Cov tshuaj tua kab mob yog cov kev kho mob zoo rau kev tua kab mob. Cov kws kho mob thiab cov kws kho mob sib kis tsis yog lawv lawm. Cov kab mob tau txais cov tshuaj tiv thaiv kab mob. Cov tshuaj tua kab mob uas siv ntau tshaj plaws yog penicillins thiab cephalosporins, thiab cov kab mob tsim cov beta-lactamases los tiv thaiv lawv (penicillins thiab cephalosporins tseem hu ua beta-lactam tshuaj tua kab mob). Hauv cov xwm txheej zoo li no, cov neeg sawv cev ntxiv tau siv coj los tua kab mob sib kis, xws li clavulanic acid.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Hauv Latin, lub npe ntawm cov tshuaj nquag raug sau ua acidum clavulanicum.
Thaum cov tshuaj tua kab mob ua tsis tiav, lawv siv lwm txoj hauv kev los tiv thaiv tus kab mob, xws li clavulanic acid.
Ath
J01C R02.
Tso cov ntawv thiab cov nyob ua ke
Ntsiav tshuaj
Hauv cov ntawv tsim, clavulanate yog siv ua ke nrog amoxicillin. Daim ntawv noj tshuaj no yooj yim tshaj rau cov neeg laus, vim tias tus neeg mob siab rau kev kho mob siab dua, qhov yooj yim dua thiab tsawg dua nws yuav tsum tau noj tshuaj. Tsuas tshuaj - 125 mg ntawm clavulanate ua ke nrog cov tshuaj tiv thaiv kab mob.
Hauv cov ntawv tsim, clavulanate yog siv ua ke nrog amoxicillin.
Ncos
Lawv siv rau hauv cov menyuam yaus hnub nyoog qis dua 1 xyoos, vim daim ntawv no tuaj yeem muab rau tus menyuam tsis tas yuav ntshai tias nws yuav daig caj pas.
Hmoov
Muaj nyob hauv hnab, siv los npaj kev ncua.
Syrup
Daim foos no tsuas siv rau cov me nyuam mos thiab cov me nyuam hnub nyoog 1 xyoos.
Kev Raug Ncua
Daim foos no tsuas siv rau cov me nyuam yaus. Qhov kev ncua yog muaj nyob hauv vials thiab npaj txhij rau kev siv.
Qhov kev npaj kua tsib tau siv rau cov menyuam mos thiab menyuam yaus txog 1 xyoos.
Mechanism ntawm kev ua
Clavulanate muaj cov tshuaj tiv thaiv kab mob tawm tsam ntau yam kab mob. Nws cov kev ua tawm tsam cov kab mob tawm tsam cov tshuaj tiv thaiv cov kab mob beta-lactam yog qhov tshwj xeeb tshaj tawm (feem ntau nws yog staphylococci, me ntsis tsawg dua - streptococci). Ntxiv rau kev ua haujlwm ntawm cov tshuaj tua kabmob, cov tshuaj tsis muaj zog tiv thaiv cov kab mob lactamases, tiv thaiv lawv los tiv thaiv cov tshuaj tua kabmob uas tsis muaj kev tiv thaiv. Vim tias muaj cov cuab yeej no, clavulanate feem ntau siv rau hauv kev sib xyaw nrog lwm cov tshuaj tua kab mob, uas ob leeg tau txais txiaj ntsig qhov kev txiav txim ntawm ob qho yeeb tshuaj.
Cov Tshuaj Pharmacokinetics
Cov tshuaj nquag muaj cuam tshuam sai los ntawm kev mob plab. Qhov siab tshaj plaws ntawm cov tshuaj nquag hauv cov ntshav tshwm sim hauv 1 teev tom qab kev coj noj coj ua. Cov tshuaj yeeb dej caw tsis khi rau cov ntshav protein, tshuav nyob hauv ntshav tsis hloov pauv. Cov tshuaj siv tawm yog tsuas yog los ntawm lub raum.
Kev ntsuas rau siv
Nws yog siv rau cov kabmob los ntawm cov kabmob, xws li:
- Cov kab mob muaj kab mob hauv lub qhov ntswg, mob siab.
- Acute purulent mob nruab nrab ntawm pob ntseg nruab nrab.
- Cov kab mob ua ke thiab lacunar tonsillitis, uas yog nrog los ntawm tso tawm pus los ntawm tonsils.
- Mob ntsws thiab mob txhaws ntshav ntev.
- Mob ntsws thiab mob ntsws ua qog ua ntshav.
- Kev mob ntsws ntawm ntau qhov chaw ua haujlwm, tus neeg sawv cev uas yog pneumococci, staphylococci, streptococci.
- Mob ntsws thiab mob pyelonephritis ntev.
- Mob cystitis, uas yog nrog cov tsub zuj zuj ntawm cov kua paug.
- Cov mob osteomyelitis mob (feem ntau ntawm cov menyuam yaus dua li cov neeg laus).
- Mob peritonitis los ntawm kev tshwm sim ntawm cov qog ntawm lub plab hnyuv siab raum mus rau hauv plab plab.
- Tej yam mob uas muaj mob xws li mob septicemia, septicopyemia.
Cov Yuav Tsum Muaj
Nws tsis muaj qhov tsis muaj tseeb contraindications rau kev siv cov tshuaj uas muaj clavulanate. Nws tsis pom zoo kom noj tsuas yog thaum muaj kev txheeb xyuas tus kheej kev tsis txaus ntseeg rau cov tshuaj ntawm cov tshuaj.
Thaum lub plab tsis zoo los yog lub siab ua haujlwm, cov tshuaj tsis raug siv.
Yuav noj cov tshuaj clavulanic acid li cas
Kev npaj muaj clavulanate yuav tsum tau siv li ntawm 7 mus rau 14 hnub, nyob ntawm seb qhov tsos mob ntawm tus kab mob. Siv tsawg dua 7 hnub tsis pom zoo, vim tias cov kab mob muaj peev xwm muaj sia nyob thiab tsim kev tawm tsam rau cov tshuaj nquag. Tsuas tshuaj rau cov neeg laus - 125 mg ntawm poov tshuaj clavulanate thiab 875 mg ntawm amoxicillin trihydrate (hauv koob tshuaj ua ke). Nrog tus mob sib khuav me me, cov tshuaj yog 500 mg ntawm amoxicillin thiab 125 mg ntawm clavulanate.
Cov tshuaj rau cov menyuam yog 30 mg ntawm amoxicillin thiab 15 mg ntawm clavulanate rau 1 kg ntawm lub cev qhov hnyav hauv ib hnub. Cov ntsiav tshuaj zoo tshaj plaws nrog noj mov, vim tias qhov nqus thiab bioavailability ntawm cov tshuaj yuav siab dua.
Cov tshuaj rau cov menyuam yog 30 mg ntawm amoxicillin thiab 15 mg ntawm clavulanate rau 1 kg ntawm lub cev qhov hnyav hauv ib hnub.
Noj cov tshuaj rau ntshav qab zib
Mob ntshav qab zib mellitus tuaj yeem ua ke nrog cov ntshav qab zib nephropathy, vim qhov kev ua haujlwm ntawm lub raum tsis tuaj yeem ua haujlwm. Txij li thaum siv yeeb siv tshuaj tawm ntawm cov raum feem ntau, qhov no yuav tsum tau coj mus rau hauv kev kho mob ntawm cov neeg mob ntshav qab zib mellitus.
Phiv cov clavulanic acid
Cov kev mob tshwm sim tau muab faib raws li lub cev.
Kev kho mob txoj hnyuv
Clavulanate tuaj yeem ua rau txhua hom kev tsis haum siab tsis haum. Qhov no tsuas yog nce peristalsis, uas tuaj yeem pom los ntawm raws plab. Tus mob no yuav tsum paub qhov txawv ntawm cov tshuaj tua kab mob ntsig txog tus kab mob, uas tshwm sim vim kev tuag ntawm microflora thiab qhov ntau ntawm cov kab mob pathogenic hauv txoj hnyuv.
Clavulanate tuaj yeem ua rau txhua hom kev tsis haum siab tsis haum.
Thaum kho nrog cov tshuaj, cholestatic jaundice yuav tshwm sim, uas yog pom los ntawm kev daj ntawm daim tawv thiab mob hauv txoj cai hypochondrium. Tsis tas li ntawd, muaj kev pheej hmoo ntawm cov tshuaj tiv thaiv kab mob siab, uas muaj ntau dua rau cov txiv neej laus thiab tshwm sim los ntawm kev siv lub sijhawm ntev ntawm cov tshuaj no.
Hematopoietic plab hnyuv siab raum
Cov tshuaj no cuam tshuam rau cov qe dawb ntawm cov pob txha pob txha, ua rau thim rov qab (qib tau rov qab tom qab nres cov tshuaj) qhov txo qis hauv qib ntawm leukocytes, neutrophils. Ua ke nrog leukocytes, qib platelet poob qis thaum lub sijhawm tswj hwm, uas tuaj yeem ua rau cov ntshav coagulation tsis muaj zog.
Nruab nrab hauv lub paj hlwb
Kiv taub hau lossis mob taub hau tuaj yeem tshwm sim thaum siv tshuaj clavulanate. Tsis tshua muaj mob, chua leeg ntawm central genesis muaj peev xwm. Kev chua leeg yog cuam tshuam nrog kev ua tsis tau zoo los ntawm cov tshuaj los ntawm lub cev lossis siv cov koob tshuaj loj.
Kiv taub hau lossis mob taub hau tuaj yeem tshwm sim thaum siv tshuaj clavulanate.
Kev ua xua
Hauv kev kho cov clavulanate, muaj ntau yam kev ua xua tuaj yeem tshwm sim, xws li urticaria, Stevens-Johnson syndrome, atopic dermatitis. Cov kev mob tshwm sim tsis tshua muaj tshwm sim vim qee tus neeg tsis quav yeeb rau cov tshuaj. Txhawm rau kom tsis txhob tshwm sim ntawm cov xwm txheej no, ib qho kev sim rau rhiab ntawm cov tshuaj yuav tsum tau ua.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Cov kev mob tshwm sim muaj xws li kiv taub hau, uas tuaj yeem cuam tshuam txoj kev nco qab ntawm lub siab. Yog li, thaum kho nrog cov tshuaj no, nws yog ib qho tsim nyog yuav tsum tsis txhob tsav lub tsheb lossis cov txheej txheem uas yuav tsum muaj kev mloog ntxiv.
Cov lus qhia tshwj xeeb
Ntxiv nrog rau qhov kev ntsuas uas yuav tsum tau ua rau cov tib neeg muaj kev cuam tshuam rau cov tshuaj, koj yuav tsum ua kom ntseeg tau tias tus neeg mob tsis muaj kev tawm tsam rau cov tshuaj tua kab mob ntawm penicillins, cephalosporins lossis lwm yam tshuaj tua kab mob beta-lactam.
Yog tias koj muaj kev fab tshuaj rau amoxicillin (ib pawg ntawm ib nrab hluavtaws penicillins), ceftazidime (lossis lwm yam tshuaj tua kab mob los ntawm pawg ntawm cephalosporins), ticarcillin lossis penicillin, cov tshuaj no tsis yog siv hauv keeb kwm. Hauv cov xwm txheej zoo li no, nws yog ib qho tsim nyog yuav tau xav txog kev kho mob nrog macrolides (piv txwv li, azithromycin), uas yuav tsis ua rau muaj kev fab tshuaj hla.
Cov tshuaj no yuav tsum tau siv nrog ceev faj hauv cov neeg kev txom nyem los ntawm kev sib kis mob mononucleosis, vim tias nyob rau hauv cov neeg mob zoo li no, thaum siv cov tshuaj, cov pob khaus zoo xws li mob qhua pias yuav tshwm sim.
Cov tshuaj no yuav tsum tau siv nrog ceev faj hauv cov neeg kev txom nyem los ntawm kev sib kis mob mononucleosis, vim tias nyob rau hauv cov neeg mob zoo li no, thaum siv cov tshuaj, cov pob khaus zoo xws li mob qhua pias yuav tshwm sim.
Yog tias tus neeg mob lub raum tsis ua haujlwm nrog creatinine tshem tawm hauv qab 30 mg rau ib feeb, tom qab ntawd siv cov tshuaj tsis pom zoo, vim tias nws yuav nyuaj rau tshem tawm cov tshuaj los ntawm lub raum thiab kev sib txuam ntawm cov tshuaj hauv cov nqaij thiab cov plab hnyuv siab raum. Nyob rau hauv rooj plaub thaum qhov kev tshem tawm ntawm endogenous creatinine ntau dua 30 mg ib feeb, tsis tas yuav kho cov tshuaj ntau npaum li cas.
Yog tias tus neeg mob tau ua txhaum ntawm lub xeev kev ua haujlwm ntawm lub siab (piv txwv li, muaj kab mob siab lossis mob cholestatic), clavulanate tau txais kev ceeb toom nrog kev ceev faj, soj ntsuam qhov txaus ntshai thiab qhov tshwm sim zoo.
Clavulanate uas muaj cov tshuaj tiv thaiv yuav tsum tau siv tsuas yog muaj kab mob loj txaus los tiv thaiv cov tshuaj tua kab mob uas tsis muaj tshuaj tiv thaiv. Yog tias pom tau tias cov kab mob me me tsis tsim cov tshuaj uas rhuav tshem cov tshuaj tiv thaiv uas tsis muaj kev tiv thaiv, ces tsuas yog siv tshuaj tua kab mob uas tsis muaj clavulanate yuav tsum yog qhov zoo dua.
Clavulanate tuaj yeem ua rau qhov tsis tseem ceeb ntawm kev txhaj tshuaj tiv thaiv kabmob immunoglobulin G thiab albumin ntawm erythrocyte membranes, uas tuaj yeem ua rau qhov tsis zoo tshwm sim hauv kev kuaj sim Coombs. Qhov no yuav tsum tau txiav txim siab thaum kho nrog cov tshuaj no.
Siv thaum cev xeeb tub thiab lactation
Cov ntaub ntawv hais txog kev siv yeeb tshuaj hauv cov poj niam cev xeeb tub tsis txaus, thiab nws tsis tuaj yeem hais txog kev ua kom nyab xeeb rau kev noj qab haus huv ntawm leej niam thiab menyuam hauv plab. Yog tias nws yuav tsum tau noj clavulanate, tus kws kho mob yuav tsum sib piv cov kev pheej hmoo txaus ntshai nrog kev cia siab ntawm kev kho mob thiab tsuas yog tom qab ntawd txiav txim siab txog lub hom phiaj ntawm cov tshuaj.
Tsis muaj cov ntaub ntawv txaus ntawm kev siv tshuaj rau hauv cov poj niam cev xeeb tub, thiab nws tsis tuaj yeem hais txog kev ua kom tiav kev nyab xeeb rau kev noj qab haus huv ntawm leej niam thiab menyuam hauv plab.
Xaj cov tshuaj clavulanic acid rau menyuam yaus
Cov menyuam tuaj yeem yog cov tshuaj noj uas muaj clavulanate txij thawj hnub ntawm lub neej. Rau cov menyuam mos thiab menyuam yaus, cov ntawv siv tshuaj rau qhov raug ncua lossis kua phoov yog siv, vim tias lawv yooj yim dua dua thiab muab rau cov menyuam yooj yim dua.
Siv rau lub sijhawm qub
Hauv lub hnub nyoog laus, clavulanate yog kho nrog ceev faj tsuas yog nyob ntawm qhov muaj mob raum lossis mob siab. Thaum tsis muaj kev ua txhaum hauv cov kab ke no, cov tshuaj no tsis tas yuav txwv rau kev siv.
Hauv lub hnub nyoog laus, clavulanate yog kho nrog ceev faj tsuas yog nyob ntawm qhov muaj mob raum lossis mob siab.
Clavulanic acid noj ntau dhau
Kev noj tshuaj ntau dua yog nrog los ntawm kev nce ntxiv hauv kev phiv los ntawm txoj hnyuv. Nws tuaj yeem ua rau mob xeev siab, ntuav, raws plab. Muaj tseem ua txhaum ntawm cov dej-electrolyte tshuav, uas yuav tsum tau kho ua ntej ntawm txhua yam nrog dej-ntsev infusion daws. Kev noj ntau dhau yog tshwm sim los ntawm kev zoo siab, pw tsaug zog, kiv taub hau, mob nriaj (hauv cov neeg tsis tshua muaj qhov cuam tshuam nrog dej-electrolyte cuam tshuam).
Kev cuam tshuam nrog lwm yam tshuaj
Txij li thaum clavulanate cuam tshuam rau kev sib xyaw ntawm lub plab hnyuv microflora (tshwj xeeb nrog kev siv ntev), nws tuaj yeem txo qhov nqus ntawm estrogens thiab yog li txo cov txiaj ntsig zoo ntawm lub qhov ncauj ua ke kev tiv thaiv kev tiv thaiv.
Cov nyhuv ntawm microflora tseem ua tau nws tus kheej hauv kev ua haujlwm ntau ntxiv ntawm anticoagulants tsis ncaj, vim hais tias cov kab mob ntawm cov plab hnyuv me yog lub luag haujlwm rau cov synthesis ntawm vitamin K (ib qho ntawm cov teeb meem coagulation, lub hom phiaj rau indirect anticoagulants) thiab nqus cov vitamin E (cov kab mob antioxidant).
Ib qho uas nquag tshwm sim thiab qhov zoo tshaj plaws uas cuam tshuam los ntawm cov tshuaj yog so hauv plab thiab, vim li ntawd, tshwm sim ntawm kev zawv plab. Yog li, kev sib xyaw nrog kev siv clavulanate thiab tshuaj laxatives tuaj yeem ua rau mob plab zawv plab. Xws li kev sib xyaw ua ke yuav tsum tau zam, vim tias qhov no yuav ua rau dej-electrolyte cuam tshuam thiab ua rau muaj kev pheej hmoo ntawm qaug dab peg. Cov kws kho mob txo qis qhov nqus ntawm qhov tshuaj, yog li txo nws cov haujlwm antimicrobial.
Ib qho uas nquag tshwm sim thiab qhov zoo tshaj plaws uas cuam tshuam los ntawm cov tshuaj yog so hauv plab thiab, vim li ntawd, tshwm sim ntawm kev zawv plab.
Ascorbic acid tuaj yeem nce ntxiv qhov nqus ntawm cov tshuaj no, yog li ua rau nws cov nyhuv antimicrobial.
Thaum kho, nws yog qhov yuav tsum tau kuaj xyuas lub raum ua haujlwm nrog kev sim ntsuas.
Cawv tau zoo
Tsis muaj cov tshuaj lom biochemical uas cawv thiab clavulanate sib tshuam, yog li peb tsis tuaj yeem tham txog lawv cov kev tsis sib xws. Tab sis thaum lub sij hawm ntawm kev kho mob, koj tseem yuav tsum yauv tsum haus cawv kom txo qhov ua rau lub siab.
Thaum kho lub sijhawm, koj yuav tsum tsis kam haus cawv kom txo qhov ua rau lub siab.
Analogs
Cov analogues hauv qab no yog nthuav tawm ntawm kev ua lag luam - Panclave, Ecoclave, Augmentin, Amoxiclav, Flemoxin Solutab.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Kuv tuaj yeem yuav yam tsis tas yuav tshuaj
Cov tshuaj no tuaj yeem muas tom qab tsis tas yuav tshuaj, tab sis ua ntej siv, koj yuav tsum sab laj nrog kws kho mob thiab noj nws raws li cov lus qhia.
Tus nqi ntawm clavulanic acid
Tus nqi nws txawv ntawm 150 txog 300 rubles, nyob ntawm seb tus tsim khoom.
Cia rau cov neeg mob rau cov tshuaj
Khaws cov tshuaj rau hauv nws cov ntawv ntim thawj hauv chav sov. Khaws tsis ncav cuag ntawm cov menyuam yaus.
Hnub tas sij hawm
3 xyoos txij li hnub ntawm kev tsim khoom lag luam, uas tau qhia rau hauv daim ntawv uas tau los qhia.
Chaw tsim tshuaj paus
Sandoz (Poland).
Clavulanic acid tshuaj xyuas
Cov kws kho mob
Inna, 36 xyoo, tus kws kho mob kis tus kab mob: "Kuv sau ntawv rau clavulanate rau lacunar thiab follicular tonsillitis. Nws muab cov txiaj ntsig zoo nrog cov kab mob tiv thaiv penicillins. Thaum kho mob luv luv, cov neeg mob tau mob raws plab, tab sis cov mob no yooj yim kho nrog tshuaj."
Sergey, 52 xyoo, tus kws tshaj lij: "Kuv siv cov tshuaj no rau kev kho mob ntawm cov neeg mob ntsws me thiab mob ntsws me ntsis. Nws zoo los tiv thaiv kev mob ntsws, tshwj xeeb tshaj yog thaum rov kho dua tom qab siv penicillins. Yuav luag tsis muaj teeb meem nrog cov quav ntawm cov neeg mob, yog tias muaj - yooj yim kho nrog Loperamide. "
Cov neeg mob
Andrey, 23 xyoo: “Kuv tau siv nws li 2 lub lis piam thaum kuv mob ntsws hnoos. Qhov tshwm sim ntawm txoj kev kho tau tuaj rau hnub thib peb, qhov kub tsis txias thiab qhov mob tsawg zuj zus. Kuv tau mob me ntsis thaum noj mov, tab sis qhov no tsis tsum. kev kho mob. "
Eugenia, hnub nyoog 19 xyoo: "Tus kws kho mob paub zoo Augmentin rau kev kho mob tonsillitis. Tonsils tseem mob ntev thiab nrog txhaws, tab sis sai sai rov zoo li qub tom qab kev kho mob. Qhov tseem ceeb tshaj plaws yog ua kom pleev tshuaj rau qhov tshuaj tua kab mob ua ntej kho thiab paub meej txog qhov zoo ntawm cov tshuaj."
