Ntxiv nrog rau kev kho kev noj zaub mov, ntau cov tshuaj siv los kho cov mob xws li mob atherosclerosis.
Ib qho ntawm lawv yog fluvastatin, uas yog cov tshuaj tiv thaiv hypocholesterolemic los tawm tsam cov rog nyob hauv tib neeg cov ntshav ntxiv.
Fluvastatin yog cov tshuaj muaj cov hmoov uas muaj cov xim dawb lossis daj me ntsis. Zoo soluble hauv dej, qee cov cawv, muaj cov khoom hygroscopic.
Ib qho ntawm cov yeeb tshuaj analogues (generics), uas suav nrog cov tshuaj cuam tshuam ntawm fluvastatin, yog Leskol Forte. Nws yog cov ntsiav tshuaj ua haujlwm ntev uas yog txheej. Lawv muaj puag ncig, biconvex duab nrog beveled sawv. Muaj 80 mg ntawm fluvastatin hauv 1 ntsiav tshuaj.
Nws yog ib qho tshuaj tiv thaiv synthesized hypocholesterolemic tshuaj. Nws inhibits kev ua haujlwm ntawm HMG-CoA reductase, ib qho ntawm cov haujlwm uas yog kev hloov pauv ntawm HMG-CoA mus rau lub zog ntawm cov tshuaj sterols, uas yog roj, mevalonate. Nws qhov kev nqis tes ua nyob rau hauv lub siab, qhov twg muaj qhov txo qis hauv cov cholesterol, qhov kev nce ntawm qhov kev txiav txim siab ntawm LDL receptors, kev nce siab hauv kev coj ntawm txav LDL cov kab mob. Raws li qhov txiaj ntsig, raws li qhov txiaj ntsig ntawm kev ua ntawm txhua cov txheej txheem no, muaj kev ua kom ntshav plasma tsawg.
Cov kws tshawb fawb tau ua pov thawj tias nrog ntau dua qhov LDL cov roj (cholesterol) thiab triglycerides nyob rau hauv cov ntshav ntshav, atherosclerosis kev loj hlob thiab txoj kev pheej hmoo ntawm kev tsim lwm yam mob plawv thiab vascular nce, uas feem ntau ua rau tuag. Txawm li cas los xij, ib qho kev nce qib hauv lipoprotein ntau ntau muaj cov lus qhia rov qab.
Koj tuaj yeem soj ntsuam cov kab mob soj ntsuam thaum noj cov tshuaj tom qab 2 lub lis piam, nws qhov kev mob siab tshaj plaws tau tiav hauv ib hlis txij li hnub pib kho thiab muaj kev tswj hwm thoob plaws lub sijhawm siv fluvastatin.
Qhov siab tshaj plaws, lub sijhawm ua haujlwm thiab ib nrab-lub neej ncaj qha nyob ntawm:
- Daim ntawv ntau npaum uas siv cov tshuaj;
- Qhov ua tau zoo thiab lub sijhawm noj mov, cov ntsiab lus ntawm cov rog hauv nws;
- Lub sijhawm tiv thaiv lub sijhawm siv;
- Cov yam ntxwv ntawm tib neeg cov txheej txheem hauv kev zom zaub mov.
Thaum fluvastatin sodium tau siv rau hauv cov neeg mob hypercholesterolemia los yog sib xyaw dyslipidemia, muaj qhov tseem ceeb txo qis hauv LDL thiab triglyceride qib thiab qhov nce ntawm HDL cov cholesterol.
Thaum lub sijhawm mus ntsib nws yog qhov tsim nyog kom ua raws li cov lus qhia tshwj xeeb.
Yog tias ib tus neeg muaj kab mob siab, muaj kev mob siab rau rhabdomyolysis, kev siv lwm yam tshuaj ntawm pawg statin lossis kev haus cawv cov cawv, fluvastatin yog cov tshuaj nrog ceev faj. Qhov no yog vim muaj teeb meem tshwm sim ntawm daim siab, yog li ntawd, ua ntej noj nws, tom qab 4 lub hlis lossis thaum lub sijhawm nce ntxiv cov tshuaj, txhua tus neeg mob yuav tsum tawm tsam qhov mob ntawm lub siab. Muaj pov thawj tias feem ntau tsis tshua muaj, kev siv tshuaj muaj txiaj ntsig tau ua rau pib mob siab, uas tau pom thaum lub sijhawm kho xwb, thiab thaum kawg tau dhau los;
Kev siv cov fluvastatin hauv qee kis tuaj yeem ua rau pom kev ntawm myopathy, myositis thiab rhabdomyolysis. Cov neeg mob yuav tsum tau ceeb toom cov kws kho mob paub txog qhov tshwm sim ntawm cov leeg mob, mob nqaij los yog cov leeg tsis muaj zog, tshwj xeeb yog thaum muaj qhov kub nce siab;
Txhawm rau tiv thaiv txoj kev loj hlob ntawm rhabdomyolysis ua ntej siv, nws raug nquahu kom kawm txog kev tsim lub siab ntawm creatine phosphokinase nyob rau hauv muaj mob raum hauv cov neeg mob; cov thyroid kab mob; txhua hom kabmob muaj keeb kabmob ntawm cov leeg ua haujlwm; haus dej caw.
Hauv cov neeg mob uas laus dua 70 xyoo, qhov yuav tsum tau txiav txim siab txog qib theem ntawm CPK yuav tsum raug soj ntsuam thaum muaj lwm yam cuam tshuam rau kev txhim kho rhabdomyolysis.
Hauv txhua kis no, tus kws kho mob uas tuaj koom yuav tshuaj xyuas qhov muaj txiaj ntsig ntawm kev kho thiab qhov cuam tshuam nrog. Cov neeg mob nyob hauv qab thiab saib xyuas txhua lub sijhawm. Nyob rau hauv qhov xwm txheej ntawm qhov nce ntxiv ntawm qhov kev xav ntawm CPK, nws rov raug txiav txim siab tom qab ib lub lim tiam. Yog tias cov txiaj ntsig tau paub tseeb, kev kho mob tsis pom zoo.
Nrog kev ploj ntawm cov tsos mob thiab ib txwm ua haujlwm ntawm kev saib xyuas ntawm creatine phosphokinase, kev rov pib dua ntawm kev kho nrog fluvastatin lossis lwm yam statins tau pom zoo kom pib nrog kev siv tshuaj qis thiab nyob rau hauv kev saib xyuas tas li.
Ib qho tseem ceeb yog qhov kev saib xyuas ntawm cov zaub mov hypocholesterol ob leeg ua ntej pib kev kho mob thiab thaum kho.
Nws yog noj ntawm qhov ncauj, tsis hais noj mov. Nws yog ib qho tsim nyog yuav tsum nqos cov ntsiav tshuaj tag nrho, ntxuav nrog ib qho tseem ceeb ntawm cov dej dawb, 1 zaug hauv ib hnub.
Txij li qhov muaj txiaj ntsig hypolipidemic ntau yog sau tseg los ntawm 4 lub lim tiam, kev tshuaj xyuas cov koob tshuaj yuav tsum tsis txhob tshwm sim ntxov dua lub sijhawm no. Kev ua rau txoj kev kho tus mob ntawm Lescol Forte pheej tseem nyob nrog siv ntev.
Txhawm rau pib kho, qhov koob tshuaj pom zoo yog 80 mg ib hnub ib zaug, uas zoo ib yam rau 1 ntsiav tshuaj ntawm Leskol Forte 80 mg. Thaum muaj mob ntsws me ntsis, 20 mg fluvastatin, lossis 1 lub tshuaj ntsiav Leskol 20 mg, tuaj yeem kho tau. Txhawm rau xaiv cov koob tshuaj thawj zaug, tus kws kho mob txheeb xyuas theem pib ntawm cov roj cholesterol hauv cov ntshav ntawm tus neeg mob, tsim lub hom phiaj ntawm txoj kev kho thiab coj mus rau hauv tus account tus yam ntxwv ntawm tus neeg mob.
Thaum tus neeg mob tau mob plawv los ntawm kev mob plawv thiab tau txais kev phais mob angioneoplastic, qhov kev xav pom zoo thawj zaug yog kev siv 80 mg rau ib hnub.
Koob tshuaj hloov kho tsis raug ua nyob hauv cov neeg mob uas lub raum lub raum tsis ua haujlwm. Qhov no yog vim qhov tseeb hais tias feem ntau ntawm Fluvastatin yog ua kom lub siab, thiab tsuas yog ib feem me me ntawm cov khoom uas tau txais hauv lub cev yog tawm hauv cov zis.
Thaum ua qhov kev tshawb fawb, nws tau ua pov thawj tias qhov ua tau zoo thiab muaj kev zam zoo tsis yog rau cov neeg mob hluas xwb, tab sis kuj rau cov neeg laus dua 65 xyoo.
Hauv cov hnub nyoog muaj hnub nyoog tshaj 65 xyoos, cov lus teb rau kev kho tau ntau dua, thaum tsis muaj ntaub ntawv qhia tias muaj kev ua siab phem ntxiv.
Cov tshuaj muaj ntau tus lej:
- Thrombocytopenia tsis tshua pom;
- Tej zaum qhov tshwm sim ntawm kev ntxhov siab pw tsaug zog, mob taub hau, paresthesia, dysesthesia, hypesthesia;
- Cov tsos ntawm vasculitis yog qhov tsis tshua muaj;
- Cov tsos ntawm kev cuam tshuam ntawm tus mob plab zom mov - dyspepsia, mob plab, xeev siab;
- Cov tsos ntawm kev tsis haum ntawm tawv nqaij hloov pauv, eczema, dermatitis;
- Cov leeg mob, mob myopathy, myositis, rhabdomyolysis, thiab qhov mob zoo li lupus tsis tshua muaj tshwm sim.
Cov tshuaj yog raug pom zoo rau kev siv los ntawm cov neeg mob laus:
- Thaum kuaj pom tias muaj cov theem ntawm cov roj (cholesterol) tag nrho, triglycerides, qis lipoprotein cov roj (cholesterol), apolipoprotein B, nrog thawj hypercholesterolemia thiab hyperlipidemia;
- Nyob rau ntawm qhov muaj mob ntawm cov hlab plawv txhawm rau txhawm rau ua kom qeeb ntawm kev txhim kho atherosclerosis;
- Raws li kev tiv thaiv cov tshuaj tom qab angioplasty.
Cov tshuaj yog contraindicated rau siv nyob rau hauv lub xub ntiag ntawm kev tsis haum rau lub Cheebtsam; cov neeg mob muaj kab mob siab, nrog rau kev nce qib ntawm daim siab enzymes; thaum cev xeeb tub thiab lactation hauv poj niam; cov me nyuam qis dua 10 xyoo.
Nrog kev ceev faj, nws yog qhov tsim nyog los sau tshuaj kho cov neeg mob uas muaj mob vwm, nrog rau kev quav dej quav cawv, lub raum tsis ua hauj lwm thiab mob myalgia.
Kev phiv tshuaj tsis pom zoo nrog ib koob tshuaj 80 mg.
Cov kev kho mob rau cov neeg mob noj tshuaj rau hauv daim ntawv ntawm cov ntsiav tshuaj nrog rau kev tso tawm qeeb hauv qhov ntau npaum li 640 mg rau 14 hnub, qhov tshwm sim ntawm kev mob tshwm sim los ntawm kev mob plab, nce ntxiv hauv plasma theem ntawm transaminases, ALT, AST.
Cytochrome isoenzymes koom tes hauv cov metabolism hauv cov tshuaj. Hauv kev tshwm sim qhov kev ua tsis tau ntawm ib qho ntawm cov teeb meem metabolic tshwm sim, nws tau them rau kev siv nyiaj ntawm lwm tus.
Kev siv ua ke ntawm cov tshuaj Fluvastatin thiab HMG-CoA reductase inhibitors tsis pom zoo.
Cov tshuaj me me thiab cov ua kom tsis haum ntawm CYP3A4 system, erythromycin, cyclosporin, intraconazole muaj kev cuam tshuam me ntsis ntawm qhov chaw muag tshuaj ntawm cov tshuaj.
Txhawm rau nce cov nyhuv ntxiv, colestyramine raug pom zoo kom siv tsis pub dhau 4 teev tom qab fluvastatin.
Tsis muaj kev tiv thaiv kev sib xyaw rau kev sib xyaw nrog cov tshuaj nrog digoxin, erythromycin, itraconazole, gemfibrozil.
Kev sib koom tes ntawm cov tshuaj nrog phenytoin tuaj yeem ua rau nce ntshav plasma concentration ntawm tom kawg, yog li ceev faj yuav tsum tau siv thaum ntsuas cov tshuaj no. Qee qhov xwm txheej, yuav tau kho ntau npaum li cas.
Muaj kev nce ntxiv hauv cov ntsiab lus hauv cov ntshav ntshav ntawm diclofenac thaum noj ua ke nrog fluvastatin.
Tolbutamide thiab losartan tuaj yeem siv txhij.
Thaum muaj ib tus neeg raug tus mob ntshav qab zib hom 2 ntshav qab zib mellitus thiab noj tshuaj fluvastatin, yuav tsum tau siv ntau tshaj plaws thiab yuav tsum muaj kev saib xyuas mob tas mus li, tshwj xeeb tshaj yog thaum ntxiv tshuaj fluvastatin rau 80 mg ib hnub twg.
Thaum cov tshuaj sib xyaw ua ke nrog ranitidine, cimetidine thiab omeprazole, qhov tseem ceeb nce siab ntau tshaj plaws ntshav plasma concentration thiab AUC ntawm cov tshuaj yog pom, thaum lub plasma tshem ntawm Fluvastatin txo qis.
Nrog ceev faj, muab cov tshuaj no sib xyaw nrog cov tshuaj tiv thaiv ntawm cov tshuaj warfarin. Nws raug nquahu kom kuaj xyuas lub sijhawm prothrombin kom sai, yog tias tsim nyog, kho qhov ntau npaum li cas.
Tam sim no, cov tshuaj yeeb yam yog pom los ntawm ntau qhov kev tshuaj xyuas los ntawm cov neeg mob uas coj nws ua kev kho mob. Nws yuav tsum raug sau tseg tias txhawm rau kom ua tiav cov txiaj ntsig siab tshaj plaws, nws yuav tsum ua raws li txoj kev noj qab haus huv, muaj kev noj zaub mov kom zoo thiab kev tawm dag zog lub cev. Tsis tas li ntawd, kev siv sijhawm ntev yog raug pom zoo, txij li thaum cov tshuaj muaj qhov ua kom ntev, nyob rau hauv uas nws muaj cov txiaj ntsig zoo ntawm cov roj cholesterol hauv cov ntshav.
Cov tshuaj noj uas muaj fluvastatin yuav tsum tau yuav hauv khw muag tshuaj nrog rau cov tshuaj noj.
Cov kws tshaj lij yuav tham txog cov statins hauv kev yees duab hauv kab lus no.
