Hauv qhov kev pab cuam "Noj Qab Nyob Zoo" Elena Malysheva tau ua ib lub suab nrov uas metformin ua rau lub neej ntev dua.
Qhov no puas yog tiag?
Ua ntej koj yuav tsum xyuas seb nws yog hom tshuaj dab tsi, nws cov khoom yog dab tsi thiab vim li cas nws siv.
Dab tsi yog metformin?
Metformin yog cov ntsiav tshuaj uas siv rau hom 2 ntshav qab zib. Nws yog rau chav kawm ntawm biguanides. Nws yog ib qho ntawm cov laus tshaj plaws thiab ib qho tshuaj tau zoo tshaj plaws uas tau siv los kho tus mob no. Los ntawm chav kawm ntawm biguanides, qhov no tsuas yog cov tshuaj uas tsis cuam tshuam loj rau cov neeg mob lub plawv tsis ua haujlwm. LEEJ TWG muab nws tso rau hauv cov npe tshuaj tseem ceeb.
Metformin yog lub npe siv rau cov tshuaj tsis raug cai. Cov npe lag luam tawm hauv qab no yog muab tso rau cov khw muag tshuaj: Glucofage, Glycomet, Bagomet, Diaformin, Insufor, Langerin, Meglifort, Metamine, Metfogamma, Metformin Sandoz, Metformin-Teva, Panfor Sr, Siofor, Zukronorm.
Tau ntev, cov tshuaj siv tshwj rau kev kho mob ntshav qab zib. Tom qab xyoo ntawm kev tshawb fawb, nws pom tias nws txo cov rog rog. Thaum muaj mob ntshav qab zib, tuaj yeem siv los txo qhov muaj feem ntawm kev txhim kho tus kab mob. Nws kuj tseem siv rau polycystic ovaries thiab ib tug xov tooj ntawm lwm cov pathologies nyob rau hauv uas insulin tsis tseem ceeb.
Cov txiaj ntsig ntawm metformin raug pom:
- nrog ntshav qab zib;
- nrog cov kab mob metabolic;
- hauv kev tiv thaiv cov kab mob plawv;
- hauv kev tiv thaiv mob qog noj ntshav.
Cov txiaj ntsig ua tau zoo ntawm cov tshuaj hauv kev tawm tsam kev laus. Tus nqi tseem ceeb - txo qis qhov pib rau kev tuag ntawm cov mob plawv. Nws tseem ua pov thawj tias nws txo txoj kev pheej hmoo ntawm kev tsim oncology hauv cov neeg mob ntshav qab zib, mob metabolic. Hormone resistance yog ib qho kev pheej hmoo ntawm kev mob qog. Cov tshuaj insulin txhawb kev loj hlob ntawm cov nqaij mos, nrog rau cov tsis zoo heev.
Cov tshuaj ua haujlwm li cas?
Cov tshuaj txo cov concentration ntawm cov piam thaj hauv cov ntshav thiab cov synthesis ntawm qabzib hauv lub siab. Ntxiv nrog rau qhov kev kho mob hypoglycemic, nws zoo cuam tshuam rau lipid complex. Lowers triglycerides thiab cov roj (cholesterol) phem (LDL). Nws yog cov tshuaj nkaus xwb, raws li kev tshawb fawb, uas txo cov neeg lub plawv thiab mob nkees.
Ib qho zoo ntawm cov tshuaj yog tias nws tsis nce hauv lub cev qhov hnyav piv nrog rau lwm cov tshuaj hypoglycemic. Txog rau cov ntshav qab zib, nws pab kom txhaws ntev thiab ua kom lub neej muaj txiaj ntsig thiab muaj txiaj ntsig zoo. Nws qhov kev ua yog tsom rau qhov poob phaus. Nws yog tshuaj rau kev rog, yog tias kev noj zaub mov noj tsis tau nqa cov txiaj ntsig kom raug.
Cov tshuaj ua rau qhov qab plab thiab nqus ntawm cov piam thaj hauv cov hnyuv. Kev ua kom muaj zog ntawm cov tshuaj insulin tsis tshwm sim, cov nyhuv hypoglycemic yog ua tiav los ntawm kev txhim kho rhiab rau cov tshuaj hormones thiab ntau dua nqus ntawm cov piam thaj. Raws li kev noj tshuaj, cov txheej txheem pathological uas tiv thaiv keeb kwm ntawm tus kab mob qeeb. Nws tuaj yeem siv rau hauv pathologies uas ua pov thawj cov tshuaj tiv thaiv insulin. Qhov ua tau zoo ntawm cov tshuaj tshwm sim hauv cov hlwv zes qe menyuam, ntshav qab zib, qee yam kab mob siab, thiab kev rog dhau.
Metformin txo cov suab thaj ua ke tsawg zuj zus hauv lub siab thiab nce glycogen synthesis. Raws li tshuaj ntawm cov tshuaj, ntshav ncig hauv lub siab ua haujlwm, qib ntawm triglycerides thiab roj cholesterol yuav txo qis. Cov piam thaj los ntawm cov leeg nqaij, cov neeg siv lub zog loj, tau yooj yim. Kev noj ntau ntxiv ntawm cov piam thaj hauv qab yog piav qhia los ntawm qhov tseeb tias nws nkag tau yooj yim dua rau cov nqaij mos.
Qhov tshwm sim ntawm kev noj tshuaj:
- qab zib txo;
- txo qis xav tau cov tshuaj insulin endogenous;
- kev cuam tshuam cov insulin tsis kam;
- maj mam muaj qhov muaj mob lossis kev loj hlob ntawm atherosclerosis;
- txo hauv triglycerides thiab LDL;
- txo hauv siab, txo qis hauv cov piam thaj ntawm cov protein;
- thaiv cov hlab enzymes uas rhuav tshem cov hlwb;
- vascular tiv thaiv.
Cov Yuav Tsum Muaj
Ntawm cov contraindications rau siv:
- raum tsis ua hauj lwm;
- hypersensitivity rau cov tshuaj;
- cov kab mob sib kis hauv cov theem mob ceev;
- ketoacidosis;
- daim siab ua haujlwm siab;
- plawv nres;
- ua ntej thiab tom qab kuaj cov duab hluav taws xob nrog kev qhia ntawm kev sib piv;
- ua ntej thiab tom qab phais kev cuam tshuam;
- hnub nyoog siab heev;
- malabsorption B12.
Kho ntshav qab zib
Yav dhau los, Metformin tau siv tshwj rau kev kho mob ntshav qab zib. Cov kev tshawb fawb pom tau tias cov tshuaj lag luam nthuav tawm lwm yam khoom. Nws yog siv rau polycystic zes qe menyuam, rog rog, thiab rau kev tiv thaiv mob ntshav qab zib.
Tseem, lub ntsiab tseem ceeb ntawm metformin yog kev kho mob ntshav qab zib hom 2. Nws txo cov ntshav qab zib ntau ntau thiab gluconeogenesis, pes tsawg txo triglycerides thiab LDL, thiab me ntsis kev qab los noj mov. Txo cov kua nplaum nyob rau ntawm lub plab khoob thiab tom qab noj mov. Nqaij cov leeg nqaij tau txais ntau dua cov piam thaj vim tias nce ntxiv hauv nws txoj kev noj. Qhov nqus ntawm cov piam thaj hauv cov zom plab yog qhov txo tsawg.
Cov tshuaj tsis txhawb kev tsim tawm ntawm lub cev. Cov nyhuv suab thaj yog ua tiav los ntawm kev txhim kho qhov nqus ntawm cov piam thaj los ntawm cov ntaub so ntswg. Thaum kho nrog Metformin, kev xav tau cov tshuaj insulin txo qis. Lub cuab tam txo cov kev pheej hmoo ntawm cov teeb meem thiab kev ploj tuag los ntawm kwv yees li 35% piv nrog lwm cov tshuaj hypoglycemic thiab insulin txhaj.
Kev nce qib hauv cov ntshav qabzib tas li yog qhov txaus ntshai rau cov hlab plawv. Ib hom scum ntawv ntawm phab ntsa ntawm cov hlab, microcirculation tau ntxhov. Txij ntawm no muaj qhov txhab ntawm lub qhov muag, cov hlab ntshav ntawm lub paj hlwb thiab lub siab, cov hlab ntsha ntawm ob txhais ceg thiab cov zoo li.
Thaum noj cov tshuaj, muaj zog hypoglycemic nyhuv tsis pom. Ua raws li theem ntawm cov piam thaj thiab nres glycemia, tus neeg mob yuav tsum tau haus lwm yam ntxiv. Tab sis thaum tau muab tshuaj rau noj, nws muaj peev xwm txo qis kev pheej hmoo ntawm cov kab mob plawv los ntawm ib feem peb.
Metformin tsis ua rau kev txhim kho ntshav qab zib thaum noj qhov raug. Nws tau pom hauv qee qhov xwm txheej tsawg kawg nrog kev tawm dag zog ntawm lub cev lossis kev siv cov tshuaj nrog lwm tus neeg mob hypoglycemic. Hauv cov neeg mob noj qab nyob zoo, nws tsis txo qis piam thaj.
Lub cev laus
Raws li tau hais los saum no, Elena Malysheva tau hais hauv nws txoj haujlwm tias Metformin inhibits kev laus. Nws kuj tau hais txog qhov tuaj yeem ncua lub neej tag nrho thiab lub neej zoo. Tam sim no nyob rau hauv ntau dua kom meej txog cov ntaub ntawv.
"Laus" yog cov paj lug paj lug. Nws txhais tau tias ua ntej laus los ntawm tus kab mob. Hauv lwm lo lus, qhov no yog lub hnub nyoog lom ntawm lub cev, uas tsis raug rau lub cim hauv daim ntawv hla tebchaws.
Nyob rau txoj haujlwm "Noj Qab Nyob Zoo", ib qho kab ke raug teeb tsa raws hluav taws xob nplai, uas ntsuas hnub nyoog roj ntsha.
Lub ntsiab ntawm kev laus li no yog nce qib siab ntawm cov piam thaj hauv cov ntshav. Raws li qhov tshwm sim, cov roj ntsha muaj suab thaj (qhov no suav nrog cov nqaij ntshiv ntawm daim tawv nqaij), uas ua rau kev tsim cov tawv nqaij. Cov kab nrib pleb tsim nyob rau hauv cov hlab ntsha nyob rau hauv tus ntawm nce qab zib.
Los ntawm 1 lub suab thaj molecule, 2 triglyceride lwg me me tau, i.e. rog. Cov rog rog sib sau ua ke hauv cov kab nrib pleb, sib sau cov lus sib hu ua atherosclerotic plaques. Cov tshuaj yog tsim los nres cov txheej txheem no uas tshwm sim hauv cov hlab.
Thoob plaws hauv lub xyoo pua 20, ntau cov kev tshawb fawb txog cov tshuaj tau tshwm sim. Thaum kawg ntawm 2015, kev tshawb fawb txog kev tshawb fawb (kav ntev 25 xyoos) ntawm Metformin hauv University of Askiv tau ua tiav.
Cov uas tuaj koom kev tshawb nrhiav yog cov neeg muaj ntshav qab zib hom 2 zoo tshaj. Raws li kev twv, lawv tsuas muaj 8 xyoo nyob xwb. Tab sis tsis muaj leej twg tuag thaum sim. Lawv xaus lus tias cov tshuaj ncaj qha thawb qhov pib ntawm kev tuag thiab laus tuag.
Video nrog tshuaj xyuas ntawm Dr. Malysheva txog Metformin:
Ua rau lub cev hnyav
Metformin tsis cuam tshuam rau qhov hnyav dua li piv nrog sulfonylureas. Ntawm qhov tsis sib xws, nws yog siv hauv kev kho mob nyuaj rau kev rog. Nws tau pom tias cov tshuaj txo cov rog tsawg.
Kev noj qab haus huv rau cov neeg muaj piam thaj tsis txaus siab uas xav kom poob ceeb thawj tuaj yeem noj tshuaj. Kev noj haus ib txwm tshem tawm qhov nruab nrab ntawm 2.5-3 kg thiab txo cov zaub mov noj kom tsawg. Hauv cov neeg muaj kev noj qab haus huv, cov tshuaj tsis txo cov ntshav qab zib, yog li nws tuaj yeem siv rau hauv cov koob tshuaj me ntsis.
Malysheva program hais tias Metformin ua hauj lwm zoo rau poob phaus.
Daim ntawv thov rau polycystic ovary
Metformin yog ib hom tshuaj pab uas siv los kho cov mob muaj pob txha tsis tau zoo. Qee cov kws tshaj lij pom zoo siv nws ua cov tshuaj thib ib-kab, lwm tus ua kab thib ob.
Nws stimulates ovulation thiab pab tus poj niam cev xeeb tub. Thiab raws li koj paub, polycystic ovary yog endocrinological pathology ua rau ntxiv lawm tshob. Tus poj niam muaj tshuaj tiv thaiv insulin.
Yog li, Metformin yog qhov tseem ceeb rau kev kho tus mob no. Nws yog tshuaj hauv kev tswj hwm nrog cov tshuaj hormones thiab lwm yam tshuaj.
Sab sij huam
Nrog rau txhua qhov zoo ntawm cov tshuaj, koj yuav tsum tsis txhob tam sim ntawd mus rau lub tsev muag tshuaj. Nws noj rau cov mob thiab raws li kws kho mob tau sau tseg. Ua ntej tshaj plaws, nws yog ib qho tseem ceeb kom nkag siab tias Metformin yog tshuaj siv. Thiab ib qho tshuaj twg, raws li koj paub, ua rau muaj kev mob tshwm sim.
Qhov tshwm sim feem ntau cov kev tsis zoo tshwm sim yog qhov qhia tau ntawm txoj hnyuv plab hnyuv. Xeev siab pib, ib xim hlau tshwm rau hauv qhov ncauj, chim quav. Cov tshuaj yuav cuam tshuam nrog kev nqus ntawm B12, uas ua rau kom muaj kev sib koom tes tsis zoo thiab nco qab.
Ib qhov tsawg kawg tab sis muaj kev tuag tshwm sim ntawm kev siv cov tshuaj Metformin yog cov kab mob lactic acidosis, ib rooj plaub tshwm sim rau 10 txhiab.
Txawm li cas los xij, kev ceev faj yuav tsum tau ua:
- kev pub nkag yog tso cai rau lub raum kom zoo thiab txoj haujlwm ua haujlwm ntawm glomerular pom;
- tsis tau muab rau cov neeg qub;
- creatinine qib yuav tsum tsis pub dhau ib txwm muaj;
- nrog rau kev pw hauv tsev kho mob, txais tos kom nres, tshwj xeeb tshaj yog kev tshawb nrhiav xoo hluav taws xob.
Metformin muaj ntau qhov kev zoo hauv nws cov kev kho mob, tab sis nws tsis yog qhov meej pem panacea. Nws yog coj raws li kws kho mob tau sau tseg thiab rau kev kho mob. Tab sis yog tias ib tus neeg tau kuaj mob ntshav qab zib, kev noj tshuaj yog qhov xav tau thiab siv tau zoo.
