Hmoov tsis zoo, nws tsis tuaj yeem tswj tau theem qab zib nrog kev tawm dag zog lub cev thiab kev noj zaub mov kom zoo. Tom qab ntawd koj yuav tsum siv, piv txwv li, Galvus, domestic analogues, tus nqi ntawm uas nws yog ntau tsawg dua li cov tshuaj yeeb yaj kiab, uas cuam tshuam nrog kev txo nqi ntawm kev thauj mus los, kev tuav pov hwm, kev ntim khoom.
Vim tias nws tus nqi siab, feem ntau cov neeg mob uas tau nyiaj tsawg thiab nruab nrab tau hloov mus rau kev kho mob nrog analogues. Tab sis dab tsi yog qhov zoo dua rau xaiv? Qhov no yuav sib tham ntxiv mus, tab sis ua ntej ntawm tag nrho cov, koj yuav tsum paub koj tus kheej nrog cov tshuaj Galvus.
Cov nquag ua haujlwm ntawm tus neeg sawv cev hypoglycemic yog vildagliptinum, tab sis muaj cov kev xaiv rau kev sib xyaw nrog metformin. Thaum mus yuav tshuaj hauv chaw muag tshuaj, tus kws muag tshuaj muaj ntau yam tshuaj - 50 mg, nrog rau kev sib xyaw nrog metformin 50/500 mg, 50/850 mg thiab 50/1000 mg.
Vildagliptin yog ib pawg tshuaj uas txhim kho kev ua haujlwm ntawm alpha thiab beta hlwb uas tsim cov islets ntawm Langerhans rau hauv lub txiav thiab txwv qhov kev txiav txim ntawm dipeptidyl peptidase-4. Qhov enzyme tshwj xeeb no rhuav tshem glucagon-zoo li hom 1 peptide (GLP-1) thiab cov kua nplaum-insulinotropic polypeptide (HIP).
Cov yam ntxwv dav dav ntawm cov tshuaj
Ua tsaug rau vildagliptin, qhov tshwm sim tsis zoo ntawm dipeptidyl peptidase-4 raug txo qis, thiab kev tsim tawm ntawm GLP-1 thiab HIP, ntawm qhov tsis sib xws, tau kho kom zoo dua. Thaum cov theem ntawm cov tshuaj no hauv cov ntshav nce siab, vildagliptin txhim kho qhov ua rau muaj kev cuam tshuam ntawm cov hlwb ua rau cov kua nplaum tsim, thiaj li ua kom cov khoom qab zib-txo cov tshuaj hormones. Nws yuav tsum raug sau tseg tias qhov muaj nuj nqis ntawm kev ua kom zoo ntawm kev ua haujlwm ntawm cov hlwb hlwb yog nyob ntawm qib ntawm lawv qhov kev rhuav tshem. Yog li, hauv cov neeg muaj ntshav qab zib li qub, vildagliptin tsis cuam tshuam rau cov kua dej insulin thiab, yog lawm, cov piam thaj ntau ntau.
Cov nquag tivthaiv tsub kom qhov feem pua ntawm GLP-1 thiab sai li sai tau nce qhov rhiab ntawm alpha hlwb ntawm islet apparatus rau qabzib. Raws li qhov tshwm sim, glucagon ntau lawm zuj zus. Kev poob qis hauv nws qib nce nyob rau thaum lub caij noj mov ua rau muaj qhov nce siab ntawm cov hlwb sib luag mus rau cov ntshav qab zib.
Thaum lub sijhawm nce ntxiv ntawm cov piam thaj, cov qib glucagon thiab insulin nce ntxiv, uas ncaj qha rau cov khoom tawg ntawm GLP-1 thiab HIP, thiab cov txheej txheem ntawm cov piam thaj hauv cov ntshav ua rau tag nrho ob qho tib si thaum noj mov thiab tom qab nws, uas ua rau muaj qhov txo qis hauv cov ntau ntau ntawm cov piam thaj hauv cov ntshav. Nws yuav tsum raug sau tseg tias qhov kev tiv thaiv tsis txaus ntseeg cov ntsiab lus ntawm GLP-1 tuaj yeem ua rau cov txheej txheem ntawm lub plab zom mov, txawm hais tias nyob rau hauv kev siv txoj kev kho tsis tau ua rau muaj kev txhim kho ntawm qhov tshwm sim.
Kev siv ntau ntawm ob feem - metformin thiab vildagliptin, txawm tias zoo dua tswj cov qib ntawm glycemia hauv ntshav qab zib rau 24 teev.
Cov lus qhia rau kev siv ntsiav tshuaj
Noj mov tsis muaj kev cuam tshuam rau kev siv tshuaj Galvus lossis Galvus Met.
Ua ntej siv cov tshuaj, nws yog qhov yuav tsum tau nrhiav kev pab ntawm tus kws tshaj lij uas yuav txiav txim qhov tsuas tshuaj ib tus zuj zus.
Hauv cov lus qhia txuas rau tshuaj Galvus 50 mg, noj tshuaj yog qhia tau tuaj yeem hloov kho los ntawm tus kws kho mob tau koom nrog:
- Nrog rau kev kho mob monotherapy lossis hauv kev sib xyaw nrog kev siv tshuaj insulin, thiazolidinedione, metformin - 50-100 mg.
- Cov neeg muaj mob ntshav qab zib ntau dua yuav noj 100 mg ib hnub twg.
- Txais tos ntawm vildagliptin, derivatives ntawm sulfonylurea thiab metformin - 100 mg rau ib hnub.
- Kev siv ntau ntawm sulfonylurea thiab Galvus derivatives qhia ib koob tshuaj ntawm 50 mg rau ib hnub.
- Yog hais tias tus mob ntshav qab zib tau mob pes tsawg thiab siab lub raum ua haujlwm, qhov tshuaj txhua hnub yog 50 mg.
Cov lus ntxig muaj cov ncauj lus uas qhia txog kev noj tshuaj 50 mg yuav tsum noj ib zaug thaum sawv ntxov, thiab 100 mg yuav tsum muab faib ua ob zaug - thaum sawv ntxov thiab yav tsaus ntuj.
Dosages ntawm cov tshuaj Galvus Met kuj tau txiav txim siab los ntawm tus kws kho mob, coj mus rau hauv tus account theem ntawm qab zib thiab kev zam ntawm cov feem ntawm cov tshuaj rau tus neeg mob. Phau ntawv qhia cov kev siv nyiaj hauv qab no:
- nrog qhov tsis muaj txiaj ntsig ntawm kev siv vildagliptin, nws raug nquahu kom noj 50/500 mg ob zaug ib hnub;
- yog tias kev siv cov metformin yog qhov tsis muaj txiaj ntsig, noj 50/500 mg, 50/850 mg lossis 50/1000 mg ob zaug ib hnub, nyob ntawm seb cov metformin siv yav tas los;
- nrog rau kev sib txuam tsis zoo ntawm vildagliptin thiab metformin, 50/500 mg, 50/850 mg lossis 50/1000 mg ob zaug ib hnub siv, nyob ntawm cov khoom siv uas siv;
- thaum pib kho nrog cov tshuaj vim tsis muaj txiaj ntsig ntawm kev noj haus thiab kev tawm dag zog lub cev, noj 50/500 mg ib hnub ib zaug;
- ua ke nrog kev siv tshuaj insulin thiab sulfonylurea derivatives, ntau npaum ntawm vildagliptin yog 50 mg ob zaug ib hnub, thiab metformin yog tib yam li nrog kev kho mob tshuaj.
Kev siv cov tshuaj yog nruj me ntsis txwv rau cov neeg mob ntshav qab zib raug kev txom nyem los ntawm lub raum tsis ua haujlwm thiab lwm txoj kev ua haujlwm ntawm cov khoom no. Ntxiv rau, kev saib xyuas tshwj xeeb yog tsim rau cov neeg mob ntawm cov hnub nyoog laus dua (ntau dua 65 xyoos), vim lawv feem ntau muaj lub raum ua haujlwm tsawg dua.
Tus kws kho mob tuaj yeem nce qhov ntau ntxiv ntawm cov tshuaj, txawm li cas los xij, nws yog txwv tsis pub koom nrog kev kho mob ntawm koj tus kheej, qhov no tuaj yeem ua rau tsis muaj qhov xav tau thiab tsis cuam tshuam qhov tshwm sim.
Cov txheej txheem sib tsoo thiab cov phom sij uas yuav muaj
Cov tshuaj muaj tshuaj ntau dhau, nrog rau lwm cov tshuaj.
Yeej, contraindications yog txuam nrog kev muaj peev xwm ntawm qee cov tib neeg lub cev kom tshem tawm cov tshuaj nquag tawm ntawm lub cev.
Nws yog txwv tsis pub siv txoj kev ntawm Galvus thiab Galvus Met rau cov neeg mob ntshav qab zib raug kev txom nyem lossis kev txom nyem los ntawm qee qhov mob:
- Cov raum tsis ua haujlwm lossis lub raum tsis ua haujlwm (cov ntsiab lus creatinine yog ntau dua 135 μmol / L hauv cov txiv neej, ntau dua 110 μmol / L hauv tus poj niam).
- Pathologies uas ua rau muaj kev pheej hmoo ntawm kev tsim cov raum ua haujlwm tsis zoo. Cov no suav nrog lub cev qhuav dej (ntuav lossis zawv plab), ua npaws, kis mob, thiab lub xeev ntawm hypoxia.
- Daim siab ua hauj lwm.
- Qhov pib ntawm lactic acidosis.
- Kev txhim kho ntawm kev ua tsis taus pa.
- Kev loj hlob ntawm lub plawv tsis ua haujlwm nyob rau hauv mob thiab mob ntev, nrog rau cov mob myocardial infarction.
- Metabolic acidosis, suav nrog qhov pib ntawm ketoacidosis, coma, precoma.
- Lub sijhawm thaum xeeb menyuam thiab pub niam mis.
- Ntshav qab zib mob insulin.
- Kev phais mob.
- Koj tuaj yeem siv tsis tau cov tshuaj ob hnub ua ntej thiab tom qab radiological thiab radioisotope kev soj ntsuam nrog kev qhia ntawm cov khoom sib xyaw uas muaj iodine.
- Intoxication nrog cawv lossis nws daim ntawv ntev.
- Kev noj zaub mov kom tsawg (tsawg dua 1000 kcal ib hnub).
- Tsis muaj hnub nyoog qis dua 18 xyoo.
- Ib leeg tsis zwm rau vildagliptin, metformin thiab lwm yam.
Yog tias cov tshuaj siv tsis tsim nyog lossis rau cov laj thawj dhau ntawm kev tswj hwm ntawm tus neeg mob, qhov tshwm sim tsis zoo yuav tshwm sim, piv txwv:
- mob taub hau thiab kiv taub hau;
- kev tsis tuaj yeem ua rau mob leeg (tshee) thiab ua daus no;
- gastroesophageal reflux;
- bouts ntawm xeev siab thiab ntuav;
- raws plab lossis quav tawv;
- kev siv roj ntxiv hauv cov hnyuv;
- hloov pauv hauv saj
- ntshav tshuaj qis;
- kev nkees;
- hyperhidrosis;
- ua pob rau ntawm daim tawv nqaij, khaus, urticaria;
- ntu khoom haum;
- arthralgia (mob pob qij txha);
- exfoliation ntawm daim tawv nqaij;
- qhov pom ntawm cov hlwv;
- lactic acidosis;
- vitamin B12 tsis muaj peev xwm;
- pancreatitis
Tsis tas li, kab mob siab tuaj yeem pib ua hauv lub cev.
Tus nqi, tshuaj xyuas thiab cov lus txhais
Tus tsim cov tshuaj yog Swiss tuam txhab tshuaj Novartis, uas ua cov tshuaj vildagliptin lossis nrog sib xyaw nrog vildagliptin nrog metformin.
Cov tshuaj muaj peev xwm xaj online online lossis mus rau qhov chaw muag tshuaj nyob ze. Tus nqi ntawm cov tshuaj nyob ntawm nws daim ntawv tso tawm. Tus nqi ntau yog raws li nram no:
- Galvus 50 mg (28 ntsiav tshuaj) - 765 rubles.
- Galvus Met 50/500 mg (30 ntsiav tshuaj) - 1298 rubles.
- Galvus Met 50/850 mg (30 ntsiav tshuaj) - 1380 rubles.
- Galvus Met 50/1000 mg (30 ntsiav tshuaj) - 1398 rubles.
Raws li koj tuaj yeem pom, cov tshuaj tsis pheej yig. Tsis yog txhua tus yuav muaj peev xwm them taus tas li nrog cov tshuaj no, yog li yuav tsum xaiv cov tshuaj zoo sib xws, uas yuav tham tom qab.
Raws li rau lub tswv yim ntawm cov tshuaj Galvus, lawv feem ntau zoo. Kev tshuaj xyuas ntawm feem ntau ntawm cov neeg mob noj cov tshuaj qhia tau tias tom qab 1-2 lub hlis ntawm noj Galvus, cov cim qhia qabzib rov qab tsis tau. Ntxiv rau, cov ntshav qab zib tau zoo li thaum lub sijhawm siv cov tshuaj koj tuaj yeem noj cov zaub mov txwv ua ntej. Galvus Met, ua tsaug rau nws cov metformin, pab ua kom poob phaus 3-4 hauv cov neeg mob rog rog. Txawm li cas los xij, cov tshuaj muaj ib qho loj tsis txaus - nws yog nws tus nqi siab.
Yog hais tias tus neeg mob raug txwv tsis pub siv Galvus vim yog qhov tsis sib xws los yog kev mob tshwm sim, tus kws kho mob tau sau ntawv rau lwm cov tshuaj. Cov no tuaj yeem txhais tau, uas yog, cov khoom lag luam uas muaj cov tib lub tshuaj nquag, qhov sib txawv tsuas yog hauv cov sib txuas ntxiv. Galvus Met yog tib qho lus rau Galvus; cov no yog ob qho kev npaj muaj vildagliptin.
Txawm li cas los xij, cov tshuaj no muaj ntau cov tshuaj zoo sib xws nrog cov kev kho mob zoo sib xws, uas yuav tau tham txog tom qab.
Cov tshuaj ntawm cov tshuaj Galvus
Cov tshuaj pab pawg no suav nrog cov nquag ua haujlwm - vildagliptin. Cov no suav nrog Vipidia, Onglisa, Januvius thiab Trazent cov nyiaj. Hauv Lavxias, kev npaj muaj vildagliptin tsis tsim, yog li peb yuav tham txog cov tshuaj txawv teb chaws.
Vipidia yog cov tshuaj txo ntshav qab zib uas yog npaj rau tshuaj tua kab mob los yog kev kho mob ntshav qab zib hom 2. Nws tso tawm hauv cov qauv ntsiav tshuaj, qhov siab tshaj txhua hnub yog 25 mg thiab tsis nyob ntawm qhov noj mov. Tus neeg sawv cev hypoglycemic tuaj yeem siv tsis tau los ntawm cov neeg mob ntshav qab zib nrog lub raum, mob ntshav siab, lub plawv tsis ua haujlwm, uas muaj ketoacidosis uas muaj ntshav qab zib thiab muaj cov ntshav qab zib insulin. Cov kev mob tshwm sim yog zoo li cov nyhuv tsis zoo ntawm cov tshuaj Galvus. Vim tias tsis muaj cov ntaub ntawv hais txog qhov tshwm sim ntawm cov tshuaj rau cov menyuam yaus hnub nyoog qis dua 18 xyoo thiab poj niam cev xeeb tub, nws tsis tau hais txog rau cov neeg mob ntawd. Tus nqi nruab nrab ntawm Vipidia (25 mg 28 ntsiav tshuaj) yog 1239 rubles.
Onglisa yog qhov ua tau zoo npaj rau kev tswj cov ntshav qabzib hauv lub plab thiab tom qab noj mov tas. Ua tsaug rau cov tshuaj tseem ceeb saxagliptin, cov tshuaj kuj tseem tswj cov ntsiab lus ntawm glucagon. Nws tuaj yeem siv ob qho tib si raws li lub cuab tam ruaj khov thiab hauv kev sib xyaw nrog lwm cov tshuaj. Onglis tshuaj yog contraindicated nyob rau hauv kev kho mob insulin, hom 1 mob ntshav qab zib thiab ketoacidosis. Qhov tseem ceeb tsis zoo yog mob taub hau, o, mob caj pas. Tus nqi nruab nrab ntawm cov tshuaj (5 mg 30 ntsiav tshuaj) yog 1936 rubles.
Januvia yog tus neeg sawv cev hypoglycemic, uas suav nrog kev ua haujlwm ntawm sitagliptin. Kev siv cov tshuaj pab ua kom ib txwm muaj qib ntawm glycemia thiab glucagon. Cov koob tshuaj yog txiav txim siab los ntawm tus kws kho mob tuaj koom, uas yuav siv mus rau hauv tus account cov piam thaj, kev noj qab haus huv dav thiab lwm yam. Cov tshuaj Januvia yog contraindicated nyob rau hauv cov ntaub ntawv ntawm insulin-tiv thaiv cov ntshav qab zib thiab ib tug neeg tsis kam rau lub Cheebtsam. Thaum siv, mob taub hau, mob plab zom mov, mob pob txha, thiab mob ua pa tuaj yeem tshwm sim. Qhov nruab nrab, tus nqi tshuaj (100 mg 28 ntsiav tshuaj) yog 1666 rubles.
Trazhenta yog yeeb tshuaj uas tsim nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj nrog lub zog tshuaj lignagliptin. Nws tsis muaj zog gluconeogenesis thiab tswj qib ntshav qab zib. Tus kws kho mob xaiv cov tshuaj ntau npaum li cas rau txhua tus neeg mob.
Nws tsis tuaj yeem siv rau ketoacidosis, hom 1 mob ntshav qab zib thiab mob tsis txaus rau cov tshuaj uas muaj. Tus nqi nruab nrab (5 mg 30 ntsiav tshuaj) yog 1769 rubles.
Cov tshuaj ntawm cov tshuaj Galvus Met
Txog rau Galvus Met siv yeeb tshuaj, cov kab mob sib piv yog Avandamet, Glimecomb, Combogliz Prolong ntawm Lavxias ntau lawm, muaj cov tshuaj ob feem tseem ceeb rau kev ua haujlwm zoo dua qab zib.
Avandamet yog ib qho ua ke nrog hypoglycemic tus neeg sawv cev uas muaj ob lub ntsiab lus tseem ceeb - rosiglitazone thiab metformin. Cov tshuaj yog siv rau hauv kev kho mob ntawm qhov tsis muaj tshuaj lom ntshav-ntshav qab zib tsis txaus. Qhov kev ua ntawm rosiglitazone yog ua kom muaj kev cuam tshuam ntawm kev nkag siab ntau ntxiv ntawm cov cell receptors rau insulin, thiab metformin - ntawm kev ua kom cov ntshav qabzib los ntawm lub siab. Tus nqi nruab nrab ntawm cov tshuaj (500/2 mg 56 ntsiav tshuaj) yog 210 rubles, yog li nws yog tus nqi pheej yig.
Glimecomb yog lwm cov tshuaj zoo uas tswj tau theem ntawm qabzib ntshav qab zib. Nws muaj ob lub ntsiab - gliclazide thiab metformin. Cov tshuaj tiv thaiv kom tsis txhob siv cov tshuaj no yog cov ntshav qab zib insulin-tiv thaiv cov ntshav qab zib, coma thiab precoma, hypoglycemia, cev xeeb tub, pub niam mis thiab lwm yam kab mob pathologies. Tus nqi nruab nrab (40/500 mg 60 ntsiav tshuaj) yog 440 rubles.
Combogliz Prolong suav nrog cov hauv paus ntsiab lus xws li metformin thiab saxagliptin. Nws yog siv rau cov ntshav qab zib hom 2, thaum ua si lub cev thiab khoom noj tshwj xeeb tsis tuaj yeem muab cov kua nplaum txo qis. Cov tshuaj pab insulin tawm hauv beta hlwb thiab txhim kho qhov ua rau muaj kev cuam tshuam ntawm cov hlwb rau nws. Cov tshuaj tiv thaiv tsis zoo rau kev siv tshuaj yog ib tus neeg mob rhiab rau cov tshuaj ntawm cov tshuaj, insulin-tiv thaiv cov ntshav qab zib, menyuam yaus, kabmob menyuam, lactation, lub raum tsis ua haujlwm, mob siab, metabolic acidosis thiab lwm yam. Tus nqi nruab nrab ntawm cov tshuaj (1000/5 mg 28 ntsiav tshuaj) yog 2941 rubles.
Raws li contraindications, muaj peev xwm ua mob thiab tus nqi siab ntawm cov tshuaj, nws tuaj yeem hloov los ntawm lwm tus. Raws li koj tuaj yeem pom, cov tshuaj hauv no series yuav luag txhua qhov kim. Ntawm lawv, ob qho tshuaj yeeb yaj kiab tuaj yeem sib txawv - Glimecomb thiab Avandamet, uas yog cov pheej yig tshaj plaws ntawm lwm cov tshuaj hypoglycemic. Thaum xaiv cov kev xaiv zoo tshaj plaws, ob tus kws kho mob thiab tus neeg mob coj mus rau hauv ob qho tseem ceeb tshaj plaws - tus nqi thiab kev kho mob ntawm cov tshuaj.
Cov lus qhia txog cov tshuaj kho ntshav qab zib zoo tshaj plaws tau muab tso rau hauv cov yeeb yaj kiab hauv tsab xov xwm no.
