Trazhenta yog qhov tshuaj hypoglycemic rau kev siv sab hauv. Cov khoom yog tsim nyob rau hauv daim ntawv ntawm puag ncig, ci liab ntsiav tshuaj nrog convex sab thiab ntug beveled. Ntawm ib sab ntawm cov ntsiav tshuaj yog lub tuam txhab logo, thiab nyob rau lwm yam, kos npe D5.
Lub ntsiab ua haujlwm tseem ceeb ntawm cov tshuaj yog 5 mg ntawm linagliptin, lub koom haum pabcuam ntawm cov tshuaj yog pob kws nplej siab, mannitol, magnesium stearate, copovidone, pregelatinized starch. Koj tuaj yeem yuav cov tshuaj hauv cov blisters txhuas ntawm 7 ntsiav tshuaj txhua.
Cov tshuaj raug pom zoo rau kev siv nrog hom 2 mob ntshav qab zib mellitus, cov cuab yeej no yuav dhau los ua ib qho tshuaj zoo tshaj plaws yog tias, tiv thaiv keeb kwm yav dhau los ntawm kev tawm dag zog lub cev thiab kev noj haus, nws tsis tuaj yeem ua kom cov ntshav qab zib nyob rau hauv ib qib.
Cov tshuaj yuav tsum yog kws tshuaj yog tias cov mob ntshav qab zib muaj keeb kwm ntawm lub raum tsis ua haujlwm, Metformin yog contraindicated lossis tus neeg tsis zam cov tshuaj no. Trazent yuav siv tau ua ke nrog:
- sulfonylurea derivatives;
- Thiazolidine;
- Metformin.
Tsis tas li, ib qho tshuaj yog tsim nyog yog tias kev kho mob nrog cov tshuaj no tsis txhim kho tus neeg mob tau zoo.
Trazenta, tus nqi rau 30 ntsiav tshuaj ntawm 5 mg yuav yog txog 1,500 rubles, koj tuaj yeem yuav nws hauv chaw muag tshuaj thiab chaw muag tshuaj online. Cov tshuaj tau nkag mus rau hauv radar (sau npe ntawm cov tshuaj). Cov tshuaj noj (analogue) ntawm cov tshuaj: Nesina, Onglisa, Yanuviya, Galvus, Komboglisa, pheej yig analogues tsis muaj nyob.
Cov lus qhia rau kev siv tshuaj
Cov lus qhia tau qhia tias cov tshuaj yuav tsum tsis txhob kho thaum cev xeeb tub, mob ntshav qab zib hom 1, thaum pub niam mis, menyuam yaus hnub nyoog qis dua 18 xyoo, nrog rau qhov tshwm sim ntawm qee yam tshuaj, ketoacidosis tshwm sim los ntawm ntshav qab zib mellitus.
Kev noj tshuaj rau ib tus neeg mob laus yog 5 mg, koj yuav tsum tau noj tshuaj peb zaug ib hnub. Thaum cov tshuaj raug coj nrog Metformin, nws cov tshuaj tsis raug hloov pauv. Cov tshuaj rau cov neeg mob ua tsis taus lub raum tsis xav kom hloov kho.
Thaum lub sij hawm kawm ntawm pharmacokinetics, nws tau pom tias nrog teeb meem daim siab nws muaj peev xwm hloov pauv ntau npaum li cas ntawm cov tshuaj, Txawm li cas los xij, lub sijhawm tam sim no, tsis muaj kev paub tiav nrog kev siv cov tshuaj no hauv cov neeg mob ntshav qab zib.
Tsis tas yuav kho qhov koob tshuaj rau cov neeg laus, tab sis:
- txawm li cas los xij, nws tsis pom zoo rau cov neeg mob laus dua 80 xyoo los noj cov tshuaj, vim tias tsis muaj kev sim tshuaj;
- yog li nws tsis tau tsim nws tus kheej li kev nyab xeeb kev kho mob rau menyuam yaus thiab tub ntxhais hluas
Thaum tus mob ntshav qab zib siv tshuaj kho Trazent tas li thiab tsis nco qab koob tshuaj, nws yuav tsum noj tshuaj ntxiv sai li sai tau, tab sis nws qhov tshuaj tsis tuaj yeem muab ob npaug. Cov tshuaj yog noj thaum twg los tau, tsis hais noj zaub mov.
Kev kho mob tuaj yeem tshwm sim raws li ntau tus qauv. Cov ntsiav tshuaj tau siv los ua kev kho mob ntshav qab zib rau cov neeg mob ntshav qab zib nrog kev tswj tsis tau glycemic tiv thaiv keeb kwm ntawm cov khoom noj muaj ntshav qab zib kom tsawg, ua kom lub cev qoj ib ce, yog tias ib tug neeg tsis zam Metformin, cov tshuaj zoo sib xws.
Cov tshuaj yuav dhau los ua ib feem ntawm kev tiv thaiv ob yam nrog Metformin, thiazolidinediones, sulfonylurea derivatives thaum tsis muaj txiaj ntsig ntawm kev kho mob monotherapy hu ua tshuaj, kev tsis muaj zog ntawm kev tawm dag zog thiab kev noj haus.
Cov tshuaj yog siv los ua peb qho kev sib xyaw ua ke nrog kev kho mob zoo nrog tshuaj sib pauv ntawm Metformin. Tus kws kho mob tseem sau ntawv yuav tshuaj nrog rau:
- cov tshuaj insulin;
- Pioglitazone;
- sulfonylurea derivatives.
Tom qab thov 5 mg ntawm cov tshuaj hauv, cov tshuaj yeeb dej caw pib tsom, nce mus txog qhov xav tau siab tshaj plaws tom qab 1.5 teev. Qhov siab yuav txo qis raws li cov txheej txheem peb-theem, lub davhlau ya nyob twg ib nrab-lub neej yog ntau tshaj 100 teev, uas yog tshwm sim los ntawm ruaj khov, khov kho khi ntawm linagliptin.
Kev zoo ib nrab-lub neej los ntawm lub cev tom qab rov ua dua ntawm cov tshuaj yuav yog 12 teev.
Tom qab siv ib zaug nkaus ntawm cov tshuaj, cov ntsiab lus ruaj khov ntawm cov tshuaj tau pom tom qab hais txog koob thib peb.
Cov mob ntawm kev noj ntau dhau, phiv tsis zoo ntawm lub cev
Cov ntaub ntawv tshawb fawb txog kev kho mob qhia tau hais tias kev siv ib zaug nkaus xwb ntawm 600 mg ntawm cov tshuaj tsis ua rau noj tshuaj ntau dhau thiab tsis ua mob rau cov ntshav qab zib. Nws tsis muaj cov ntaub ntawv hais txog cov teeb meem no ntau tshaj ntawd. Txawm li cas los xij, txhawm rau kom muaj kev nyab xeeb, thaum siv ntau dhau ntawm cov tshuaj, nws yog ib qho tseem ceeb kom tshem tawm lub plab los ntawm kev yaug lossis ntxias kom ntuav.
Nco ntsoov hu kws kho mob lossis hu rau pab neeg mob lub tsheb tos neeg mob. Tej zaum yuav muaj kev ua txhaum ntawm kev noj qab haus huv, nws yuav tsim nyog los sau tshuaj kho kom zoo.
Ib qho ntxiv yog qhov tsis zoo ntawm lub cev, tus naj npawb ntawm cov kev coj tsis zoo no yog sib npaug ntawm tus naj npawb ntawm cov txiaj ntsig tsis zoo thaum kev noj cov placebo. Yog li, tus neeg mob tuaj yeem pib: tus txheej txheem ua mob rau hauv cov txiav, hnoos tawm tsam, nasopharyngitis, muaj kev cuam tshuam rau qee yam tshuaj, hypertriglyceridemia.
Koj yuav tsum paub tias cov tshuaj nquag ntawm cov tshuaj yuav ua rau kiv taub hau, yog li ntawd:
- nws yog qhov zoo dua rau kev thim rov qab ntawm kev tsav tsheb thiab lwm yam txheej txheem kev sib xyaw;
- Zam kev tawm dag zog lub cev.
Cov kev tsis zoo tshuaj feem ntau tshwm sim thaum kho nrog Trazent nrog rau sulfonylurea derivatives thiab Metformin.
Thaum kev sib koom tes nrog kev sib xyaw nrog cov tshuaj ntawm linagliptin lossis pioglitazone feem ntau ua, kev mob ntshav qab zib feem ntau ua rau hnyav, mob pancreatitis, kev tiv thaiv kab mob hauv lub cev tiv thaiv kab mob yuav pib.
Cov lus qhia tshwj xeeb
Cov tshuaj tsis tau teev tseg rau cov poj niam cev xeeb tub, nws cov nyhuv ntawm tus poj niam lub cev thaum menyuam muaj menyuam tseem tsis tau kawm txog hnub. Txawm li cas los xij, kev kho mob hauv cov tsiaj tsis pom muaj qhov tsis zoo rau kev ua me nyuam. Cov kev sim ntawm tus poj niam lub peev xwm xeeb tub tsis tau ua, kev sim rau tsiaj tsis pom tias muaj qhov tsis zoo.
Cov ntaub ntawv uas tau txais thaum lub sij hawm kev tshawb pharmacodynamic ntawm cov tsiaj qhia pom kev nkag mus ntawm cov tshuaj mus rau hauv niam mis. Vim li no, cov nyhuv ntawm cov tshuaj rau ntawm tus menyuam tsis raug cais tawm. Qee qhov xwm txheej, cov kws kho mob hais txog kev tsis ua lactation hauv ib tus poj niam, yog tias muaj qhov xav tau ceev nrooj yuav tsum tau taw nws ncaj qha Trazhenta.
Cov lus qhia Trazenta rau kev siv qhia tias nws yog qhov yuav tsum khaws cov tshuaj ntawm qhov kub tsis tshaj 25 degrees hauv qhov chaw tsaus, kom deb ntawm cov menyuam yaus. Txee lub neej yog 2.5 xyoo.
Endocrinologist tsis txhob muab tshuaj rau cov neeg mob noj:
- nrog ntshav qab zib hom 1;
- nrog mob ketoacidosis.
Cov mob ntshav qab zib tuaj yeem ua rau tus mob ntshav qab zib tsawg, qhov laj thawj yuav cuam tshuam nrog kev sib koom tes kho nrog sulfonylureas.
Tsis muaj cov ntaub ntawv hais txog kev cuam tshuam ntawm cov tshuaj nrog cov tshuaj insulin; cov neeg mob raum tsis zoo yog raug kho nrog rau lwm cov tshuaj kom ua rau lub cev tsis zoo. Trazenta tshuaj xyuas yog ib txwm tsuas yog qhov zoo.
Thaum siv concomitantly nrog cov tshuaj, Ritonavir yuav nce linagliptin los ntawm li 2-3 zaug, tsis pom qhov cuam tshuam (feem ntau yog 1% ntawm kev kho tshuaj), thiab yuav nce 5 zaug tom qab sib xyaw tshuaj no. Cov kev hloov pauv hauv pharmacokinetics tsis tau txiav txim siab yog qhov tseem ceeb hauv tsev kho mob, vim li no tsis muaj kev cuam tshuam loj nrog lwm cov tshuaj tiv thaiv kab mob, kev cia tshuaj yuav tsis tshuaj xyuas.
Thaum kho nrog Rifampicin, muaj ib qho kev txo qis hauv pharmacokinetics ntawm ob qho tshuaj los ntawm 39 mus rau 43%, qhov txo qis hauv cov dej hauv qhov ua kom tsis haum los ntawm 30%. Qhov ua tau zoo ntawm kev kho yog tswj tseg, tab sis qhov no tsis tshwm sim hauv qhov puv.
Thaum lub sij hawm daim ntawv thov ntawm Trazhenty nrog Digoxin, kev sib txuam tsis tshwm sim, txawm tias xws li kev sib koom siv:
- pheej hais tas;
- nyob rau hauv ntau yam tshuaj.
Rov qab siv cov tshuaj ntawm cov tshuaj ntawm 5 mg / hnub tsis tuaj yeem hloov pauv pharmacokinetics ntawm Warfarin. Yog tias Simvastatin thiab nce ntxiv ntawm linagliptin siv dua, ib qho cuam tshuam rau lub pharmacokinetics ntawm thawj cov tshuaj tshwm sim. Qhov tshwm sim no zoo li qub; kev hloov kho ntawm cov tshuaj pom zoo tsis tsim nyog. Tom qab kev kho mob tsis tu ncua nrog Trazenta hauv ib qho nyiaj nce thiab Simvastatin 40 mg, qhov kev ua haujlwm ntawm tom kawg tau nce los ntawm 34%, hauv cov ntshav nce li 10%.
Thaum twg ib hom 2 mob ntshav qab zib siv tshuaj tiv thaiv qhov ncauj thaum kho nrog Trazenta, tsis muaj kev txhawb nqa thiab kev hloov pauv tseem ceeb hauv pharmacokinetics ntawm cov tshuaj no.
Lub tuam txhab tshuaj xyuas
DPP-4 cov tshuaj tiv thaiv (cov tshuaj yog pab pawg rau pawg) yog qhov txawv tsis yog los ntawm qhov pom cov ntshav qab zib kom qis qis dua, tab sis kuj los ntawm kev nce qib ntawm kev nyab xeeb, vim lawv tsis tuaj yeem ua rau lub cev nce ntxiv ntawm cov ntshav qab zib thiab hypoglycemic lub xeev. Cov tshuaj ntawm cov pab pawg no tau pom tias yog qhov ua tau zoo tshaj plaws thiab tau cog lus zoo hauv kev kho mob ntshav qab zib hom 2 hauv cov menyuam yaus thiab cov laus.
Qhov ua tau zoo ntawm kev kho mob tau lees paub los ntawm ntau txoj kev tshawb fawb, nws yog ib qho tsim nyog yuav tsum pib chav kawm ntawm kev kho mob tshwj xeeb nrog kev sib xyaw nrog lwm cov tshuaj. Nyob rau hauv lub xub ntiag ntawm ib tug predisposition rau sib txawv nyob rau hauv cov piam thaj thiab nws ntse txo, kev hloov pauv rau sulfonylureas yog qhia.
Qee lub sij hawm nws tau txiav txim siab los siv cov tshuaj raws li txhais tau tias kev kho mob monotherapy nrog lub cev tiv thaiv cov tshuaj hormone insulin thiab rog dhau. Tam sim no tom qab 3 lub hlis ntawm txoj kev kho, qhov txo qis hauv qhov hnyav qhia tau pom tias.
Cov lej tseem ceeb ntawm kev tshuaj xyuas tau txais los ntawm cov neeg mob ntshav qab zib uas tau siv 5 mg ntawm cov tshuaj ua ib feem ntawm txoj kev kho mob. Hauv kev pom txog qhov no, nws nyuaj nyuaj rau kev tshuaj xyuas qhov tseeb los ntawm Trazhent los ntawm nws:
- cov hauj lwm zoo;
- kev ruaj ntseg.
Txawm li cas los xij, yuav luag txhua tus neeg mob paub tseeb tias nws yog cov tshuaj no uas pab lawv poob phaus.
Txawm hais tias muaj qee qhov kev txwv ntawm kev siv Trazent, nws yog tshuaj rau cov neeg mob ntshav qab zib hom thib ob ntawm txhua lub hnub nyoog, suav nrog cov neeg laus, kev txom nyem los ntawm cov kab mob ntawm lub raum, daim siab, lub siab. Feem ntau cov kev mob tshwm sim ntawm kev kho mob no yog nasopharyngitis.
Cov ntaub ntawv hais txog kev nqis tes ntawm DPP-4 inhibitors muaj nyob hauv video hauv tsab xov xwm no.
