Cov tib neeg uas muaj mob ntshav qab zib hom 2 mellitus tsis tuaj yeem tuav cov ntshav qabzib hauv lub cev ib txwm muaj los ntawm tsuas yog ib lub cev kev ua si thiab kev noj zaub mov tshwj xeeb uas tsis suav nrog cov khoom noj zom tau yooj yim carbohydrates thiab cov rog.
Qhov tshwm sim no feem ntau tshwm sim nrog lub caij nyoog ntev ntawm tus kab mob, txij li txhua txhua xyoo muaj peev xwm ua haujlwm ntawm tus txiav ua tsis taus. Tom qab ntawd Galvus ntsiav tshuaj tuaj rau txoj kev cawm, uas txo qis thiab ncua sij hawm qab zib li qub.
Ntau tus neeg mob ntshav qab zib tau xav txog qhov tias ib qho tshuaj muaj vildagliptin zoo npaum li cas. Yog li no, tsab xov xwm no yuav nthuav qhia cov txheej txheem ntawm kev ua ntawm cov tshuaj thiab cov yam ntxwv ntawm nws siv, kom txhua tus neeg tuaj yeem txiav txim siab rau lawv tus kheej qhov tseem ceeb ntawm cov tshuaj hypoglycemic
Pharmacological kev txiav txim
Vildagliptin (Latin version - Vildagliptinum) belongs rau cov chav kawm ntawm cov tshuaj uas txhawb cov islets ntawm Langerhans hauv lub cev ua kom zoo nkauj thiab inhibit cov kev ua ntawm dipeptidyl peptidase-4. Cov nyhuv ntawm qhov enzyme no ua rau muaj kev puas tsuaj rau hom 1 glucagon-zoo li peptide (GLP-1) thiab piam thaj-insulinotropic polypeptide (HIP).
Raws li qhov tshwm sim, qhov kev txiav txim ntawm dipeptidyl peptidase-4 yog suppressed los ntawm cov tshuaj yeeb dej caw, thiab kev tsim tawm ntawm GLP-1 thiab HIP yog txhim kho. Thaum lawv cov ntshav nce ntxiv, vildagliptin txhim kho qhov rhiab ntawm beta hlwb rau cov piam thaj, uas ua rau cov insulin ntau ntxiv. Qhov feem pua ntawm qhov nce ntawm kev ua haujlwm ntawm beta hlwb yog ncaj qha nyob ntawm qib ntawm lawv qhov kev puas tsuaj. Yog li, hauv cov neeg muaj nuj nqi li qub ntawm cov piam thaj thaum siv tshuaj muaj vildagliptin, nws tsis cuam tshuam rau cov khoom noj suab thaj txo qis thiab, ntawm chav kawm, qabzib.
Tsis tas li ntawd, thaum cov tshuaj tsub kom cov ntsiab lus ntawm GLP-1, tib lub sijhawm, qabzib rhiab zuj zus hauv alpha hlwb. Xws li cov txheej txheem xav kom muaj kev nce ntxiv hauv cov txheej txheem qabzib nyob ntawm kev tsim cov keeb ntawm alpha cell, hu ua glucagon. Txo nws cov ntsiab lus ntau ntxiv thaum siv cov tais diav pab tshem tawm cov kab mob tiv thaiv cell mus rau cov tshuaj insulin.
Thaum qhov piv ntawm insulin thiab glucagon nce, uas yog txiav txim siab los ntawm tus nqi nce ntawm HIP thiab GLP-1, nyob rau hauv lub xeev hyperglycemic, qabzib hauv lub siab pib tsim tawm mus rau qhov tsawg dua, ob qho tib si thaum noj zaub mov noj thiab tom qab nws, uas ua rau txo qis cov piam thaj hauv ntshav ntshav ntawm cov ntshav qab zib.
Nws yuav tsum raug sau tseg tias, siv Vildagliptin, ntau npaum li cas ntawm cov lipids tsawg dua tom qab noj mov. Qhov kev nce ntawm cov ntsiab lus ntawm GLP-1 qee zaum ua rau lub qeeb hauv kev tso tawm ntawm lub plab, txawm hais tias xws li cov nyhuv tsis pom thaum lub sijhawm noj.
Ib txoj kev tshawb fawb tsis ntev los no uas muaj txog li 6,000 tus neeg mob ntev dua 52 lub limtiam tau ua pov thawj tias kev siv vildagliptin tuaj yeem txo cov piam thaj hauv lub plab thiab glycated hemoglobin (HbA1c) thaum siv cov tshuaj:
- raws li lub hauv paus ntawm kev kho tshuaj;
- xyaw nrog metformin;
- txuam nrog sulfonylureas;
- txuam nrog thiazolidinedione;
Cov kua nplaum hauv lub ntsej muag kuj txo qis nrog kev siv ua ke ntawm vildagliptin nrog cov kua dej.
Cov lus qhia rau kev siv ntsiav tshuaj
Hauv khw muag tshuaj, koj tuaj yeem nrhiav tau ob yam tshuaj muaj vildagliptin.
Qhov sib txawv hauv cov khoom siv sib xyaw: hauv thawj kis, nws tsuas yog vildagliptin, thiab hauv ob - vildagliptin, metformin.
Cov chaw tsim tshuaj txog cov tshuaj yog lub tuam txhab Swiss Novartis.
Cov tshuaj muaj nyob hauv cov ntawv hauv qab no:
- Vildagliptin yam uas tsis muaj cov khoom siv ntxiv (hauv cov ntsiav tshuaj 28 daim ntim hauv 50 mg);
- Vildagliptin txuam nrog Metformin (30 ntsiav tshuaj hauv ib pob ntawm 50/500, 50/850, 50/1000 mg).
Ua ntej tshaj plaws, tus neeg mob uas tsis muaj ntshav qab zib kom tsis txhob insulin yuav tsum sab laj nrog tus kws kho mob uas yuav sau ntawv yam tsis tas yuav poob. Yog tsis muaj nws, koj tsis tuaj yeem nrhiav tshuaj kho. Tom qab ntawd tus neeg mob yuav tsum ua tib zoo nyeem qhov ntxig thiab, yog tias koj muaj lus nug, nug lawv tus kws kho mob. Cov lus qhia rau kev siv tshuaj muaj ib daim ntawv teev cov tshuaj uas pom zoo uas tuaj yeem hloov kho los ntawm kws kho mob.
Vildagliptin 50 mg, yog cov khoom siv tseem ceeb, ib qho ua ke nrog thiazolidinedione, Metformin lossis insulin txoj kev kho, yog noj rau hauv kev siv tshuaj txhua hnub ntawm 50 lossis 100 mg. Tus mob ntshav qab zib, uas tus kab mob loj zuj zus ntxiv nrog kev siv tshuaj insulin ntau dua, noj 100 mg ib hnub twg.
Ob chav sib xyaw ua ke ntawm cov tshuaj (vildagliptin thiab sulfonylurea derivatives) pom zoo kom noj txhua hnub ntawm 50 mg rau thaum sawv ntxov.
Ib qho kev sib koom ua ke ntawm cov tshuaj, uas yog, Vildagliptin, Metformin thiab sulfonylurea derivatives, qhia ib koob tshuaj txhua hnub ntawm 100 mg.
Kev noj tshuaj rau txhua hnub ntawm 50 mg yog siv rau ib lub sijhawm thaum sawv ntxov, thiab 100 mg hauv ob koob tshuaj thaum sawv ntxov thiab yav tsaus ntuj. Cov koob tshuaj hloov kho hauv cov neeg uas muaj mob los ntawm mob raum los yog mob raum (tshwj xeeb, nrog rau cov tsis muaj mob txaus) yuav tsum tau.
Cov tshuaj raug khaws cia rau hauv qhov chaw tsis pom kev zoo rau cov menyuam yaus, ntawm qhov kub tsis tshaj 30C. Lub sijhawm cia yog 3 xyoo, thaum lub sijhawm qhia xaus, cov tshuaj tsis tuaj yeem siv.
Cov txheej txheem sib tsoo thiab cov phom sij uas yuav muaj
Vildagliptin tsis muaj ntau yam kev sib kis. Lawv muaj feem xyuam nrog tus neeg mob tsis kam lees rau tus neeg mob mus rau cov khoom ua kom nquag muaj zog thiab lwm yam khoom ntxiv, nrog rau cov caj ces tsis haum rau galactose, lactase deficiency thiab glucose-galactose malabsorption.
Nws yuav tsum tau rov qab hais tias vim tsis muaj kev tshawb nrhiav, kev nyab xeeb ntawm kev siv cov tshuaj hauv cov menyuam yaus thiab cov hluas (muaj hnub nyoog qis dua 18 xyoo) tseem tsis tau kawm tag.
Tsis muaj cov ntaub ntawv tshawb fawb txog kev siv vildagliptin thaum cev xeeb tub thiab pub niam mis, yog li kev siv tshuaj nyob rau lub sijhawm no yuav tsum txwv.
Nyob ntawm seb Vildagliptin siv los ua kev kho mob lossis nrog lwm txoj hauv kev, ntau cov kev mob tshwm sim tuaj yeem tshwm sim:
- monotherapy (Vildagliptin) - lub xeev ntawm kev ntshav qab zib, mob taub hau thiab kiv taub hau, cem quav, peripheral edema;
- Vildagliptin, Metformin - lub xeev ntog ntshav qab zib, tshee, dias taub hau thiab mob taub hau;
- Vildagliptin, sulfonylurea derivatives - lub xeev ntawm cov ntshav qab zib tsawg, tshee, dias taub hau thiab mob taub hau, asthenia (kev puas siab puas ntsws);
- Vildagliptin, derivatives ntawm thiazolidinedione - lub xeev ntawm cov ntshav qog ntshav nce siab, nce me ntsis hauv qhov hnyav, mob pob txha;
- Vildagliptin, insulin (ua ke nrog lossis tsis muaj metformin) - ib lub xeev ntawm lub cev tsis muaj ntshav qab zib, mob taub hau, lub plab zom mov (ntuav cov ntsiab lus ntawm lub plab mus rau txoj hlab nqos mov), ua daus no, xeev siab, ua kom pa roj ntau dhau, raws plab.
Thaum lub sijhawm tshuaj ntsuam xyuas tom qab tau tshaj tawm, ntau tus neeg mob ntshav qab zib noj Vildagliptin tau sau tseg txog cov kev mob tshwm sim xws li tus kab mob siab, mob urticaria, exfoliation ntawm daim tawv nqaij, tsim cov hlwv thiab kev txhim kho ntawm pancreatitis.
Txawm li cas los xij, txawm tias cov tshuaj no muaj ntau yam tshwm sim ntawm cov kev mob tshwm sim, qhov ntxim nyiam ntawm lawv tshwm sim yog tsawg. Nyob rau hauv feem ntau cov xwm txheej, lawv yog cov kev hloov kho ib ntus thiab txawm tias nrog lawv qhov tshwm sim, txoj kev tshem tawm txoj kev kho mob tsis tas yuav tsum tau.
Noj ntau dhau thiab cov lus pom zoo siv
Feem ntau, Vildagliptin tau txais txiaj ntsig zoo los ntawm cov neeg mob nyob rau ntawm kev siv tshuaj txhua hnub ntawm 200 mg, tab sis tsis muaj ntxiv. Thaum siv cov koob tshuaj ntau dua li qhov xav tau, muaj qhov siab qhov tshwm sim ntawm cov cim ntawm kev haus ntau tshaj ntawm cov tshuaj.
Nws yuav tsum raug sau tseg tias thaum koj tsum tsis noj tshuaj, tag nrho cov tsos mob ploj mus.
Cov tsos mob ntawm ib qho overdose ncaj qha nyob ntawm nws qhov degree, piv txwv:
- Thaum siv tshuaj 400 mg, mob leeg, o, khaus thiab loog ntawm qhov kawg ntawm lub ntsws (lub ntsws thiab qhov hloov), qhov nce ntawm lipase cov ntsiab lus tshwm sim. Tsis tas li, qhov kub tuaj yeem sawv nrog ntshav qab zib.
- Thaum siv 600 mg, o ntawm tes thiab taw tshwm, nrog rau lawv lub loog thiab tingling, qhov nce ntawm cov ntsiab lus ntawm ALT, CPK, myoglobin, nrog rau C-reactive protein.
Thaum pib kho, koj yuav tsum yauv mus ua kev kawm txog biochemical tsis dhau ntawm daim siab. Yog tias qhov tshwm sim qhia pom ntau dua transaminase kev ua ub no, qhov kev soj ntsuam yuav tsum tau rov ua dua thiab khiav tsis tu ncua kom txog rau thaum cov ntsuas ntsuas no txav mus. Yog tias qhov txiaj ntsig ntawm kev tshuaj ntsuam pom tias ALT lossis AST kev ua haujlwm, uas yog 3 zaug siab dua VGN, cov tshuaj yuav tsum tau lawb tawm.
Yog tias tus neeg mob tau ua txhaum lub siab (piv txwv li daj, tus neeg daj ntseg), kev siv cov tshuaj tam sim ntawd tsis tu. Thaum lub siab ua haujlwm tsis zoo li qub, kev kho mob raug txwv.
Thaum xav tau cov tshuaj insulin, vildagliptin tsuas yog siv nrog hormone. Tsis tas li, nws qhov kev siv yog qhov tsis pom zoo rau kev kho mob ntawm cov tshuaj insulin-tiv thaiv cov ntshav qab zib (hom 1) lossis kev noj haus cov zaub mov uas ua rau cov metabolism hauv cov ntshav qab zib - ntshav qab zib ketoacidosis.
Lub peev xwm ntawm vildagliptin los cuam tshuam cov xim tsom tsis tau to taub tag nrho. Txawm li cas los xij, yog hais tias kiv taub hau tshwm sim, cov neeg mob uas tsav tsheb los yog ua lwm yam kev ua haujlwm nrog cov tshuab yuav tsum tso tseg txoj haujlwm no txaus ntshai rau lub sijhawm kho.
Nqi, tshuaj xyuas thiab analogues
Txij li thaum siv yeeb siv tshuaj Vildagliptin yog txawv teb (chaw tsim tshuaj paus Switzerland), raws li nws tus nqi yuav tsis qis heev. Txawm li cas los xij, txhua tus neeg mob nrog cov nyiaj khwv tau los nruab nrab tuaj yeem them cov tshuaj. Cov cuab yeej yuav tuaj yeem yuav tom chaw muag tshuaj lossis xaj online.
Tus nqi ntawm cov tshuaj (28 ntsiav tshuaj ntawm 50 mg ntsiav tshuaj) nws txawv ntawm 750 txog 880 rubles Lavxias.
Raws li kev xav ntawm kws kho mob thiab tus neeg mob hais txog kev siv tshuaj, kev tshuaj xyuas feem ntau yog qhov zoo.
Cov neeg mob uas mob ntshav qab zib mellitus ntawm yam thib ob uas tau noj tshuaj qhia qhov zoo hauv qab no ntawm cov tshuaj:
- Cov piam thaj sai sai thiab khaws ua kom tsis pub dhau ib txwm;
- yooj yim ntawm kev siv ntawm daim ntawv tshuaj noj;
- Tsis tshua muaj kev nthuav qhia tsis tshua pom kev tshwm sim tsis zoo ntawm cov tshuaj.
Raws li qhov no, cov tshuaj tuaj yeem suav hais tias yog ib qho tshuaj tiv thaiv ntshav qab zib kom zoo los pab kho mob ntshav qab zib hom 2. Tab sis qee zaum nyob rau hauv kev sib txuas nrog contraindications los yog tsim kev phom sij, koj yuav tsum tsis kam siv cov tshuaj. Hauv cov xwm txheej zoo li no, cov kws kho mob tshwj xeeb muaj cov tshuaj analogues - cov neeg sawv cev uas muaj cov kev kho mob zoo ib yam li Vildagliptin. Cov no suav nrog:
- Onglisa. Cov tshuaj phiv yog saxagliptin. Tus nqi sib txawv hauv cov kev txwv ntawm 1900 rubles.
- Trazenta. Tus nquag ua hauj lwm yog linagliptin. Tus nqi nruab nrab yog 1750 rubles.
- Januvius. Cov tshuaj phiv yog sitagliptin. Tus nqi nruab nrab yog 1670 rubles.
Raws li koj tuaj yeem pom, analogues muaj cov khoom sib txawv hauv lawv cov muaj pes tsawg leeg. Hauv qhov no, tus kws kho mob yuav tsum xaiv cov tshuaj zoo li no thiaj li ua rau nws tsis tuaj yeem tshwm sim tsis zoo hauv tus neeg mob. Nws yuav tsum raug sau tseg tias analogues raug xaiv raws li tus nqi ntsuas, nws tseem ua lub luag haujlwm tseem ceeb.
Cov tshuaj Galvus vildagliptin (Latin - Vildagliptinum), tuaj yeem suav hais tias yog ib qho tshuaj tiv thaiv hypoglycemic zoo, uas tau noj ob qho tib si ua lub hauv paus thiab hauv kev sib xyaw nrog lwm cov tshuaj. Piv txwv, kev sib xyaw ntawm vildagliptin, metformin nrog sulfonylurea derivatives. Kev ywj pheej siv cov tshuaj yog txwv tsis pub, koj yuav tsum ua raws li kws kho mob cov lus pom zoo. Zoo, nyob rau hauv rooj plaub thaum cov tshuaj tsis tuaj yeem noj rau qee qhov laj thawj, tus kws kho mob tau sau ntawv siv analogues. Daim yeeb yaj kiab hauv tsab xov xwm no yuav txuas ntxiv cov ncauj lus ntawm cov tshuaj rau ntshav qab zib.
