Atorvastatin 10 yog hais txog cov enzyme inhibitors uas cuam tshuam rau hauv cov txheej txheem ntawm cov cholesterol. Nws feem ntau tau sau tseg rau cov kab mob hauv lub plawv los ntawm kev ua rau lub cev tsis muaj roj lipid, nrog rau kev ua kom zoo ntxiv ntawm txoj kev kho raws li kev tswj hwm kev noj haus.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Atorvastatin (hauv Latin - atorvastatin).
ATX
C10AA05
Tso cov ntawv thiab cov nyob ua ke
Hauv cov khw muag tshuaj koj tuaj yeem pom tsuas yog 1 yam tshuaj - nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj. Lub cuab tam yog hais txog cov tshuaj tiv thaiv ib leeg. Atorvastatin ua rau muaj kev txo qis hauv cov ntsiab lus lipid, thiab cov tshuaj no suav nrog hauv kev npaj hauv daim ntawv ntawm calcium ntsev (calcium trihydrate). Hauv kev xaiv cov tshuaj hauv cov lus nug, qhov ntau npaum ntawm cov khoom siv nquag yog hloov tawm - 10 mg. Tus nqi no muaj nyob hauv 1 ntsiav tshuaj. Cov tshuaj tsis nthuav tawm cov kev ua yeeb yam cuam tshuam vim muaj qhov ua yeeb yaj kiab zaj duab xis.
Atorvastatin tuaj yeem nqus tau hauv cov ntawv ntim ntawm tes. Txhua tus muaj 10 ntsiav tshuaj. Tus naj npawb tag nrho cov hlwv hauv ib daim thawv ntawv yog 1, 2, 3, 4, 5, lossis 10 pcs.
Atorvastatin 10 yog hais txog cov enzyme inhibitors uas cuam tshuam rau hauv cov txheej txheem ntawm cov cholesterol.
Pharmacological kev txiav txim
Cov tshuaj yog ib qho inhibitor ntawm cov enzyme hydroxymethylglutaryl-CoA reductase. Nws muaj qhov xaiv xaiv. Lub cuab tam muaj qhov cuam tshuam zoo dua rau cov txheej txheem uas pab txhawb tsim cov roj (cholesterol). Atorvastatin inhibits lwm cov tshuaj lom biochemical hauv lub cev ntau dua li siv zog.
Lub enzyme HMG-CoA reductase ua rau kom muaj kev sib xyaw ntawm cov roj (cholesterol), tab sis tsuas yog nyob rau theem pib. Nws cov txheej txheem ntawm kev ua yog raws li kev muaj peev xwm hloov HMG-CoA rau cov tshuaj yeeb tshuaj (mevalonic acid), los ntawm cov roj hauv cov roj ntsha tawm. Vim tias tseem muaj peev xwm txhawm rau ua txoj haujlwm ntawm cov enzyme no, atorvastatin inhibits qhov nce ntxiv ntawm cov cholesterol.
Cov txheej txheem tau piav qhia yog qhov ua rau muaj txiaj ntsig ntxiv rau qhov kev ua ntawm tsawg lipoprotein receptors. Raws li qhov tshwm sim, kev nthuav tawm ntawm LDL los ntawm ntshav yog ceev. Raws li qhov tshwm sim, qhov kev kub siab ntawm apolipoprotein B, LDL cov roj (cholesterol) thiab cov roj (cholesterol) tag nrho yog txo. Vim tias qhov no, muaj qhov txo qis ntawm qhov pheej hmoo ntawm kev txhim kho pathological tej yam kev mob ntawm cov hlab plawv.
Cov tshuaj muaj cov nyhuv zoo hauv lub cev vim kev thaiv qhov kev sib txuas ntawm cov hlwb nyob hauv cov hlab ntsha.
Tsis tas li ntawd, cov tshuaj muaj cov zoo nyob rau hauv lub cev vim qhov inhibition ntawm cov txheej txheem ntawm cell synthesis sab hauv cov hlab ntsha. Raws li qhov tshwm sim, lumen ntawm cov leeg thiab cov hlab ntsha tsis kam ua, uas cuam tshuam ncaj qha rau kev nrawm ntawm cov ntshav khiav, kev siv ntshav txaus rau cov nruab nrog cev sab hauv, lub xeev ntawm lub hlwb, lub hlwb thiab lub cev. Kev hnyav lub cev thiab ua haujlwm nce ntxiv ntawm cov hlab plawv - cov txiaj ntsig ntawm kev nce ntxiv hauv cov concentration ntawm HDL, hom A apolipoproteins.
Cov tshuaj nyob rau hauv kev txiav txim siab zwm rau cov pab pawg ntawm statins; hauv cov ntshav plasma thaum kho, cov ntsiab lus ntawm qee qhov ntawm cov khoom siv yog ib txwm muaj (cov roj cholesterol hauv lawv). Txawm li cas los xij, atorvastatin kuj ua tau nws tus kheej los ua ib qho tshuaj tiv thaiv kab mob hauv lub cev. Ua tsaug rau nws, qhov kev siv ntawm platelet txuas nrog rau sab hauv puab ntawm cov hlab ntsha poob qis. Txawm li cas los xij, muaj txo qis ntshav viscosity, uas tseem ua rau muaj kev hloov kho ntawm cov ntshav ntshav.
Ua ke nrog cov txheej txheem piav qhia, macrophage metabolism rov qab. Nyob rau tib lub sijhawm, lawv cov haujlwm raug kaw. Raws li qhov tshwm sim, qhov kev pheej hmoo ntawm kev sib tawg ntawm cov atherosclerotic quav hniav yog txo.
Thaum noj cov tshuaj, qhov txo qis hauv viscosity yog sau tseg, uas tseem ua rau muaj qhov tsis sib luag ntawm cov ntshav ncig.
Cov Tshuaj Pharmacokinetics
Lub bioavailability ntawm cov tshuaj yog tsawg (tsis ntau tshaj 14%). Atorvastatin nqus tau nrawm. Tus txheej txheem no tau ua haujlwm nyob rau thawj ob teev tom qab noj ib koob ntawm cov tshuaj. Txawm hais tias zoo tshuaj pharmacokinetics, cov tshuaj ua rau qeeb. Yog li, kho cov nyhuv tawm tuaj yeem pom tsis muaj ntxov dua 2 lub lis piam tom qab. Qib siab kawg ntawm kev ua haujlwm ntawm atorvastatin tau tiav 4 lub lis piam tom qab pib lub sijhawm ntawm kev kho thiab nrog kev siv cov tshuaj tsis tu ncua.
Hauv cov neeg mob ntawm cov poj niam txiv neej sib txawv thiab hnub nyoog, cov chaw muag tshuaj tsis sib txawv, uas txhais tau tias tsis tas yuav rov qab noj ntau npaum li cas thaum muab tshuaj rau cov neeg mob ntawm cov pab pawg no. Tus nqi ntawm kev khi ntawm atorvastatin kom ntshav cov protein yog qhov siab - nws nce mus txog 98%. Qhov ua tau zoo ntawm cov tshuaj no yog vim los ntawm kev tso tawm ntawm cov tshuaj tiv thaiv metabolites, uas kuj koom nrog kev txwv tsis pub roj (synthesis).
Kev tshem tawm ib nrab-lub neej ntawm cov khoom tseem ceeb yog 14 teev. Atorvastatin raug tshem tawm ntawm lub cev nrog rau cov kua tsib. Feem ntau yog raug tawm thaum tso quav. Qhov me me ntawm cov tshuaj yog thaum tso zis.
Kev tshem tawm ib nrab-lub neej ntawm cov khoom tseem ceeb yog 14 teev. Atorvastatin raug tshem tawm ntawm lub cev nrog rau cov kua tsib.
Dab tsi yog sau tseg?
Cov chaw tseem ceeb hauv daim ntawv thov:
- nce qhov kev ua tau zoo ntawm cov tshuaj uas lawv ua yog ua rau txo qis cov roj (cov Atorvastatin yog txoj cai ntawm kev kho mob nyuaj), ua tiav cov txiaj ntsig uas xav tau nrog kev noj zaub mov noj;
- kev kho mob ntawm cov hlab plawv, tiv thaiv kev txhim kho ntawm cov teeb meem tshwm sim los ntawm kev nce ntshav ntau dhau, cov roj hauv siab, nqaim ntawm cov hlab ntsha.
Cov Yuav Tsum Muaj
Atorvastatin tsis tau siv ntau qhov mob:
- intolerance rau ib qho twg hauv cov lus;
- nce kev ua si ntawm hepatic transaminases;
- tsis muaj lactase, qhov tshwm sim tsis zoo rau ib tus neeg lactose, piam thaj-galactose malabsorption.
Nrog saib xyuas
Hauv qhov no, cov tshuaj tau raug sau tseg yog tias muaj txiaj ntsig zoo tshaj qhov tsim kev puas tsuaj nyob rau hauv kev siv. Tus txheeb ze contraindications:
- kev quav cawv;
- keeb kwm txog kab mob siab;
- kev pheej hmoo ua rau kev nthuav dav ntawm myopathy mob siab heev, thaum cov txheej txheem ntawm kev puas tsuaj cell pib.
Qhov ntxim nyiam ntawm myopathy nce nyob rau hauv lub hnub nyoog laus, nrog kab mob siab, mob pathological, ua kom pom los ntawm kev ua txhaum ntawm cov leeg ua haujlwm, tawm tsam keeb kwm ntawm kev quav dej quav cawv.
Yuav ua li cas noj atorvastatin 10?
Pharmacodynamics tsis yog nyob ntawm kev noj zaub mov, koj tuaj yeem noj cov tshuaj ntawm lub plab lossis lossis tom qab noj mov tas. Cov lus qhia rau kev siv:
- koob tshuaj txhua hnub - 10 mg;
- cov tshuaj yuav tsum tau noj ib zaug thiab tib lub sijhawm.
Raws li koj noj cov tshuaj, koj yuav tsum tswj hwm qhov theem ntawm lipids, thiab kev sim tshuaj yuav tsum tau kuaj 1 zaug nyob rau txhua 2-4 lub lis piam.
Raws li koj noj cov tshuaj, koj yuav tsum tswj hwm qhov theem ntawm lipids, thiab kev sim tshuaj yuav tsum tau kuaj 1 zaug nyob rau txhua 2-4 lub lis piam. Ntau cov tshuaj noj uas cov tshuaj lom ntawm lub hauv paus pib nyob ntawm hom mob:
- nrog homozygous hypercholesterolemia, tsev neeg tsa 80 mg ntawm atorvastatin (lossis 8 ntsiav tshuaj) ib hnub;
- heterozygous hypercholesterolemia yog tsev neeg: nyob rau theem pib ntawm kev kho mob - 10 mg rau ib hnub, tom qab ntawd cov koob tshuaj tau nce mus rau 40 mg ib hnub, qhov nyiaj ntawm cov tshuaj yuav tsum tau nce zuj zus (cov kev hloov pauv hloov txhua 4 lub lis piam).
Noj cov tshuaj rau ntshav qab zib
Cov tshuaj yog tshuaj hauv cov txheej txheem loj ntawm -10 mg ib hnub. Nrog txoj kev kho mob, txoj kev kho mob yuav hloov pauv, nyob ntawm tus neeg mob lub cev.
Sab sij huam
Nce kev ua ntawm creatine phosphokinase (CPK), aminotransferases. Ib tus mob febrile yuav pib loj hlob tuaj, ntau zaus nkees tshwm sim.
Hauv cov kab mob ntshav qab zib mellitus, cov tshuaj yog kws kho hauv cov qauv tshuaj ntawm -10 mg rau ib hnub.
Kev kho mob txoj hnyuv
Kev tsim cov pa roj ntau dhau, xeev siab, ntuav, nyuaj tso quav, lossis, hloov pauv, kev ua kua. Kev hnov mob hauv plab yog sau tseg. Kev mob pancreatitis tsis tshua muaj tshwm sim.
Nruab nrab hauv lub paj hlwb
Kev hnov mob hauv lub cev, mob taub hau, kiv taub hau, puas siab puas ntsws, hloov pauv hauv qhov qab, puas hlwb, nco tsis meej, thiab mob hnyav, nws ua tiav.
Los ntawm lub tshuab ua pa
Mob ntsws muaj mob, tshwm sim los ntawm cov txheej txheem mob, ua txhaum ntawm tus qauv ntawm cov phab ntsa ntawm alveoli. Cov tsos ntawm nosebleeds tau sau tseg.
Ntawm ib sab ntawm daim tawv nqaij
Cov pob xoo, qhov tshwm sim ntawm uas nrog nrog khaus. Tsis tshua muaj mob erythema, alopecia, necrolysis, Stevens-Johnson mob.
Los ntawm cov hlab plawv system, thaum noj tshuaj, mob hauv siab kuj tshwm sim.
Los ntawm genitourinary system
Tsis hlauv.
Los ntawm cov hlab plawv system
Kev mob hauv siab.
Los ntawm cov leeg musculoskeletal
Mob leeg, sab nraub qaum, o ntawm cov pob qij txha, myopathy, genopathy, nqaij mos mob plab.
Kev ua xua
Urticaria, mob hlwb.
Cov lus qhia tshwj xeeb
Ua ntej pib txoj kev kho mob nrog Atorvastatin, kev noj haus raug raws kev cai, uas ua kom muaj kev txo qis lipid concentration. Tsis tas li ntawd, cov neeg mob rog rog tau pom zoo kom ua kom lub cev, vim tias lub cev qhov hnyav yuav poob qis, nws yuav ua tau kom tswj ntsuas qhov ntsuas thaum hypercholesterolemia.
Kev ntsuas KFK yog qhov yuav tsum tau ua yog tias muaj kev pheej hmoo rau kev loj hlob ntawm daim siab ua haujlwm.
Ua ntej pib txoj kev kho mob nrog Atorvastatin, kev noj haus raug raws kev cai, uas ua kom muaj kev txo qis lipid concentration.
Coj mus rau hauv tus account tias qhov zoo li ntawm qhov tshwm sim ntawm myopathy nce nrog kev siv Atorvastatin txoj kev kho, nws raug nquahu kom sab laj nrog kws kho mob yog tias mob leeg.
Cawv tau zoo
Koj yuav tsum tsis txhob muab cov tshuaj no nrog cov cawv uas muaj cawv.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Tsis muaj kev txwv nruj, txawm hais tias qhov kev pheej hmoo loj ntawm kev txhim kho kev cuam tshuam ntawm lub hauv nruab nrab lub paj hlwb (kiv taub hau), nco ploj. Nws raug tso cai tsav tsheb nrog Atorvastatin kho mob, tab sis kev ceev faj yuav tsum siv.
Siv thaum cev xeeb tub thiab lactation
Tsis txhob xaj cov tshuaj thaum nqa menyuam. Thaum pub mis niam, cov khoom lag luam tsis siv vim tias tsis muaj cov ntaub ntawv hais txog kev siv khov ntawm nws nkag mus rau niam cov kua mis.
Atorvastatin 10 cov menyuam yaus
Cov tshuaj yeeb yaj kiab tuaj yeem siv rau hauv kev kho mob ntawm cov neeg mob hnub nyoog qis dua 18 xyoo tsuas yog tias tsev neeg hypercholesterolemia ntawm hom mob heterozygous tshwm sim. Hauv qhov no, qhia tias kev kho tus mob raug xaiv kom raug, cov chaw muag tshuaj ntawm cov tshuaj yuav zoo ib yam li kev kho rau cov neeg laus. Qhov twj txwv tsis pub siv yog tias tus me nyuam tsis tau txog 10 xyoo.
Lub cuab yeej raug txwv rau siv yog tias tus me nyuam tsis txog 10 xyoo.
Siv rau lub sijhawm qub
Cov tshuaj no ntau dua rau cov neeg hluas. Qhov no yog vim muaj kev poob qis hauv kev tshem tawm ntawm atorvastatin thiab nws cov metabolites. Txawm li cas los xij, hauv qhov no, tsis tas yuav hloov kho qhov ntau ntawm cov tshuaj.
Daim ntawv thov rau lub raum khiav tsis zoo
Cov kev kho mob tawm tsam nrog cov kab mob hauv thaj chaw mob hauv lub cev no tsis hloov. Qhov no yog vim lub fact tias ob lub raum mus rau ib qho me me koom nrog cov metabolism hauv ntawm atorvastatin.
Siv rau lub siab ua haujlwm tsis zoo
Cov tshuaj yog txwv rau kev mob siab ntawm lub siab thiab lwm yam kab mob ua ke nrog cov tsos mob tshwm sim ntawm kev puas tsuaj rau cov kab mob no. Qhov siab tshaj plaws ntawm atorvastatin ntau dhau ntawm qib ib txwm yog 11-16 zaug.
Txoj kev kho mob tawm tsam tus kab mob nrog rau qhov chaw hauv lub qhov txhab mob hauv ob lub raum tsis hloov.
Noj ntau dhau
Nrog kev nce qib tsis tu ncua txhua hnub, qhov kev siv ntau ntawm cov kev coj ntawm cov kev mob tshwm sim nce ntxiv. Txhawm rau ua kom lub xeev tsis sib xws ntawm lub cev, kev kho cov tsos mob kom ua. Hemodialysis tsis muab cov txiaj ntsig xav tau.
Kev cuam tshuam nrog lwm yam tshuaj
Muaj qhov nce ntawm lipid-txo cov nyhuv hauv kev sib xyaw nrog cov chaw sawv cev thiab tshuaj yeeb dej caw:
- tshuaj tua kab mob
- cov kab mob tiv thaiv HIV tiv thaiv kabmob;
- tshuaj siv rau kev kho mob ntawm mycoses;
- Nefazodon.
Kev tswj hwm tib lub sij hawm ntawm atorvastatin nrog ezetimibe yog qhov ua rau kev txhim kho ntawm kev phiv tshuaj.
Qhov txo qis hauv kev mloog zoo ntawm cov tshuaj hauv cov lus nug yog vim raug rau cov neeg sawv cev los ntawm pawg ntawm qhov cuam tshuam ntawm CYP3A4 isoenzyme. Inhibitors ntawm no isoenzyme, ntawm qhov tsis tooj, ua rau muaj kev nce ntxiv hauv cov concentration ntawm atorvastatin.
Cov tshuaj hauv cov nqe lus nug tuaj yeem cuam tshuam tsis zoo rau cov tshuaj hormones steroid.
Thaum lub sij hawm kho nrog Atorvastatin, qhov nqus ntawm qhov ncauj tshuaj tiv thaiv ntau dua.
Qhov kev txiav txim siab ntawm cov tshuaj hauv cov lus nug nce ntxiv nrog kev siv tib lub sijhawm ua kua txiv kab ntxwv qaub.
Qhov kev txiav txim siab ntawm cov tshuaj hauv cov lus nug nce ntxiv nrog kev siv tib lub sijhawm ua kua txiv kab ntxwv qaub.
Analogs
Cov tshuaj hauv qab no yog siv los hloov:
- Atoris;
- Atorvastatin Teva;
- Atorvastatin Canon;
- Atorvox;
- Torvakard.
Cov lus piv txwv yuav muaj ntau hom kev tso tawm: txhaj tshuaj, lyophilisate, tsiav tshuaj. Yog tias tus qauv ntawm cov hloov pauv thiab Atorvastatin sib txawv, yuav tsum tau hloov dua siab tshiab ntau npaum li cas.
Cov nqe lus so So Atorvastatin 10 los ntawm cov chaw muag tshuaj
Cov tshuaj yog rau cov pab pawg muab tshuaj.
Kuv puas yuav tau yam tsis muaj daim ntawv yuav tshuaj?
Yuav tsum teem sijhawm mus ntsib kws khomob.
Nqi
Tus nqi nruab nrab: 135-265 rubles.
Cia rau cov neeg mob rau cov tshuaj
Pom zoo rau huab cua kub hauv tsev tsis siab dua + 25 ° С.
Hnub tas sij hawm
Cov tshuaj tsis poob khoom rau 2 xyoos txij li hnub tso tawm.
Atorvastatin chaw tsim tshuaj paus 10
Krka (Slovenia).
Atorvastatin 10 Xyuas
Cov kws kho mob
Zafiraki V.K., 42 xyoo, Saratov
Kuv pom zoo kom noj atorvastatin ua ib feem ntawm Liprimar cov khoom lag luam tsim los ntawm Pfizer. Lwm lub tuam txhab tseem tso cov tshuaj no, tab sis feem ntau cov naj npawb ntawm cov kev mob tshwm sim ntau ntxiv. Atoris tuaj yeem sib txawv ntawm analogues. Nyob rau hauv cov nqe lus ntawm lub zog thiab qib ntawm kev txhoj puab heev ntawm lub cev, cov tshuaj no zoo dua rau lwm qhov kev hloov pauv Atorvastatin.
Gubarev I.A., 35 xyoo, Tula
Thaum mus khomob, yuav tsum mus kuaj cov ntshav kuaj sim ntsuas niaj zaus. Yog tias qhov kev pom zoo no tsis ua raws li, qhov kev pheej hmoo ntawm kev mob tshwm sim nce. So ntawm Atorvastatin yog ib qho tshuaj zoo heev, vim tias nws pheej yug thiab ua haujlwm zoo.
Cov neeg mob
Eugenia, 38 xyoo, Vladimir
Tus kws kho mob tau sau cov tshuaj no tawm tsam keeb kwm ntawm cov roj (cholesterol) siab. Kuv yuav tsum tau coj mus sij hawm ntev, vim hais tias cov tshuaj tam sim ntawd tsis muab cov nyhuv tsim nyog.
Galina, 35 xyoo, Samara
Cov cuab yeej pab yog tias kev noj zaub mov kom ua raws. Tswj cov khoom noj kom zoo yog qhov nyuaj, yog li kuv cov qib roj cholesterol feem ntau nce ntxiv. Txhua zaus kuv yauv mus kho mob Atorvastatin. Qhov zoo ntawm cov tshuaj muaj nqi tsawg.
