Thioctic acid yog cov tshuaj zoo li vitamin, ib hom tshuaj tua kab mob antioxidant. Daim ntawv ntau npaum li cas yog cov tshuaj hauv kev xaiv hauv kev kho mob ntawm endothelioneural ua hauj lwm (kev ua tsis tau zoo thiab kev mob ntawm cov hlab ntsha poob siab vim los ntawm kev poob qis hauv cov ntshav vim vascular endothelial pathologies) thiab oxidative kev nyuab siab.
Npe
Lipoic acid, alpha lipoic acid, thioctacid yog cov ntsiab lus rau thioctic acid.
Hauv Lus Askiv, cov tshuaj hu ua Thioctic acid. Hauv Latin - Acidum thiocticum (genus Acidi thioctici). Lub npe kev lag luam yuav txawv (Oktolipen, Berlition 600, thiab lwm yam).
Thioctic acid yog cov tshuaj zoo li vitamin, ib hom tshuaj tua kab mob antioxidant.
ATX
ATX code yog A16AX01.
Tso cov ntawv thiab cov nyob ua ke
Muaj li:
- ntsiav tshuaj
- daws rau kev txhaj tshuaj, 1 ml ntawm uas muaj 25 mg ntawm α-lipoic acid;
- mloog zoo rau kev daws rau Txoj kev lis ntshav.
Thioctacid muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj coated.
Ntsiav tshuaj
Thioctacid muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj coated hauv qhov ntau npaum ntawm 200 thiab 600 mg ntawm cov tshuaj nquag.
Hmoov
Hauv daim ntawv ntawm hmoov, cov khoom siv rau kev kho mob tsis siv, vim hais tias soluble tsuas yog hauv ethanol.
Pharmacological kev txiav txim
Ua lub tshuaj tiv thaiv ntuj, thioctacid tiv thaiv kev ua kom tawg ntawm nuclear factor kappa-bi vim yog cov dawb radicals. Kev ua txhaum ntawm nws txoj kev cai ua rau autoimmune kab mob, cell phaum distortion thiab apoptosis (tuag) ntawm cov hlwb.
Qhov zoo tshaj plaws nosological yog vim nws lub zog:
- kev koom tes hauv cov tshuaj tiv thaiv ntawm decarboxylation ntawm alpha-keto acids - ua kom lub zog ntawm tes sib pauv thiab tiv thaiv DKA;
- muaj peev xwm los txo theem ntawm fatty acids, roj cholesterol;
- antioxidant - khi ntawm cov radicals tsis zoo, cov xim ua pa, rov qab los ntawm glutathione;
- kev tsuj ntawm kev ua ke ntawm nitric oxide los ntawm daim siab mob hlwb - kev tiv thaiv thiab nyem ntawm phlebopathy;
- radioprotective.
Los ntawm kev coj ua ntawm endothelium ntawm cov hlab ntsha, lipoic (thioctic) acid txo kev puas tsuaj rau lawv txheej sab hauv, txo qis lumen, tsis ruaj khov thiab muaj kev pheej hmoo ntawm cov ntshav txhaws.
Ua tsaug rau cov peev txheej no ntawm thioctacide, cov tshuaj muaj cov nyhuv ntau yam ntawm lub cev:
- activates ntshav khiav neural;
- tiv thaiv kev tsuj ntawm NO synthetase, uas tiv thaiv ischemic kev puas tsuaj rau cov ntaub so ntswg ntawm lub paj hlwb;
- accelerates tus cwj pwm ntawm cov paj impulses;
- tswj kev ua si ntawm glutathione;
- inhibits kev puas tsuaj rau cov cell week.
Qhov tshwm sim ntawm kev ntsuas ntawm kev txiav txim ntawm tus neeg sawv cev yog:
- normalization cov roj;
- txo qis hauv insulin tsis kam;
- nce glycemic tswj;
- kev tiv thaiv ntawm pancreatic islet ua cov kua dej;
- kev txo qis hauv lipid, uas qhia txog cov txiaj ntsig zoo ntawm kev kho mob rog;
- kev tiv thaiv ntawm cell edema vim yog kev txuam nrog ntawm sorbitol hauv lawv;
- txhim kho ntawm cov khoom siv elastic thiab microcirculation ntawm cov hlab ntshav;
- txo ntawm anti-inflammatory yam nyob rau hauv cov ntshav ntshav;
- txhim kho detoxification kev ua haujlwm ntawm daim siab, tsim tawm cov kua tsib kua qaub thiab tiv thaiv cov qog ntawm lub cev ntawm kev ua haujlwm ntawm kev puas tsuaj.
Kev ua ntawm endothelium ntawm cov hlab ntsha, lipoic (thioctic) acid txo kev puas tsuaj rau lawv txheej sab hauv, txo qhov lumen, brittleness thiab kev pheej hmoo ntawm cov ntshav txhaws, cov txheej txheem ua mob.
Cov kua qaub yooj yim dhau ntawm cov ntshav-hlwb teeb meem, uas txiav txim siab nws cov hauj lwm zoo hauv kev kho mob rau cov kab mob encephalopathy thiab lub hauv nruab nrab cov hlab ntsha: Alzheimer thiab Parkinson.
Cov Tshuaj Pharmacokinetics
Thaum noj ntawm qhov ncauj, cov tshuaj yuav luag txhua yam hauv lub plab zom mov. Co-administration ntawm cov tshuaj nrog zaub mov txo nws lub plab. Kev ua haujlwm siab (Cmax) ntawm cov tshuaj yog pom ib lub hlis twg ntawm ib teev lossis ib teev tom qab kev tswj hwm. Hauv lub siab, cov kab mob biotransformation ntawm alpha lipoic acid tshwm sim thaum lub sijhawm pib los ntawm phab ntsa ntawm txoj hnyuv, daim siab, lub ntsws, uas ua rau lub bioavailability ntawm cov khoom nce mus txog 30-60%.
Thaum noj ntawm qhov ncauj, cov tshuaj yuav luag txhua yam hauv lub plab zom mov.
Nws Vp (ntim ntim) yog kwv yees li 450 ml / kg, uas qhia tau tias muaj ntau yam tshuaj nyob rau hauv cov ntaub so ntswg ntawm lub cev. Ib nrab-lub neej (T1 / 2), lossis lub sijhawm poob ntawm 50% kev ua haujlwm, ntawm lipoic acid yog 20-50 feeb, uas yog vim yog kev tshem tawm ntawm cov khoom ntawm kev hloov pauv ntawm cov tshuaj uas tshwm sim hauv lub siab los ntawm lub raum. Tus nqi ntawm kev ua kom huv ntawm ntshav ntshav (Cl plasma) los ntawm cov tshuaj yog 10-15 ml / min.
Dab tsi xav tau rau
Thioctacid yog siv rau hauv kev kho mob los ntawm kev mob tshwm sim los ntawm oxidative kev nyuaj siab, hyperinsulinemia, insulin tsis kam, endothelial kawg. Siv nyob rau hauv kev kho mob ntawm:
- Cov neeg mob ntshav qab zib thiab nws cov teeb meem, xws li:
- mob ntshav qab zib polyneuropathy;
- cov kab mob encephalopathy mob ntshav qab zib;
- daim siab ua rog nyob hauv tus neeg mob insulin tsis kam;
- cov kab mob ntshav qab zib;
- hlab plawv autonomic neuropathy;
- rog dhau
- Polycystic zes qe menyuam mob rau cov poj niam.
- Cov mob siab ua mob rau hauv kev quav cawv nrog cawv, tshuaj hnyav, tshuaj lom neeg lom; kev qhia ntawm tus neeg sawv cev kis mob (tus kab mob siab C, B).
- Tus kab mob quav dej caw.
- Pob Kws Ntaus Pob Kws.
Cov khoom siv, nrog kev muaj peev xwm tswj hwm kev ua kom rog thiab roj metabolism, yog siv los ntawm kev noj zaub mov kom txo qhov hnyav thiab kho kev rog.
Hauv cosmetology, kua qaub yog siv rau:
- tshem tawm cov mob o;
- kev tiv thaiv los ntawm kev cuam tshuam ntawm qhov teeb meem sab nraud cuam tshuam ua rau wrinkles, wilting ntawm daim tawv nqaij;
- qhia meej, tiv thaiv UV;
- cov ntaub so ntswg ua kom rov qab;
- glycation inhibition - cov txheej txheem ntawm "gluing" collagen fibers nrog piam thaj;
- rejuvenation.
Cov tshuaj ua kom zoo dua rau cov nyhuv ntawm cov tawv nqaij thiab lub cev ntawm cov vitamin D, ascorbic acid thiab tocopherol.
Cov tshuaj pleev ib ce khoom tsis muaj ntau tshaj 10% lipoic acid raws li EU Txoj Cai. Lawv siv yog qhia rau cov poj niam nrog daim tawv nqaij laus, hyperpigmentation, ib tug nyiam mus rau o, voos. Tsis tas li, tshuaj pleev ib ce nrog thioctacid yog siv yog tias daim tawv nqaij yog oily, nrog thaj hws loj thiab ua pob ntxau.
Cov Yuav Tsum Muaj
Txij li thaum lipoleic acid nyob rau hauv qhov xav tau yuav ua tau endogenously synthesized hauv tib neeg lub cev, nws xyaum tsis muaj contraindications rau lub hom phiaj. Lub ntsiab contraindication yog hypersensitivity rau cov tshuaj. Siv cov tshuaj nrog ceev faj nrog:
- cev xeeb tub thiab lactation;
- lub hnub nyoog ntawm tus neeg mob mus txog 6 xyoo.
Lub ntsiab contraindication yog hypersensitivity rau cov tshuaj.
Qhov kev txwv yog vim tsis muaj kev paub hauv kev siv tshuaj nyob rau hauv cov neeg mob ntawm cov pab pawg no thiab qhov tsis muaj ntau tus lej ntawm kev nyab xeeb tau.
Hauv cov tshuaj kho mob, qhov muaj lactose ua cov muab tub lim yuav tsum tau txiav txim siab. Lub hom phiaj ntawm cov yeeb tshuaj yog contraindicated rau hauv cov neeg mob malabsorption - kev tiv thaiv kab mob lactose tsis haum.
Yuav ua li cas noj thioctic acid
Kev kho mob yog pib nrog kev siv thioctic acid los ntawm kev tso ntshav los yog infusion thawj coj ntawm cov tshuaj. Thaum tus mob yog khov kho, kev saib xyuas kev kho mob nrog ntsiav tshuaj yog tshuaj.
Hauv kev tsim cov tshuaj pleev ib ce los ntawm kev mloog zoo hauv ampoules, lawv cov ntsiab lus yog diluted nrog ntsev ua kua - NaCl daws.
Txog kev tswj hwm (hauv qhov ncauj) kev tswj hwm, cov lus pom zoo hauv qab no tau coj ua:
- noj ua ntej noj mov ib hnub ib zaug;
- tsis txhob zom, nqos, haus dej ntau;
- tom qab ib nrab teev koj yuav tsum muaj tshais;
- qhov siab tshaj plaws txhua hnub koob feem ntau tsis ntau tshaj 600 mg ntawm thioctacide;
- chav kawm ntawm kev kho mob yog 3 hli, raws li kev taw qhia, lub sijhawm ntawm kev kho mob tuaj yeem txuas ntxiv.
Kev kho yog pib nrog kev siv thioctic acid los ntawm kev ua haujlwm siab ntawm tus neeg sawv cev.
Kev kho mob ntawm cov ntsiav tshuaj yog tawm tom qab 2-4 lub lim tiam ntawm cov tshuaj tso quav lossis infusion tswj cov tshuaj.
Tso rau hauv tshuaj, tshuaj yog maj mam muab kom tsis txhob muaj kev phiv. Lub dropper yog tswj hwm ntawm kev qhia qeeb poob. Qhov ntim tau yog 300-600 mg.
Thioctic acid tseem siv rau kev tswj hwm intramuscular. Txhawm rau kom tsis txhob muaj qhov tsis zoo, nws tsis pom zoo kom txhaj ntau dua 2 ml ntawm cov tshuaj hauv ib qho chaw.
Thioctic acid nyob rau hauv kev tawm dag zog
Hauv kev tawm dag zog lub cev, kev tawm dag zog thiab kev ua kis las, thioctacid yog siv los txo oxidative kev nyuab siab tom qab kev tawm dag zog lub cev. Lub peev xwm los txo cov piam thaj hauv kev ua haujlwm thiab hloov nws mus rau cov khoom siv hluav taws xob siab tseem ua lub luag haujlwm tseem ceeb: cov cuab yeej ntawm cov tshuaj no pab muab lub zog rau cov leeg pob txha thiab tau txais cov txiaj ntsig tshaj plaws los ntawm kev cob qhia. Tsis tas li ntawd, acid ntxiv txhim kho thermogenesis, pab kom tshem ntawm cov rog cia hauv thaj chaw muaj teeb meem, yog li nws tau raug txiav txim tsis tsuas yog hauv kev ua kis las, tab sis kuj ua rau poob phaus.
Hauv kev tawm dag zog lub cev, kev tawm dag zog thiab kev ua kis las, thioctacid yog siv los txo oxidative kev nyuab siab tom qab kev tawm dag zog lub cev.
Cov neeg loj ncaws pob tau pom tias txhaj tshuaj 50 mg 3-4 zaug ib hnub ib nrab teev tom qab noj mov. Nrog kev kawm paub ntau, ntau npaum li cas ntawm cov tshuaj tau nce rau 300-600 mg ib hnub.
Noj cov tshuaj rau ntshav qab zib
Hauv cov kab mob ntshav qab zib mellitus, cov tshuaj pib tau txais kev tswj hwm ua niam txiv (bypassing txoj hnyuv). Cov tshuaj muaj zog yog diluted hauv 100-250 mg ntawm 0.9% sodium chloride thiab hauv qhov ntim ntawm 600 mg yog muab cov tshuaj dropwise ncaj ncees rau 15 hnub. Cov tshuaj tau muab rau hauv cov voj voog ntawm 5 hnub nrog 2-hnub so nruab nrab ntawm lawv. Nyob rau hauv tag nrho, 15 ampoules raug siv rau chav kho mob.
Tom qab ua tiav ntawm kev txhaj tshuaj tiav, tus neeg mob pauv mus rau thioctacid ntsiav tshuaj, 1 pc. ib hnub ua ntej noj tshais.
Hauv cov kab mob ntshav qab zib mellitus, cov tshuaj pib tau txais kev tswj hwm ua niam txiv (bypassing txoj hnyuv).
Kev ua dej qabzib rau lub cev thiab ua kom lub cev tsim cov tshuaj insulin koj yuav tsum tau txhaj tshuaj insulin thiab txo cov ntshav qab zib. Nyob rau hauv cov nyom loj heev, chav kawm ntawm kev kho mob tuaj yeem yog 3-5 hlis.
Sab sij huam
Cov kev mob tsis zoo raug sau tseg hauv 1 qhov xwm txheej ntawm 10,000 tus neeg mob. Qhia nyob rau hauv daim ntawv ntawm:
- kev ua xua ntawm daim tawv;
- ntshav tshuaj qis;
- nrog rau qhov ncauj siv, dyspeptic cuam tshuam, kub siab, mob epigastric yog ua tau;
- nrog rau iv, hnoos ntshav, nce ntshav siab thiab ntshav siab intracranial, ob lub zeem muag, ua pa, mob pob txha, thiab ntshav los ntshav yuav tshwm sim.
Kev tshwm sim ploj thaum koob tau txo lossis tom qab tswj hwm cov tshuaj yeeb dej caw.
Cov lus qhia tshwj xeeb
Cov neeg mob ntshav qab zib yuav tsum saib xyuas cov ntshav qabzib tas li. Cov kev npaj daws tau daws teeb meem, yog li lawv tau siv tam sim ntawd tom qab dilution los yog tiv thaiv nrog lub vijtsam hluav taws xob.
Cawv tau zoo
Cov tshuaj siv yog txuam nrog dej cawv, vim hais tias ethanol txo cov kev ua tau zoo ntawm kev sib xyaw ua ke.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Nws tsis ncaj qha cuam tshuam rau tus nqi ntawm cov neuromuscular tshua, tab sis qhov tshwm sim tsis zoo xav tau ceev faj thaum kho.
Siv thaum cev xeeb tub thiab lactation
Nws yog txoj kev lees txais los sau tshuaj thaum lub sijhawm cev xeeb tub yog tias cov txiaj ntsig ntawm kev kho mob tshaj qhov txaus ntshai tau. Nyob rau hauv rooj plaub thaum kev kho mob tsim nyog thaum pub niam mis, nws yog qhov yuav tsum tau hloov tus menyuam mus rau kev pub mis.
Nws yog txoj kev lees txais los sau tshuaj thaum lub sijhawm cev xeeb tub yog tias cov txiaj ntsig ntawm kev kho mob tshaj qhov txaus ntshai tau.
Khaws cov thioctic acid rau menyuam yaus
Cov lus qhia rau kev siv tshuaj tsis pom zoo rau nws siv rau cov menyuam yaus uas muaj hnub nyoog qis dua 6 xyoo. Txawm li cas los xij, raws li kev qhia, cov tshuaj tuaj yeem ua raws li tus nqi:
- 0.012 g 2-3 zaug ib hnub rau cov menyuam yaus hnub nyoog qis dua 7 xyoo;
- 0.012-0.024 g 2-3 zaug ib hnub rau cov menyuam yaus hnub nyoog dhau 7 xyoo.
Noj ntau dhau
Qhov ntxim nyiam ntawm kev noj ntau dua yog qhov me me, tab sis nrog kev rhiab ntawm ib tus neeg lossis ib qho kev ua txhaum ntawm kev tswj hwm txheej txheem, cov hauv qab no yuav tshwm sim:
- mob taub hau
- xeev siab thiab ntuav.
Thaum qaug cawv, kho mob yog ua los pab thum qhov tsos mob.
Nrog kev noj tshuaj ntau dhau hwv lawm, mob taub hau tshwm.
Kev cuam tshuam nrog lwm yam tshuaj
Acid tsis sib xws nrog:
- Lub nplhaib cov kev daws teeb meem thiab lwm tus neeg sawv cev uas muaj cov calcium thiab magnesium;
- hlau npaj;
- ethanol.
Cov tshuaj pab kho qhov ua tau zoo ntawm cov tshuaj insulin thiab cov tshuaj tiv thaiv kab mob hypoglycemic.
Analogs
Cov tshuaj ntawm Acidum thiocticum yog cov tshuaj:
- Alpha lipon;
- Berlition;
- Thioctacid;
- Thiogamma;
- Oktolipen;
- Lipoic acid, ib lub npe hu ua vitamin N;
- Lipothioxone;
- Neuroleipone;
- Xwm.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Los ntawm tshuaj.
Kuv tuaj yeem yuav yam tsis tas yuav tshuaj
Tsis yog.
Tus nqi ntawm thioctic acid
Nyob ntawm cov neeg tsim khoom thiab daim ntawv tso tawm, tus nqi ntawm cov tshuaj nws txawv ntawm 40 (50 ntsiav tshuaj) txog 2976 (100 ntsiav tshuaj) rubles. Thioctacid 600 hauv ampoules tus nqi 1,539 rubles. rau kev ntim khoom. Hauv Ukraine, tus nqi yog li ntawm 92 txog 292 UAH.
Cia rau cov neeg mob
Sau B - Khaws rau hauv qhov chaw txias thiab tsaus.
Cov tshuaj yuav tawm tsuas yog tus neeg mob tau siv tshuaj kho mob.
Hnub tas sij hawm
3 xyoos
Kev Tshawb Xyuas Thioctic Acid
Cov tshuaj tau ntev ntev tsis ua rau kev sib cav ntawm cov neeg siv thiab cov kws tshaj lij. Thiab cov tsos ntawm cov ntaub ntawv niaj hnub nrog qhov tsawg kawg ntawm kev phiv ua rau kev soj ntsuam zoo.
Cov kws kho mob
Elena Sergeevna, kws kho mob, Kiev: "Kuv yog tus neeg mob ntshav qab zib thiab tau ntsib qhov ua tau haujlwm ntawm thioctic acid, yog li ntawd, nrog lub siab xav, Kuv tau sau ntawv Thioctacid BV rau cov neeg mob."
Inga Olegovna, tus kws kho mob endocrinologist, Kostroma: "Hauv kev xyaum ntawm tus kws kho mob, nws yog ib qho tseem ceeb kom paub meej txog qhov ua tau zoo thiab kev nyab xeeb ntawm cov tshuaj. Kuv tau rov hais dua tias ntau npaum li cas ntawm kev kho nrog tshuaj Thioctacid BV yog li tau tshaj tawm."
Cov neeg mob
Mirra, 45 xyoo, Krivoy Rog: "Rau lub hlis dhau los, Kuv tau pib xav tias tsis muaj loog hauv kuv tus ntiv tes thiab tes. Tus kws kho mob tau hais tias qhov ua rau yog ntshav qab zib, thiab tau noj cov tshuaj ntawm Thioctacid BV. Kuv haus tag nrho ib nrab xwb, thiab kuv txoj kev noj qab haus huv tau zoo tuaj."
Oksana, 31 xyoo, Odessa: "Cov lus qhia qhia tias muaj kev fab tshuaj muaj peev xwm ua tau, tab sis cov tshuaj tsis txawm ua rau muaj kev tsis haum tshuaj, txawm tias kuv yog ib tus neeg muaj kev tsis haum."
Anna, uas muaj 40 xyoo, Kazan: “Ntxiv rau cov ntshav qab zib, muaj teeb meem loj heev ntawm txha nraub qaum. Kuv tau noj tshuaj ntau dua 3 lub hlis. Txawm hais tias kuv haus ntau lwm yam tshuaj ntxiv rau nws, tsis muaj kev phiv, txawm tias qhov hnyav poob qis me ntsis yam tsis muaj zaub mov noj "
