Glurenorm yog tshuaj uas muaj qhov cuam tshuam hypoglycemic. Ntshav qab zib Hom 2 yog ib qho tseem ceeb heev rau kev kho mob vim nws qhov muaj ntau tshaj thiab ntau yam ntxiv muaj qhov tsis zoo. Txawm hais tias muaj jumps me me hauv cov piam thaj hauv siab, qhov ntxim nyiam ntawm retinopathy, lub plawv nres lossis mob hlab ntsha tawg yog nce ntxiv.
Glurenorm yog ib qho tsawg tshaj plaws txaus ntshai tej kev phiv los ntawm cov neeg sawv cev antiglycemic, tab sis nws tsis qis qis dua rau qhov ua tau zoo rau lwm cov tshuaj hauv pawg no.
Kws Tshuaj
Glurenorm yog ib tus neeg sawv cev hypoglycemic coj noj ntawm qhov ncauj. Cov tshuaj no yog sulfonylurea derivative. Nws muaj pancreatic nrog rau kev ua yeeb yaj kiab ntxiv. Nws txhim kho kev tsim tawm cov tshuaj insulin los ntawm kev cuam tshuam cov piam thaj hauv kev sib txuas ntawm cov tshuaj no.
Cov nyhuv hypoglycemic tshwm sim tom qab 1.5 teev tom qab kev tswj hwm tshuaj sab hauv, qhov siab ntawm cov nyhuv no tshwm sim tom qab ob rau peb teev, kav ntev li 10 teev.
Cov Tshuaj Pharmacokinetics
Tom qab noj ib qho tshuaj nyob rau sab hauv, Glyurenorm yog nqus tau sai heev thiab yuav luag tag nrho (80-95%) los ntawm cov hnyuv los ntawm kev nqus.
Cov tshuaj nquag - glycidone, muaj kev sib txuam zoo rau cov protein nyob hauv ntshav ntshav (tshaj li 99%). Tsis muaj ntaub ntawv qhia txog kev hla lossis hla ntawm qhov tso tawm ntawm cov tshuaj no lossis nws cov khoom lag luam metabolic rau ntawm BBB lossis ntawm lub tsho me nyuam, nrog rau kev tso tawm ntawm glycvidone mus rau hauv cov mis ntawm lub tsev laus thaum pub mis.
Feem ntau cov khoom siv glycidone metabolism tawm hauv lub cev, ua rau dhau ntawm txoj hnyuv. Ib feem me me ntawm cov khoom tawg tsis sib xws ntawm cov khoom tawm los ntawm lub raum.
Cov kev tshawb fawb pom tau tias tom qab kev tswj hwm sab hauv, kwv yees li ntawm 86% ntawm cov tshuaj isotope uas muaj tshuaj yog tso tawm los ntawm txoj hnyuv. Tsis hais txog qhov loj npaum li cas ntawm cov koob tshuaj thiab cov txheej txheem ntawm kev tswj hwm los ntawm ob lub raum, kwv yees li 5% (nyob rau hauv daim ntawv ntawm cov khoom lag luam metabolic) ntawm cov tshuaj uas lees txais yuav raug tso tawm. Cov theem ntawm cov tshuaj tso tawm los ntawm ob lub raum tseem nyob rau qhov tsawg kawg nkaus, txawm tias siv sijhawm tsis tu ncua.
Qhov taw qhia ntawm pharmacokinetics ua ke nrog cov laus thiab cov neeg mob hnub nyoog nruab nrab.
Ntau tshaj 50% ntawm glycidone raug tso tawm los ntawm txoj hnyuv. Raws li qee cov ntaub ntawv, cov tshuaj metabolism hauv lub cev tsis hloov pauv txhua txoj kev yog tias tus neeg mob lub raum tsis ua haujlwm. Txij li glycidone tawm hauv lub cev los ntawm ob lub raum mus rau ib qho tsawg heev, hauv cov neeg mob uas lub raum tsis ua haujlwm, cov tshuaj tsis txuam hauv lub cev.
Cov Khoom Qhia
Ntshav qab zib Hom 2 nyob rau nruab nrab thiab hnub nyoog laus.
Cov Yuav Tsum Muaj
- Yam 1 ntshav qab zib
- Ntshav qab zib mob ntsig txog acidosis;
- Mob plab zom mov coma
- Tsis muaj daim siab ua haujlwm hauv qhov hnyav;
- Ib yam kab mob kis;
- Hnub nyoog qis dua 18 xyoo (vim tias tsis muaj ntaub ntawv hais txog kev nyab xeeb ntawm Glyurenorm rau pawg neeg mob no);
- Cov tib neeg lub cev muaj qhov tso tshuaj sulfonamide.
Ntxiv kev ceev faj yog yuav tsum tau thaum noj Glyurenorm nyob ib puag ncig pathologies hauv qab no:
- Ua npaws
- Mob qog;
- Kev haus cawv mus ntev
Koob tshuaj
Glurenorm yog npaj rau kev siv sab hauv. Yuav tsum ua raws li cov kev kho mob hais txog kev noj thiab kev noj haus. Koj tsis tuaj yeem txwv qhov kev siv Glyurenorm yam tsis tau sab laj nrog koj tus kws kho mob.
Thawj zaug tshuaj yog ib nrab tshuaj noj nrog pluas tshais.
Glurenorm yuav tsum tau noj nyob rau theem pib ntawm kev tau txais zaub mov.
Tsis txhob hla khoom noj tom qab noj cov tshuaj.
Thaum noj ib nrab ntawm cov ntsiav tshuaj tsis ua hauj lwm zoo, koj yuav tsum tau sab laj nrog kws kho mob uas, feem ntau, yuav maj mam nce qhov ntau ntxiv.
Thaum hais txog kev muab tshuaj ntau dua li cov kev txwv saum toj saud, ib qho txiaj ntsig ntxiv tuaj yeem ua tiav yog tias qhov faib ib koob tshuaj txhua hnub ua ob lossis peb koob tshuaj. Qhov loj tshaj plaws hauv qhov no yuav tsum tau noj thaum noj tshais. Kev nce ntxiv rau koob rau plaub lossis ntau daim ntawv sau tauj ib hnub, raws li txoj cai, tsis ua rau muaj kev nce siab hauv kev ua haujlwm.
Qhov siab tshaj plaws hauv ib hnub yog plaub ntsiav tshuaj.
Rau cov neeg mob uas lub raum tsis ua hauj lwm zoo
Kwv yees li 5 feem pua ntawm Glurenorm cov khoom lag luam metabolic tawm hauv lub cev los ntawm lub raum. Yog tias tus neeg mob lub raum tsis ua haujlwm, tsis tas yuav hloov kho koob.
Rau cov neeg mob uas muaj mob hepatic
Thaum siv cov tshuaj hauv koob tshuaj ntau dua li 75 mg rau cov neeg mob uas ua rau mob tsis haum xeeb, kev saib xyuas los ntawm tus kws kho mob yog qhov tsim nyog. Glurenorm yuav tsum tsis txhob noj nrog qhov muaj mob hepatic hnyav, vim 95 feem pua ntawm cov tshuaj yog ua tiav hauv lub siab thiab tawm hauv lub cev los ntawm cov hnyuv.
Kev sib txuas ua ke
Thaum tsis tshua muaj txiaj ntsig ntawm kev siv Glyurenorm yam tsis muaj kev sib txuas nrog lwm cov tshuaj, tsuas yog kev coj ntawm metmorphine raws li ib tus neeg sawv cev ntxiv yog qhia.
Sab sij huam
- Kev mob ntshav qab zib: hypoglycemia;
- CNS: nce tsaug zog, mob taub hau, mob nkees feem ntau, kab mob pob txha;
- Lub plawv: hypotension;
- Lub plab zom mov: tsis nco qab, ntuav, raws plab, tsis xis nyob hauv plab, cholestasis.
Noj ntau dhau
Qhov tshwm sim: nce hws, tshaib plab, mob taub hau, txob taus, insomnia, tsaus muag.
Kev Kho Mob: yog tias muaj cov ntshav qabzib (hypoglycemia), yuav tsum muaj ntshav qabzib sab hauv lossis cov khoom muaj cov carbohydrates ntau. Hauv cov ntshav qog ntshav hnyav (nrog mob tsaus muag lossis hnov qab), kev saib xyuas ntawm dextrose yog qhov tsim nyog.
Kev sib txuam ntawm Pharmacological
Glurenorm tuaj yeem txhim kho qhov ua haujlwm hypoglycemic yog tias nws tau noj nrog rau ACE inhibitors, allopurinol, tshuaj tua kab mob, chloramphenicol, clofibrate, clarithromycin, sulfanilamides, sulfinpyrazone, tetracyclines, cyclophosphamides noj ntawm qhov ncauj los ntawm cov tshuaj hypoglycemic.
Tej zaum yuav muaj qhov kev ua kom tsis muaj zog ntawm hypoglycemic piv rau cov thawj coj ntawm glycidone nrog aminoglutethimide, sympathomimetics, glucagon, thiazide diuretics, phenothiazine, diazoxide, thiab cov tshuaj uas muaj cov tshuaj nicotinic.
Cov lus qhia tshwj xeeb
Cov neeg mob ntshav qab zib yuav tsum ua raws nraim li cov lus qhia ntawm tus kws kho mob saib xyuas. Nws yog qhov yuav tsum tau ua kom zoo tshaj plaws los saib xyuas tus mob thaum xaiv cov koob lossis hloov mus rau Glyrenorm los ntawm lwm tus neeg sawv cev uas tseem muaj cov nyhuv hypoglycemic.
Cov tshuaj uas muaj cov nyhuv hypoglycemic, noj ntawm qhov ncauj, tsis muaj peev xwm ua qhov hloov tag rau kev noj zaub mov noj uas tso cai rau koj los tswj tus neeg mob lub cev qhov hnyav. Vim tias tsis noj zaub mov los yog ua txhaum cov kws kho mob cov tshuaj yuav ua rau cov ntshav qabzib poob, ua rau tsaus muag. Yog tias koj noj tshuaj ua ntej noj mov, es tsis txhob noj thaum pib noj mov, cov nyhuv ntawm Glyrenorm ntawm cov ntshav qabzib muaj zog dua, yog li, qhov ntxim nyiam ntawm lub qog ntshav nce siab.
Yog tias pom muaj cov ntshav qog ntshav qab zib, yuav tsum tau noj cov zaub mov sai sai uas muaj cov piam thaj ntau. Yog tias cov ntshav qog ntshav qab zib tseem nyob, txawm tias tom qab qhov no koj yuav tsum nrhiav kev pab kho mob sai.
Vim yog kev ntxhov siab ntawm lub cev, cov nyhuv hypoglycemic yuav nce ntxiv.
Vim yog haus dej cawv, qhov nce lossis txo qis hauv cov nyhuv hypoglycemic yuav tshwm sim.
Glyurenorm ntsiav tshuaj muaj lactose hauv ib qho npaum li 134.6 mg. Cov tshuaj no yog contraindicated rau cov neeg kev txom nyem los ntawm qee cov keeb kwm kab mob.
Glycvidone yog sulfonylurea derivative, ua haujlwm los ntawm qhov kev txiav txim siab luv luv, vim tias nws siv los ntawm cov neeg mob ntshav qab zib hom 2 thiab muaj qhov yuav ua rau muaj ntshav qab zib tsawg.
Txais tos ntawm Glyurenorm los ntawm cov neeg mob uas mob ntshav qab zib hom 2 thiab mob siab ua ib txwm muaj kev nyab xeeb. Qhov tshwj xeeb tsuas yog ua kom qeeb qeeb ntawm kev siv cov khoom tsis muaj glycidone metabolism hauv cov neeg mob ntawm cov qeb no. Tab sis nyob rau hauv cov neeg mob uas tsis muaj peev xwm ua rau hepatic, cov tshuaj no yog qhov tsis xav noj.
Cov kev sim tau pom tias kev siv Glyurenorm rau ib thiab ib nrab thiab tsib xyoos tsis ua rau nce hauv lub cev hnyav, txawm tias qhov hnyav me me hauv lub cev hnyav tuaj yeem ua tau. Kev tshawb fawb sib piv ntawm Glurenorm nrog rau lwm cov tshuaj, uas yog neeg mob ntawm sulfonylureas, qhia txog qhov tsis muaj qhov hnyav pauv hauv cov neeg mob uas siv cov tshuaj no ntau dua ib xyoos.
Tsis muaj xov xwm qhia txog cov nyhuv ntawm Glurenorm ntawm lub peev xwm los tsav tsheb. Tab sis tus neeg mob yuav tsum ceeb toom qhia txog cov cim yuav ua tau kom muaj ntshav qab zib tsawg. Tag nrho cov kev tshwm sim no tuaj yeem tshwm sim thaum kho nrog cov tshuaj no. Ceev faj yuav tsum muaj thaum tsav tsheb.
Cev xeeb tub, pub niam mis
Tsis muaj cov ntaub ntawv qhia txog kev siv Glenrenorm los ntawm cov poj niam lub sijhawm cev xeeb tub thiab lactation.
Nws tsis paub meej tias glycidone thiab nws cov khoom lag luam metabolic nkag mus rau hauv niam mis. Cov poj niam cev xeeb tub uas muaj ntshav qab zib yuav tsum tau saib xyuas lawv cov ntshav qab zib kom ze.
Kev siv cov tshuaj tiv thaiv ntshav qab zib rau cov poj niam cev xeeb tub tsis tsim cov kev tswj hwm tsim nyog ntawm cov metabolism hauv cov metabolism. Vim li no, noj cov tshuaj no thaum cev xeeb tub thiab lactation yog contraindicated.
Yog tias cev xeeb tub tshwm sim lossis yog tias koj npaj ua lub sijhawm kho nrog tus neeg sawv cev no, koj yuav tsum tso Glyurenorm thiab hloov mus rau insulin.
Yog tias mob raum
Txij li qhov sib npaug ntawm Glyurenorm yog tawm hauv cov hnyuv, hauv cov neeg mob uas lub raum tsis ua haujlwm, kev sib txuam ntawm cov tshuaj no tsis tshwm sim. Yog li, nws tuaj yeem raug xa mus yam tsis muaj kev txwv rau cov neeg uas yuav muaj nephropathy.
Kwv yees li 5 feem pua ntawm cov khoom lag luam metabolic ntawm cov tshuaj no tau tawm los ntawm ob lub raum.
Kev tshawb nrhiav los sib piv cov neeg mob ntshav qab zib thiab lub raum tsis zoo ntawm ntau qib mob, nrog rau cov neeg mob kuj tau mob ntshav qab zib, tab sis tsis muaj qhov ua tsis tau mob lub raum, tau qhia tias kev siv 50 mg ntawm cov tshuaj no muaj feem cuam tshuam rau cov piam thaj.
Tsis muaj qhov tshwm sim ntawm kev mob ntshav qab zib tau sau tseg. Nws ua raws los ntawm qhov no uas rau cov neeg mob uas tsis hnov mob raum lub raum, kev hloov tshuaj ntau dua tsis tsim nyog.
