hlwb, 10 ntsiav tshuaj hnyav 80 mg tau muab ntim nrog cov khoom xyaw nquag gliclazide. Nws yog ntxiv nrog cov zam ntxiv: cov hmoov txhuv nplej siab, magnesium stearate, sodium starch glycolate, mis qab zib, hypromellose, MCC, talc.

1 ntsiav tshuaj ntawm cov tshuaj Glidiab MV muaj 30 mg ntawm gliclazide. Nws yog ntxiv los ntawm MCC, hypromellose, magnesium stearate, aerosil.

Pharmacological tau

Cov lus tshaj tawm kev kho mob ntawm cov tshuaj yog muab los ntawm gliclazide, uas yog thib ob tiam sulfonylurea pawg tshuaj.

Tsis zoo li cov kab ua ntej dhau los ntawm cov tshuaj, Glidiab tsis muaj tshuaj lom tsawg dua thiab muaj txiaj ntsig zoo dua, thiab nws cov yam ntxwv hypoglycemic yog ua raws li qhov tseeb uas nyob hauv qab ntawm Glidiab:

  • Txhawb cov insulin ntau ntxiv los ntawm β-hlwb;
  • Kev tsim cov tshuaj tiv thaiv hepatic glycogen yog qhib rau;
  • Receptor proteins inhibit gluconeogenesis;
  • Endogenous insulin kev ua si tau txhim kho;
  • Cov synthesis ntawm cov piam thaj los ntawm cov protein thiab rog hauv lub siab tau txhaws;
  • Lub siab thiab cov leeg pob txha nqus cov piam thaj ntau nquag;
  • Ua qeeb qeeb lipolysis nyob rau hauv cov ntaub so ntswg.

Txog Glidiab, kev tshuaj xyuas ntawm cov kws kho mob hais rau peb tias nrog rau kev siv tshuaj, kev tawm tsam insulin ntawm peripheral cov ntaub so ntswg txo, cellular enzymes, tshwj xeeb tshaj tawm glycogen synthetase, yog kev ua haujlwm, lub sijhawm nruab nrab ntawm cov zaub mov thiab insulin nce yog txo.

Piv rau lwm cov tshuaj ntawm cov pab pawg sulfonylurea (glibenclamide, chlorpropamide), uas ua haujlwm tseem ceeb nyob rau theem ob ntawm cov tshuaj tua hluav taws xob, glycoslide pab ua kom lub zog thaum kawg ntawm insulin ntau lawm thiab txo glycemia tseem ceeb. Ntxiv rau kev ua kom lub cev tsis ua haujlwm zoo ntxiv, cov tshuaj kho txhim kho capillary ntshav txaus, txo cov platelet adhesion thiab kev sib sau ua ke, thiaj li tso tseg kev ua cov quav hniav.

Raws li cov lus qhia, gliclazide:

  • Txhim kho vascular permeability thiab elasticity;
  • Siv los tiv thaiv microthrombosis;
  • Nws ua rau qhov rhiab heev ntawm cov hlab ntsa mus rau adrenaline;
  • Restore physiological fibrinolysis (ntxuav los ntawm cov ntshav txhaws);
  • Txo cov ntsiab lus ntawm cov roj (cholesterol) tag nrho, muaj cov tshuaj tiv thaiv atherogenic (tiv thaiv thiab regression ntawm atherosclerosis);
  • Ncua kev nce qib ntawm retinopathy nyob rau theem tsis-loj zuj zus.

Siv lub sijhawm ntev dua ntawm Glidiab los ntawm cov neeg mob ntshav qab zib nrog nephropathy txhim kho kev ua kom cov protein ntau hauv cov zis. Cov tshuaj tsis pab txhawb rau qhov hnyav ntxiv, vim tias nws cov haujlwm tseem ceeb yog nyob rau thaum ntxov tshaj plaws ntawm kev tsim cov tshuaj insulin, uas tsis ua rau muaj kev tiv thaiv hyperinsulinemia. Cov tshuaj tso cai rau cov rog ntshav qab zib rau qee yam uas poob phaus, raug rau kev hloov ua neej.

Pharmacokinetics ntawm cov tshuaj

Kev ntsuas ntawm kev nqus ntawm gliclazide nyob rau hauv lub plab zom mov tom qab qhov ncauj tswj hwm ntawm cov tshuaj yog siab. Kev noj ib koob ntawm cov tshuaj (80 mg) muab qhov siab tshaj plaws ntawm cov kev ua haujlwm hauv ntshav ntshav tom qab 4 teev. Cov tshuaj txiav txim siab nyob hauv daim siab yog biotransformed: oxidation, hydroxylation thiab glucuronidation ua rau tsim cov 8 metabolites uas tsis nyob nruab nrab nrog rau kev ua kom qabzib. Ib qho ntawm cov tshuaj metabolites muaj peev xwm cuam tshuam rau microcirculation. Cov khoom noj tsis zoo ua rau lub raum (70%) thiab txoj hnyuv (12%). Hauv nws daim ntawv qub, tsuas yog 1% ntawm Glidiab yog tshem tawm. Qhov kev tshem tawm ib nrab-lub neej yog tsau nyob rau hauv thaj tsam ntawm 8-11 teev.

Leej twg yog tus kws kho mob Glidiab

Glidiab raws li cov lus qhia raug rau kev siv yog pom zoo rau cov neeg mob ntshav qab zib nrog hom 2 mob ntawm cov mob nyhav, thaum muaj teeb meem xws li microangiopathy twb tau tsim. Nws raug tso cai siv cov tshuaj rau kev kho mob monotherapy lossis hauv kev kho mob nyuaj, nrog lwm cov tshuaj tiv thaiv hypoglycemic. Glidiab yog tshuaj noj nrog rau lwm cov tshuaj rau ntshav qab zib kom tiv thaiv hemorheological teeb meem ntawm ntshav qab zib.

Hauv txhua kis, cov tshuaj tau muab tshuaj nrog kev ua haujlwm tsis txaus ntawm kev kho tsis siv tshuaj lossis ntxiv rau kev hloov kho hauv lub neej.

Muaj peev xwm ua mob tau los ntawm gliclazide

Glyclazide-raws li cov tshuaj yog contraindicated:

  • Tus mob ntshav qab zib nrog hom 1;
  • Nrog rau txoj kev loj hlob ntawm cov ntshav qab zib hom 2;
  • Nrog ketoacidosis;
  • Cov neeg mob nrog insuloma;
  • Hauv cov xwm txheej uas ua rau npau taws thiab ntshav qab zib;
  • Cov neeg mob raum thiab mob siab tsis txaus;
  • Nrog mob microangiopathy loj;
  • Cov neeg mob ntshav qab zib nrog lub cev tsis nco qab rau sulfonylureas;
  • Nyob rau hauv lub sijhawm ntawm kis kab mob;
  • Thaum cev xeeb tub thiab lactation;
  • Hauv thaum yau (tsis muaj ntaub ntawv hais txog cov txiaj ntsig thiab kev nyab xeeb);
  • 48 teev ua ntej thiab tom qab phais loj.

Kev saib xyuas tshwj xeeb thiab kev txwv yog qhov yuav tsum tau ua thaum xaiv Glidiab rau cov neeg mob hauv lub xeev febrile, nrog lub qog ua haujlwm, nrog pyelonephritis (mob ntev), nrog kev haus cawv thiab nephroangiopathy (hom mob ntshav qab zib), adrenal tsis ua hauj lwm.

Yuav thov cov tshuaj

Ua ntej teeb tsa kev kho mob, tus kws kho mob soj ntsuam cov xwm txheej ntawm tus neeg mob, hnub nyoog, theem ntawm tus kab mob, thiab cuam tshuam nrog cov kev cuam tshuam. Raws li kev ntsuas ntawm kev yoo mov thiab postprandial glycemia, nrog rau muaj cov tshuaj tiv thaiv kab mob lwm yam uas tus neeg mob siv sib luag, qhov nqi niaj hnub ntawm Glidiab yog xam. Tus neeg mob qhov tshuaj tiv thaiv rau cov tshuaj kuj tseem ua rau suav nrog.

Rau cov tshuaj kho mob ib txwm

Txhawm rau Glidiab yooj yim, cov lus qhia rau kev siv pom zoo pom zoo ib koob ntawm cov tshuaj - 80 mg / hnub., Qhov nruab nrab - 160 mg, siab tshaj plaws - 320 mg. Siv ob: thaum sawv ntxov thiab yav tsaus ntuj, 1 ntsiav tshuaj ua ntej noj mov. Hauv raum pathologies, yog tias cov creatinine tshem tawm tsawg dua 15 units, kev hloov kho koob tshuaj yog tsis tsim nyog.

Rau variant Glidiab MV

Hauv cov neeg mob ntshav qab zib (suav nrog hom kab mob gerontological), cov qauv tshuaj ntawm cov tshuaj uas muaj lub siab ntev ntawm qhov pib chav kawm yog 30 mg. Kev kho ntawm cov qauv yog tau tom qab 14 hnub. Qhov ntau kawg ntawm qhov Glidiab MV, raws li cov lus qhia rau kev siv, yog 120 mg / hnub. Qhov no sib haum rau 4 pcs. ntsiav tshuaj. Cov tshuaj yog coj qhov ncauj nrog pluas tshais. Nws raug tso cai coj lwm tus neeg sawv cev hypoglycemic nyob rau hauv parallel: biguanides, α-glucosidase enzyme inhibitors, insulin.

Yam tsis tau xav txog

Txog Glidiab kev txheeb xyuas qhia tias qee kis, kev kho yog nrog cov xwm txheej tsis paub txog.

Cov neeg mob ntshav qab zib yws yws txog kev qaug zog, kiv taub hau, mob taub hau, pancytopenia, ua xua, pruritus, photosensitization, dyspeptic cuam tshuam, asthenia, epigastric tsis xis nyob, hnov ​​tsis hnov ​​mob, raws plab.

Cov mob uas tsis tshua pom muaj yog hypoglycemia, paresis, thrombocytopenia, leukopenia, agranclocytosis, anemia. Feem ntau, tag nrho cov kev mob tshwm sim yuav thim rov qab: tom qab tsis txiav cov tshuaj, lawv ploj lawv tus kheej.

Txhawm rau kom tsis txhob mob ntshav qab zib thiab lwm yam kev tsis txaus siab, nws yog ib qho tseem ceeb kom meej meej txog sijhawm siv cov ntsiav tshuaj rau kev noj zaub mov, kom tsis txhob tshaib plab thiab tshem tawm cov cawv los ntawm kev noj zaub mov kom tiav.

Kev Yeeb Tshuaj Sib Tham nrog Glidiab

Lub npe tshuajMuaj feem tshwm sim
Tshuaj EthanolCov neeg mob ntshav qab zib tsawg, hypoglycemic coma vim yog inhibition ntawm kev them nyiaj cov tswv yim los ntawm kev haus cawv.
MiconazoleTej yam kev mob hypoglycemic (suav nrog coma). Txwv tsis pub sib xyaw!
Β-adrenergic blockers Npog qhov ncauj qhia ntawm yuav luag hypoglycemia.
SulfonamidesCov suab thaj-txo cov nyhuv ntawm gliclazide yog nce zuj zus.
Salicylic Acid DerivativesNce Glidiab lub peev xwm.
MAO inhibitorsKev tiv thaiv ntshav qab zib cov yam ntxwv yog ua kom zoo dua qub.
TheophyllineLawv txhim kho hypoglycemic lub zog ntawm cov tshuaj.
SalbutamolQabzib toxicity ntau dua.
BarbituratesTxwv tsis pub ua cov haujlwm ntawm Glidiab.
Estrogen-muaj cov khoom lag luamKev pheej hmoo ntawm hyperemia.
TerbutalineKev loj hlob ntawm cov piam thaj muaj tshuaj lom.
FluconazoleKev hem thawj ntawm hypoglycemia.
CaffeineTxhim kho qhov taw qhia hypoglycemic.
TetracosactideKev phom sij ntawm kev tsim ketoacidosis.
FluoxetineGlidiab hypoglycemic catalyst.
Lub qog ua haujlwm Tawm tsam qhov txaus siab ntawm cov tshuaj.
Lithium Raws TshuajBlock hypoglycemic cov yam ntxwv.
ACE inhibitorsUa kom sai cov nyhuv hypoglycemic.
Kev tshuaj ntsuabKev pheej hmoo ntawm cov piam thaj muaj tshuaj lom.
CimetidineGlidiab Catalyst
ProgestinsHyperemia.
GlucocorticosteroidsQog Ntshav.
Kev Txij NkawmLub cev muaj zog ntawm cov piam thaj kom lom.
Estrogens thiab progestogensKev loj hlob ntawm glycemic ntsuas.

NSAIDsHyperemia.
Ritodrin Kev phom sij ntawm hyperglycemia.
SulfonamidesQhov ntxim nyiam ntawm hypoglycemic.
FenfluramineGlyclazide Kev Noj Qab Haus Huv Catalyst.
FeniramidolNce hypoglycemic nyhuv.
FibratesTxhim khu lub peev xwm ntawm cov tshuaj.
ChloramphenicolQhov catalyst rau lub peev xwm ntawm cov tshuaj.
Mob GlycosidesMuaj qhov ntxim nyiam ntawm ventricular extrasystole.

Noj ntau dhau

Nrog rau qhov nce hauv cov koob tshuaj ntau dua dhau los kho kev mob, muaj qhov tshwm sim ntawm qhov txo qis hauv glycemic qhov ntsuas. Kev haus ntau dhau lawm tuaj yeem pab txhawb kev txhim kho ntawm glycemic coma. Yog hais tias tus neeg raug tsim txom nco qab thiab tuaj yeem nqos cov ntsiav tshuaj, nws tau muab sucrose, dextrose, piam thaj lossis tsuas yog cov khoom noj qab zib (tsis muaj khoom qab zib).

Hauv cov neeg mob tsis nco qab lawm, cov tshuaj tau muab tshuaj rau txoj leeg (40% dextrose) lossis intramuscularly (1-2 g ntawm glucagon). Tom qab rov nco qab, tus neeg raug tsim txom yuav tsum tau muab cov roj sai sai rau txoj kev tiv thaiv kom tsis txhob rov huam mob.

Dosage daim ntawv

Cov tshuaj noj hauv qhov ncauj hauv cov khw muag tshuaj tuaj yeem nqus tau hauv daim ntawv ncoo. Nws yog tsim tawm ua ob hom: Glidiab zoo tib yam (6 daim hlau ntawm 10 pcs. Ib pob) thiab Glidiab MV, ua cim los ntawm kev hloov pauv ntawm cov tshuaj nquag (3 lossis 6 daim hlau ntawm 10 pcs. Hauv ib lub thawv).

Ntawm kev yooj yim Glidiab tus nqi yog pheej yig heev - 106-136 rubles. rau 60 ntsiav tshuaj ntawm 80 mg. Ntawm Glidiab MV, tus nqi hauv khw muag tshuaj hauv online yog me ntsis siab dua: 160-166 rubles. rau 60 ntsiav tshuaj ntawm 30 mg.

Cov cai cia

Glidiab tsis tas yuav muaj cov xwm txheej tshwj xeeb. Cov khoom pabcuam xub thawj yuav tsum muab tso kom deb ntawm qhov chaw noo, ntxig hluav taws xob ultraviolet thiab saib xyuas ntawm menyuam yaus, tsiaj thiab cov neeg xiam oob khab. Kev ntsuas kub thiab txias - txog 25 ° С. Cov ntsiav tshuaj siv nyob rau hauv lub sijhawm tas sijhawm: 4 xyoos rau cov tshuaj Glidiab thiab 1 xyoo rau nws qhov hloov kho ntawm Glidiab MV. Thaum kawg ntawm lub sijhawm tas sijhawm teem los ntawm cov kws tsim khoom, cov tshuaj yuav tsum tau muab pov tseg, vim tias nws cov haujlwm tau txo, thiab tus lej ntawm cov kev mob tshwm sim yog loj zuj zus.

Cov Txhais Lus thiab cov duab ntawm Glidiab

Cov tshuaj qub yog Gliclazide nrog tib yam tshuaj muaj sia, txhua tus so yog generics. Glidiab hauv qeb duas yog suav tias yog qhov ua tau zoo tshaj plaws. Raws li cov khoom siv sib xyaw (gliclazide) thiab cov pab pawg (cov tshuaj tiv thaiv kab mob hauv qhov ncauj), cov analogues nrog Glidiab yog tib yam: Gliclazide, Diagnizid, Diatika, Diabinax, Diabefarm, Diabresid, Diabetalong, Glioral, Predian, Gliclada, Glucostabil, Diabeton, Diabon Panmicron, Gluktam, Glisid, Medoklazid.

Ntawm cov analogues uas kev teem caij yog tib yam (hom 2 ntshav qab zib), feem ntau nrov yog: Lymphomyozot, Januvia, Multisorb, Bagomet, Glemaz, Metamin, Baeta, Apidra, Glyurenorm, Formmetin, Glyukobay, Novoformin, Levemir Flekspen, Formin, Levemir Penfill, Avavia, Pioglar.

Cov lus pom zoo ntxiv

Qhov tshwm sim ntawm kev kho mob nrog Glidiab yuav ua rau qis dua yam tsis muaj kev hloov kho rau tus mob ntshav qab zib lub neej: kev noj haus cov zaub mov tsis zoo rau lub cev, kev tawm dag zog lub cev kom txaus, tswj lub xeev psychoemotional, ua raws li kev pw tsaug zog thiab so.

Nws yog ib qho tseem ceeb uas yuav tsum tau saib xyuas koj cov glycemic profile tas li los ntawm kev txheeb xyuas qib hauv cov suab thaj hauv tsev thiab hauv chav kuaj.

Nrog glucometer, kev yoo mov glycemia yog saib xyuas ntawm lub plab khoob thaum sawv ntxov, 2 teev tom qab noj mov thiab ua ntej yuav mus pw, nyob rau yav tsaus ntuj.

Cov neeg mob ntshav qab zib tau txais kev sib xyaw ua ke nrog kev npaj tshuaj insulin yuav tsum saib xyuas cov ntshav sib xyaw ua ntej txhua qhov txhaj tshuaj ntawm cov tshuaj hormones. Nws yog ib qho tseem ceeb kom taug qab qhov muaj zog ntawm kev hloov pauv hauv qhov ntsuas thoob plaws ib hnub, nrog rau kev saib xyuas qhov kev nyeem nruab nrab hauv lub hli - los ntawm ib tus kws kho mob qhov kev sab laj mus rau lub rooj sib tham tom ntej.

Yog hais tias tom qab noj cov tshuaj muaj cov kev hnov ​​tshiab - malaise, mob taub hau thiab lwm yam mob, koj yuav tsum qhia rau tus kws kho mob txog qhov tshwm sim ntawm lub cev. Tom qab kuaj xyuas ntxiv, nws yuav txo qhov tsawg lossis hloov cov tshuaj.

Cov tshuaj yog tuaj yeem muaj kev cuam tshuam zoo rau lub cev kev xav. Qhov no tuaj yeem tsim teeb meem thaum tsav tsheb, tsav kev siv lub tshuab ua haujlwm, ua haujlwm ntawm qhov siab thiab lwm yam haujlwm muaj peev xwm txaus ntshai uas yuav tsum muaj kev kub siab.

Yog hais tias Glidiab qhia rau tus niam laus, nws tuaj yeem siv tsuas yog tom qab hloov tus menyuam mus rau kev pub mis.

Glidiab tshuaj xyuas

Olga Valerievna “Kuv yog tus mob ntshav qab zib nrog qhov kev paub dhau los, txog tam sim no kuv tau kws kho mob ntshav qab zib, thiab nws haum kuv zoo kawg nkaus. Cov tshuaj yog lub sijhawm kuaj, muab tawm pub dawb, qab zib yog qhov qub. Lub sijhawm kawg lawv tau sau tawm Glidiab, vim tias tsis muaj neeg mob ntshav qab zib. Lawv tau hais tias cov no yog ntsiav tshuaj ntawm tib pab pawg, tab sis cov tshuaj tus nqi pheej yig dua, yog li kuv tsis ntseeg nws. Kuv tsis paub, tej zaum los ntawm kuv qhov kev ua xyem xyav, tab sis kuv qab zib tau nce los ntawm 6.5 thaum sawv ntxov mus txog 7.3 mmol / L. Kuv yuav nug tus kws kho mob txog kev hloov tshuaj noj. "

Irina “Kuv tau noj Glidiab MV ua ke nrog Glucophage 1000 tau ib xyoos lawm. Thaum sawv ntxov kuv haus ib ntsiav tshuaj (30 mg) thiab mus ua haujlwm. Nws yooj yim heev: koj tsis txhob hnov ​​qab txog lub sijhawm thiab tsis txhob txhawj xeeb txog cov piam thaj txhua hnub, qhov tseem ceeb yog noj rau sijhawm. Tsis muaj kev mob tshwm sim tam sim no, tab sis thaum xub thawj muaj kev rhuav tshem thiab muaj qee qhov kev cuam tshuam ntawm lub plab txhua lub sijhawm. Qhov chaw hauv ib hlis, txhua yam mus nws tus kheej. Glidiab MV khaws suab thaj thaum kuv tsis ua txhaum nrog kev noj zaub mov noj. "

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