Atherosclerosis yog ib yam mob tshwm sim rau lub sijhawm tam sim no. Nws yog qhov txawv txav los ntawm kev txuam nrog cov roj cholesterol, lossis theej, cov roj cholesterol, hauv tib neeg lub cev, thiab ntau qhov tshwj xeeb hauv nws cov hlab ntsha.
Hauv cov hlab ntsha ntawm cov neeg mob atherosclerosis, cov plahaum roj (cholesterol) plaques yog tso cia, uas ua rau cov ntshav khiav tsis zoo thiab tuaj yeem ua rau muaj kev cuam tshuam zoo li myocardial infarction thiab mob stroke. Atherosclerosis cuam tshuam txog li 85-90% ntawm cov neeg nyob hauv lub ntiaj teb, vim tias ntau ntau ntawm ntau yam los pab rau txoj kev loj hlob ntawm cov kab mob no. Yuav ua li cas rau kev kho mob thiab tiv thaiv tus kab mob no?
Rau kev kho tshuaj ntawm atherosclerosis thiab qee lwm cov kab mob metabolic, cov pawg tshuaj no yog siv los ua statins (Lovastatin, Atorvastatin, Rosuvastatin), fibrates (Fenofibrate), anion-txauv cov kab mob, npaj muaj nicotinic acid thiab tshuaj zoo li vitamin (Lipoic acid).
Cia peb tham ntau ntxiv txog cov tshuaj zoo li vitamin ntawm tus piv txwv ntawm lipoic acid.
Tus txheej txheem ntawm kev txiav txim thiab cuam tshuam ntawm lipoic acid
Lipoic acid, los yog alpha lipoic, los yog thioctic yog cov tshuaj lom neeg lom neeg lub cev.
Lipoic acid belongs rau cov pab pawg ntawm cov sib txuas uas muaj cov tshuaj xws li vitamin.
Acid siv rau hauv kev kho mob los kho ntau yam mob.
Nws qhov tseem ceeb raws roj ntsha yog raws li nram no:
- lipoic acid yog cofactor - cov tshuaj tsis muaj protein ntau, uas yog cov khoom tseem ceeb ntawm cov enzyme;
- ncaj qha koom tes hauv cov txheej txheem ntawm anaerobic (tshwm sim yam tsis muaj lub cev oxygen) glycolysis - kev puas tsuaj ntawm cov dej qabzib molecules rau pyruvic acid, lossis, raws li nws tau hu ua hauv kev hais luv luv, pyruvate;
- potentiates cov nyhuv ntawm cov vitamins B thiab tshuaj rau lawv - koom nrog cov metabolism hauv cov rog thiab carbohydrates, pab kom nce thiab nqis ntawm glycogen hauv daim siab, txo cov ntshav qab zib;
- txo cov intoxication ntawm kev muaj kab mob ntawm lub hauv paus chiv keeb, txo cov nyhuv pathogenic ntawm co toxins ntawm cov kabmob thiab cov nqaij;
- belongs rau cov pab pawg neeg muaj cov tshuaj tiv thaiv kab mob vim muaj peev xwm khi dawb radicals uas lom rau peb lub cev;
- qhov zoo thiab tiv thaiv cuam tshuam rau daim siab (cov kab mob hepatoprotective);
- txo qis cov roj (cov nyhuv hypocholesterolemic);
- ntxiv rau ntau qhov kev daws teeb meem npaj rau kev txhaj tshuaj, txhawm rau txo qhov ntxim nyiam ntawm kev phiv tshuaj.
Ib qho ntawm cov npe ntawm lipoic acid yog vitamin N. Nws tuaj yeem muab tsis tau nrog tshuaj noj nkaus xwb, tab sis kuj noj txhua hnub nrog zaub mov. Vitamin N pom muaj hauv cov khoom noj xws li tsawb, nqaij nyuj, dos, mov, qe, zaub qhwv, nceb, zaub mov mis thiab legumes. Txij li thaum cov khoom lag luam no suav nrog hauv kev noj zaub mov ntawm yuav luag txhua tus neeg, muaj qhov tsis txaus lipoic acid tsis tuaj yeem tshwm sim tas li. Tab sis tseem nws yog tsim tau. Thiab nrog qhov tsis muaj alpha-lipoic acid, qhov pom hauv qab no tuaj yeem pom:
- Kiv taub hau, mob taub hau, nrog rau cov hlab ntshav muag, uas qhia txog kev loj hlob ntawm cov neuritis.
- Kev tsis ncaj ncees ntawm daim siab, uas tuaj yeem ua rau nws cov rog rog tsis txaus thiab ua kom lub cev tsis txaus ntawm kev tsim cov kua tsib.
- Cov txhab tso nyiaj ntawm atherosclerotic plaques rau ntawm cov phab ntsa ntawm cov hlab ntshav.
- Kev hloov pauv ntawm cov kua qaub-lub hauv paus sib npaug rau cov acid sab, vim qhov kev tshwm sim ntawm cov metabolic acidosis.
- Spontaneous spasmodic nqaij mob ntxiv.
- Myocardial dystrophy yog qhov ua txhaum ntawm kev noj haus thiab ua haujlwm ntawm lub siab nqaij.
Raws li zoo li tsis muaj peev xwm, kev dhau los ntawm lipoic acid nyob rau hauv tib neeg lub cev tuaj yeem tshwm sim. Qhov no yog ua pov thawj los ntawm cov tsos mob xws li:
- Kev mob siab;
- hyperacid lub plab zom mov vim qhov tshwm sim hnyav ntawm hydrochloric acid ntawm lub plab;
- mob hauv cheeb tsam epigastrium thiab epigastric;
Ntxiv rau, kev fab tshuaj ntawm txhua yam tuaj yeem tshwm sim ntawm daim tawv nqaij.
Kev taw qhia thiab contraindications rau kev siv ntawm lipoic acid npaj
Alpha lipoic acid muaj nyob hauv ntau hom tshuaj. Qhov tshwj xeeb tshaj yog cov ntsiav tshuaj thiab kev txhaj tshuaj hauv ampoules.
Cov ntsiav tshuaj muaj qhov tshuaj ntau npaum 12,5 txog 600 mg.
Lawv muaj cov xim daj nyob hauv txheej tshwj xeeb. Thiab txhaj tshuaj ampoules muaj kev daws ntawm peb feem pua kev xav.
Cov tshuaj yog ib feem ntawm ntau cov tshuaj noj hauv qab lub npe thioctic acid.
Ib qho tshuaj twg uas muaj lipoic acid yog tshuaj raws li cov cim hauv qab no:
- Atherosclerosis, uas feem ntau cuam tshuam cov hlab ntshav hlab ntsha.
- Cov txheej txheem o ua rau lub siab ua mob los ntawm cov kab mob, thiab nrog mob daj ntseg.
- Ntev mob ua rau daim siab ua ntu zus.
- Tsis hnov qab lipid metabolism hauv lub cev.
- Mob siab ua hauj lwm tsis zoo.
- Lub ntsej muag rog lub siab.
- Kev qaug dab tsi tshwm sim los ntawm cov tshuaj, dej cawv, kev siv nceb, hlau hnyav.
- Cov mob tshwm sim hauv cov hlab ntaws txiav los ntawm kev haus cawv ntau dhau.
- Mob neuropathy mob ntshav qab zib.
- Ua ke ua ke ntawm lub gallbladder thiab txiav ua tus qauv mob ntev.
- Cov mob voos ua paug rau lub siab (tag nrho cov hloov ntawm nws cov parenchyma nrog cov nqaij sib txuas).
- Kev kho mob kom zoo los pab txhawb rau chav ntawm oncological ua haujlwm nyob rau hauv kev tsis tuaj yeem.
Cov kev txwv tsis pub siv rau ib qho tshuaj twg uas muaj lipoic acid yog li hauv qab no:
- tej yam tshwm sim yav dhau los tsis haum ntawm cov tshuaj no;
- cev xeeb tub thiab lactation;
- hnub nyoog 16 xyoo.
Tsis tas li, tag nrho cov tshuaj muaj cov kev mob tshwm sim:
- Ua xua qhov tshwm sim.
- Mob hauv lub plab mog sab sauv.
- Kev poob qis hauv cov ntshav qab zib, uas yog qhov txaus ntshai heev rau cov neeg mob ntshav qab zib;
- Doubling nyob rau hauv lub qhov muag.
- Kev ua tsis taus pa.
- Cov tawv nqaij ua pob raws ntau yam.
- Coagulation ntshawv siab, tshwm sim ua qauv ntawm los ntshav.
- Cov neeg phais ib ce
- Ntuav thiab xeev siab.
- Xaus kev tshwm sim.
- Nce siab intracranial.
Tsis tas li ntawd, cov tsos ntawm pinpoint hemorrhages ntawm daim tawv nqaij thiab cov qog ua kua.
Cov lus qhia rau kev siv tshuaj
Lipoic acid yuav tsum ua tib zoo saib, ua raws nkaus li kev kho mob ntawm koj tus kws kho mob. Tus naj npawb ntawm cov txais tos thaum nruab hnub yog txiav txim los ntawm qhov pib ntau npaum ntawm cov tshuaj. Qhov siab tshaj plaws ntawm thioctic acid hauv ib hnub, uas muaj kev nyab xeeb thiab tuaj yeem lees txais, yog 600 mg. Qhov kev tswj hwm tshaj plaws yog txog li plaub zaug hauv ib hnub.
Cov ntsiav tshuaj tau noj ua ntej noj mov, ntxuav nrog lub qhov ntim ntawm cov dej hauv tag nrho daim ntawv, tsis tas yuav zom. Rau cov kab mob siab nyob hauv qib mob hnyav, 50 mg ntawm lipoic acid yuav tsum noj plaub zaug ib hnub rau ib hlis.
Tom ntej no, koj yuav tsum tau mus so, lub sijhawm uas tus kws kho mob yuav txiav txim siab. Tsis tas li, raws li tau hais ua ntej, ntxiv rau cov ntawv sau, cov txau tshuaj kuj tseem muaj. Lipoic acid yog muab tso rau hauv cov leeg kab mob thiab mob hnyav. Tom qab qhov no, cov neeg mob feem ntau hloov mus rau kev siv cov ntsiav tshuaj, tab sis tib lub sijhawm uas cov tshuaj tau ua - uas yog, ntawm 300 txog 600 mg rau ib hnub.
Ib qho tshuaj twg uas muaj cov tshuaj lipoic yog tso rau hauv cov tshuaj, vim tias lawv tau tshaj tawm cov dej num thiab tsis tuaj yeem siv nrog lwm cov tshuaj.
Kev npaj hauv txhua daim ntawv tso tawm (cov ntsiav tshuaj lossis ampoules) yuav tsum muab cia rau hauv qhov chaw qhuav, tsaus thiab txias.
Nrog kev siv ntau tshaj ntawm cov vitamin N, kev siv tshuaj ntau dhau yuav tshwm sim:
- kev tsis haum tshuaj, suav nrog anaphylaxis (kev tsis haum nrawm nrawm);
- mob thiab rub ncus hauv lub epigastrium;
- ib qho kev poob hauv cov ntshav qab zib ntau - hypoglycemia;
- mob taub hau;
- xeev siab thiab kev zom zaub mov tsis meej pem.
Thaum cov tsos mob zoo li no tshwm sim, nws yog ib qho tsim nyog yuav tsum tshem tawm cov tshuaj thiab pib cov kev mob tshwm sim nrog kev rov ntxiv ntawm lub zog nqi ntawm lub cev.
Lwm cov teebmeem ntawm thioctic acid
Ntxiv rau txhua qhov cuam tshuam saum toj no ntawm lipoic acid, nws tuaj yeem pab cov neeg rog dhau. Lawm, tsuas yog siv cov tshuaj tsis muaj lub cev ua kom lub cev thiab qee yam zaub mov noj haus yuav tsis ua rau kom qhov xav tau sai thiab kav ntev. Tab sis nrog kev sib koom ua ke ntawm tag nrho cov ntsiab cai ntawm kev poob ceeb thawj, txhua yam yuav tsum ua haujlwm. Hauv cov xwm txheej no, lipoic acid tuaj yeem noj 30 feeb ua ntej lossis tom qab noj tshais, 30 feeb ua ntej noj hmo lossis tom qab kev tawm dag zog lub cev. Qhov yuav tsum tau muab rau kom poob phaus yog los ntawm 25 txog 50 mg rau ib hnub. Hauv qhov no, cov tshuaj muaj peev xwm txhim kho cov metabolism hauv cov rog thiab carbohydrates thiab siv cov roj atherogenic.
Tsis tas li, npaj thiab ntxiv rau hauv lipoic acid kuj tseem siv tau los ntxuav cov teeb meem ntawm daim tawv nqaij. Lawv tuaj yeem raug siv ua cov khoom siv ib cheeb tsam lossis ntxiv rau cov tshuaj pleev kom qhuav thiab cov khoom noj kom zoo. Piv txwv, yog tias koj ntxiv ob peb tee ntawm kev txhaj tshuaj thioctic acid rau txhua lub ntsej muag qab zib lossis mis nyuj, siv nws txhua hnub thiab tsis tu ncua, tom qab ntawd koj tuaj yeem txhim kho cov tawv nqaij kom huv, ntxuav nws thiab tshem tawm cov av tsis huv.
Ib qho tseem ceeb tshaj plaws ntawm thioctic acid yog nws cov nyhuv hypoglycemic (muaj peev xwm txo cov ntshav qab zib). Qhov no tseem ceeb heev rau cov neeg muaj ntshav qab zib hom 1 thiab ntshav qab zib hom 2. Hauv thawj hom kab mob no, tus txiav, vim los ntawm kev puas tsuaj autoimmune, tsis muaj peev xwm muab cov tshuaj insulin rau, nws yog lub luag haujlwm rau txo qis ntshav qabzib, thiab hauv cov nqaij thib ob ntawm lub cev tiv taus, uas yog, insensitive rau qhov kev ua ntawm insulin. Xav txog txhua yam cuam tshuam los ntawm insulin, lipoic acid yog nws cov kev thaiv kev.
Vim tias lub ntsej muag hypoglycemic, nws tuaj yeem tiv thaiv kev txhim kho ntawm cov teeb meem xws li mob ntshav qab zib angioretinopathy (tsis pom kev tsis pom kev), nephropathy (tsis zoo li lub raum ua haujlwm), neuropathy (mob siab, tshwj xeeb tshaj yog ntawm ob txhais ceg, uas yog fraught nrog kev txhim kho ntawm ko taw caj dab). Tsis tas li ntawd, thioctic acid yog cov tshuaj tiv thaiv kab mob thiab thaiv cov txheej txheem ntawm peroxidation thiab tsim cov dawb radicals.
Nws yuav tsum nco ntsoov tias thaum noj alpha-lipoic acid nyob rau hauv cov ntshav qab zib, koj yuav tsum tau kuaj ntshav tsis tu ncua thiab soj ntsuam nws cov kev ua tau zoo, ntxiv rau ua raws li kws kho mob cov lus pom zoo.
Analogs thiab tshuaj xyuas ntawm cov tshuaj
Kev tshuaj xyuas txog cov tshuaj muaj lipoic acid feem ntau zoo. Ntau tus hais tias alpha lipoic acid kom txo qis cov roj cholesterol yog qhov cuab yeej siv tsis tau. Thiab qhov no yog qhov tseeb tiag tiag, vim tias nws yog "haiv neeg ib txwm muaj" rau peb lub cev, tsis zoo li lwm cov tshuaj tiv thaiv kev tsis haum xeeb zoo li statins thiab fibrates. Tsis txhob hnov qab tias atherosclerosis feem ntau cuam tshuam nrog ntshav qab zib, thiab hauv qhov no, thioctic acid ua cov txheej txheem nyuaj ntawm kev saib xyuas kev kho.
Cov tib neeg uas tau sim cov kev kho mob no tau hais tias lawv tau sau tseg tias lawv muaj qhov xwm txheej zoo ntawm lawv tus mob. Raws li lawv, lawv tau txais lub zog thiab qaug zog ploj zuj zus, qhov kev xav ntawm lub cev tsis tshua muaj zog thiab ua rau lub cev tawv nqaij ploj zuj zus, lub ntsej muag yog pom tau tias ntxuav muag, tawm pob thiab ntau yam tawv nqaij tsis zoo, lub cev hnyav yog txo thaum noj tshuaj nrog kev tawm dag zog thiab kev noj haus, thiab ntshav qab zib tsawg zuj zus ntshav qabzib, txo qis hauv cov roj cholesterol hauv cov neeg mob atherosclerosis. Qhov yuav tsum tau ua ua ntej kom ua tiav cov txiaj ntsig xav tau yog kev ntseeg hauv kev kho thiab kev kho chav kawm.
Lipoic acid yog ib feem ntawm xws li cov tshuaj thiab cov tshuaj lom neeg mob ntxiv rau Oktolipen, Berlition 300, Complivit-Shine, Espa-Lipon, Alphabet-Diabetes, Tiolepta, Dialipon.
Hmoov tsis zoo, tag nrho cov cuab yeej no tsis pheej yig, tab sis muaj txiaj ntsig zoo.
Lipoic acid tau piav qhia hauv cov yeeb yaj kiab hauv tsab xov xwm no.
