Hauv lub caij nyoog ntawm cov ntaub ntawv thev naus laus zis thiab tiam tshiab ntawm cov tshuaj tiv thaiv kev tiv thaiv, cov sij hawm ntsuas cov tshuaj classic tseem nyob hauv kev xav tau. Cov neeg nyiam tshaj plaws yog cov uas txhawb kev txiav caj dab los tsim cov tshuaj insulin ntxiv. Peb tab tom tham txog derivatives ntawm sulfonylurea series thiab nesulfanylurea secretagogues - clayides.
Repaglinide kuj yog pab pawg kawg. Nws lub ntsiab sib txawv yog qhov cuam tshuam rau thawj theem ntawm kev tso tawm cov tshuaj hormone rau hauv cov hlab ntshav, thaum tom qab noj mov hauv ntshav muaj lub ntsej muag zoo nyob hauv cov piam thaj, thiab lub cev ntawm cov ntshav qab zib (nrog hom 2) tsis tuaj yeem tiv nrog nws.
Tom qab nyeem cov lus qhia, ntsuas tag nrho cov zoo thiab kev pom zoo, koj tuaj yeem sib tham nrog koj tus kws kho mob txog kev kho mob ntshav qab zib.
Cov lus sib xyaw thiab kev piav qhia ntawm cov tshuaj
Txhua lub ntsiav tshuaj muaj 0.5 lossis 1 mg ntawm cov tshuaj tivthaiv uas tseem ceeb ntawm micronized repaglinide ntxiv nrog cov khoom siv pabcuam: calcium hydrogen phosphate anhydrous, colloidal silicon dioxide, microcrystalline cellulose, croscarmellose sodium, hydroxypropyl cellulose, meglumine, magnesium stearate, thiab dyes.
Round biconvex ntsiav tshuaj tuaj yeem txheeb xyuas los ntawm kev kos nrog cov lej qhia tias ntau npaum li cas. Nrog rau qhov cim ntawm 0.5, lawv yog dawb, nrog 1 mg - lavender lossis daj. Sab nraub qaum koj tuaj yeem pom tus tsiaj ntawv RP, J thiab lwm tus. 10 ntsiav tshuaj yog pob nyob rau hauv blisters. Yuav muaj ob peb daim phiaj no nyob hauv plawv thawv ntawv.
Muaj tshuaj kws kho mob muab tauCov. Tus nqi rau Repaglinide yog qhov kev siv nyiaj ntau: 30 ntsiav tshuaj ntawm 2 mg hauv Moscow tuaj yeem yuav rau 200-220 rubles. Lawv tso tshuaj rau hauv Denmark, Israel, Is Nrias teb thiab lwm lub tebchaws, suav nrog thaj chaw tom qab Soviet.
Lub txee lub neej ntawm cov tshuaj, tshaj tawm los ntawm cov chaw tsim khoom, yog nyob nruab nrab 3 xyoos. Cov tshuaj tsis tas yuav tshwj xeeb rau kev khaws cia. Tom qab lub sijhawm tau teev tseg, cov ntsiav tshuaj yuav tsum tau muab pov tseg.
Cov yam ntxwv ntawm Pharmacological
Cov nyhuv tseem ceeb ntawm cov tshuaj yog hypoglycemic. Cov tshuaj thaiv ATP-dependant potassium cov chaw nyob hauv lub b-cell membrane, pab txhawb lawv txoj kev tso dag thiab tso cov calcium. Yog li, cov lus zais cia ntxias kev cuam tshuam cov tshuaj hormones.
Cov kev tshawb fawb soj ntsuam tseem tsis pom muaj mutagenic, teratogenic, carcinogenic cov teebmeem nyob rau hauv cov tsiaj thiab lub cev tsis taus.
Repaglinide yog nqus sai thiab ua tiav ntawm cov hnyuv, ncav nws qhov siab tshaj plaws hauv cov ntshav hauv ib teev.
Yog hais tias noj nrog zaub mov noj, Cmax raug txo qis li 20%. Qhov kev kub siab ntawm cov tshuaj poob tawm sai thiab tom qab 4 teev nce mus txog qhov cim tsawg kawg. Cov tshuaj khi rau cov ntshav plasma protein yuav luag tiav (ntawm 98%) nrog kev ntsuas kev noj qab haus huv ntawm 56%. Biotransformation nrog kev tsim cov inert metabolites tshwm sim hauv lub siab.
Cov tshuaj tau tshem tawm nyob rau hauv 4-6 teev nrog ib nrab-lub neej ntawm 1 teev. Thaum 90% nws kis tau los ntawm cov kab mob txoj hauv plab, txog 8% yog tawm ntawm lub raum.
Leej twg yog Repaglinide npaj rau?
Cov tshuaj yog tsim los tswj cov ntshav qab zib hom 2 yog tias kev hloov pauv ntawm kev ua neej (noj zaub mov kom tsawg, ua kom cov leeg nqaij txaus, tswj lub xeev) tsis muab glycemic tswj tiav.
Nws yog qhov tsim nyog los siv glinide hauv kev kho mob nyuaj nrog metformin thiab thiazolidinediones, yog tias monotherapy, kev noj haus kho mob thiab kev ua kom lub cev tsis ua kom tau qhov txiaj ntsig yam xav tau.
Rau leej twg Repaglinide yog contraindicated
Ntxiv nrog rau kev txwv ib txwm muaj (ib leeg tsis kam lees, cev xeeb tub, menyuam yaus, pub niam mis), cov tshuaj yog contraindicated:
- Tus mob ntshav qab zib nrog hom 1;
- Nrog cov ketoacidosis uas mob ntshav qab zib;
- Nyob rau hauv lub xeev tsis nco qab thiab precoma;
- Yog tias tus neeg mob tau mob lub raum thiab lub siab ua haujlwm tsis zoo;
- Nyob rau hauv cov xwm txheej xav tau ib qho kev hloov chaw mus ib ntus rau insulin (mob, mob, phais, phais).
Tshwj xeeb kev saib xyuas yuav tsum tau them rau kev sau ntawv rau glinides rau kev haus dej cawv, cov neeg muaj mob raum, thiab kub taub hau.Cov. Muaj kev txwv lub hnub nyoog: tsis txhob muab tshuaj rau cov neeg mob ntshav qab zib ua ntej 18 thiab tom qab 75 xyoo vim tsis muaj pov thawj rau cov pawg no.
Txoj kev ntawm daim ntawv thov
Txog qhov rov ua dua, cov lus qhia rau kev siv pom zoo kom noj cov ntsiav tshuaj ua ntej (ua ntej noj mov). Tus kws kho mob yuav xaiv cov koob tshuaj uas tsim nyog rau kev tswj glycemic zoo raws li cov txiaj ntsig ntawm kev tshuaj ntsuam, theem ntawm tus kabmob, concomitant pathologies, hnub nyoog, tus neeg lub cev tawm tsam cov av nplaum.
Txhawm rau kom meej meej cov tshuaj kho mob tsawg kawg nkaus, nws yog ib qho tsim nyog yuav tsum tswj cov suab thaj tshaib plab thiab qab zib tom tsev thiab hauv chav kuaj mob. Thaum kho cov kev cai ntawm cov tshuaj, lawv kuj tau coj los ntsuas ntawm glycated hemoglobin.
Kev tshuaj xyuas yog tsim nyog los txheeb xyuas qhov tsis ua thawj thiab theem nrab tsis ua haujlwm, thaum qib glycemia poob qis dua li qub thaum pib ntawm chav kawm lossis tom qab lub sijhawm pib kho.
Lub sijhawm rau noj cov tshuaj repaglinide tsis nruj: 15-30 feeb ua ntej noj mov lossis tam sim ntawd thaum pib noj mov. Yog tias muab khoom noj txom ncauj ib qho ntxiv (lossis dhia dua), tom qab ntawd muab lwm cov ntsiav tshuaj ntxiv (lossis dhia dua).
Yog tias cov ntshav qab zib tsis tau txais cov tshuaj muaj suab thaj, qhov pib ntawm cov av nplaum yuav tsum muaj tsawg - 0.5 mg ua ntej txhua pluas noj. Yog tias nws hloov mus rau repaglinide nrog lwm cov tshuaj tiv thaiv kab mob, koj tuaj yeem pib nrog 1 mg ua ntej txhua pluas noj.
Nrog rau kev kho mob, kev pom zoo kom noj tshuaj tsis dhau 4 mg ua ntej noj mov loj. Kev noj haus txhua hnub ntawm cov av nplaum yuav tsum tsis pub tshaj 16 mg.
Nrog rau kev kho mob nyuaj, qhov koob tshuaj ntawm repaglinide tsis hloov, thiab cov cai ntawm lwm yam tshuaj raug xaiv nyob rau hauv raws li kev nyeem ntawv ntawm glucometer thiab kev kho mob yav dhau los.
Yam tsis tau xav txog
Ntawm cov kev mob tshwm sim hnyav tshaj plaws ntawm cov glinids, mob ntshav qab zib yog qhov txaus ntshai tshwj xeeb. Thaum sau daim ntawv yuav tshuaj, tus kws kho mob yuav tsum qhia cov neeg mob rau nws cov tsos mob thiab cov hau kev ntawm kev pabcuam ua ntej thiab kev saib xyuas tus kheej rau tus neeg raug mob.
Ntawm lwm yam xwm txheej tsis xav tau:
- Dyspeptic cuam tshuam;
- Kev ua txhaum ntawm lub suab sib dhos ntawm txoj hnyuv;
- Cov tawv nqaij ua xua ua xua;
- Dysfunction ntawm daim siab ua ke hauv kev ua haujlwm ntawm transistor nce hauv transaminase kev ua;
- Kev pom kev puas vim yog qhov sib txawv ntawm qib glycemic.
Qhia Txog Kev Sib Koom Tes Nrog Tshuaj
Nrog rau txoj kev siv hluav taws xob sib xyaw nrog β-blockers, ACE inhibitors, chloramphenicol, haus dej cawv, MAO inhibitors, tsis siv tshuaj tua kabmob ntawm NSAIDs, probenecid, salicylates, sulfonamides, anabolic steroids, qhov ua tau zoo ntawm av nplaum nce.
Kev tswj hwm tib lub sijhawm ntawm cov tshuaj repaglinide thiab calcium channel blockers, corticosteroids, thiazide diuretics, isoniazid, nicotinic acid nyob rau hauv cov tshuaj noj tsis raws qauv, estrogen (muaj nyob hauv cov tshuaj tiv thaiv), sympathomimetics, phenothiazines, phenytoin, cov thyroid hormones txo cov peev xwm ntawm glinides.
Pab nrog overdose
Tus mob no tuaj yeem lees paub los ntawm:
- Paub tswj tus kheej tsis qab los;
- Qaug Zog;
- Siab zam;
- Nce kev ntxhov siab;
- Pw tsis tsaug zog;
- Hloov pauv hloov tus cwj pwm (ib qho xwm txheej zoo ib yam li kev haus cawv haus cawv);
- Hais lus thiab pom qhov muag tsis zoo;
- Tsis muaj kev sib koom tes thiab saib xyuas;
- Tsis meej pem nco qab;
- Tawv nqaij daj;
- Tachycardia;
- Mob leeg pob txha;
- Kev tawm hws ntau heev;
- Tsaus muag, tsis nco qab.
Pab tus neeg raug tsim txom yog tus yam ntxwv thiab txhawb nqa. Yog tias cov ntshav qab zib tau nco qab, nws yuav tsum tau muab cov carbohydrates sai sai (qab zib, qab zib), tom qab ib pliag, kev kub ntxhov ntawm lub cev nrog cov piam thaj yuav tsum tau rov ua dua, vim tias muaj qhov ua tau ntawm rov mob.
Yog hais tias tus neeg mob tsis muaj cov cim ntawm kev nco qab, cov kua nplaum tov (50%) tau txhaj tshuaj, txhawm rau kom cov qib glycemic siab dua 5.5 mmol / l, ib qho dej ntws tawm tau nrog 10% kua nplaum tov. Thaum muaj mob hnyav, yuav tsum tau pw hauv tsev kho mob sai.
Cov lus pom zoo ntxiv
Kev saib xyuas tshwj xeeb (tswj kev yoo mov thiab tom qab qab zib, kev ua haujlwm ntawm lub hom phiaj plab hnyuv siab raum) thaum sau cov av nplaum yog qhov yuav tsum tau ua los ntawm cov neeg mob ntshav qab zib nrog lub raum thiab hepatic pathologies. Lawv yuav tsum paub tias yog tias muaj kev ua txhaum ntawm kev noj tshuaj thiab kev noj tshuaj, kev haus cawv, kev noj zaub mov kom tsawg, ua kom lub cev tsis muaj zog, kev ntxhov siab, nws yog qhov tsim nyog los kho cov koob tshuaj repaglinide, txij li cov xwm txheej no tuaj yeem ua rau ntshav qab zib tsawg.
Hauv kev sib txuas nrog kev phiv loj, yuav tsum ceev faj thaum tsav tsheb thiab cov khoom siv phom sij, phom sij, thaum ua haujlwm ntawm qhov siab, thiab lwm yam.
Txhawm rau tiv thaiv hypoglycemia, cov neeg mob ntshav qab zib nrog cov tsos mob tsis muaj zog ntawm kev tuaj yeem ua ntej, nrog rau cov neeg uas muaj tej yam xwm txheej zoo li no tsis yog qhov tsis tshua pom tshwm sim, koj yuav tsum tau ceev faj ntxiv, ntsuas kev pheej hmoo thiab nws qhov tuaj yeem.
Repaglinide - analogues
Repaglinide tso tawm nyob rau hauv ntau lub npe lag luam: NovoNorm, Diclinid, Iglinid, Repodiab.
Raws li ATX txoj cai ntawm qib 4, cov tshuaj tiv thaiv kab mob hauv Bayeta txhaj tshuaj nrog cov nquag tiv thaiv exenatide thiab Viktoza nrog cov tshuaj sib xyaw nrog liraglitide coincide nrog nws.
Qee tus neeg mob ntshav qab zib kho lawv tus kab mob raws li qhov ua tsis tiav, tsis paub txog tias qhov mob vwm no tuaj yeem xa mus rau lwm lub ntiaj teb tam sim.
Repaglinide yog ib tus kabmob hypoglycemic loj, kev sim ua tshuaj rau tus kheej thiab hloov pauv yog qhov muaj kev phom sij rau kev noj qab haus huv, vim tias cov tshuaj tau nrawm nrawm, nrog rau cov npe loj ntawm contraindications thiab phiv. Yog tias koj tau kuaj mob ntshav qab zib mellitus, koj yuav tsum tau kho mob hnyav, tsis tas yuav tsum muab tso kom txog tom qab.
Ntawm kev kho mob rau kev kho mob ntshav qab zib hom 2 tuaj yeem nrhiav pom ntawm video.
