Cov tshuaj Gluconorm rau cov ntshav qab zib - cov lus qhia rau kev siv

Gluconorm yog ib ntawm cov tshuaj coj los kho ntshav qab zib hom 2. Cov tshuaj muaj cov nyhuv hypoglycemic.

Gluconorm muaj nyob hauv daim ntawv foos thiab tau npaj rau kev tswj hwm qhov ncauj.

Cov ntaub ntawv dav dav, muaj pes tsawg leeg thiab cov ntawv tso tawm

Gluconorm yog ib lub tshuaj hypoglycemic hauv Is Nrias teb. Ntxiv rau cov nyhuv hauv lub ntsej muag hypoglycemic, cov tshuaj yuav pab txo qis qis cov roj cholesterol hauv cov ntshav ntawm tus neeg mob.

Nws raug tso cai kom faib nyiaj raws li cov ntawv xaj ntawm tus kws tshaj lij tuaj koom. Cov tshuaj yeeb yaj kiab tau siv rau 3 xyoos txij li hnub ntawm nws cov chaw tsim khoom.

Nws yog ib qho tsim nyog yuav tau soj ntsuam qhov chaw cia khoom ntawm cov tshuaj no. Nws muab khaws cia rau hauv qhov chaw tsaus tsis muaj menyuam nkag mus. Qhov zoo tshaj plaws cia cia kub yog 20-23⁰C.

Tsis tas li ntawd, Gluconorm nrog blueberries nyob rau hauv daim ntawv ntawm tshuaj ntsuab tshuaj ntsuab yog tsim, uas tsis yog tshuaj, tab sis yog noj raws li cov piam thaj hauv dej qab zib.

Cov tshuaj tseem ceeb ntawm cov tshuaj yog Metformin Hydrochloride thiab Glibenclamide. Cov ntsiab lus ntawm thawj qhov tshuaj hauv 1 ntsiav tshuaj yog 400 mg, thib ob - 2.5 mg. Cellulose hauv microcrystals thiab colloidal silicon dioxide yog tam sim no ntxiv raws cov khoom hauv kev npaj ntawm kev npaj ua. Kuj tseem sau tseg cov kab ntawm croscarmellose, diethyl phthalate thiab glycerol.

Ntawm lwm yam tshuaj ntawm cov tshuaj, sodium carboxymethyl hmoov txhuv nplej siab, magnesium stearate thiab cellacephate tau sau tseg. Hauv qee qhov ntau, talc nrog pob kws hmoov txhuv nplej thiab gelatin muaj nyob rau hauv qhov muaj pes tsawg leeg tshuaj.

Ib pob tshuaj muaj pob 1-4 lub hlwv. Sab hauv lub hlwv tuaj yeem yog 10, 20, 30 ntsiav tshuaj ntawm cov tshuaj. Cov ntsiav tshuaj ntawm cov tshuaj yog dawb thiab muaj daim biconvex puag ncig. Thaum lub sijhawm so, cov ntsiav tshuaj yuav muaj me ntsis greyish zas.

Gluconorm blueberry tshuaj yej tsis muaj qhov feem cuam hauv cov ntsiav tshuaj. Nws yog tsim los ntawm cov tshuaj ntsuab hauv lub cev thiab muag hauv cov qauv ntawm lub hnab ntim. Lub chav kawm ntawm kev pub nkag yog tsim rau 3 lub lis piam.

Cov chaw muag tshuaj thiab tshuaj pharmacokinetics

Gluconorm muaj ob lub ntsiab: Glibenclamide thiab Metformin. Ob qho tshuaj yeeb dej caw ua rau kev sib koom ua ke, nce qhov kev ua tau zoo ntawm cov tshuaj.

Glibenclamide yog 2 tiam sulfonylurea derivative. Vim nws qhov kev txiav txim, insulin secretion yog tsa, thiab kuj tseem yuav muaj cov tshuaj insulin ua rau muaj cov hlwb tseem ceeb ntau ntxiv.

Glibenclamide txhawb nqa lub zog tso tawm ntawm insulin thiab txhim kho nws cov nyhuv ntawm kev nqus ntawm cov piam thaj los ntawm daim siab, ua rau cov leeg. Raws li qhov kev ua ntawm cov tshuaj, cov txheej txheem ntawm kev sib cais cov rog hauv cov ntaub so ntswg adipose qeeb qeeb.

Metformin yog cov khoom siv loj loj. Vim tias qhov kev nqis tes ua no, cov ntsiab lus ntawm cov piam thaj hauv cov ntshav ntawm tus neeg mob tau raug txo qis, muaj kev nce siab ntxiv cov piam thaj los ntawm cov ntaub so ntswg.

Qhov tshuaj zoo ua rau muaj kev txo cov ntshav hauv cov ntshav siab. Vim tias kev ua ntawm Metformin, qhov nqus ntawm cov carbohydrates hauv lub plab thiab cov hnyuv poob qis. Cov tshuaj cuam tshuam loj tuaj yeem tiv thaiv kev tsim cov piam thaj hauv lub siab.

Glibenclamide thiab Metformin, uas yog ib feem ntawm cov tshuaj, muaj cov tshuaj txawv txawv.

Qhov nqus ntawm glibenclamide tom qab kev noj haus ntawm lub plab thiab cov hnyuv nce mus txog 84%. Qhov siab tshaj plaws ntawm ib qho khoom tuaj yeem mus txog hauv ib teev lossis ob teev. Cov tshuaj yog zoo txuam nrog cov ntshav protein. Tus nqi ntsuas yog 95%. Qhov tsawg kawg nkaus ib nrab-lub neej yog 3 teev, qhov siab tshaj yog 16 teev. Cov tshuaj yog qee tawm ntawm lub raum, ib feem los ntawm txoj hnyuv.

Qhov siab tshaj plaws ntawm lub cev ntawm Metformin tsis yog ntau tshaj 60%. Noj ua rau qeeb qeeb dua qhov nqus ntawm metformin. Cov tshuaj tawm ntawm lub plab tas yog nqus tau los ntawm lub plab thiab txoj hnyuv.

Tsis zoo li Glibenclamide, nws muaj qhov tsis tshua muaj khi tiv thaiv cov ntshav protein. Nws yog tawm los ntawm lub raum. 30% ntawm cov tshuaj yuav tuaj yeem nyob hauv tus neeg mob quav. Qhov kev tshem tawm ib nrab-lub neej mus txog 12 teev.

Kev taw qhia thiab contraindications

Qhov qhia tseem ceeb rau kev noj cov tshuaj no yog qhov muaj tus mob ntshav qab zib hom II hauv tus neeg mob. Tsis tas li, cov tshuaj tau raug sau tseg thaum tsis muaj txiaj ntsig ntawm kev kho mob nrog rau kev noj zaub mov zoo, kev tawm dag zog thiab kev kho mob raws li kev noj cov tshuaj Metformin nrog Glibenclamide.

Cov tshuaj tseem yog qhia rau cov neeg mob uas muaj ntshav qab zib thiab cov ntshav qab zib kom ruaj khov, tab sis tus neeg uas xav tau hloov los kho nrog Glibenclamide thiab Metformin.

Ib tug tseem ceeb tus naj npawb ntawm contraindications yog cov yam ntxwv ntawm cov tshuaj:

• daim siab ua haujlwm;
• txo qis hauv cov ntshav qab zib cov ntsiab lus (hypoglycemia);
• siab rhiab heev rau cov tshuaj ntawm cov tshuaj;
• hom I ntshav qab zib mellitus;
• cawv ntev ntev;
• cev xeeb tub
• lub raum tsis ua haujlwm vim muaj kab mob, poob siab;
• ketoacidosis;
• kev siv ntawm miconazole;
• lub xub ntiag ntawm cov roj hauv lub cev;
• lub plawv tsis ua hauj lwm;
• pub niam mis;
• ntau yam kab mob;
• mob dias taub;
• lub raum tsis ua haujlwm;
• myocardial infarction;
• ua kev phais mob sab nraud;
• lactic acidosis;
• dej cawv lom;
• ua pa tsis ua haujlwm;
• kuaj mob ntshav qab zib;
• Kab mob porphyrin.

Cov lus qhia rau kev siv

Cov tshuaj yog coj nrog noj mov. Rau txhua tus neeg mob, ib tus neeg tshuaj ntawm Gluconorm yog tau tsim muaj.

Kev kho nrog cov tshuaj tshwm sim nyob rau ntau theem. Thaum pib theem, 1 ntsiav tshuaj ntawm cov tshuaj tau noj txhua hnub. Kev kho mob raws li cov txheej txheem no kav 14 hnub. Yav tom ntej, cov koob tshuaj yuav hloov pauv mus rau hauv tus account tus neeg mob lub cim thiab ntsuas ntawm qab zib hauv nws cov ntshav.

Thaum hloov txoj kev kho, tus neeg mob yuav siv 1-2 ntsiav tshuaj ntawm cov tshuaj. Qhov siab tshaj plaws tau siv nyob rau hnub no yog 5 ntsiav tshuaj.

Cov Neeg Mob Tshwj Xeeb thiab Cov Lus Qhia

Cov tshuaj no yog txwv rau tus poj niam cev xeeb tub. Nws kuj tseem tsis tuaj yeem lees txais cov tshuaj thaum lub sijhawm npaj kev xeeb tub.

Gluconorm yuav tsum tsis txhob noj lactating poj niam, txij li Metformin nquag nkag rau niam mis thiab tuaj yeem cuam tshuam loj rau kev noj qab haus huv ntawm tus menyuam mos. Hauv cov rooj plaub no, kev hloov pauv cov tshuaj nrog kev kho mob insulin yog kev pom zoo.

Cov tshuaj tsis pom zoo rau cov neeg laus laus uas lawv hnub nyoog tshaj 60 xyoo. Ua ke nrog kev hnyav, Gluconorm tuaj yeem ua rau lactic acidosis hauv pawg neeg no.

Cov tshuaj yuav tsum ua tib zoo saib xyuas los ntawm cov neeg mob kev txom nyem los ntawm:

• adrenal tsis txaus ntseeg;
• ua npaws;
• cov thyroid kab mob.

Txog tshuaj, ntau cov lus qhia tshwj xeeb yog muab:

• thaum kho, yuav tsum saib xyuas cov ntshav qabzib nyob ntawm lub plab thiab tomqab noj mov tas;
• txwv tsis pub sib koom tes thiab haus cawv;
• nws yog qhov yuav tsum tau hloov cov tshuaj nrog kev kho mob insulin yog tias tus neeg mob muaj kev raug mob, kis mob, kub taub hau, hlawv, kev ua haujlwm dhau los;
• 2 hnub ua ntej kev qhia ntawm cov tshuaj radiopaque uas muaj iodine rau hauv tus neeg mob lub cev, nws yog qhov yuav tsum tau tsum tsis txhob noj cov tshuaj (tom qab 2 hnub, rov qab muab tshuaj kom rov ua haujlwm);
• kev sib koom tes tswj hwm ntawm Gluconorm nrog ethanol provokes hypoglycemia, nws kuj tshwm sim thaum yoo mov thiab noj cov tshuaj tiv thaiv kev tiv thaiv ntawm ib hom tshuaj tsis-tshuaj;
• cov tshuaj cuam tshuam rau tus neeg mob lub peev xwm los tsav lub tsheb (koj yuav tsum tsis kam tsav tsheb thaum lub sijhawm kho nrog cov tshuaj).

Phiv thiab haus tshaj

Hauv kev siv tshuaj kho mob, tus neeg mob yuav muaj kev mob tshwm sim:

• txo cov ntshav qabzib (hypoglycemia);
• tsis qab los noj mov;
• leukopenia;
• kiv taub hau;
• khaus ntawm daim tawv nqaij;
• lactic acidosis;
• xeev siab ntuav nrog ntuav;
• thrombocytopenia;
• nkees
• urticaria;
• ua pa tsis ua haujlwm nrog rau ua npaws nyob rau hauv lub ntsej muag thiab tachycardia, raws li cov lus teb rau cov haus cawv ib txhij;
• mob plab
• anemia
• mob taub hau;
• ua npaws;
• tsawg rhiab heev;
• cov tsos ntawm ib co kua nplaum ntawm cov protein nyob rau hauv cov zis;
• dajntoo
• kab mob siab nyob rau hauv tsawg zaus.

Kev siv ntau dhau ntawm cov tshuaj tuaj yeem tshwm sim raws li:

• lactic acidosis;
• ntshav qog.

Cov kab mob lactic acidosis ua rau cov leeg mob, ntuav, thiab mob plab. Cov tsos mob ntawm tus kab mob yuav tsum muaj kev tsis muaj tshuaj sai thiab muab tus neeg mob tso pw hauv tsev kho mob. Qhov kev xaiv ua tau zoo tshaj plaws yog kev lim ntshav ntxiv ntawm cov ntshav (hemodialysis).

Glibenclamide tuaj yeem ua rau hypoglycemia hauv tus neeg mob. Thaum nws tshwm sim tsaug zog, mob taub hau. Kuj tseem sau tseg: pallor, kev ua haujlwm tsis zoo, tawm hws, tsis nco qab.

Kev mob ntshav qab zib tsawg hauv kev mob me thiab mob nrab yog tshem tawm los ntawm kev noj kua qab zib rau cov neeg mob. Hauv qhov xwm txheej loj, nws tau txhaj nrog 40% kua nplaum ntawm cov tshuaj. Cov kev qhia yog nqa tawm ntawm txoj leeg thiab intramuscularly.

Kev sib cuam tshuam txog Yeeb Tshuaj thiab Analogs

Cov yam ntxwv hauv qab no ntawm kev cuam tshuam nrog lwm yam tshuaj yog cov yam ntxwv ntawm cov tshuaj:

• ethanol thiab gluconorm ua ke provoke lactic acidosis;
• cationic tshuaj (Vancomycin, Morphine, Quinine, Amiloride) nce qhov concentration ntawm Metformin los ntawm 60%;
• barbiturates, zoo li clonidine, furosemide,Danazole, Morphine, lithium ntsev, estrogens, Baclafen, Glucagon, cov thyroid hormones, Phenytoin, Epinephrine, Chlortalidone, nicotinic acid, Triamteren, Acetazolamide txo cov tshuaj tiv thaiv zoo;
• Cimetidine, hypoglycemic agents, Tetracycline, Ethionamide, Guanethidine, fibrates, antifungals, enalapril, Theophylline, Cyclophosphamide, salicitates, Pentoxifylline, Pyridoxine, Reserpine, anabolic steroids txhim kho cov tshuaj tiv thaiv kab mob;
• calcium chloride ua ke nrog ammonium chloride, thiab ntxiv rau ascorbic acid ntau heev, txhim kho cov nyhuv tshuaj;
• Furosemide cuam tshuam cov ntsiab lus ntawm metformin hauv cov kev taw qhia ntawm nws nce li 22%.

Ntawm cov analogues tseem ceeb ntawm cov tshuaj yog:

• Metglib Kev Yuam;
• Glibomet;
• Glucophage;
• Glucovans;
• Hlau;
• Bagomet Ntxiv.

Cov khoom siv ua vis dis aus hais txog kev txo ntshav qab zib hauv ntshav qab zib hom 2

Tus neeg mob lub tswv yim

Ntau cov kev ntsuam xyuas ntshav qab zib txog cov tshuaj Gluconorm muaj feem ntau qhov tshuaj tiv thaiv zoo rau kev noj tshuaj, txawm li cas los xij, cov kev mob tshwm sim tau hais tseg, ntawm cov uas xeev siab thiab mob taub hau feem ntau tau ntsib, uas tau raug tshem tawm los ntawm kev kho kom haum.

Cov tshuaj yog qhov zoo, nws txo qis suab thaj zoo. Kuj ceeb tias, Kuv tsis pom muaj cov kev mob tshwm sim uas yog li feem ntau sau txog. Tus nqi pheej yig heev. Kuv yuam Gluconorm ntawm kev txuas ntxiv mus.

Svetlana, 60 xyoo

Kuv tau raug tus mob ntshav qab zib hom 2 tau ntau xyoo. Tus kws kho mob mus koom kws kho mob hais tias pom tus mob Gluconorm. Thaum xub thawj, muaj kev mob tshwm sim: feem ntau muaj mob, muaj kiv taub hau. Tab sis yav tom ntej peb tau kho qhov koob tshuaj, thiab txhua yam dhau. Cov cuab yeej siv tau zoo yog tias koj sib xyaw ua ke nws nrog kev noj haus.

Tatyana, 51 xyoo

Gluconorm yog ntseeg tau tag nrho. Hauv kuv qhov xwm txheej, Kuv pab kho ntxiv qhov hnyav. Cov tshuaj txo cov qab los noj mov. Ntawm cov minuses, Kuv yuav hais txog phiv phiv. Muaj ntau ntawm lawv. Ib lub sij hawm, kuv taub hau mob thiab mob heev.

Eve, 43 xyoo

Tsis ntev dhau los, tus endocrinologist tau ua qhov kev kuaj mob tsis txaus siab - hom ntshav qab zib 2. Gluconorm tau raug tso cai kho ntshav ntshav qab zib. Tshaj tag nrho zoo siab nrog kev kho mob. Nrog cov piam thaj siab, cov tshuaj muaj peev xwm txo nws qib mus rau 6 mmol / L. Muaj qee qhov tshwm sim, tab sis lawv raug tshem tawm. Qhov kev yoo khoom noj yog xav tau.

Anatoly, 55 xyoo

Tus nqi ntawm gluconorm nyob rau ntau thaj tsam ntawm lub teb chaws muaj kev sib txawv. Tus nqi nruab nrab hauv lub tebchaws yog 212 rubles. Tus nqi ntau ntawm cov tshuaj yog 130-294 rubles.