TRAGENT - COV LUS QHIA RAU KEV SIV, NQE, XYUAS THIAB ANALOGUES

Send

Trazhenta (npe thoob ntiaj teb Trajenta) yog chav kawm tshiab ntawm kev kho mob tshuaj tiv thaiv kab mob ntshav qab zib. DPP-4 cov tshuaj tiv thaiv nrog lub qhov ncauj ntawm kev tswj hwm tau ua tiav siv los tswj cov ntshav qab zib hom 2;

Cov tshuaj tiv thaiv nquag ntawm cov tshuaj yog linagliptin. Tshwj xeeb yog ris txiaj ntsig rau nws cov txiaj ntsig yog cov neeg mob ntshav qab zib nrog lub raum pathologies, vim tias cov tshuaj tsis tawm tsam ntxiv rau lawv.

Trazhenta - muaj pes tsawg leeg thiab daim ntawv noj tshuaj

Cov chaw tsim khoom, BOEHRINGER INGELHEIM PHARMA (Lub teb chaws Yelemees) thiab BOEHRINGER INGELHEIM ROXANE (USA), tso cov tshuaj ua qauv ntawm convex round liab ntsiav tshuaj. Cov cim ntawm cov chaw tsim tshuaj tiv thaiv cov tshuaj los ntawm fakes yog sau rau ntawm ib sab, thiab cim "D5" tau kos rau sab tod.

Txhua ntawm lawv muaj 5 mg ntawm cov nquag muaj cov khoom xyaw linagliptin thiab ntau yam xws li hmoov txhuv nplej siab, zas xim, hypromellose, magnesium stearate, copovidone, macrogol.

Txhua cov hlwv dej sib xyaw ntim 7 lossis 10 ntsiav tshuaj ntawm cov tshuaj Trazhenta, yees duab uas tuaj yeem pom hauv tshooj no. Hauv lub thawv lawv tuaj yeem yog tus lej sib txawv - los ntawm ob txog yim daim phiaj. Yog tias muaj 10 lub hlwb nrog cov ntsiav tshuaj hauv lub hlwv, ces yuav muaj 3 lub phaj ntim hauv lub thawv.

Kws Tshuaj

Cov peev xwm ntawm cov tshuaj tau muaj kev vam meej tiav vim yog kev thaiv kev ua si ntawm dipeptidyl peptidase (DPP-4). Qhov enzyme no yog kev puas tsuaj

ntawm cov tshuaj hormones HIP thiab GLP-1, uas yog lub luag haujlwm tseem ceeb hauv kev tswj hwm cov piam thaj hauv qab. Lub incretins txhim kho insulin ntau lawm, pab tswj glycemia, thiab inhibit qhov tsis zais ntawm glucagon. Lawv cov haujlwm yog luv-nyob ntev; tom qab, HIP thiab GLP-1 zom cov enzymes. Trazhenta thim rov qab cuam tshuam nrog DPP-4, qhov no tso cai rau koj los tswj kev noj qab haus huv ntawm incretins thiab txawm tias nce qib lawv.

Lub tshuab ntawm cawv ntawm Trazhenty yog zoo ib yam li cov qauv ntawm kev ua haujlwm ntawm lwm yam tshuaj tiv thaiv - Januvius, Galvus, Ongliza. HIP thiab GLP-1 yog tsim thaum khoom noj khoom haus nkag mus rau hauv lub cev. Qhov ua tau zoo ntawm cov tshuaj tsis cuam tshuam nrog kev tsa ntawm lawv cov ntau lawm, cov tshuaj tsuas yog nce lub sijhawm ntawm lawv kis. Vim tias cov xeeb ceem no, Trazhenta, zoo li lwm yam nce ntxiv, tsis cuam tshuam kev txhim kho ntawm cov ntshav qab zib thiab qhov no yog qhov tseem ceeb dua lwm cov chav kawm ntawm cov tshuaj tiv thaiv hypoglycemic.

Yog tias cov piam thaj hauv cov ntshav qab zib tsis txaus, ntau zog yuav pab ntxiv cov tshuaj endogenous insulin los ntawm β-hlwb. Qhov tshuaj hormones GLP-1, uas muaj cov npe tseem ceeb ntau dua piv rau GUI, txwv cov khoom ntawm glucagon hauv cov qog hlwb. Tag nrho cov txheej txheem no pab kom ruaj khov kho glycemia nyob rau hauv qib kom zoo - kom txo qis glycosylated hemoglobin, yoo cov suab thaj thiab ntshav qab zib tom qab kev qoj ib ce nrog ob-teev sib nrug. Hauv kev kho ua ke nrog metformin thiab sulfonylurea kev npaj, glycemic tsis txhim kho yam tsis muaj qhov hnyav hnyav.

Nws yog ib qho tseem ceeb tias linagliptin tsis ua rau muaj kev pheej hmoo mob plawv (qhov ntxim nyiam ntawm lub plawv nres nrog lub txiaj ntsig tuag).

Cov Tshuaj Pharmacokinetics

Tom qab nkag mus rau hauv lub plab zom mov, cov tshuaj tau nrawm nrawm, Cmax muaj kev pom tom qab ib teev thiab ib nrab. Qhov kev txiav txim siab poob qis ua ob ntu.

Kev siv cov ntsiav tshuaj nrog zaub mov noj lossis cais ntawm tus kws kho mob ntawm cov tshuaj tsis muaj kev cuam tshuam. Lub bioavailability ntawm cov tshuaj yog li 30%. Qhov feem pua me me yog metabolized, 5% ua tawm los ntawm lub raum, 85% nrog quav ua quav. Ib qho kab ke ntawm lub raum tsis tas yuav tshem tshuaj lossis hloov koob tshuaj. Cov yam ntxwv ntawm pharmacokinetics thaum yau tseem tsis tau kawm.

Yog leej twg noj tshuaj rau

Kev siv tshuaj yog tus kws kho mob thawj zaug los sis ua ke nrog lwm cov tshuaj txo suab thaj.

Tshuaj Kho Mob. Yog tias tus mob ntshav qab zib tsis kam ua cov tshuaj ntawm cov chav kawm ntawm bigudins xws li metformin (piv txwv li, nrog lub raum pathologies lossis tus neeg tsis haum rau nws cov khoom siv), thiab kev hloov kho hauv lub neej tsis coj cov txiaj ntsig xav tau.
Ob-tivthaiv Circuit Court. Trazent yog tshuaj ua ke nrog sulfonylurea npaj, metformin, thiazolidinediones. Yog tias tus neeg mob tau tshuaj insulin, incretinomimetic tuaj yeem pab ntxiv nws.
Peb-tivthaiv xaiv. Yog tias qhov kev kho mob dhau los ua tsis tau zoo, Trazhenta ua ke nrog cov tshuaj insulin thiab qee yam tshuaj tiv thaiv kab mob uas muaj kev sib txawv ntawm cov tshuaj.

Uas tsis tau muab rau Trazhent

Linagliptin yog contraindicated rau cov pawg ntawm cov ntshav qab zib:

Ntshav Qab Zib Hom 1;
Ketoacidosis provoked los ntawm ntshav qab zib;
Cev xeeb tub thiab lactating;
Cov menyuam yaus thiab cov hluas;
Kev ua haujlwm tsis haum xeeb rau cov khoom xyaw ntawm cov mis.

2 hnub ua ntej kev phais mob, ntshav qab zib tau tshais tawm los ntawm cov tshuaj tiv thaiv kab mob rau qhov ncauj mus rau insulin, qhov kev txhaj tshuaj raug muab tso tseg 2 hnub tom qab ua haujlwm tiav

Yam tsis tau xav txog

Ntawm keeb kwm ntawm kev noj cov tshuaj linagliptin, cov kev mob tshwm sim tuaj yeem tsim:

Nasopharyngitis (kab mob uas kis rau lub neej);
Caj dab tsis zoo;
Kev ua haujlwm tsis zoo;
Kev mob caj dab
Kev nce hauv triglycerol (thaum ua ke nrog sulfonylurea chav tshuaj);
Nce LDL cov nuj nqis (nrog rau kev tswj hwm ntawm pioglitazone);
Kev hnyav lub cev;
Cov tsos mob hypoglycemic (tawm tsam keeb kwm yav dhau los ntawm ob - thiab peb-txheej kev kho).

Qhov ntau zaus thiab cov lej ntawm cov nyom uas tshwm sim tom qab siv Trazhenta zoo ib yam li cov tshuaj tiv thaiv tom qab siv cov placebo. Feem ntau, cov kev mob tshwm sim rau hauv triple txoj kev kho ntawm Trazhenta nrog metformin thiab sulfonylurea derivatives.

Cov tshuaj yuav ua rau muaj kev sib koom tes tsis sib haum, qhov no tseem ceeb uas yuav tau xav txog thaum tsav tsheb thiab cov txheej txheem nyuaj.

Noj ntau dhau

Cov neeg koom tau muab 120 ntsiav tshuaj (600 mg) ib zaug. Ib qho kev noj qab haus huv ib zaug tsis muaj kev cuam tshuam txog kev noj qab haus huv ntawm cov neeg ua haujlwm pab dawb los ntawm cov pab pawg noj qab haus huv. Ntawm cov neeg mob ntshav qab zib, kev haus dej cawv ntau dhau tsis tau sau tseg los ntawm kev kho mob. Thiab tsis tas li, yog tias muaj xwm txheej los yog txhob txwm siv ntau lub koob tshuaj tib lub sijhawm, tus neeg mob yuav tsum yaug lub plab thiab cov hnyuv kom tshem tawm ib feem ntawm qhov tsis noj tshuaj, muab sorbents thiab lwm yam tshuaj raws li cov tsos mob, qhia tus kws kho mob.

Yuav ua li cas thiaj yuav siv cov tshuaj

Ua raws li cov lus qhia rau kev siv yuav tsum tau noj peb zaug ib hnub, 1 ntsiav tshuaj (5 mg). Yog tias cov tshuaj siv rau hauv cov kev kho mob hauv kev sib xyaw nrog cov tshuaj metformin, tom qab ntawd cov tshuaj ntawm qhov kawg yog tswj tau.

Tus mob ntshav qab zib nrog lub raum lossis hepatic tsis txaus tsis xav tau kev hloov kho koob. Cov cai tsis txawv rau cov neeg mob hnub nyoog tiav. Hauv senile (los ntawm 80 xyoo) hnub nyoog, Trazhent tsis raug tshuaj vim tsis muaj kev soj ntsuam hauv cov kws muaj hnub nyoog no.

Yog tias lub sijhawm noj tshuaj tsis zoo, koj yuav tsum haus ib lub ntsiav tshuaj sai li sai tau. Nws yog tsis yooj yim sua ob npaug rau cov cai. Kev siv cov tshuaj tsis khi rau lub sijhawm noj mov.

Cawv ntawm trazhenti rau cev xeeb tub thiab lactation

Cov txiaj ntsig ntawm kev siv tshuaj los ntawm cov poj niam cev xeeb tub tsis tau luam tawm. Txog tam sim no, cov kev tshawb fawb tau tsuas yog ua los ntawm cov tsiaj, thiab tsis muaj cov tsos mob ntawm kev muaj me nyuam muaj mob lom. Thiab tsis tau, thaum cev xeeb tub, cov poj niam tsis tau sau tshuaj siv.

Hauv kev sim coj cov tsiaj, nws pom tias cov tshuaj muaj peev xwm nkag mus rau leej niam cov kua mis ntawm tus poj niam. Yog li no, thaum lub sijhawm pub mis rau poj niam, Trazhent tsis yog yam tshuaj. Yog tias lub xeev kev noj qab haus huv xav tau cov kev kho mob, tus menyuam pauv mus rau khoom noj khoom haus khoom neeg tsim.

Cov kev sim rau kev cuam tshuam ntawm cov tshuaj ntawm kev muaj peev xwm xeeb tub hauv tus menyuam tsis tau ua tiav. Cov kev sim zoo sib xws ntawm cov tsiaj tsis qhia txog kev phom sij ntawm sab no.

Yeeb tshuaj sib cuam tshuam

Kev siv ib txhij ntawm Trazhenta thiab Metformin, txawm tias cov koob tshuaj ntau dua li cov qauv, tsis ua rau muaj qhov sib txawv tseem ceeb hauv cov khw muag tshuaj ntawm cov tshuaj.

Kev siv tam sim no ntawm Pioglitazone kuj tsis hloov pauv ntawm pharmacokinetic peev ntawm ob qho tshuaj.

Cov kev kho mob nyuaj nrog Glibenclamide tsis txaus ntshai rau Trazhenta, rau tom kawg, Cmax qis me ntsis (los ntawm 14%).

Qhov tshwm sim zoo sib xws hauv kev sib cuam tshuam yog qhia los ntawm lwm cov tshuaj ntawm chav kawm sulfonylurea.

Kev sib xyaw ntawm ritonavir + linagliptin nce Cmax los ntawm 3 zaug, cov kev hloov pauv no tsis tas yuav tshuaj kho kom haum.

Sib xyaw nrog Rifampicin provoke ib qho kev txo qis hauv Cmax Trazenti. Qee feem, cov chaw kuaj mob tau khaws cia, tab sis cov tshuaj tsis ua haujlwm 100%.

Nws tsis yog qhov txaus ntshai tias yuav sau Digoxin tib lub sijhawm li lynagliptin: lub chaw muag tshuaj ntawm ob qho tshuaj tsis hloov.

Trazhent tsis cuam tshuam rau lub peev xwm ntawm Varfavin.

Cov kev hloov pauv me tau pom nrog txoj kev siv sib txig sib xyaw ntawm linagliptin nrog simvastatin, tab sis kev hloov zuj zus tsis cuam tshuam loj heev rau nws tus yam ntxwv.

Tawm tsam keeb kwm ntawm kev kho mob nrog Trazhenta, tshuaj tiv thaiv qhov ncauj tuaj yeem siv dawb do.

Cov lus pom zoo ntxiv

Kev siv tshuaj tsis zoo yog siv rau kev mob ntshav qab zib hom 1 thiab rau ketoacidosis, uas yog ib qho mob ntshav qab zib.

Qhov tshwm sim ntawm hypoglycemic qhov xwm txheej tom qab kho nrog linagliptin, siv los kho mob monotherapy, yog qhov txaus rau tus lej ntawm cov mob no nrog cov placebo.

Cov kev sim tshuaj tau pom tias qhov ntau zaus ntawm kev tshwm sim ntawm kev mob ntshav qab zib thaum siv Trezhenta hauv kev sib xyaw ua ke tsis suav nrog, vim tias qhov mob tseem ceeb tsis ua rau linagliptin, tab sis metformin thiab tshuaj ntawm thiazolidinedione pab pawg.

Kev ceev faj yuav tsum tau pom thaum teem caij Trazhenta ua ke nrog kev siv tshuaj ntawm sulfonylurea chav kawm ntawv, vim lawv ua rau hypoglycemia. Hauv kev pheej hmoo siab, nws yog ib qhov tsim nyog yuav tau kho cov tshuaj ntau npaum li cas ntawm sulfonylurea pawg.

Linagliptin tsis cuam tshuam qhov tshwm sim ntawm kev txhim kho pathologies ntawm lub plawv thiab cov hlab ntshav.

Hauv kev kho ua ke, Trazhent yuav siv tau txawm tias muaj qhov ua rau lub raum tsis zoo ua haujlwm.

Hauv cov neeg mob ntawm cov neeg laus (ntau dua 70 xyoo), Trezenta kho tau pom tias HbA1c zoo: qhov pib glycosylated hemoglobin yog 7.8%, zaum kawg - 7.2%.

Cov tshuaj tsis ua rau muaj kev cuam tshuam txog kev mob plawv hauv lub plawv ntau dua. Thawj qhov kawg ntawm lub cev muaj pes tsawg zaus thiab lub sijhawm tshwm sim ntawm kev tuag, lub plawv nres, mob hlab ntsha tawg, mob qog ntshav siab tsis txaus uas yuav tsum tau mus pw hauv tsev kho mob, cov neeg mob ntshav qab zib uas tau coj linagliptin tsawg dua thiab tom qab tshaj cov neeg pab dawb hauv pawg tswj hwm uas tau txais cov tshuaj placebo lossis kev sib piv cov tshuaj.

Qee qhov xwm txheej, kev siv cov linagliptin ua rau muaj kev tawm tsam ntawm kev mob taub hau sai.

Yog tias muaj cov cim ntawm nws (mob hnyav rau hauv lub phaus mob, mob plab tsis txaus, ua kom tsis muaj zog), cov tshuaj yuav tsum nres thiab sab laj nrog koj tus kws kho mob.

Kev kawm txog kev cuam tshuam ntawm Trazhenta ntawm kev muaj peev xwm tsav tsheb thiab cov cuab yeej siv tsis yooj yim tsis tau ua, tab sis vim muaj kev cuam tshuam tsis zoo, siv cov tshuaj yog tias tsim nyog, muaj qhov kub siab ntawm kev saib xyuas thiab cov tshuaj tiv thaiv sai sai nrog ceev faj.

Kev ntsuas thiab tus nqi ntawm cov tshuaj

Rau cov tshuaj Trazhenta, tus nqi yog li ntawm 1500-1800 rubles rau 30 ntsiav tshuaj nrog qhov ntau npaum ntawm 5 mg. Cov tshuaj kws kho mob muab tawm.

Cov tshuaj tawm qauv ntawm tib chav kawm ntawm DPP-4 inhibitors muaj xws li Januvia raws li synagliptin, Onglizu raws li saxagliptin thiab Galvus nrog lub vildagliptin uas nquag ua haujlwm. Cov tshuaj no sib phim nrog ATX qib 4 tus lej.

Ib qho kev cuam tshuam zoo sib xws yog siv cov tshuaj Sitagliptin, Alogliptin, Saksagliptin, Vildagliptin.

Tsis muaj cov kev cai tshwj xeeb rau kev khaws cia ntawm Trazenti hauv cov lus qhia. Rau peb lub xyoo (raws li lub sijhawm tas sijhawm), cov ntsiav tshuaj yog khaws cia hauv chav kub (txog +25 degrees) hauv qhov chaw tsaus uas tsis muaj menyuam nkag mus. Cov tshuaj uas tas sij hawm tuaj yeem siv tsis tau, lawv yuav tsum muab pov tseg.

Tus mob ntshav qab zib thiab kws kho mob hais txog Trazhent

Cov hauj lwm siab ntawm Trazenti hauv ntau cov kev sib txuas tau paub tseeb los ntawm kev tshawb fawb thoob ntiaj teb thiab kev kho mob. Endocrinologist nyiam siv linagliptin ua thawj cov tshuaj lossis hauv kev kho ua ke. Nrog ib qho kev nyiam ntawm cov ntshav qog ntshav qab zib (kev tawm dag lub cev hnyav, khoom noj tsis zoo), es tsis txhob sulfonylurea cov tshuaj hauv chav kawm, lawv raug kho rau Trazent, muaj kev tshuaj xyuas txog cov tshuaj ntawm cov tshuaj rau insulin tsis kam thiab rog dhau. Ntau tus neeg mob ntshav qab zib tau txais cov tshuaj ua ib feem ntawm txoj kev kho mob nyuaj, yog li nws tsis yooj yim los soj ntsuam nws cov txiaj ntsig, tab sis feem ntau, txhua tus neeg zoo siab nrog qhov tshwm sim.

Alina, Ryazan, 32 xyoo “Kuv tau haus Trazhent tau ib hlis. Kuv tuaj rau hauv cov ntsiav tshuaj no tom qab kev sim ntev ntev thiab tsis ua tiav nrog kev noj qab haus huv. Tom qab yug menyuam tas, kuv tau hnyav ntau. Rau lub hlis tom qab, kuv lub zais zis tau tshem tawm thiab kev noj haus tau raug txwv. Yav dhau los, Kuv yuav tau tam sim ntawd poob ceeb thawj rau cov zaub mov zoo li ntawd, tab sis tom qab ntawd kuv tau zoo tu, txawm tias kuv tus menyuam nyob tsis tswm. Tus kws kho mob tau qhia tias kuv kos cov piam thaj. Tom qab kuaj ntshav qabzib qhia tau cov tshuaj insulin kuj. Tus kws endocrinologist tau hais tias nrog kev tshuaj xyuas no nws tsis zoo rau kev tsim txom koj tus kheej nrog kev tshaib plab, thiab xaiv tsa Trazhent. Rau ib hlis, nrog rau kev yoo mov thiab tshuaj noj, Kuv poob 4 kg. Qhov no yog qhov txiaj ntsig zoo rau kuv. Yog li kuv xav kom txhua tus uas muaj teebmeem kev nyhav dhau heev yog pib los ntawm kev sim, tsis noj zaubmov. "

Tatyana, Belgorod “Kuv tus txiv muaj teeb meem sib thooj. Tom qab qhov kev huam yuaj, nws pw nrog lub ntsej muag ntev ntev nrog tus ceg tsis zoo, tom qab ntawd taug kev saum tus pas nrig. Thaum lub thauj tau tsawg heev, Kuv nce 32 kg ntawm qhov hnyav dua. Sai li nws tau zoo, nws pib tawm tsam rog, tab sis tsis muaj qhov to taub. Tus kws endocrinologist tau tiv toj kawg. Ua tsaug rau Vajtswv, nws tsis muaj ntshav qab zib, tab sis keeb kwm keeb kwm yav dhau los yog qhov uas tsawg kawg ib zaub noj nws rau qhov poob phaus. Kev huam yuaj, tshuaj, hloov pauv ntawm ib txwm nyob hauv lub neej - txhua tus tau ua lub luag haujlwm. Nws pib noj Trazhenta thiab mus rau hauv lub chaw qoj ib ce. Qhov hnyav pib tawm - 15 kg hauv 2 lub hlis. Lawv hais tias nws tsis tuaj yeem ua kom poob ceeb thawj, tab sis nws tsis tuaj yeem nrog nws nyob tau. Nws yog qhov zoo uas peb muaj lub sijhawm kho: tus nqi ntawm Trazhenta tom, nrog kev lees paub tsis tu ncua, Kuv yuav tsum khaws cov nyiaj sib piv. "

Anatoly Ivanovich, 55 xyoo, Naberezhnye Chelny "Kuv haus ntshav qab zib thaum sawv ntxov, thiab Trazhenta cov ntsiav tshuaj thaum tsaus ntuj. Qab zib yog nyob hauv thaj tsam ntawm 6 txog 8 mmol / L. Rau cov muaj ntshav qab zib ua tau ntev, qhov no ua tau zoo. Thaum noj Diabeton ib leeg, glycated hemoglobin yog 9.2%, thiab tam sim no 6.5%. Kuv kuj muaj pyelonephritis, tab sis cov tshuaj ua maj mam rau ntawm lub raum. Tus nqi, ntawm chav kawm, tsis yog rau cov nyiaj laus, tab sis cov ntsiav tshuaj tsim nyog lawv cov nyiaj. "

Nina Petrovna, 67 xyoo, Voskresensk "Thaum sawv ntxov kuv haus ib ntsiav tshuaj ntawm Trazhenta thiab ib hnub ob zaug - Glucofage. Kuv tau siv kuv lub sijhawm teem tshiab rau 4 lub hlis, Kuv tau siv Siofor, thiab txhua yam haum kuv kom txog rau theem ntawm creatinine thiab urea hauv kev kuaj ntshav tau nce, thiab hauv cov zis - protein. Tus kws kho mob endocrinologist tau hais tias tiv thaiv keeb kwm ntawm ntshav qab zib, kuv txhim kho kev tsis txaus ntseeg - nephropathy. Nws muab tshuaj rau ib ntsiav tshuaj mus rau Trazent. Yooj yim heev - Kuv haus dej thaum sawv ntxov thiab tsis xav txog kev kho mob txhua hnub. Kuv xav tias zoo, tab sis qhov tseem ceeb tshaj plaws yog tias qhov kev ntsuas tau zoo tuaj thiab tsis muaj kev phiv, Kuv txawm poob ib qho kev hnyav me me. "

DPP-4 cov tshuaj tiv thaiv kab mob, uas Trazhenta belongs, yog qhov txawv tsis yog los ntawm kev muaj peev xwm tiv thaiv tsis tau, tab sis kuj los ntawm kev muaj kev nyab xeeb ntau ntxiv, vim tias lawv tsis ua rau cov nyhuv hypoglycemic, tsis pab txhawb rau qhov hnyav nce, thiab tsis txhob ua kom lub raum tsis ua haujlwm. Txog hnub no, cov hom tshuaj no suav hais tias yog ib qho muaj peev xwm tshaj plaws rau kev tswj hwm ntawm tus mob ntshav qab zib hom 2.

Send