Tegretol CR - ib qho tshuaj tiv thaiv kev puas tsuaj uas nce qhov pib ntawm kev tshaj tawm kev txawj xav, yog li tiv thaiv qhov tshwm sim ntawm kev tawm tsam.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Carbamazepine.
Tegretol CR - ib qho tshuaj tiv thaiv kev puas tsuaj uas nce qhov pib ntawm kev pom meej.
ATX
Qhov ATX code yog N03AF01.
Tso cov ntawv thiab cov nyob ua ke
Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj coated. Cov ntsiav tshuaj muaj biconvex oval duab.
Lub ntsiab lus tseem ceeb ntawm cov tshuaj hauv cov ntsiav tshuaj yuav yog 200 mg lossis 400 mg. Cov tshuaj phiv yog carbamazepine.
200 mg ntsiav tshuaj muaj nyob rau hauv cov thawv pob ntawm 50 daim. Sab hauv pob ntawm 5 blisters ntawm 10 daim.
Cov ntsiav tshuaj 400 mg muaj nyob rau hauv pob ntawm 30 daim. Sab hauv pob muaj 3 blisters ntawm 10 daim.
Pharmacological kev txiav txim
Carbamazepine yog qhia rau kev puas tsuaj ntawm kev mob huam nriaj. Lub ntsiab nquag ua hauj lwm ntawm cov tshuaj yog cov dibenzoazepine derivative. Nws muaj cov nyhuv antiepileptic nrog rau cov neurotropic thiab raws li psychotropic.
Lub pharmacological kev ua ntawm cov tshuaj tsis tau kawm tag nrho. Muaj cov ntaub ntawv hais tias cov nquag ua haujlwm cuam tshuam rau cov cell puas ntawm neurons, ua rau lawv nyob ruaj khov thiab tiv thaiv kev ua kom dhau hwv. Qhov no kuj tshwm sim vim yog kev tsuj tawm ntawm lub zog neuronal sai sai, vim qhov ntawd muaj qhov hyperactivation ntawm cov leeg hlwb.
Kev siv Tegretol hauv cov neeg mob qaug dab peg yog nrog los ntawm kev tsuj cov khoom muaj kev puas hlwb.
Lub ntsiab feem ntawm cov kev ua ntawm cov tshuaj yog thaiv qhov rov ua kom zoo siab ntawm cov neurons tom qab depolarization. Qhov no yog vim qhov tsis ua haujlwm ntawm cov ion channel uas muab cov thauj sodium.
Cov kev tshawb fawb pom tau tias kev siv Tegretol hauv cov neeg mob qaug dab peg yog nrog kev tawm ntawm cov tshwm sim ntawm cov kev mob hlwb: kev nyuaj siab tsis zoo, kev ntxhov siab thiab kev ntxhov siab ntau ntxiv.
Tsis muaj qhov tseeb ntawm qhov tseeb seb puas yuav cuam tshuam cov carbamazepine rau kev xav txog kev puas siab puas ntsws psychomotor thiab lub peev xwm ntawm cov neeg mob. Thaum qee qhov kev tshawb fawb, cov ntaub ntawv muaj teeb meem tau tau, lwm tus qhia tau tias cov tshuaj txhim kho lub peev xwm ntawm kev txawj ntse.
Cov nyhuv neurotropic ntawm Tegretol tso cai rau koj siv nws rau kev kho mob ntawm neurological pathologies. Nws yog kho rau cov neeg mob neuralgia n. trigeminus rau kev kho mob ntawm kev tawm tsam tshwm sim los ntawm qhov mob.
Cov neeg mob uas thim tawm ntawm cov cawv tau raug xaj kom txo qis kev phom sij.
Cov neeg mob uas thim tawm ntawm cov cawv tau raug xaj kom txo qis kev phom sij. Nws tseem yuav txo qhov mob ntawm cov kab mob pathological ua pov thawj ntawm tus mob huam.
Hauv cov neeg muaj ntshav qab zib insipidus, kev siv cov tshuaj no normalizes diuresis.
Cov txiaj ntsig kev siab ntsws ntawm tegretol yog siv los kho cov teeb meem mob hlwb. Nws tuaj yeem siv ob qho tib si nyias thiab muaj kev sib xyaw nrog lwm cov tshuaj tiv thaiv kev mob, tshuaj tiv thaiv kev ntxhov siab. Kev tsuj ntawm kev mob tshwm sim yog piav qhia los ntawm kev txwv tsis pub muaj kev cuam tshuam ntawm dopamine thiab norepinephrine.
Cov Tshuaj Pharmacokinetics
Kev nqus ntawm cov txheej txheem nquag tshwm sim los ntawm kev mob plab hnyuv. Nws tso tawm los ntawm cov ntsiav tshuaj yog qeeb, uas tso cai rau ua kom lub zog ntev. Qhov siab tshaj plaws ntawm ib yam khoom hauv cov ntshav tau txog hauv 24 teev. Nws yog ¼ qis dua kev saib xyuas thaum noj cov qauv txheem ntawm cov tshuaj.
Vim los ntawm kev tso tawm qeeb qeeb ntawm cov tshuaj nquag, hloov pauv nyob rau hauv nws cov peev txheej hauv cov ntshav tsis tseem ceeb. Lub bioavailability ntawm carbamazepine thaum noj cov tshuaj ncua ntxiv yog txo los ntawm 15%.
Thaum nws nkag rau hauv cov ntshav, cov nquag tiv thaiv khi kom thauj peptides los ntawm 70-80%. Nws hla lub plab thiab nkag rau hauv niam mis. Cov ntsiab lus ntawm cov tshuaj rau tom kawg tuaj yeem ntau dua 50% ntawm tib qhov ntsuas hauv cov ntshav.
Lub bioavailability ntawm carbamazepine thaum noj cov tshuaj ncua ntxiv yog txo los ntawm 15%.
Cov metabolism hauv cov tshuaj nquag tshwm sim nyob rau hauv kev cuam tshuam ntawm daim siab enzymes. Raws li kev hloov pauv hauv tshuaj lom neeg, cov nquag metabolite ntawm carbamazepine thiab nws cov khoom sib txuas nrog glucuronic acid yog tsim. Ntxiv rau, ib qho me me ntawm kev siv lub cev tsis muaj zog metabolite yog tsim.
Muaj ib qhov zom zaubmov tsis cuam tshuam txog cytochrome P450. Yog li monohydroxylated tshuaj sib txuas ntawm carbamazepine yog tsim.
Ib nrab-lub neej ntawm cov khoom nquag yog 16-36 teev. Ua raws li lub sijhawm kho. Nrog rau kev ua kom lub siab enzymes los ntawm lwm yam tshuaj, ib nrab lub neej yuav raug txo kom tsawg.
2/3 ntawm cov tshuaj tau tawm los ntawm ob lub raum, 1/3 - los ntawm txoj hnyuv. Cov tshuaj yuav luag tag nrho tshem tawm nyob rau hauv daim ntawv ntawm metabolites.
Kev ntsuas rau siv
Kev qhia siv rau cov cuab yeej no yog:
- qaug dab peg (tshuaj rau ob qho yooj yim thiab sib xyaw thiab theem nrab dav dav chua leeg);
- kev puas siab bipolar;
- mob hlwb mob hlwb hnyav;
- trigeminal neuralgia;
- mob ntshav qab zib neuropathy, nrog mob;
- ntshav qab zib insipidus nrog nce diuresis thiab polydipsia.
Cov Yuav Tsum Muaj
Kev siv Tegretol yog contraindicated nyob rau hauv cov teeb meem hauv qab no:
- ib tug neeg lub cev sib xyaw rau cov tshuaj nquag lossis lwm yam tshuaj;
- atrioventricular thaiv;
- haus dej cawv haus cawv siab;
- kev ua txhaum ntawm hematopoietic kev ua haujlwm ntawm cov pob txha pob txha;
- mob sib kis;
- kev sib xyaw ntawm cov tshuaj nrog monoamine oxidase inhibitors.
Yuav ua li cas coj Tegretol CR
Noj mov tsis cuam tshuam rau qhov ua tau zoo ntawm cov tshuaj. Cov ntsiav tshuaj noj tag nrho thiab ntxuav nrog qhov xav tau ntawm cov dej.
Kev kho mob Monotherapy nrog Tegretol yog ua tau, nrog rau nws cov kev sib xyaw nrog lwm tus neeg sawv cev.
Cov kev cai tswj hwm rau kev siv tshuaj muaj ob zaug kev tswj hwm cov ntsiav tshuaj. Vim tias cov tshuaj pharmacological zoo nrog cov nyhuv ntev ntev, qhov nce ntxiv ntawm kev noj tshuaj txhua hnub yuav tsum tau.
Cov ntsiav tshuaj noj tag nrho thiab ntxuav nrog qhov xav tau ntawm cov dej.
Cov neeg mob qaug dab peg yog pom zoo tegretol monotherapy. Ua ntej, cov koob tshuaj tsawg kawg yog tawm kho, uas maj mam nce mus rau tus qauv. Qhov pom zoo thaum pib ntawm cov tshuaj yog 100 mg 1 lossis 2 zaug ib hnub. Qhov zoo tshaj plaws koob tshuaj yog 400 mg 2-3 zaug ib hnub. Qee qhov xwm txheej, koj yuav tsum nce ntxiv qhov kev noj tshuaj txhua hnub rau 2000 mg.
Nrog neuralgia n. trigeminus qhov kev muab tshuaj rau txhua hnub yog txog li 400 mg. Ntxiv mus nce rau 600-800 mg. Cov neeg laus cov neeg laus tau txais 200 mg ntawm cov tshuaj ib hnub.
Cov neeg uas thim cov cawv cawv tau sau tseg los ntawm 600 txog 1200 mg / hnub. Hauv cov tsos mob hnyav tshem tawm, cov tshuaj tau nrog cov tshuaj sedative.
Cov neeg mob uas muaj mob vwm manic los ntawm 400 mus rau 1600 mg ntawm Tegretol ib hnub. Kev kho mob pib nrog kev siv tshuaj tsawg, uas maj mam nce.
Nrog ntshav qab zib
Carbamazepine yog qhia rau cov neeg mob uas mob neuropathy mob ntshav qab zib. Cov tshuaj nres qhov mob uas tshwm sim vim kev hloov pauv hauv metabolic cov hlab ntsha poob siab. Qhov pom zoo kom noj tshuaj rau txhua hnub rau mob ntshav qab zib neuropathy yog 400 txog 800 mg.
Carbamazepine yog qhia rau cov neeg mob uas mob neuropathy mob ntshav qab zib.
Qhov tshwm sim ntawm Tegretol CR
Ntawm ib feem ntawm cov khoom hauv nruab nrog kev pom
Tej zaum yuav tshwm sim:
- kev ntxhov siab nyob rau hauv kev saj rau;
- pom kev o;
- tinnitus;
- hypo-hyperacusia;
- clouding ntawm lub lens.
Los ntawm cov leeg nqaij thiab pob txha sib txuas
Cov kev mob tshwm sim nram qab no tej zaum yuav tshwm sim:
- mob leeg
- mob tej pob txha.
Kev kho mob txoj hnyuv
Qhov tshwm sim ntawm qhov kev tsis haum siab xav tau yog muaj:
- xeev siab
- ntuav
- o ntawm cov qog ua kua ntawm qhov ncauj;
- hloov pauv ntawm qhov xwm ntawm rooj zaum;
- mob caj dab;
- hloov hauv theem ntawm kev ua si ntawm daim siab enzymes.
Hematopoietic plab hnyuv siab raum
Lawv tuaj yeem teb tau rau kev kho mob nrog rau qhov pom ntawm:
- leukopenia;
- thrombocytopenia;
- agranulocytosis;
- anemia
- txo cov tshuaj folic acid ntau ntau.
Hematopoietic plab hnyuv siab raum yuav teb rau kev kho mob nrog thrombocytopenia.
Nruab nrab hauv lub paj hlwb
Tej zaum yuav teb rau txoj kev kho nrog cov kev mob tshwm sim hauv qab no:
- Kiv taub hau
- mob taub hau
- peripheral neuropathy;
- paresis;
- hais lus tsis meej;
- leeg tsis muaj zog;
- tsaug zog
- Cov tsos mob hallucinatory;
- nce kev txob taus;
- depressive kev ntshawv siab;
- ob lub zeem muag
- txav mus los;
- rhiab siab tsis xis nyob;
- nkees.
Lub hauv nruab nrab cov hlab hlwb tuaj yeem teb rau kev kho mob nrog ob lub zeem muag.
Los ntawm cov kab mob zis
Yuav muaj cai:
- jade;
- pollakiuria;
- kev tso zis cia.
Los ntawm lub tshuab ua pa
Muaj tshwm sim:
- txog siav
- mob ntsws.
Ntawm ib sab ntawm daim tawv nqaij
Yuav muaj cai:
- kev ua kom zoo nkauj;
- dermatitis;
- khaus
- erythema;
- hirsutism;
- pigmentation;
- ua pob;
- hyperhidrosis.
Los ntawm genitourinary system
Ib ntus impotence yuav tshwm sim.
Los ntawm cov kab ke genitourinary, kev ua tsis taus ib ntus tej zaum yuav tshwm sim.
Los ntawm cov hlab plawv system
Tej zaum yuav tshwm sim:
- atrioventricular thaiv;
- arrhythmia;
- lub plawv dhia qis;
- exacerbation cov tsos mob ntawm cov kab mob plawv.
Endocrine system
Qhov pom tau:
- o tuaj;
- gynecomastia;
- hyperprolactinemia;
- hypothyroidism.
Los ntawm ib sab ntawm cov metabolism
Tej zaum yuav tshwm sim:
- tshuaj tiv thaiv hyponatremia;
- siab triglycerides;
- nce rau hauv cov roj (concentration).
Kev ua xua
Qhov pom tau:
- kev siv tshuaj tiv thaiv qhov tsis haum;
- lymphadenopathy;
- npaws
- mob hlwb;
- aseptic mob rau daim npluag qhwv.
Los ntawm noj Tegretol CR ua cov kev mob tshwm sim, tus neeg mob tuaj yeem soj ntsuam kub ib ce.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Cov xwm txheej uas tshwm sim muaj feem cuam tshuam nrog kev nce siab mloog yuav tsum zam thaum noj cov tshuaj carbamazepine. Qhov no yog vim qhov muaj peev xwm yuav muaj kev phiv los ntawm kev mob hlwb.
Cov lus qhia tshwj xeeb
Siv rau lub sijhawm qub
Qee qhov xwm txheej, yuav tau kho qhov tshuaj txhua hnub.
Txiag tej menyuam
Cov tshuaj tuaj yeem tsim kho rau menyuam yaus. Qhov kev siv tshuaj txhua hnub txij li 200-1000 mg, nyob ntawm seb tus neeg mob hnub nyoog thiab hnyav. Thaum muab tshuaj rau, cov menyuam yaus hnub nyoog qis dua 3 xyoos raug pom zoo kom xaiv cov tshuaj hauv cov kua txiv.
Siv thaum cev xeeb tub thiab lactation
Kev kho mob nrog carbamazepine thaum cev xeeb tub yuav tsum tau ua nrog ceev faj heev. Nco ntsoov qhov tseeb tias tegretol tuaj yeem nce qhov tsis muaj peev xwm ntawm cov vitamin B12 rau cov poj niam cev xeeb tub.
Thaum kho tus niam laus nrog carbamazepine, nws yuav tsum muaj peev xwm hloov tus me nyuam mus rau khoom noj khoom haus dag. Txuas ntxiv kev pub mis yog ua tau nrog kev soj ntsuam tas li ntawm tus kws kho mob menyuam yaus. Yog tias tus me nyuam twg muaj qhov tshwm sim tsis zoo, yuav tsum tsis txhob pub mis ntxiv.
Daim ntawv thov rau lub raum khiav tsis zoo
Muab Tagretol yog qhov tsim nyog tom qab ntsuam xyuas lub raum ua haujlwm. Nws tsis pom zoo kom siv cov tshuaj rau hauv cov neeg mob uas mob raum tsis zoo.
Muab Tagretol yog qhov tsim nyog tom qab ntsuam xyuas lub raum ua haujlwm.
Siv rau lub siab ua haujlwm tsis zoo
Keeb kwm txog kab mob siab yog lub laj thawj rau kev ceeb toom thaum noj cov tshuaj. Kev saib xyuas lub sijhawm ua haujlwm ntawm lub siab ua haujlwm yog qhov tsim nyog kom tsis txhob muaj kev nce ntxiv ntawm cov kab mob ntawm daim siab mob hepatobiliary.
Noj tshuaj ntau ntawm Tegretol CR
Vim tias muaj ntau dhau ntawm carbamazepine, cov tsos mob pathological tshwm sim nyob rau ib feem ntawm cov leeg poob siab, txoj hlab tu siab thiab lub siab ua haujlwm. Ntuav, anuria, dav dav inhibition kuj tshwm sim.
Overdose cov tsos mob tau nres los ntawm kev ntxuav lub plab thiab siv sorbents. Kev kho mob yuav tsum tau nqa tawm hauv tsev kho mob. Kev kho mob, kev saib xyuas ntawm cov kev ua rau lub plawv qhia.
Kev cuam tshuam nrog lwm yam tshuaj
Thaum Tegretol koom ua ke nrog lwm tus neeg sawv cev uas hloov theem ntawm kev ua haujlwm ntawm CYP3A4 isoenzyme, qhov kev txiav txim ntawm carbamazepine hauv cov ntshav pauv. Qhov no yuav ua rau txo qis hauv kev kho kom zoo. Xws li kev sib txuam ntawm cov tshuaj yuav xav tau ntau npaum li tau kho.
Txo qhov kev cia siab ntawm cov tshuaj nquag nyob rau hauv ua ke nrog phenobarbital.
Macrolides, azoles, histamine receptor blockers, tshuaj rau kev kho mob rov qab tuaj yeem ua rau kom muaj qhov nce ntxiv ntawm cov tshuaj nquag hauv cov hlab ntshav.
Kev sib xyaw ua ke nrog phenobarbital, valproic acid, rifampicin, felbamate, clonazepam, theophylline, thiab lwm yam, txo cov tshuaj lom ntawm cov tshuaj nquag.
Kev tswj hwm tib lub sijhawm siv qee cov tshuaj yuav tsum tau hloov kho lawv cov koob tshuaj: tricyclic antidepressants, corticosteroids, protease inhibitors, calcium channel blockers, estrogens, antiviral agents, antifungal drugs.
Kev sib xyaw nrog qee cov tshuaj diuretics ua rau txo cov ntshav plasma concentration ntawm sodium. Carbamazepine tuaj yeem txo qis kev ua haujlwm ntawm kev kho mob nrog rau kev ua kom tsis txhob mob qhov ua rau cov leeg mob ua si.
Kev siv qhov tseeb nrog kev tiv thaiv qhov ncauj tuaj yeem ua rau qhov chaw mos los ntshav.
Cawv tau zoo
Nws tsis pom zoo kom haus txhua yam cawv thaum siv Tegretol.
Analogs
Cov qauv ntawm cov cuab yeej no yog:
- Finlepsin Retard;
- Finlepsin;
- Carbamazepine.
Ib qho ntawm qhov ntsuas ntawm cov tshuaj yog Finlepsin Retard.
Qhov sib txawv ntawm Tegretol thiab Tegretol CR
Cov tshuaj no txawv ntawm txheem Tegretol hauv lub sijhawm tso tawm carbamazepine. Cov ntsiav tshuaj muaj qhov cuam tshuam lub sijhawm ntev.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Daim ntawv yuav tshuaj.
Kuv tuaj yeem yuav yam tsis tas yuav tshuaj
Tsis yog.
Nqi
Nyob ntawm qhov chaw ntawm yuav khoom.
Cia rau cov neeg mob rau cov tshuaj
Yuav tsum muab cia rau qhov chaw qhuav ntawm qhov kub tsis tshaj + 25 ° C.
Hnub tas sij hawm
Raug rau cov khoom lag luam cia, lub txee lub neej yog 3 xyoos txij li hnub pib.
Chaw tsim tshuaj paus
Cov tshuaj yog tsim los ntawm Novartis Pharma.
Xyuas
Artem, 32 xyoo, Kislovodsk
Tegretol yog cov tshuaj zoo uas pab daws kev qaug dab peg. Pib noj tshuaj tiv thaiv no, Kuv tau txais dua kev ua lub neej zoo. Cov ntsiav tshuaj daws nrog ob qho me me thiab loj chua leeg. Kuv tsis tau pom tias muaj kev phiv thaum lub sijhawm thov. Kuv qhia txhua tus neeg uas muaj mob vwm.
Nina, 45 xyoo lawm, Moscow
Siv cov cuab yeej no ib xyoo dhau los. Cov tshuaj antiepileptic qub ua rau kev quav ntxiv, tus kws kho mob tau sau tshuaj Tegretol ua qhov hloov pauv. Kuv haus cov ntsiav tshuaj rau txog 2 lub lis piam. Tom qab ntawv muaj teebmeem tshwm tuaj. Xeev siab thiab ntuav tshwm sim. Kuv txoj kev noj qab haus huv zuj zus, Kuv txhawj xeeb txog kev kiv taub hau. Kuv yuav tsum mus ntsib kws kho mob. Nws ua cov khoom tshuaj ntsuam. Cov tshuaj ua rau cov ntshav hematological: anemia thiab thrombocytopenia tsim. Kuv yuav tsum tau hloov cov tshuaj sai sai.
Cyril, 28 xyoo, Kursk
Tus kws kho mob tau muab cov tshuaj no tso rau hauv kev sib xyaw nrog lwm tus rau kev kho mob trigeminal neuralgia. Kuv tsis paub yog tias Tegretol lossis lwm yam tshuaj puas pab, tabsis cov tsos mob ploj mus. Kev tawm tsam ntawm kev mob tau pib thab tawm ntau tsawg dua. Ib zaug ntxiv kuv muaj peev xwm tsaug zog thiab noj mov ib txwm ua. Kuv tuaj yeem pom zoo cov tshuaj no rau txhua tus neeg uas tau ntsib cov teeb meem zoo sib xws.
