Dalacin C yog cov tshuaj tua kab mob uas siv los tshem tawm cov txheej txheem tiv thaiv cov keeb kwm yav dhau los ntawm kev kis tus kab mob los ntawm cov kab mob lom. Cov tshuaj tua kab mob pab tua cov kab mob ntawm cov kab mob aerobic gram zoo. Cov tshuaj muaj peev xwm nthuav tawm ob qho tib si bacteriostatic thiab bactericidal cuam tshuam rau microbes. Cov nyhuv ntawm cov tshuaj yog raws li clindamycin, uas tau txais synthetically los ntawm lincosamide. Cov tshuaj tua kab mob tsis yog siv rau cov poj niam cev xeeb tub.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Clindamycin.
Tshuaj tua kab mob Dalacin C pab tua cov kab mob ntawm cov kab mob aerobic gram-zoo.
ATX
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Tso cov ntawv thiab cov nyob ua ke
Cov tshuaj yuav tsim nyob hauv tsuas 2 daim ntawv cov tshuaj.
Tshuaj
Cov tshuaj tov tau muab faib rau 2, 4 lossis 6 ml iav ampoules. Vials tau ntim rau hauv cov thawv ntawv uas yog 1 lossis 10 pcs. 1 ml ntawm daim ntawv qhia ua kua tau muaj 150 mg ntawm qhov nquag ua haujlwm - clindamycin phosphate. Cov tshuaj ntxiv uas tsim cov tshuaj suav daws xws li haus dej cawv benzyl, disodium ntsev thiab dej tsis huv rau kev txhaj tshuaj.
Cov tshuaj ntsiav
Cov tshuaj nquag yog cov hmoov dawb ntawm clindamycin hydrochloride nrog koob tshuaj 150 lossis 300 mg, uas tau muab ntim rau hauv cov tawv plooj ntawm cov tshuaj ntsiav.
Cov tshuaj yeeb tshuaj active Dalacin C yog hmoov dawb ntawm clindamycin hydrochloride, uas tau ntim rau hauv lub plhaub tawv ntawm cov tshuaj ntsiav.
Ua ke nrog cov kev sib txuas tam sim no muaj cov ntxiv:
- mis nyuj qab zib;
- pob kws nplej siab;
- magnesium stearate;
- titanium dioxide thiab gelatin sib sau ua lub plhaub sab nraud.
Cov tshuaj ntsiav tau pleev xim dawb, tau kos rau saum npoo nrog "P&U 395". Cov chav nyob ntawm cov tshuaj raug ntim rau hauv blister ntim ntawm 8 pcs. Ib pob ntawv cardboard muaj 2 lub hlwv (16 tsiav tshuaj).
Daim ntawv tsis muaj
Cov tshuaj tsis muaj nyob hauv daim ntawv cov tshuaj pleev thiab ntsiav tshuaj.
Pharmacological kev txiav txim
Cov tshuaj tua kab mob yog rau cov chav kawm ntawm lincosamide antimicrobials. Cov tshuaj hauv cov tshuaj me me ua cov bacteriostatically, cuam tshuam rau kev faib me me ntawm cov kab mob microflora pathogen. Nrog rau kev nce ntxiv hauv kev siv rau kev siv ib zaug, clindamycin pib ua cov kab mob bactericidal: nws tsis tsuas yog cuam tshuam cov txheej txheem ntawm kev ua tiav ntawm tes, tab sis kuj rhuav tshem cov protein ntau hauv lub cell membrane ntawm microorganism.
Dalacin C cuam tshuam cov txheej txheem ntawm kev ua tiav ntawm tes, thiab kuj rhuav tshem cov khoom sib txuas protein hauv cov cell ua raws ntawm cov kab mob me.
Nrog txoj kev poob ntawm lub zog ntawm lub plhaub sab nraud, osmotic siab tawg tsoo cov kab mob.
Cov Tshuaj Pharmacokinetics
Cov tshuaj ua kom muaj zog yog nqus tau los ntawm lub plab hnyuv phab ntsa rau hauv lub txaj arterial. Tom qab kev tswj hwm ntawm qhov ncauj, ntau qhov dej siab tshaj plaws ntawm clindamycin yog tsau tom qab 45 feeb. Noj qeeb qeeb tus nqi nqus ntawm cov tshuaj sib txuas, tab sis tsis cuam tshuam rau qhov ua tiav ntawm kev nqus thiab bioavailability.
Nrog v / m tswj hwm, clindamycin phosphate nce mus txog qhov siab tshaj plaws tom qab 1-3 teev, nrog rau kev lis ntshav rau 18-20 feeb.
Hauv cov hlab ntsha, cov tshuaj khi rau cov nqaijrog los ntawm 40-90%. Hauv qhov no, cov tshuaj tsis sib haum hauv cov qauv hauv cov ntaub so ntswg ntawm lub cev, tusyees faib dua kev ua kom pom tseeb ntawm cov txheej txheem pathological. Clindamycin yuav luag hloov pauv hauv hepatocytes ntawm nplooj siab. Qhov kev tshem tawm ib nrab-lub neej ua rau 90-210 feeb. 10-20% ntawm cov tshuaj tawm hauv lub cev rau hauv nws daim ntawv qub los ntawm qhov mob txeeb zig, 4% yog tawm hauv cov quav. Tus so tau tawm hauv cov kab tsib los yog los ntawm txoj hnyuv hauv daim ntawv tsis ua haujlwm.
Cov tshuaj hauv cov lus nug yuav luag hloov pauv hauv daim siab hepatocytes ntawm lub siab.
Nws yog dab tsi rau?
Clindamycin ua hauj lwm zoo tiv thaiv kev sib kis thiab cov txheej txheem tshwm sim los ntawm cov kab mob pathogenic nkag rau qhov nquag:
- kev poob qis ntawm qhov qis dua (cov kab mob ntsws, ua pa rau empyema, nthuav dav ntawm purulent exudate hauv lub ntsws, mob ntsws) thiab sab saud (mob ntawm cov qog ua ntshav thiab txhaws, mob pob ntseg hauv nruab nrab, ua pob liab vog) ntawm txoj hlab pa;
- mob qhov txhab thiab kev puas tsuaj rau cov nqaij mos, kis mob ntawm daim tawv nqaij, suav nrog furunculosis, mob pob txuv streptococcal, mob qog ntshav, mob qog nqaij hlav hauv cov nqaij rog subcutaneous, erysipelas, paronychia;
- mob qog ntawm peritoneum thiab mob plab zom mov, peritonitis (clindamycin yog ua ke nrog cov tshuaj muaj txiaj ntsig tawm tsam anaerobes);
- cov kab mob sib kis ntawm cov leeg nqaij: pob txha txha caj qaum, mob caj dab;
- endocarditis, periodontitis;
- encephalitis ua mob los ntawm toxoplasma, thiab mob ntsws o vim yog muaj cov kab mob HIV.
Clindamycin nquag tawm tsam cov kab mob ntawm cov kab mob gynecological (tsub zuj zuj ntawm purulent exudate nyob rau hauv cov kab noj hniav ntawm lub zes qe menyuam, txoj hlab qe menyuam, cov txheej txheem ua mob hauv plab hnyuv plab, qhov txhab ntawm lub qhov paum ntawm lub paum). Thaum muaj kev kis mob rau lub ncauj tsev menyuam los ntawm tus mob chlamydia nyob rau hauv cov kev tshawb fawb soj ntsuam, tau pom tias kev siv tshuaj kho mob nrog clindamycin tuaj yeem tshem tawm cov kab mob pathogenic microflora.
Cov Yuav Tsum Muaj
Cov tshuaj yog contraindicated nyob rau hauv lub xub ntiag ntawm nce raug taus ntawm cov ntaub so ntswg mus rau cov tshuaj uas tsim cov tshuaj.
Nrog saib xyuas
Cov tshuaj tau raug pom zoo kom siv nyob rau hauv kev saib xyuas kev kho mob nruj rau cov neeg muaj ntxhiab thiab mob txhab ntawm lub plab zom mov, myasthenia gravis thiab lub siab ua haujlwm tsis zoo.
Yuav coj Dalacin C li cas?
Cov tshuaj yog npaj rau kev txhaj tshuaj rau pob ntseg los yog tso ntshav ua kom ntshav qab zib. Cov neeg mob loj hauv kev kho mob ntawm kev mob hnyav hauv lub plab zom mov, pelvic plab hnyuv siab raum nyob rau hauv cov poj niam lossis cov teeb meem tshwm sim yog muab tshuaj rau txhua hnub ntawm 2400-2700 mg ntawm cov tshuaj. Qhov koob tshuaj tau muab faib ua 2-4 hno. Nrog rau qhov mob siab thiab hnyav ntawm cov txheej txheem pathological, 1.2-1.8 g ib hnub, muab faib ua 3-4 koob, yog txaus kom ua tiav txoj kev kho kom zoo.
Qhov noj tshuaj ntau tshaj plaws yog 4.8 g nyob rau ib hnub.
Nrog / / kev taw qhia, ib koob tshuaj yuav tsum tsis pub tshaj 600 mg.
Nrog rau mob pelvic plab hnyuv siab raum, cov tshuaj tau muab tshuaj nyob rau ntawm 900 mg nrog tus so ntawm 8 koob ntawm ib teev.
Tsuas yog tus kws kho mob tau koom nrog txhawm rau kho cov tshuaj ntau npaum li cas, nyob ntawm qhov ua tiav ntawm cov nyhuv kho, cov duab kho mob ntawm tus mob, thiab cov yam ntxwv ntawm tus neeg mob:
| Cov txheej txheem pathological | Txoj kev kho tus qauv |
| Kab Mob Beta Hemolytic Streptococcus Cov Kab Mob | Lub chav kawm ntawm kev kho mob yog 10 hnub. 1200-1800 mg tau sau tseg rau ib hnub, muab faib ua 3 tus thawj coj. |
| Kev mob ntsws muaj dej rau cov neeg mob AIDS | I / O 0.6-0.9 g txhua txhua 6 teev lossis 900 mg nrog ib ncua sijhawm ntawm 8 teev rau 21 hnub. |
| Mob Lub Pelvic | 900 mg iv nrog ib tus caij nyoog nruab nrab ntawm cov koob tshuaj 8 teev. Nws raug nquahu kom muab cov tshuaj tua kab mob sib kis nrog cov tshuaj uas ua tawm tsam gram-negative aerobes. Clindamycin raug tswj hwm iv hauv 4 hnub thiab 2 hnub tom qab kev txhim kho ntawm kev mob nkeeg rau tus neeg mob. Tom qab txhaj tshuaj, lawv hloov mus rau txoj kev tswj hwm qhov ncauj ntawm cov tshuaj ntsiav ntawm Dalacin C nrog ib koob ntawm 450-600 mg nrog ib nrab nrog 6 teev. Lub chav kawm ntawm kev kho mob kav ntev li 10 txog 14 hnub. |
| Tiv thaiv kev kis mob thaum phais mob ntawm lub taub hau thiab caj dab | 900 mg ntawm cov tshuaj yog diluted hauv 1000 ml ntawm ib qho isotonic 0.9% sodium chloride tov thiab siv dej thaum phais, qhib qhov txhab ntawm lub taub hau thiab caj dab ua ntej plooj npoo. |
| Tus mob Toxoplasma encephalitis vim mob HIV | Hauv / hauv kev qhia ntawm 0.6-1.2 g txhua txhua 6 teev rau 2 lub lis piam, tom qab los ntawm kev tswj hwm qhov ncauj ntawm 1-2 tsiav tshuaj ntawm 300 mg txhua 6 teev. Cov tshuaj tua kab mob ua ke nrog pyrimethamine ntau npaum ntawm 25-75 mg. Nrog kev qhia txog kev noj tshuaj ntau, cov tshuaj folinic acid yog tshuaj 10-25 mg. |
| Kev tiv thaiv ntawm endocarditis nyob rau hauv muaj cov hypersensitivity rau penicillin pawg | IV 600 mg ib teev ua ntej tswj hwm penicillin. |
Nrog ntshav qab zib
Cov neeg mob ntshav qab zib tau pom zoo kom teem caij noj tshuaj raws txheej txheem.
Cov neeg mob ntshav qab zib tau pom zoo kom teem caij noj tshuaj raws txheej txheem.
Phiv los ntawm Dalacin Ts
Cov kev xav tsis zoo tshwm sim nrog kev siv tshuaj tsis raug lossis ib qho tshuaj ntawm qhov siab.
Kev kho mob txoj hnyuv
Nrog rau kev txhim kho kev phiv hauv lub plab zom mov, cov hauv qab no yuav tshwm sim:
- mob epigastric;
- gagging;
- plab hnyuv dysbiosis;
- qhov ncauj qhuav
- txoj hlab pas;
- cholestatic jaundice;
- daim siab ua haujlwm siab;
- pseudomembranous enterocolitis.
Nruab nrab hauv lub paj hlwb
Tsis muaj qhov tshwm sim tsis zoo ntawm cov tshuaj ntawm cov kev ua ntawm lub paj hlwb tau pom.
Los ntawm cov kab mob zis
Muaj feem ntau qhov mob ntawm chaw mos.
Ib qho kev mob tshwm sim ntawm Dalacin C yog qhov ntxim nyiam ntawm chaw mos ntawm lub paum.
Los ntawm lub tshuab ua pa
Hauv cov menyuam yaus ua ntej hnub yug, vim tias pom tias benzyl cawv hauv cov tshuaj Dalacin C, qhov kev txhim kho ntawm lub caj pas ua pa yog qhov ua tau.
Ntawm ib sab ntawm daim tawv nqaij
Thaum tswj hwm intramuscularly, tawv nqaij tawv yuav tshwm sim, thiab mob thiab voos yuav tshwm sim. Hauv qee kis, pom tus mob thrombophlebitis.
Kev ua xua
Hauv cov neeg mob uas nquag muaj kev tawm tsam ntawm kev tawm tsam tsis haum, feem ntau, cov pob xoo tas li tau pom ntawm daim tawv nqaij ntawm qhov mob sib khuav thiab mob hnyav. Cov pob khaus no pom kom zoo li ua qoob.
Cov kws kho mob tau sau tseg pom kev tshwm sim ntawm pob khaus maculopapular, khaus, urticaria.
Muaj qee zaus, Stevens-Johnson erythema multifocal erythema, anaphylactic shock, angioedema thiab exfoliative dermatitis tau tsim.
Hauv cov neeg mob tshwm sim ua rau muaj kev fab tshuaj, thaum noj Dalacin C, cov kab xoo tas li tau pom ntawm daim tawv nqaij.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Cov tshuaj tsis cuam tshuam rau lub cev kev ua haujlwm ntawm lub nruab nrog cov hlab ntsha hauv nruab nrab lub cev thiab tsis ua rau lub hlwb tsis zoo. Yog li no, thaum kho nrog clindamycin, tsav tsheb tau tso cai, koj tuaj yeem koom nrog kev sib tw kis las thiab tswj cov cuab yeej ua haujlwm uas yuav tsum muaj kev xav thiab qhov ua kom muaj kev cuam tshuam thaum ua haujlwm.
Cov lus qhia tshwj xeeb
Cov tshuaj sib xyaw ua ke ntawm cov tshuaj kho mob suav nrog benzyl cawv. Lub koom haum pabcuam tuaj yeem ua rau roj khoob khoob khoob khoob lossis cov tsos mob dyspnea syndrome, uas tuaj yeem ua rau tus menyuam tuag tshiab.
Hauv lub sijhawm tom qab kev tshaj tawm, cov tsos mob ntawm cov tsos mob pseudomembranous colitis tawm tsam keeb kwm ntawm mob raws plab ntev tau sau tseg, yog li ntawd, nrog cov tsos ntawm cov quav xoob, nws yog qhov tsim nyog kom tshem tawm cov kev pheej hmoo ntawm tus kabmob.
Yog tias muaj kev ua xyem xyav ntawm kev txhim kho pseudomembranous enterocolitis, nws yuav tsum tau muab ncua kev noj lossis kev txhaj tshuaj ntawm Dalacin C.
Thaum kuaj pom tseeb lawm, cov tshuaj tua kab mob tso tseg. Qhov ntxim nyiam ntawm tus kab mob nce zuj zus yog tias cov ntshav txhaws nyob hauv cov quav.
Nws yog ib qho tseem ceeb kom nco ntsoov tias antimicrobials inhibit lub ntuj microflora hauv txoj hnyuv.
Nws yog ib qho tseem ceeb kom nco ntsoov tias antimicrobials inhibit lub ntuj microflora hauv txoj hnyuv. Qhov no tuaj yeem ua rau txoj kev loj hlob ntawm clostridia thiab kev txwv tsis pub muaj kev sib txuas ntawm cov vitamins K. Clostridium difficile tuaj yeem ua rau mob pseudomembranous mob plab, qhov mob hnyav ntawm qhov uas yuav tsum tau rov qab kho ntawm cov dej-electrolyte tshuav nyiaj li cas. Clostridium co toxins yuav pab tshem tawm qhov kev nqus ntawm 150-500 mg ntawm vancomycin.
Siv rau lub sijhawm qub
Cov neeg uas muaj 65 xyoos rov saud yuav tau noj ntau npaum li cas.
Xaj cov Dalacin Ts rau menyuam yaus
Hauv cov menyuam yaus, txij li 1 hlis, kev noj tshuaj txhua hnub yog txiav txim siab ntawm tus nqi ntawm 20-40 mg rau 1 kg ntawm lub cev qhov hnyav. Qhov koob tshuaj tau muab faib ua 3-4 qhov hno. Rau cov menyuam mos txog 30 hnub ntawm lub neej, nws raug nquahu kom siv cov tshuaj 4 zaug hauv ib hnub nrog tshuaj ntau li 15-20 mg rau 1 kg ntawm qhov hnyav.
Siv thaum cev xeeb tub thiab lactation
Clindamycin tuaj yeem hla cov nyom qhov chaw. Thaum txoj kev loj hlob ntawm tus me nyuam nyob hauv qab ntawm tshuaj tua kab mob, kev tso pob txha mos thiab cov leeg nqaij tej zaum yuav tsis muaj zog.
Rau cov poj niam cev xeeb tub, cov tshuaj yog tawm hauv cov mob hnyav.
Rau cov poj niam cev xeeb tub, cov tshuaj yog tawm hauv cov xwm txheej tseem ceeb, thaum qhov tshwm sim ntawm kev mob plab nkag rau hauv qhov embryo tsawg dua qhov kev pheej hmoo rau leej niam lub neej.
Thaum kho, nws yog ib qho tsim nyog yuav tsum ncua kev pub mis niam.
Noj tshuaj ntau dhau ntawm Dalacin Ts
Muaj tsis muaj cov kev mob ntawm overdose. Hauv cov neeg mob uas tsis tau npaj cia, cov tshuaj tiv thaiv anaphylactoid tuaj yeem tsim tawm, qhia txog qhov pom ntawm angioedema thiab kev txhim kho ntawm kev poob siab anaphylactic. Hauv qhov no, kev qhia ntawm adrenaline lossis GCS (glucocorticosteroids) yog qhov tsim nyog.
Kev cuam tshuam nrog lwm yam tshuaj
Thaum lub sij hawm tshuaj tshawb, nrog kev nkag mus ib txhij ntawm clindamycin thiab erythromycin mus rau hauv lub cell, ib qho kev cuam tshuam ntawm kev ua haujlwm tau pom. Tshuaj tsis muaj cov tshuaj kho tau. Nyob rau hauv cov xwm txheej zoo li no, tshuaj lom rau lub hlwb nce, uas yog vim li cas cov tshuaj tsis suav nrog hauv txoj hauv kev kho.
Muaj qhov tsis haum ntawm pharmacological ntawm Dalacin C nrog cov leeg ua si vim qhov kev txwv tsis pub xa mus rau ntawm cov neuromuscular impulse los ntawm clindamycin.
Qhov kev sib xyaw no tsuas yog siv nyob rau hauv muaj xwm txheej loj. Thaum kws kho ob yam tshuaj, yuav tsum ua tib zoo tshuaj xyuas tus neeg mob.
Daim ntawv tshuaj cov tshuaj ntawm Dalacin C tov tshuaj yog tsis sib xws nrog ciprofloxacin.
Daim ntawv muab tshuaj ntawm cov tshuaj yog tsis sib haum nrog Ampicillin, barbiturates, sodium bicarbonate, Ciprofloxacin.
Cawv tau zoo
Hauv kev kho mob nrog Dalacin C, cawv yuav tsum tsis txhob haus cawv. Kev haus cawv Ethyl ua rau tsis zoo cuam tshuam rau kev ua haujlwm ntawm lub hauv nruab nrab hlab hlwb, cov hlab ntsha hauv lub cev thiab lub siab. Ethanol tuaj yeem ua rau lub cev tsis muaj zog ntawm cov kev kho kom zoo, nce ntxiv ntawm cov kev mob tshwm sim.
Analogs
Cov pab pawg ntawm cov qauv hloov uas muaj cov zoo ib yam li cov tshuaj thiab cov tshuaj lom neeg muaj xws li:
- Dalmatian
- Clindamycin;
- Clindacil tsiav tshuaj;
- Clindacin.
Tus kws kho mob uas tuaj koom muaj txoj cai los hloov cov tshuaj ntsiav lossis ib qho kev daws teeb meem ntawm Dalacin C thaum tsis siv tshuaj kho lossis qhov tshwm sim ntawm kev mob tshwm sim.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Tus kws tshuaj yuav tsis muag cov tshuaj yam tsis muaj ntawv kho mob.
Nqe rau Dalacin Ts
Tus nqi nruab nrab ntawm cov tshuaj ntsiav yog kwv yees li 700 rubles, tov rau kev txhaj tshuaj - 1789 rubles.
Cia rau cov neeg mob rau cov tshuaj
Nws raug nquahu kom khaws cov tshuaj nyob hauv ib qho chaw nrog cov av noo tsis tshua siab, tiv thaiv los ntawm tshav ntuj, ntawm qhov kub txog + 25 ° C.
Hnub tas sij hawm
2 xyoos
Chaw tsim tshuaj paus
Pfizer Kev Tsim Khoom, Belgium.
Cov analogue ntawm Dalacin C - cov tshuaj Clindacin raug pom zoo kom khaws cia rau hauv qhov chaw uas muaj coefficient tsawg ntawm cov av noo.
Kev txheeb xyuas txog Dalacin Ts
Antonina Efimova, 27 xyoo, Ryazan.
Kws tshuaj tsiav tshuaj Dalacin C kws kho mob poj niam. Kuv tau coj khaub ncaws tsis coj khaub ncaws vim yog txoj kev loj hlob ntawm tus kab mob microflora. Tom qab 2 lub lim piam ntawm txoj kev kho, qhov mob ploj mus, ntxiv cov kab mob loj hlob nres. Cov tshuaj yeeb tshuaj tau zoo nrog nws txoj haujlwm. Nws yuav tsum nco ntsoov tias cov tshuaj tua kab mob ua teeb meem rau kev zom zaub mov.Cov tshuaj yuav tsum tau noj nyob rau hauv ntau qhov mob raws li qhia los ntawm kws kho mob, nruj me ntsis raws li cov lus qhia.
Lidia Fedotova, 34 xyoo, Krasnodar.
Kuv nqa cov tshuaj tsiav tshuaj raws li kws kho hniav hais. Xav tau cov tshuaj tiv thaiv kab mob los tiv thaiv kev kis mob thaum phais mob nyuaj. Kuv tsis pom tias muaj kev mob tshwm sim, tsis muaj kev mob tshwm sim tom qab phais. Tab sis muaj teeb meem nrog cov hnyuv. Dysbacteriosis tsim, vim tias nws yog qhov tsim nyog yuav tau noj tshuaj probiotics.
