Atomax yog siv los kho cov neeg mob kuaj mob hypercholesterolemia, kab mob hyperlipidemia, kab mob dysbetalipoproteinemia. Tus neeg sawv cev qhov ncauj ntshav lub qhov ncauj tso cai rau koj los tiv thaiv qib ntawm lipids, qhov ntsuas ntawm cov roj (cholesterol) tag nrho, triglycerides nrog qhov tsis muaj txiaj ntsig ntawm kev noj zaub mov zoo thiab ua kom lub cev muaj zog. Kev siv tshuaj ntev ntev yuav txo qhov kev pheej hmoo ntawm atherosclerotic hloov pauv ntawm cov vuas endothelium thiab cov plahaum roj ntsha.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Atorvastatin.
ATX
C10AA05.
Tso cov ntawv thiab cov nyob ua ke
Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj rau lub qhov ncauj tswj hwm. Ib qho seem ntawm cov tshuaj muaj 10 lossis 20 mg ntawm atorvastatin calcium trihydrate ua cov tshuaj tiv thaiv kev tiv thaiv. Lub hauv paus tseem muaj cov khoom xyaw ntxiv tsim nyog txhawm rau txhim kho kev nqus thiab nqus ntawm cov khoom nquag hauv plab hnyuv:
- dehydrated silicon dioxide;
- mis nyuj qab zib;
- hmoov txhuv nplej siab;
- triacetin;
- magnesium stearate;
- povidone;
- croscarmellose sodium.
Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj rau kev siv lub qhov ncauj, txhua chav nyob ntawm cov tshuaj muaj 10 lossis 20 mg ntawm atorvastatin calcium trihydrate.
Cov ntsiav tshuaj dawb puag ncig yog coated nrog ib zaj yeeb yaj kiab nkag nrog ntawm titanium dioxide, talc, crospovidone, hypromellose.
Pharmacological kev txiav txim
Cov txheej txheem ntawm kev ua ntawm cov lipid-txo cov tshuaj noj yog raws li atorvastatin, uas yog cov khoom thaiv ntawm HMG-CoA reductase. Qhov enzyme no yog qhov tsim nyog rau kev tsim cov mevalonic acid, ib lub zog ntawm cov cholesterol. Nrog kev cuam tshuam los ntawm kev ua haujlwm ntawm HMG-CoA reductase, atorvastatin tuaj yeem nres qhov kev tsim cov roj (cholesterol), cov roj lipoproteins tsawg (LDL) thiab triglycerides hauv lub siab.
Cov tshuaj tsub kom tus naj npawb ntawm LDL receptors rau lub cell cell ntawm cov ntaub so ntswg, uas tsub kom nce siab thiab metabolism hauv lipoproteins. Tawm tsam keeb kwm yav dhau los ntawm qhov txo qis hauv LDL cov ntsiab lus, qhov nce ntawm cov neeg ntawm lipoproteins uas ntau ntom ntom nti (HDL) tau pom.
Cov Tshuaj Pharmacokinetics
Thaum nws nkag mus rau hauv lub cev, cov khoom siv txuam yuav pib nquag mus rau hauv cov phab ntsa hauv cov hnyuv. Bioavailability yog 100%. Thaum nws nkag rau hauv cov hlab ntshav, atorvastatin yauv raug cov beta-oxidation hauv cov qog hlwb nrog kev tsim cov khoom lag luam metabolic nrog lipid-txo cov nyhuv. Cov tshuaj yog biotransformed nyob ib puag ncig P450 isoenzyme. Kev ua rau txoj kev kho tau tiav los ntawm 70% vim yog muaj cov tshuaj tiv thaiv metabolites.
Atomax yog siv los kho cov neeg mob kuaj mob hypercholesterolemia, kab mob hyperlipidemia, kab mob dysbetalipoproteinemia.
Atorvastatin yog 95% ua txhua yam rau cov ntshav protein. Cov tshuaj nquag thiab cov khoom lag luam hauv lub cev tawm hauv lub cev tawm ntau los ntawm cov plab zom mov tom qab hepatic metabolism. Txog 2% ntawm cov tshuaj nyob rau hauv nws thawj daim ntawv yog tawm hauv cov zis. Ib nrab-lub neej yog 14 teev.
Kev ntsuas rau siv
Cov tshuaj yog siv los txo cov roj (cholesterol) tag nrho, triglycerides thiab LDL. Cov tshuaj no zoo rau cov neeg mob nrog:
- roj ntsha lossis hom thawj hypercholesterolemia;
- dysbetalipoproteinemia nrog noj tsis ua hauj lwm;
- ua ke hyperlipidemia;
- siab ntshav dej triglycerides.
Ua kom tiav cov nyhuv hypolipidemic ua tiav tsuas yog ua ke nrog kev kho tshwj xeeb kev noj zaub mov zoo kom txo cov cholesterol.
Cov Yuav Tsum Muaj
Cov tshuaj yog contraindicated nyob rau hauv cov mob hauv qab no:
- muaj kev cuam tshuam ntau ntxiv rau cov tshuaj uas ua rau cov tshuaj;
- nce kev ua si ntawm hepatic transaminases hauv qhov dej ntshiab tshaj qhov tshwj xeeb los ntawm tsawg kawg 3 zaug rau cov tsis paub;
- daim siab mob siab;
- poj niam cev xeeb tub thiab lactating;
- hauv cov menyuam yaus thiab tub ntxhais hluas txog 18 xyoo.
Ceev faj yuav tsum tau siv thaum noj cov ntsiav tshuaj rau cov neeg muaj kev cuam tshuam endocrine.
Ceev faj yuav tsum tau siv thaum noj cov ntsiav tshuaj rau cov neeg nrog:
- pathologies ntawm lub siab ntawm me me los sis mob hnyav:
- ntsoos ntsoos cawv cawv;
- kev ua txhaum hnyav ntawm cov dej-ntsev ntsev ntawm cov metabolism;
- endocrine system cuam tshuam;
- qaug dab peg qaug dab peg.
Yuav ua li cas Siv Atomax
Ua ntej pib Atomax txoj kev kho, tus neeg mob yog tshuaj lipid-txo cov zaub mov noj kom tsawg.
Cov tshuaj rau cov neeg laus thaum pib theem ntawm kev kho mob yog 10 mg rau ib zaug siv. Txhawm rau nce cov txiaj ntsig kho mob, lipid-txo koob tshuaj, nrog kev kam rau ua tau zoo, tuaj yeem nce txog 80 mg. Tshaj tawm ntawm kev pub nkag - 1 sijhawm ib hnub.
Txhua 14-28 hnub, koj yuav tsum tau ntsuas rau lub plasma concentration ntawm lipids. Raws li cov ntaub ntawv tau txais, qhov ntau npaum tau hloov kho los ntawm tus kws kho mob mus kawm.
Nrog rau ua ke hyperlipidemia thiab hypercholesterolemia, tus qauv muab tshuaj yog 10 mg rau ib hnub. Kev kho mob kom zoo yog pom nyob hauv 14 hnub, qhov siab tshaj plaws ntawm lipid-txo cov nyhuv yog tshwm sim 4 lub lis piam tom qab pib kho. Nrog rau kev siv Atomax lub sijhawm ntev, cov nyhuv kho tau ntev ntev.
Nrog ntshav qab zib
Cov tshuaj tsis muaj peev xwm cuam tshuam rau kev mloog ntawm cov piam thaj hauv lub cev thiab tsis muaj tshuaj lom rau beta hlwb ntawm cov txiav. Thaum lub sijhawm kev kho mob nws yog ib qho tsim nyog yuav tsum tau soj ntsuam tas li seb cov ntshav puas muaj qabzib. Thaum muaj kev hloov pauv tseem ceeb, sab laj nrog tus kws endocrinologist txog kev kho cov tshuaj ntau ntxiv ntawm cov tshuaj hypoglycemic.
Qhov tshwm sim ntawm Atomax
Cov kev xav tsis zoo tshwm sim nyob rau hauv Feem ntau nrog kev siv tsis zoo ntawm lipid-txo tus neeg sawv cev.
Ntawm ib feem ntawm cov khoom hauv nruab nrog kev pom
Qhuav conjunctiva, hemorrhage nyob rau hauv lub pob muag, ib qho kev nce ntawm intraocular siab.
Los ntawm cov leeg nqaij thiab pob txha sib txuas
Nrog kev ua txhaum nyob rau hauv cov leeg leeg txheej txheem, txhim kho mob caj dab, mob leeg, mob hauv cov pob qij txha thiab cov leeg yog qhov ua tau. Hauv qee qhov tshwj xeeb, rhabdomyolysis, myopathy kev loj hlob.
Kev kho mob txoj hnyuv
Digestive ntshawv siab yog cov cwj pwm muaj tshwm sim ntawm:
- xeev siab
- Kev mob siab;
- zawv plab
- flatulence, cem quav;
- stomatitis, glossitis;
- ulcerative erosive qhov txhab ntawm lub plab thiab duodenum;
- o ntawm tus txiav;
- nce siab hepatic aminotransferases;
- melena;
- qhov quav los ntshav.
Hematopoietic plab hnyuv siab raum
Hauv kev ua txhaum ntawm cov pob txha mob hematopoiesis, muaj pes tsawg ntawm cov qe ntshav muaj ntshav tsawg.
Nruab nrab hauv lub paj hlwb
Kev puas siab ntsws ntawm lub paj hlwb yog nrog kev loj hlob ntawm kiv taub hau thiab mob taub hau, pw tsaug zog tsis sib xws, peripheral neuropathy, poob ntawm kev tswj hwm lub siab ntsws, thiab cov tsos ntawm lub xeev kev nyuaj siab.
Los ntawm cov kab mob zis
Muaj kev pheej hmoo ntawm peripheral edema, kis kab mob ntawm cov kab mob ntawm lub tso zis, mob dysuria, mob ntawm lub raum, hematuria, los ntshav thiab urolithiasis.
Los ntawm lub tshuab ua pa
Tej zaum qhov kev txhim kho ntawm cov txheej txheem ua mob hauv bronchi, paranasal sinuses, ua pa tsis ua haujlwm.
Ntawm ib sab ntawm daim tawv nqaij
Hauv cov txiv neej, plaub hau yuav poob tawm. Muaj qhov nce siab hauv kev tawm hws, tshwm sim ntawm dandruff, eczema.
Los ntawm genitourinary system
Nrog kev ua txhaum ntawm kev siv lub zog ua haujlwm, libido poob qis, kev txhim kho erectile kawg thiab ejaculation tshwm sim.
Los ntawm cov hlab plawv system
Muaj mob hauv siab, arrhythmia, vasodilation, phlebitis thiab hypotension arterial.
Los ntawm ib sab ntawm cov metabolism
Nrog rau kev cuam tshuam ntawm cov metabolism hauv dav dav, qhov kev nce ntxiv hauv ntshav dej ntawm creatine phosphokinase yog ua tau. Kev ploj ntawm glycemic tswj, kev txhim kho ntawm albuminuria thiab nce kev ua haujlwm ntawm ALT, AST tsis raug tswj hwm. Hauv qee kis, qhov hnyav nce, exacerbation ntawm cov tsos mob ntawm gout, hyperthermia yog pom.
Kev ua xua
Kev ua xua tshwm sim hauv cov neeg mob nrog tus neeg tsis haum rau tus qauv ntawm Atomax. Ua xua tau tshwm sim los ntawm kev txhim kho pob, khaus thiab hu rau dermatitis. Tsis tshua muaj mob, mob hlwb, mob siab rau lub teeb, anaphylactic kev poob siab, Stevens-Johnson thiab Lyell mob tuaj yeem tshwm sim.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Cov tshuaj tsis cuam tshuam loj heev rau cov kev ua haujlwm ntawm peripheral thiab hauv nruab nrab lub paj hlwb thiab tsis doping, yog li thaum kho nrog Atomax nws raug tso cai los tswj cov cuab yeej ua haujlwm nyuaj thiab tsav lub tsheb.
Cov lus qhia tshwj xeeb
HMG-CoA reductase inhibitors ua rau muaj kev hloov pauv hauv cov haujlwm biochemical ntawm hepatocytes. Yog li, ua ntej pib txoj kev kho mob, thaum 6 thiab 12 lub lis piam tom qab kev teem caij ntawm Atomax, nws yog ib qho tsim nyog los soj ntsuam daim siab ua haujlwm. Nrog kev kam rau ua tau zoo thiab ua kom daim siab tso siab rau lub siab, kev tshuaj ntsuam lub siab ua haujlwm nrog qhov nce ntxiv ntawm koob tshuaj txhua hnub thiab txhua rau lub hlis.
Cov neeg rog rog yuav tsum sim tswj nws cov roj khov ua ntej pib kev kho.
Nws yog ib qho tseem ceeb kom nco ntsoov tias kev noj tshuaj atorvastatin tuaj yeem ua rau mob myopathy. Nws yog ib qho tsim nyog yuav tsum tau qhia rau tus kws kho mob txog qhov pom ntawm qhov mob thiab tsis muaj zog ntawm cov leeg, tshwj xeeb nrog kev txhim kho kev ua npaws thiab kev ua tsis zoo. Yog tias myalgia tshwm sim, nws raug nquahu kom koj tsis txhob noj tshuaj Atomax. Yog tias qhov txiaj ntsig ntawm kev ntsuas ntshav pom tias muaj kev nce ntxiv hauv cov kev ua si ntawm creatine phosphokinase, tshaj li qhov kev cai los ntawm 10 lossis ntau zaus, kev kho mob nrog atorvastatin thim tawm.
Thaum lub sijhawm cov tshuaj kho, muaj qhov pheej hmoo myoglobinuria. Tawm tsam keeb kwm ntawm cov txheej txheem pathological, rhabdomyolysis thiab mob raum ua haujlwm yuav tshwm sim. Yog tias cov tsos mob ntawm myopathy lossis lub raum tsis ua haujlwm lawm, tsum tsis txhob kho nrog Atomax.
Cov neeg rog rog ua ntej pib txoj kev kho yuav tsum sim ua kom nws cov qib roj ntsha txhawm rau siv kev kho kev noj zaub mov, ua si lub cev ntau dua thiab lwm yam kev ntsuas los txo lub cev lub cev.
Siv rau lub sijhawm qub
Thaum ncav lub hnub nyoog ntau dua 65 xyoos, nws raug nquahu kom ua raws li cov txheej txheem kev noj tshuaj thiab ua raws li cov lus pom zoo ntawm tus kws kho mob tshwj xeeb.
Txiag tej menyuam
Nws raug txwv tsis pub noj cov tshuaj rau menyuam yaus hnub nyoog qis dua 18 xyoo. Tsis muaj cov ntaub ntawv hais txog cov nyhuv ntawm atorvastatin ntawm kev loj hlob thiab kev loj hlob ntawm cov ntaub so ntswg ntawm lub cev hluas.
Siv thaum cev xeeb tub thiab lactation
Cov tshuaj yog contraindicated rau hauv cov poj niam thaum cev xeeb tub vim tias tsis muaj cov ntaub ntawv ntawm phytotoxicity ntawm Atomax. Atorvastatin tsis paub zoo kom nkag mus rau hauv niam mis, yog li ntawd, nws raug nquahu kom koj hloov menyuam mus pub mis nrog cov khoom sib tov thaum kho.
Daim ntawv thov rau lub raum khiav tsis zoo
Pathologies ntawm lub raum tsis cuam tshuam rau theem ntawm kev nthuav dav ntawm atorvastatin thiab nws cov ntsiab lus hauv cov ntshav, yog li nws raug nquahu kom noj cov tshuaj rau lub raum mob.
Siv rau lub siab ua haujlwm tsis zoo
Cov neeg mob uas muaj kab mob siab yuav tsum noj cov tshuaj raws li kev saib xyuas nruj ntawm kws kho mob. Kev zam tshwj xeeb yog cov tib neeg muaj kev ua ub ua no ntawm hepatic aminotransferases, dhau ntawm cov cai los ntawm 3 lossis ntau zaus. Hauv qhov no, tus lipid-txo qis tus neeg sawv cev yog txwv tsis pub siv.
Noj tshuaj ntau dhau ntawm Atomax
Hauv kev xyaum ua lag luam tom qab muag, tsis muaj ib qho mob ntawm kev haus dej ntau dhau. Yog tias qhov kev tso cai ntau tshaj plaws ntawm 80 mg yog dhau qhov siab tshaj, nws yog qhov ua tau kom nce lossis nce qhov tshwm sim ntawm cov kev mob tshwm sim. Vim tias tsis muaj cov ntaub ntawv, ib qho kev tiv thaiv tshwj xeeb tsis tau txhim kho. Kev kho mob yog siv los tshem tawm cov kev tsis zoo. Hemodialysis rau kev tshem tawm sai ntawm cov tshuaj yog qhov tsis muaj txiaj ntsig.
Kev cuam tshuam nrog lwm yam tshuaj
Muaj kev pheej hmoo ntawm kev txhim kho myopathy nrog cov thawj coj ua ke ntawm Atomax antifungal tus neeg sawv cev los ntawm pawg azoles, tshuaj tua kab mob cyclosporin, Niacin, fibroic acid derivatives, Erythromycin.
Nrog tib lub sijhawm siv kev ncua kev txiav txim siab uas muaj aluminium thiab ntsev ntsev, cov ntshav plasma concentration ntawm atorvastatin yog txo los ntawm 35%, thaum qib ntawm LDL-cholesterol complex tsis hloov. Cov kev ua haujlwm nquag ntawm Atomax tsis cuam tshuam rau pharmacokinetics ntawm Antipyrine, Azithromycin. Thaum siv 80 mg ntawm Digoxin, nws muaj peev xwm nce nws qib theem 20%. Cov neeg mob uas muaj qhov hloov pauv hauv Digoxin concentration no yog nyob rau hauv kev saib xyuas mob.
Atorvastatin nce ntxiv AUC ntawm ethylene estradiol-tswj kev tswj yug menyuam los ntawm 20%.
Colestipol tuaj yeem ua rau txo qis ntawm atorvastatin ntshav ntau ntau los ntawm 25%. Hauv qhov no, muaj qhov nce ntawm lipid-txo cov kev txiav txim siab.
Cawv tau zoo
Hauv lub sijhawm kho, nws tsis pom zoo kom haus dej cawv thiab tshuaj muaj yees li tsis muaj cawv. Kev haus cawv Ethyl ua rau qaug cawv, platelet thiab ntshav liab cov ntshav sib sau ua ke, uas cuam tshuam tsis zoo rau lub xeev ntawm cov hlab plawv. Muaj qhov ua kom tsis muaj zog ntawm qhov ua kom muaj txiaj ntsig thiab mob ntxiv ntawm pathologies ntawm txoj kev ncig.
Analogs
Thaum tsis muaj lipid-txo cov nyhuv, Atomax ntsiav tshuaj tuaj yeem hloov nrog ib qho ntawm cov tshuaj hauv qab no:
- Liprimar;
- Atoris;
- Liptonorm;
- Tulip;
- Vazotor;
- Atorvastatin-SZ.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Cov tshuaj yog muag los ntawm cov tshuaj kho mob.
Kuv tuaj yeem yuav yam tsis tas yuav tshuaj
Kev muag dawb ntawm lipid-txo tshuaj yog txwv vim muaj kev pheej hmoo siab ntawm kev phiv yog tias siv tsis raug.
Nqi
Tus nqi nruab nrab ntawm Atomax yog 400-500 rubles.
Cia rau cov neeg mob rau cov tshuaj
Khaws cov ntsiav tshuaj nyob rau hauv kev sib cais los ntawm tshav ntuj nyob hauv ib qho chaw nrog cov av noo qis. Nws raug nquahu kom muaj cov tshuaj ntawm qhov kub ntawm + 8 ... + 25 ° C.
Hnub tas sij hawm
2 xyoos
Chaw tsim tshuaj paus
CJSC MAKIZ-PHARMA, Russia.
Thaum tsis muaj lipid-txo cov nyhuv, Atomax ntsiav tshuaj tuaj yeem hloov nrog Liprimar.
Xyuas
Eduard Petukhov, 38 xyoo, Rostov-on-Don
Kuv xav tias cov tshuaj yog txoj hauv kev zoo los tiv thaiv cov roj (cholesterol). 6 lub hlis dhau los, lawv tau raug samfwm kom haus cov ntsiav tshuaj nrog cov cholesterol ntawm 7.5 mmol. Kev kuaj ntshav kawg 2 lub lis piam dhau los qhia tias qhov poob qis rau 6 mmol. Kuv tseem tabtom kho. Nws tsis muaj tshuaj tsis haum rau tag nrho lub sijhawm ntawm kev kho mob.
Vasily Zafiraki, kws kho plawv, St. Petersburg
Hauv chav kawm ntawm kev tshawb fawb txog kev kho kom zoo sib xws ntawm Atomax thiab Lipirimar, qib triglyceride thiab kev ua haujlwm ntawm cov vascular endothelium tau piv nrog kev siv tshuaj mus ntev. Kev tshawb nrhiav tau qhia cov txiaj ntsig ntawm Atomax. Lwm cov tuam ntxhab ntawm atorvastatin tsis ua qhov ntsuas zoo sib xws thiab sau nqi qis rau cov tshuaj noj, uas ua rau peb xav txog qhov ua tau zoo ntawm lawv cov tshuaj. Kuv nyiam tias Atomax muaj ntau txoj kev kuaj mob.
