Qee zaum cov khoom noj tshwj xeeb thiab kev tawm dag zog tsis tuaj yeem muab cov ntshav qab zib ib txwm nyob hauv cov ntshav qab zib uas muaj 2 daim ntawv ntawm tus kabmob.
Cov tshuaj nrog INN Repaglinide, qhov kev qhia ntawm uas txuas rau txhua pob ntawm cov tshuaj uas muaj nws, nws muaj qhov tsis zoo thaum tsis tuaj yeem tswj tau qhov concentration ntawm cov piam thaj hauv cov ntshav. Kab lus no yuav hais txog nqe lus nug ntawm kev siv tshuaj nrog repaglinide kom raug thiab qhov twg siv tsis tau.
Pharmacological cov yam ntxwv ntawm cov tshuaj
Cov khoom xyaw nquag, Repaglinide, muaj nyob hauv daim ntawv dawb hmoov rau kev siv sab hauv. Tus txheej txheem ntawm kev ua ntawm qhov kev sib xyaw yog qhov tso tawm ntawm insulin (suab thaj txo qis hormone) los ntawm beta hlwb nyob hauv thaj chaw txiav.
Siv cov tshuaj repaglinide ntawm cov txais tshwj xeeb, ATP-nyob rau hauv qhov chaw nyob hauv cov qog ua ke ntawm cov beta hlwb. Xws li tus txheej txheem provokes depolarization ntawm cov hlwb thiab qhib ntawm calcium calcium. Raws li qhov tshwm sim, kev tsim cov tshuaj insulin yog nce ntxiv los ntawm kev nce tus kab mob calcium.
Tom qab tus neeg mob noj tshuaj kom zoo dua ntawm Repaglinide, cov tshuaj yog nqus rau hauv cov hnyuv. Nyob rau tib lub sijhawm, tom qab 1 teev tom qab noj mov, nws yog feem ntau ua haujlwm nyob rau hauv cov ntshav ntshav, tom qab ntawd tom qab 4 teev nws tus nqi nce sai dua thiab ua qis heev. Cov kev tshawb fawb ntawm cov tshuaj tau ua pov thawj tias tsis muaj qhov sib txawv hauv pharmacokinetic qhov tseem ceeb thaum siv cov tshuaj Repaglinide ua ntej lossis thaum noj mov.
Cov tshuaj khi rau cov ntshav protein ntau dua 90%. Ntxiv mus, qhov tseeb txog kev nyab xeeb tsis pub dhau mus txog 63%, thiab nws qhov kev faib tawm yog 30 litres. Nws yog nyob rau hauv lub siab hais tias biotransformation ntawm Repaglinide tshwm sim, vim qhov kev ua haujlwm tsis muaj zog hauv cov metabolites. Yeej, lawv tau tawm nrog cov kua tsib, nrog rau cov zis (8%) thiab cov quav (1%).
30 feeb tom qab noj cov tshuaj Repaglinide, cov tshuaj hormones tso zis pib. Vim li ntawd, cov ntsiab lus ntawm cov piam thaj hauv cov ntshav tau sai heev. Nruab nrab ntawm cov pluas noj, tsis muaj kev nce insulin ntau ntau.
Hauv cov neeg mob uas tsis mob ntshav qab zib-insulin uas noj los ntawm 0.5 mus rau 4 g ntawm Repaglinide, tau pom tias koob tshuaj txo qis hauv qabzib tau pom.
Cov lus qhia rau kev siv tshuaj
Repaglinide yog cov khoom tseem ceeb ntawm NovoNorm, uas yog ua hauv Denmark. Pharmacological tuam txhab Novo Nordisk A / C tsim tawm tshuaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj nrog ntau qhov sib txawv - 0.5, 1 thiab 2 mg. Ib lub hlwv muaj 15 ntsiav tshuaj; ntau lub hlwv yuav muaj ib pob.
Hauv txhua pob ntawm cov tshuaj nrog cov tshuaj repaglinide, cov lus qhia rau kev siv yog qhov yuav tsum tau ua. Cov koob tshuaj tau xaiv ib qho zuj zus los ntawm tus kws kho mob tshwj xeeb uas ntsuas qhov tsis zoo ntawm cov piam thaj thiab cov kab mob sib deev ntawm tus neeg mob. Ua ntej siv cov tshuaj, tus neeg mob yuav tsum ua tib zoo nyeem cov lus qhia uas txuas nrog.
Qhov koob tshuaj thawj zaug yog 0.5 mg, nws tuaj yeem nce ntxiv tsuas yog tom qab ib lossis ob lub lis piam, dhau kev kuaj sim rau qib qab zib. Qhov noj tshuaj ntau tshaj plaws yog 4 mg, thiab koob tshuaj txhua hnub yog 16 mg. Thaum lub sijhawm hloov los ntawm lwm qhov txo cov tshuaj yaj yeeb tshuaj Repaglinide noj 1 mg. Nws raug nquahu kom siv cov tshuaj 15-30 feeb ua ntej noj mov loj.
NovoNorm cov tshuaj yuav tsum muab tso kom deb ntawm cov menyuam yaus ntawm qhov kub ntawm 15-25C hauv qhov chaw tiv thaiv los ntawm ya raws.
Lub txee lub neej ntawm cov tshuaj yog txog li 5 xyoos, tom qab lub sijhawm no nws tsis tuaj yeem siv ib qho haujlwm twg.
Cov txheej txheem sib tsoo thiab cov phom sij uas yuav muaj
Hmoov tsis zoo, tsis yog txhua tus neeg tuaj yeem lees txais NovoNorm. Zoo li lwm yam tshuaj, nws muaj contraindications.
Cov tshuaj repaglinide tsis tuaj yeem nqa nrog:
- hom mob ntshav qab zib insulin;
- cov ketoacidosis uas mob ntshav qab zib, nrog rau tsis nco qab lawm;
- mob rau daim siab hnyav thiab / lossis lub raum tsis ua haujlwm;
- siv ntxiv ntawm cov tshuaj uas ntxias lossis inhibit CYP3A4;
- lactose intolerance, lactase deficiency thiab glucose-galactose malabsorption;
- nce siab raug rau cov khoom;
- hnub nyoog qis dua 18 xyoo;
- npaj lossis cev xeeb tub;
- pub niam mis.
Cov ntawv soj ntsuam tau ua haujlwm ntawm cov nas ua pov thawj tias kev siv cov tshuaj repaglinide thaum lub sijhawm ua rau menyuam muaj qhov tsis zoo cuam tshuam rau lub cev hauv plab. Raws li kev haus dej, kev txhim kho ntawm sab sauv thiab qis tshaj ntawm tus me nyuam hauv lub cev tsis muaj kev cuam tshuam. Tsis tas li, kev siv tshuaj yeeb dej caw yog txwv thaum lub sijhawm lactation, vim nws kis nrog niam cov kua mis rau menyuam.
Qee lub sij hawm nrog kev siv tshuaj tsis raug cai lossis kev haus ib qho dhau hwv lawm, tshwm sim muaj cov nyom tshwm sim xws li:
- xeev cov ntshav qog ntshav qis (nce tawm hws, tshee tshee, pw tsis tsaug zog, mob tachycardia, ntxhov siab);
- kev tsis zoo ntawm lub qhov muag pom (hauv thawj theem ntawm kev noj tshuaj, tom qab ntawd dhau mus);
- lub plab zom mov (mob plab, xeev siab thiab ntuav, cem quav lossis zawv plab, nce kev ua haujlwm ntawm cov enzymes hauv daim siab);
- kev ua xua (liab ntawm daim tawv nqaij - erythema, tawm pob, khaus).
Kev siv cov tshuaj loj dua li kws kho mob tau qhia yuav luag ib txwm ua rau lub qog ntshav qab zib. Yog hais tias tus mob ntshav qab zib hnov cov tsos mob me me ntau dhau thiab nco qab, nws yuav tsum noj khoom noj uas muaj cov khoom noj uas muaj carbohydrate thiab sab laj nrog kws kho mob txog kev kho qhov ntau npaum cas.
Hauv cov ntshav qog ntshav hnyav, thaum tus neeg mob tsis nco qab lossis tsis nco qab lawm, nws tau txhaj tshuaj rau 50% kua nplaum nyob hauv qab daim tawv nqaij nrog ntxiv kev tso ntshav ntawm 10% kev daws teeb meem kom muaj suab thaj tsawg kawg yog 5.5 mmol / L.
Kev sib cuam tshuam ntawm Repaglinide nrog Lwm Yam Tshuaj
Kev siv cov tshuaj concomitant feem ntau cuam tshuam rau cov hauj lwm zoo ntawm repaglinide ntawm cov piam thaj concentration.
Nws cov nyhuv hypoglycemic yog kho kom zoo dua thaum tus neeg mob siv MAO thiab ACE inhibitors, tsis xaiv-beta-blockers, tsis-tshuaj steroidal anti-inflammatory tshuaj, salicylates, anabolic steroids, okreotide, tshuaj uas muaj ethanol.
Lub peev xwm ntawm ib yam khoom kom txo cov piam thaj yog qhov tsis zoo los ntawm cov tshuaj no:
- thiazide diuretics;
- tshuaj tiv thaiv rau kev siv ntawm qhov ncauj;
- danazole;
- glucocorticoids;
- cov thyroid hormones;
- sympathomimetics.
Tsis tas li, tus neeg mob yuav tsum coj mus rau hauv tus account uas repaglinide cuam tshuam nrog cov tshuaj uas tso tawm hauv cov kua tsib. CYP3A4 inhibitors xws li intraconazole, ketoconazole, fluconazole thiab qee yam tuaj yeem ntxiv nws cov ntshav. Kev siv CYP3A4 inducers, tshwj xeeb tshaj yog rifampicin thiab phenytoin, txo qis qib ntawm ib yam khoom hauv ntshav. Muab qhov tseeb tias qib ntawm induction tsis tau txiav txim siab, kev siv cov tshuaj Repaglinide nrog cov tshuaj no yog txwv tsis pub.
Kev pom zoo rau kev siv
Qee qhov xwm txheej, cov neeg mob yuav tsum siv cov tshuaj nrog kev ceev faj heev los ntawm kev saib xyuas ntawm tus kws kho mob uas tau sau ntawv yuav noj tsawg kawg. Cov neeg mob no suav nrog cov neeg mob uas raug mob los ntawm kab mob siab thiab / lossis ob lub raum, uas tau muaj kev phais mob ntau ntxiv, uas nyuam qhuav muaj kab mob khaub thuas lossis kis tus kab mob, cov neeg laus (los ntawm 60 xyoo) uas ua raws li cov zaub mov tsis zoo.
Yog hais tias tus neeg mob tau mob hypoglycemic lub xeev nyob rau hauv me me los yog mob me, nws tuaj yeem raug tshem tawm ntawm nws tus kheej. Txhawm rau ua qhov no, koj yuav tsum tau noj cov zaub mov uas muaj cov zom zom tau yooj yim - ib qho qab zib, qab zib, kua txiv qab zib lossis txiv hmab txiv ntoo. Hauv daim ntawv loj heev nrog qhov tsis nco qab, raws li twb tau hais los, cov kua nplaum nyob nrog kev tswj hwm tus mob.
Nws yuav tsum raug sau tseg tias cov beta-blockers muaj peev xwm ua kom npog ntsej muag cov kev tshwm sim ntawm kev mob hypoglycemia. Cov kws kho mob xav xav kom koj tsis txhob haus cawv thaum ethanol txhim kho thiab txuas ntxiv cov nyhuv hypoglycemic ntawm Repaglinide.
Tsis tas li, cov tshuaj txo qis ntawm kev mloog zoo.
Yog li, cov tsav tsheb tiv thaiv keeb kwm ntawm kev siv repaglinide, nws yog ib qho tsim nyog yuav tsum tsis txhob tsav tsheb lossis ua lwm yam kev ua haujlwm txaus ntshai thaum kev kho mob.
Nqi, tshuaj xyuas thiab analogues
Repaglinide yog cov tshuaj tseem ceeb tau siv nyob rau hauv cov tshuaj NovoNorm.
Koj mus yuav tau tom lub khw muag tshuaj lossis xaj online ntawm tus muag lub vev xaib. Txawm li cas los xij, kev yuav cov tshuaj yog ua tau tsuas yog thaum nthuav qhia los ntawm kws kho mob sau tshuaj.
Tus nqi ntawm cov tshuaj nws txawv:
- 1 mg ntsiav tshuaj (30 daim ib pob) - los ntawm 148 txog 167 rubles Lavxias;
- 2 mg ntsiav tshuaj (30 daim ib pob) - los ntawm 184 txog 254 rubles Lavxias.
Raws li koj tuaj yeem pom, tus nqi yog heev loyal rau cov neeg uas tau nyiaj tsawg. Nyeem cov kev ntsuam xyuas ntawm ntau tus neeg mob ntshav qab zib, nws tuaj yeem sau tseg tias pheej yig ntawm tshuaj yog ib qho loj ntxiv, muab nws cov hauj lwm zoo. Ib qho ntxiv, cov txiaj ntsig ntawm NovoNorm yog:
- yooj yim ntawm kev siv cov ntsiav tshuaj piv rau kev txhaj tshuaj;
- qhov ceev ntawm cov tshuaj, nyob rau hauv tsuas yog 1 teev;
- sijhawm ntev noj cov tshuaj.
Qhov kawg txhais tau tias feem ntau cov neeg mob uas kuaj ntshav tsis muaj qhov mob ntshav qab zib-insulin tau noj NovoNorm li 5 xyoos lossis ntau dua. Lawv sau tseg tias nws cov nyhuv tseem nyob li qub thiab tsis hloov qis. Txawm li cas los xij, kev tiv thaiv hypoglycemic ntawm cov tshuaj txo rau xoom yog tias TSIS:
- ua raws li kev noj haus zoo (tsis suav nrog cov khoom noj tau yooj yim thiab ua kom muaj cov carbohydrates thiab cov rog);
- soj ntsuam kev ua lub neej nquag (mus taug kev tsawg kawg 30 feeb, kev tawm dag zog lub cev, thiab lwm yam);
- pheej saib xyuas theem ntawm cov piam thaj (tsawg kawg peb zaug hauv ib hnub).
Feem ntau, cov neeg mob thiab kws kho mob suav tias NovoNorm yog tshuaj tua kabmob zoo. Tab sis qee zaum kev siv cov ntsiav tshuaj txwv tsis pub, vim tias lawv coj mus rau qhov tsis zoo tsim nyog. Hauv cov xwm txheej zoo li no, tus kws kho mob txiav txim siab hloov cov tshuaj ntawm cov tshuaj lossis mus yuav tshuaj kom yuav cov tshuaj sib txawv.
Cov lus txhais muaj tib cov tshuaj sib txuam thiab sib txawv tsuas yog hauv cov tshuaj ntxiv. NovoNorm ntsiav tshuaj tsuas muaj ib qho txhais - Diagniniside (qhov nruab nrab ntawm 278 rubles).
Zoo xws li cov tshuaj NovoNorm, uas txawv hauv lawv cov khoom sib sau, tab sis muaj cov txiaj ntsig zoo ib yam, yog:
- Jardins (tus nqi nruab nrab - 930 rubles);
- Victoza (tus nqi nruab nrab - 930 rubles);
- Saksenda (tus nqi nruab nrab - 930 rubles);
- Forsyga (nruab nrab tus nqi - 2600 rubles);
- Invokana (tus nqi nruab nrab - 1630 rubles).
Nws tuaj yeem xaus lus tias cov tshuaj NovoNorm, uas muaj cov tshuaj nquag rov ua kom zoo, zoo rau hauv kev kho mob ntshav qab zib hom 2. Nws sai sai ua rau cov piam thaj qis mus rau theem ib txwm. Yog tias koj ua raws li kev noj zaub mov zoo, kev tawm dag zog thiab nrog kev soj ntsuam cov piam thaj tsis tu ncua, koj tuaj yeem tshem tawm qhov tsis muaj ntshav qab zib thiab mob ntshav qab zib ntau. Daim vis dis aus hauv tsab xov xwm no yuav qhia koj kom paub kho ntshav qab zib li cas.
