Simvastatin yog tshuaj noj nrog lipid-txo cov khoom. Txais cov tshuaj uas siv cov tshuaj lom neeg los ntawm cov khoom lag luam ntawm cov enzymatic metabolism ntawm Aspergillus terreus.
Tus txheej txheem tshuaj lom neeg ntawm cov tshuaj yog ib hom hauv lub zog ntawm lactone. Los ntawm kev hloov pauv biochemical, cov roj (synthesis) tshwm sim. Kev siv cov tshuaj tiv thaiv cov kev txuam nrog cov tshuaj lom lipids ntau hauv lub cev.
Cov tshuaj molecules ntawm cov tshuaj pab ua rau txo qis ntshav ntau ntxiv ntawm triglycerides, atherogenic feem ntawm lipoproteins, ntxiv rau theem ntawm cov roj (cholesterol) tag nrho. Kev tsub zuj zus ntawm kev coj los ua ke ntawm atherogenic lipids tshwm sim vim yog kev tsuj tawm ntawm kev tsim cov cholesterol nyob rau hauv hepatocytes thiab qhov nce ntawm cov txheej txheem receptor rau LDL rau ntawm cov cell ua, uas ua rau kev ua kom muaj zog thiab siv LDL.
Nws tseem nce qib ntawm cov lipoproteins ntau ntom, txo qhov feem ntawm atherogenic lipids rau antiatherogenic thiab theem ntawm cov roj cholesterol dawb rau antiatherogenic feem.
Raws li kev soj ntsuam hauv chav soj ntsuam, cov tshuaj tsis ua rau muaj kev sib txuam ntawm tes. Tus nqi ntawm qhov pib ntawm txoj kev kho tau zoo Cov pib ntawm cov nyhuv yog 12-14 hnub, qhov siab tshaj plaws kho tau tshwm sim ib hlis tom qab los ntawm kev pib siv. Cov nyhuv yog mus tas li nrog lub sijhawm ntev ntawm kev kho. Yog tias koj tsum tsis noj cov tshuaj, theem ntawm cov roj endogenous rov qab los rau nws qib qub.
Cov tshuaj muaj pes tsawg leeg yog sawv cev los ntawm cov tshuaj nquag Simvastatin thiab cov khoom siv pabcuam.
Cov khoom muaj qhov siab nqus thiab tsawg bioavailability. Txhawm rau cov ntshav, khi rau albumin. Daim ntawv ua haujlwm tseem ceeb ntawm cov tshuaj yog synthesized los ntawm cov kev hloov pauv biochemical.
Simvastatin metabolism tshwm sim hauv hepatocytes. Nws muaj cov nyhuv ntawm "kev hla mus los" los ntawm lub siab ua haujlwm. Kev muab pov tseg tshwm sim los ntawm cov hnyuv (txog 60%) hauv kev ua kom tsis muaj zog. Ib feem me me ntawm cov tshuaj tau muab pov tseg los ntawm ob lub raum hauv ib daim ntawv uas tsis ua haujlwm.
Kev ntsuas rau siv
Kev kho mob nrog simvastatin yog tshuaj rau txo cov ntshav lipids, vim tias cov tshuaj siv rau cov tshuaj lipid-txo cov tshuaj.
Ib cov tshuaj raug txwv rau kev pub nkag mus tsuas yog tus kws kho mob tau koom nrog, kev tswj hwm tus kheej ntawm cov tshuaj yog nruj me ntsis txwv.
Kev qhia rau kev siv yog cov mob nrog rau cov roj (cholesterol) ntau thiab atherogenic lipids.
Cov kabmob no suav nrog cov kab hauv qab no:
- Lub xeev ntawm thawj hypercholesterolemia nrog cov tsis muaj txiaj ntsig ntawm qhov tsis yog-pharmacological tswj ntsuas hauv cov neeg mob uas muaj kev pheej hmoo rau kev txhim kho txoj hlab ntshav atherosclerosis.
- Daim ntawv sib xyaw ua ke ntawm hypercholesterolemia thiab hypertriglyceridemia, kev noj zaub mov tsis tuaj yeem tswj tau nrog cov roj (cholesterol) tsawg thiab kev ua si hauv lub cev.
- IHD rau kev tiv thaiv kev pheej hmoo ntawm kev tuag los ntawm kev mob ntsig txog mob hlwb (thiaj li ua rau muaj kev vam meej sai sai ntawm cov hlab ntshav atherosclerosis), mob hlwb tsis txaus thiab hloov pauv ntawm cov ntshav khiav ceev.
- Txo txoj kev pheej hmoo ntawm revascularization.
Daim ntawv ntau npaum ntawm cov tshuaj yog qhov ncauj qhov ncauj nrog ntau npaum ntawm 10, 20 thiab 40 milligrams. Cov ntau npaum ntawm cov tshuaj xaiv tau ntawm tus kheej, noj mus rau hauv tus account yam ntxwv ntawm tus neeg lub cev.
Cov tshuaj muaj nyob rau hauv cov npe tshuaj tsis pom zoo rau kev tswj hwm tus kheej.
Cov lus qhia rau kev siv cov simvastatin
Ua ntej pib txoj kev kho, tus neeg mob yog kws kho kev noj zaub mov hypocholesterol, uas yuav tsum tau siv sijhawm ntev rau tag nrho cov kev kho. Simvastatin ntsiav tshuaj yog npaj rau kev tswj hwm qhov ncauj. Cov tshuaj yuav tsum noj ib zaug nyob rau txhua 24 teev thaum yav tsaus ntuj, haus dej kom ntau. Thaum lub sijhawm noj cov tshuaj yuav tsum tsis txhob muaj noj mov.
Lub sijhawm kho nrog Simvastatin yog xaiv tshwj xeeb los ntawm tus neeg mob tus kws kho mob.
Nrog hypercholesterolemia, qhov zoo tshaj plaws tshuaj kho tau yog 5-80 mg ib zaug. Yog tias tsis muaj kev cuam tshuam ntawm ib zaug ntawm 40 mg, txoj kev kho yuav tsum tau hloov kho. Qhov no yog vim lub siab myotoxicity ntawm cov tshuaj hauv ib qhov tshuaj ntau dua 40 mg. Qhov siab tshaj plaws tau siv tshuaj kho tau raug muab rau cov neeg mob hauv kev kho mob nrog 40 mg yog qhov tsis muaj txiaj ntsig. Kev kho mob siab kawg yog 10 mg.
Koob tshuaj hloov kho yog pom zoo tsis ntau tshaj ib hlis ib zaug. Ntau tus neeg mob rhiab rau kev kho mob nrog kev noj tshuaj tsawg kawg.
Hauv cov neeg mob uas muaj caj hlav ntshav hypercholesterolemia, kev pom zoo ntawm kev simvastatin yog 40 mg. Qhov koob tshuaj txhua hnub yog pom zoo kom muab faib ua ob zaug. Hauv kev tiv thaiv hypercholesterolemia, kev sib ntxiv hypolipidemic kho yog pom zoo.
Txog kev kho mob rau cov neeg mob uas muaj tus mob ua rau mob hlab ntsha hlwb los yog cov muaj kev pheej hmoo rau kev loj hlob ntawm kev mob ntshav siab, txoj kev kho tau tiav nrog kev siv simvastatin los ntawm 20 txog 40 mg rau 24 teev. Nws raug nquahu kom hloov qhov tshuaj tsis pub dhau ib hlis tom qab pib siv. Qhov ua tau ntawm kev kho mob twb tuaj txog ntawm 20 mg ntawm cov tshuaj.
Yog tias tsim nyog, muab ob npaug rau koob.
Kev cuam tshuam nrog lwm yam tshuaj
Cov tshuaj yog cov neeg ua haujlwm nquag, lipid-txo qis.
Hauv qhov no, cov tshuaj nkag tau yooj yim rau kev hloov tshuaj thiab kev sib txuam ntawm pharmacological nrog rau lwm cov tshuaj.
Qhov kev cia siab txhua hnub ntawm simvastatin hauv cov neeg uas noj qee yam tshuaj yuav tsum tsis pub tshaj 10 mg.
Cov tshuaj no yog cov tshuaj tiv thaiv kab mob (cyclosporin); hluavtaws androgens (Danazole); fibrates; nicotinic acid npaj;
Rau cov neeg mob noj Amiodarone thiab Verapamil, cov tshuaj yuav tsum tsis pub ntau tshaj 20 mg. Thaum kho nrog Diltiazem, qhov siab tshaj plaws ntawm simvastatin yuav tsum yog 40 mg.
Hauv cov neeg mob ntawm cov pab pawg hnub nyoog laus dua, nrog rau cov neeg mob uas tau them nyiaj los yog lub raum tsis ua haujlwm, tsis tas yuav kho qhov tshuaj. Hauv cov neeg mob uas decompensated lub raum tsis ua haujlwm, nrog kev txo qis ntawm creatinine tshem tawm tsawg dua 30 milliliters, nws tsis pom zoo kom sau tshuaj rau hauv ib koob tshuaj ntau dua 10 mg. Yog tias nws tsim nyog yuav tau nce lub koob tshuaj, kev soj ntsuam kev noj qab haus huv ntawm pab pawg ntawm cov neeg mob no yuav tsum ua kom ntseeg tau.
Kev txiav txim siab nrog lwm cov tshuaj yuav tsum pom zoo nrog kws kho mob. Thaum thawj zaug teem caij, tus neeg mob lub keeb kwm yuav tsum ua tib zoo sau thiab cov kev kho mob kom pom tseeb.
Kev phiv tshuaj Simvastatin
Thaum noj cov tshuaj no, tag nrho cov kev phiv tshuaj tsis zoo yuav tshwm sim hauv tus neeg mob.
Kev phiv tshuaj rau simvastatin yog koob tshuaj.
Qhov ntau dua ntawm cov tshuaj noj ntau dua, qhov ntau dua ntawm cov kev mob tshwm sim.
Feem ntau cov kev phiv tshuaj ntawm simvastatin muaj xws li:
- Kev mob plab hnyuv: ua kom mob plab, cem quav lossis raws plab, tsam plab, ua tsis taus pa, malabsorption, xeev ntuav nrog ntuav, mob leeg, mob rau daim siab lossis mob siab, ua kom mob plab, ua rau lub siab tsis ua haujlwm.
- Los ntawm ib sab ntawm lub paj hlwb: asthenic syndrome, mob taub hau, paresthesia, kiv taub hau, polyneuropathy, pw tsaug zog ntxhov, tsis nco qab mnemonic kev ua haujlwm.
- Los ntawm sab hauv cov leeg mob: nqaij ntswj thiab pob tw, kev cuam tshuam chaw nyob txawv, myasthenia gravis, leeg tsis muaj zog, myopathy; rhabdomyolysis, mob leeg.
- Los ntawm cov khoom siv hluav taws xob: qhov ua txhaum ntawm saj pom.
- Cov tshuaj tiv thaiv kev npau taws: Quincke's edema, rheumatic tshua, vasculitis, dermatomyositis, urticaria, mob pruritus, tawm pob, nce rhiab rau UV hluav taws xob.
- Los ntawm cov ntshav hemopoiesis: qhov txo qis hauv cov platelets, eosinophils, kev nce ntxiv ntawm erythrocyte sedimentation tus nqi, ntshav tsis txaus.
- Los ntawm cov leeg musculoskeletal: mob caj dab, mob pob txha, mob pob txha
- Los ntawm CCC: tachycardia, nce ntshav nce ntshav.
- Tsis tshua muaj kev cuam tshuam: kev sib daj sib deev hauv cov txiv neej, alopecia.
Cov kev tsis txaus ntseeg feem ntau yog mob raum tsis ua haujlwm vim qhov mob loj heev ntawm myoglobin vim cov leeg mob thaum lub caij rhabdomyolysis.
Yog tias ib qho ntawm cov kev mob tshwm sim, koj yuav tsum ceeb toom koj tus kws kho mob tam sim ntawd. Tus kws kho mob tuaj koom yuav tsum kho qhov tshuaj ntau ntxiv.
Cov ntsiab lus tsis sib haum thiab kev txwv ntawm kev siv
Lub sijhawm ntawm simvastatin muaj ntau qhov kev txwv ntau.
Qhov no yog vim qhov tseeb tias lub cuab yeej muaj qee yam muaj txiaj ntsig rau lub cev tag nrho, tswj cov metabolism hauv cov rog.
Feem ntau, cov tshuaj tsis zoo yog tias siv tsis raug thiab siv.
Cov xwm txheej hauv qab no yog contraindications rau Simvastatin:
- pathology ntawm daim siab ua mob hauv daim ntawv nquag;
- kev ua haujlwm siab ntawm daim siab enzymes ntawm cov keeb kwm tsis paub;
- ib txhij tswj hwm ntawm Itraconazole, Ketoconazole, HAART, macrolides;
- khaub lig-ntaus pob leeg mob;
- cev xeeb tub thiab pub niam mis;
- cov menyuam hnub nyoog;
- cov roj (cholesterol) tsawg;
- lactase deficiency,
- carbohydrate malabsorption;
- hypersensitivity rau cov nquag yam khoom los yog ntu Cheebtsam,
- hypersensitivity rau statins.
Tsis txhob siv cov tshuaj simvastatin thaum cev xeeb tub thiab lactation tsis pom zoo. Qhov no yog vim qhov tseeb tias cov tshuaj muaj cov lus qhia teratogenic zoo. Tsis tas li, cov tshuaj muaj contraindicated rau hauv niam mis, vim nws tuaj yeem nkag rau hauv cov mis.
Cov poj niam ntawm kev yug menyuam yuav tsum muaj kev tiv thaiv los ntawm cev xeeb tub thaum kho nrog Simvastatin.
Hauv cov neeg mob ntawm cov hnub nyoog laus dua, tshwj xeeb, hauv cov poj niam, cov tshuaj yuav tsum tau txwv.
Cov tshuaj yog contraindicated rau hauv cov menyuam yaus.
Thaum pib ntawm kev kho mob nrog simvastatin, ib qho kev hloov pauv ntawm cov neeg hloov pauv tau sau tseg. Ua ntej pib txais tos thiab thaum lub sijhawm tswj hwm tag nrho, nws yog ib qhov yuav tsum tau soj ntsuam daim siab ua haujlwm tas li.
Nrog rau qhov kev hloov pauv ntau dua los ntawm ntau tshaj 3 zaug, kev kho nrog Simvastatin yuav tsum tsis ua mus ntxiv.
Cov yam ntxwv ntawm kev siv simvastatin
Cov tshuaj yuav tsum yog kws kho mob los yog kws kho plawv. Simvastatin yog cov tshuaj ntawm lub cim tshiab, cov lus qhia uas yuav tsum tau siv qhia txog cov yam ntxwv ntawm kev kho, uas txiav txim siab tus nqi kho siab.
Cov khoom lag luam tsim tawm thoob ntiaj teb kev txhawj xeeb ntawm tshuaj "Zentiva", nyob hauv Czech koom pheej. Cov chaw tsim tshuaj paus tsim cov tshuaj muaj ceem lub npe nrov.
Cov tshuaj sai thiab tsim nyog txo cov roj cholesterol, ua rau poob phaus thiab kev txhim kho tag nrho hauv kev mob ntawm cov neeg mob uas tsis muaj roj lipid metabolism.
Cov tshuaj yog ib qho tshuaj xaj.
Txhawm rau txuag nyiaj, koj tuaj yeem yuav qhov hloov pauv rau cov yeeb tshuaj. Cov analogues tam sim ntawm Simvastatin yog Aterostat, Zokor, Simvakard, thiab lwm yam. Npe txawv nyob ntawm qhov chaw tsim khoom.
Qhov kev puas tsuaj rau cov tshuaj, feem ntau, yog vim qhov kev ua txhaum ntawm kev coj ntawm kev tswj hwm thiab noj tshuaj.
Feem ntau, cov cuab yeej tau txais cov lus pom zoo thiab ntau cov lus teb zoo los ntawm cov kws tshaj lij hauv kev lag luam tshuaj. Cov tshuaj yog lub cim tshiab ntawm kev ua haujlwm siab thiab nrog cov tshuaj lom tsawg.
Txawm li cas los xij, tag nrho cov lus qhia rau kev siv yuav tsum tau ua raws. Nws yog txwv tsis pub haus dej cawv thaum kho. Nws yog ib qho tseem ceeb uas tswj qib ntawm glycemia thaum kho mob rau cov neeg mob ntshav qab zib, txij li cov statins cuam tshuam txog ntshav qab zib hauv cov ntshav.
Cov hau kev rau kev kho mob ntawm hypercholesterolemia thiab atherosclerosis yuav tsum muaj txhij txhua. Noj Simvastatin yuav tsum tau ua ke nrog kev noj haus kom muaj txiaj ntsig thiab kev ua si lub cev tsis tu ncua.
Nrog qhov tsis muaj txiaj ntsig ntawm kev kho nrog Simvastatin, cov tshuaj hauv qab no tuaj yeem siv tshuaj:
- Lwm tus neeg sawv cev ntawm pawg statin yog Atorvastatin, Rosuvastatin, Rosulip, thiab lwm yam.
- Fibrates.
- Nicotinic acid npaj.
- Omega fatty acids.
Txhua pawg ntawm cov tshuaj muaj ib lossis lwm qhov kev ua mob toxicity. Tsuas yog omega-3 thiab omega-6 fatty acids uas muaj kev nyab xeeb. Lawv siv tau los tiv thaiv lub hom phiaj. Nrog lawv cov lus qhia ntxov rau hauv kev noj haus, qhov kev pheej hmoo ntawm kev tuag los ntawm cov teeb meem plawv thiab leeg ntshav yog txo los ntawm 40%. Muaj kev ua kom huv ntawm cov hlab ntshav los ntawm atherosclerotic plaques thiab txo qis hauv qib ntawm atherogenic lipids.
Tus nqi nws txawv nyob Xos Vias raws li cov chaw muag tshuaj lub hnub thiab hnub yuav khoom. Cov kev soj ntsuam zoo tau txais los ntawm Czech cov tshuaj. Tus nqi hauv Lavxias pib los ntawm 93 rubles.
Cov ntaub ntawv hais txog cov tshuaj Simvastatin tau muab nyob hauv cov yeeb yaj kiab hauv tsab xov xwm no.
