Nrog lub hnub nyoog, tib neeg lub cev tsis rov tsim dua tshiab los ntawm cov tub ntxhais hluas. Yog li ntawd, cov neeg laus thiab cov neeg laus tsim kab mob ntawm yuav luag txhua yam hauv nruab nrog cev thiab kab ke.
Cov hlab ntsha feem ntau cuam tshuam rau kev hloov pauv muaj hnub nyoog, thiab vim yog lawv cov chaw hauv zos thoob plaws lub cev, txhua cov ntaub so ntswg raug kev txom nyem - sib txuas, leeg, pob txha, thiab tshwj xeeb tshaj yog poob siab.
Atherosclerosis yog kab mob uas cuam tshuam rau cov hlab ntshav ntawm cov ntshav ncig. Qhov no yog qhov kab mob ntawm cov kab mob vascular, nyob rau hauv uas tsim cov nyiaj ntawm cov cholesterol thiab cov kua roj lipoproteins tsawg kawg ntawm cov hlab ntsha tau pom.
Cov tsos mob ntawm tus kab mob pathology yog ua ntej los ntawm kev nce ntshav hauv cov ntshav ntev ntev.
Tus kab mob no nyob hauv peb theem:
- Thawj theem yog tus cwj pwm los ntawm lipid saturation. Hauv qhov no, microdamage mus rau lub intima ntawm phab ntsa vascular thiab kev txo qis hauv cov ntshav ntws ua si lub luag haujlwm txiav txim siab. Hauv 70% ntawm tus neeg mob, qhov no tau pom ntawm thaj chaw ntawm bifurcation, uas yog, ceg, piv txwv, nyob hauv qis qis ntawm aorta. Nyob rau theem no, lipids hnov mob rau qhov enzymes ntawm intima cuam tshuam thiab txuas rau nws, maj mam tsub zuj zuj;
- Qhov thib ob theem nyob hauv kev txhim kho atherosclerosis yog hu ua lipid sclerosis. Lub sijhawm no yog cim los ntawm kev qeeb qeeb ntawm atherosclerotic masses, uas yog vim muaj kev loj hlob ntawm cov nqaij mos txuas los ntawm nws. Qeb no yog nrab, uas yog, kev soj ntsuam tuaj yeem pom. Txawm li cas los xij, muaj kev txaus ntshai ntawm kev hloov pauv - cais ntawm qhov ntawm cov txhaws, uas tuaj yeem txhaws lub nkoj thiab ua rau ischemia thiab cov nqaij tuag;
- Atherocalcinosis ua tiav kev txhim kho ntawm tus kabmob. Cov tshuaj ntsev calcium tuaj nrog cov roj ntsha thiab txiav cov quav hniav, ua rau nws cov tawv nqaij tawv thiab tawg. Maj mam, cov tshuaj loj zuj zus tuaj, nws lub suab nce, qhov dej ntws dawb ntws cuam tshuam, mob ntsws ischemia tshwm sim, uas ua rau mob caj dab thiab poob ntawm cov nqaj.
Ntawm cov kws tshawb fawb, nws tau ntseeg tau tias kev kis kab mob tuaj yeem ua rau tsim kev mob atherosclerosis. Tam sim no tseem muaj kev tshawb nrhiav txog qhov teeb meem no.
Cov hauv paus ntsiab lus tseem ceeb ntawm kev kho mob ntawm hypercholisterinemia yog:
- txo qhov kev nqus ntawm cov roj cholesterol hauv lub cev thiab txwv nws cov khoom cua endogenous;
- nrawm nws txoj kev tshem tawm los ntawm kev hloov mus rau cov roj ntsha thiab los ntawm cov hnyuv;
Ib qho ntxiv, kev kho cov kab mob concomitant yog qhov yuav tsum tau - mob ntshav qab zib, mob plawv, mob ntshav siab, vascular dementia.
Cov lus qhia rau kev siv tshuaj
Muab qhov tseeb tias atherosclerosis yog ib tus kab mob tuag taus, nws tsim nyog mus rau txoj kev kho nrog lub luag haujlwm. Tus qauv kub rau kev kho yog statins.
Tus txheej txheem ntawm lawv cov kev ua yog zoo ib yam rau tag nrho pawg thiab muaj qhov thaiv ntawm HMG-CoA reductase cov enzymes uas coj cov roj cholesterol hauv lub siab.
Thaum siv cov tshuaj tsis tu ncua, cov neeg mob kho qhov sib piv ntawm lipid feem, nrog rau kev tiv thaiv cov roj (cholesterol), feem tsawg ntawm cov roj, triglycerides thiab Alipoprotein B. Cov tshuaj no txo qis kev phom sij txog kev phom sij, xws li embolism, mob myocardial infarction, mob caj dab ntawm lub siab, ischemic mob stroke thiab angina pectoris, thawj zaug.
Atorvastatin thiab lwm yam statins yog npaj rau kev siv qhov ncauj. Lawv tsuas yog noj nrog kws kho mob sau, uas yuav ua tib zoo kawm lipid profile ua ntej sau ntawv tawm tswv yim, tawm tswv yim txog kev ua neej thiab kev noj zaub mov zoo, vim tias kev hnyav dhau qhov cuam tshuam ntawm cov tshuaj ntawm cov cholesterol.
Cov koob tshuaj feem ntau raug xaiv rau qhov siab tshaj plaws ntawm tus neeg mob thiab nyob hauv ib ntsiav tshuaj, uas noj thaum lub sijhawm twg ntawm hnub, tsis hais noj mov dabtsi. Nws yog ib qho tsim nyog yuav tsum tau tswj cov kev ntsuas ib hlis ib zaug, vim tias thaum tsis muaj qhov ua kom kho tau, qhov tshuaj kho tau kho.
Hauv cov mob muaj mob hnyav, qhov nyiaj tau nce rau plaub ntsiav tshuaj ib hnub. Hauv cov neeg laus cov neeg mob, qhov noj tsawg kawg yuav tsis hloov kho, vim muaj kev pheej hmoo ntawm lub raum tsis ua haujlwm. Rau cov menyuam yaus, qhov tshuaj yuav tsum tsis pub tshaj nees nkaum milligrams ib hnub. Cov neeg mob muaj kab mob siab, tshuaj yog contraindicated.
Kev tsim kho tau ntawm kev tshwm sim tsis zoo, xws li:
- Mob taub hau, pw ntxhov.
- Mob leeg mob, mob ntswj.
- Xeev siab, ntuav, ntsim hauv qhov ncauj, pom qab, mob plab, lossis cem quav.
- Cov tawv nqaij khaus, urticaria.
Nkag mus rau hauv lub plab, lub ntsiav tshuaj yaj sai, nkag mus rau hauv cov ntshav los ntawm cov qog ua kua thiab ntws mus rau qhov chaw ntawm qhov tsis xws luag. Bioavailability yog 12%, dhau los ntawm daim siab, tshem tawm ib nrab-lub neej yog li 15 teev.
Cov neeg mob feem ntau tau tsis meej pem thaum mus yuav ib cov tshuaj, vim tias tus nqi rau cov tshuaj sib txawv, muaj ntau lub teb chaws tsim khoom, muaj ntau ntawm cov npe lag luam thiab muaj tshaj tawm kev tshaj tawm hauv Is Taws Nem thiab hauv TV.
Tag nrho cov no tsa cov lus nug, dab tsi yog qhov txawv ntawm qhov nplua mais ntawm tshuaj no.
Yuav xaiv cov tshuaj zoo li cas?
Hauv cov khw muag tshuaj, koj tuaj yeem nrhiav tau ob hom tshuaj. Qhov thib ib yog qhov qub, thawj txoj kev txhim kho ntawm cov tshuaj nroj tsuag uas muaj ntawv ua patent rau nees nkaum xyoo.
Qhov no txhais tau hais tias yuav luag ib xyoo plaub lub hlis twg, tsuas yog lub tuam txhab no tuaj yeem tsim cov tshuaj no. Thaum lub sijhawm patent tsis tau tas sijhawm, kev npaj analog tsis tuaj yeem tshwm nyob rau hauv txee. Tab sis thaum kawg ntawm lub sijhawm no, kev tiv thaiv raug muab tso tseg thiab cov ntawv luam tshwm. Hauv qhov no, qhov qub tseem yog ib qho kev txiav txim ntawm qhov ntau ntau dua.
Qhov laj thawj ntawm no yooj yim piav qhia - rau kev tsim cov khoom lag luam tshwj xeeb, cov kws tshawb fawb tau siv nyiaj ntau txhiab lab nyiaj los mus sim cov chaw kuaj mob ntev ntev thiab lees paub qhov ua tau zoo thiab kev nyab xeeb ntawm ntau cov neeg yeem yeem. Cov txheej txheem yuav siv sij hawm ntau dua kaum xyoo.
Generics (lossis generics), uas yog pab pawg thib ob, yog qhov tseem ceeb clone kev npaj nrog cov yam ntxwv zoo sib xws.
Txhawm rau ua lawv, koj yuav tsum noj mis nyuj tov npaj, ntxiv cov neeg dhau los rau qhov qub, tuaj nrog lub npe yoojyim kom nco qab thiab muab nws muag.
Cov khoom thev naus laus zis tsis yog ib txwm zoo ib yam li thawj cov tshuaj, yog li cov kev hloov pauv hauv tib neeg ua ntau.
Tus nqi nyob ntawm ntau yam: cov qauv kev tsim tawm, ntxiv cov sib txuas ntxiv, cov naj npawb ntawm cov kev soj ntsuam kuaj mob uas nws dhau los. Kev tshawb nrhiav tuaj yeem faib ua:
- Bioequivalent, uas yog, kuaj xyuas qhov sib tw nrog daim ntawv qhia;
- Kws Tshuaj - paub tseeb qhov tseeb ntawm kev ua;
- Thiab kev kho mob, kawm kev ua haujlwm ntawm cov generics rau tib neeg.
Tus nqi yog ncaj ncaj rau cov naj npawb ntawm cov kev tshawb fawb - uas yog, muaj ntau, muaj cov khoom kim dua.
Hauv pawg ntawm lipid-txo cov tshuaj, atorvastatin yog thawj. Thaum kuaj mob mus ntev kawg kaum ob lub hlis, nws pom cov lus hauv qab no:
- Qhov siab ntawm qis lipoproteins tsawg dua 55%;
- Cov roj (cholesterol) tag nrho poob 46%;
- Cov theem ntawm cov ntshav siab lipoproteins ntau ntxiv (qhov no "roj" zoo, nws tsis txhaws cov hlab ntsha) los ntawm 4%.
Qhov koob tshuaj uas siv los ntawm cov neeg ua hauj lwm pub dawb yog 10 milligrams ib hnub.
Thaum muab piv rau cov tshuaj feem ntau nrog nws, nws tau pom tias lwm cov statins xav tau ntau dua lub siab xav kom ua tiav cov nyhuv - rau Torvard nws yog 20 milligrams, rau Simvastatin - 40, thiab rau Fluvastatin ntau npaum li 80.
Cov ntaub ntawv no tsis pom zoo nyob hauv kev luam ntawv, ua qhov txawv loj.
Kev xaiv ntawm cov qauv ntau thiab thawj
Cov tshuaj Torvakard yog ib qho tseem ceeb tshaj plaws ntawm Atorvastatin.
Nws tus nqi yog ib nrab ntawm qhov uas ua rau ntau tus neeg nyiam, vim tias cov nyiaj khaws cia yog 50%. Nws tau zoo tshaj tawm, muaj kev txheeb xyuas zoo txog nws, yog li neeg coj nws nrog kev txaus siab.
Cov tshuaj sib txawv heev nyob rau hauv muaj pes tsawg leeg, yog tias nyob rau hauv thawj daim ntawv qhia muaj tsuas yog thawj cov tshuaj atorvastatin thiab kev pabcuam hauv daim ntawv ntawm lactose, tom qab ntawd hauv Torvakard muaj ntau lub koomhaum pabcuam ntxiv.
Cov tshuaj muaj pes tsawg leeg suav nrog:
- Atorvastatin calcium ntsev, 10 milligrams - cov tshuaj nquag;
- Croscarmellose sodium - ib yam tshuaj uas tsis haum uas ua kom cov ntsiav tshuaj tsis haum ntawm lub plab;
- Magnesium oxide tiv thaiv clumping;
- Lactose monohydrate - muab tub lim rau kis tau los ntawm qhov ntau txaus;
- Monocrystalline kua nplaum yog yam tsw thiab tsw qab;
- Magnesium stearate yog cov khoom coj los tiv thaiv cov khoom ua kom yooj yim rau kev tsim khoom thiab ntim.
Muaj pes tsawg leeg lub plhaub taum muaj xws li:
- titanium dioxide - cov ntxhia ntxhia hauv cov hmoov txhawm rau txhuam;
- talc yog cov khoom txav tawm uas txo cov ntxhib vim kev adsorption nyob rau saum npoo ntawm granules.
Raws li tuaj yeem pom los ntawm cov keeb kwm yav dhau los, cov tshuaj Torvakard muaj ntau yam phom sij uas ua rau hnyav nce thiab nws cov khoom siv lub cev. Rau ntau yam ntawm cov khoom no, kev tsis haum tshuaj tuaj yeem tsim kev tsis haum lossis tawm tsam kev phiv tshuaj, ntev li ntawm khaus tawv nqaij mus rau Quincke's edema, yog li lawv tsis pom zoo kom siv cov tshuaj. Lossis, ntsuas ua ntej nrog kev sim allergenic rau cov tebchaw no kom paub tseeb tias kev noj tshuaj muaj kev nyab xeeb rau kev noj qab haus huv.
Cov neeg uas mob tsis haum mis nyuj yog txwv tsis pub noj yam tshuaj muaj sia txhua yam.
Yog li dab tsi yog qhov txawv ntawm Atorvastatin thiab Torvacard?
Raws li tuaj yeem pom los ntawm cov kev tshawb fawb soj ntsuam, kev tsom xam cov tshuaj muaj pes tsawg leeg thiab kev tsis haum, Torvacard muaj qis dua me ntsis ntawm Atorvastatin. Qhov no tsis yog qhov xav tsis thoob, vim hais tias cov thev naus laus zis rau kev tsim cov generics txawv ntawm qhov qub, yog li ntawd, cov nyhuv tshuaj kho tau qis dua, thiab qhov yuav tsum tau siv ntau dua. Nws cov txiaj ntsig tseem ceeb yog tus nqi, tab sis nws tsim nyog nco ntsoov tias avaricious them ob zaug, thiab koj yuav tsum twv yuav raug tsis txuag ntawm koj kev noj qab haus huv.
Nws puas tsim nyog nws coj cov neeg txawj ntse statins yuav qhia hauv qhov yeeb yaj kiab hauv tsab xov xwm no.
