Metformin hydrochloride yog ib yam khoom ua si uas muaj suab npe txo suab thaj. Cov tshuaj no feem ntau tau sau tseg ua ib feem ntawm txoj kev kho mob ntshav qab zib hom 2.
Muaj kev txheeb xyuas qhov zoo txog kev siv cov ntsiav tshuaj rau endocrine hom 1 pathology raws li kev ntxiv rau cov tshuaj insulin.
Qhov zoo tshaj plaws ntawm kev noj tshuaj thiab ntau zaus ntawm Metformin rau cov ntshav qab zib rau ib tus neeg mob tshwj xeeb yog txiav txim los ntawm tus kws endocrinologist, suav nrog ntau yam.
Pharmacological pawg
Metformin yog cov tshuaj siv hluavtaws nrog cov nyhuv hypoglycemic. Cov tshuaj tiv thaiv kab mob hauv lub qhov ncauj tau siv rau hauv kev kho mob ntawm hom 2 endocrine pathology, tsawg dua ntau zaus - ntxiv rau insulin tswj hwm. Qhov tseem ceeb ntawm kev sib kis yog qhov txo qis hauv cov ntshav qab zib.
Kev kho mob kom zoo ntawm Metformin
Qhov cuam tshuam rau lub cev nrog cov tsis muaj tshuaj insulin-mob ntshav qab zib yog ib qho zoo ntawm kev siv tshuaj zoo. Cov tshuaj nquag tsis tsuas yog tswj cov ntshav qab zib, tab sis kuj tseem ua cov lipid metabolism. Cov tshuaj qaug zog cuam tshuam rau kev ua haujlwm ntawm lub txiav (ua kom pom qhov txawv ntawm cov nyhuv ntshav qab zib), qhov txo qis hauv cov piam thaj hauv lub ntsej muag yog xyaum cais tawm.
Tom qab noj cov tshuaj Metformin, lub cev ua rau cov tshuaj tiv thaiv kev tiv thaiv zoo:
- tus nqi ntawm cov kua nplaum tsim los ntawm lipids thiab cov protein yog txo;
- ntaub so ntswg rhiab rau insulin nce;
- glycogen los ntawm daim siab ua haujlwm tso tawm qeeb dua, cov ntshav qab zib cov ntshav rov qab mus rau qhov qub;
- cov leeg nqaij ua kom muaj qabzib cov dej qabzib ntau;
- kev tawm ntawm cov cholesterol tsis zoo yog kho kom zoo, cov metabolism hauv rog yog qhov qub;
- kev nqus ntawm cov piam thaj los ntawm txoj hnyuv yog qhov ua haujlwm tsawg dua;
- hauv cov hnyuv muaj kev hloov ua kom zoo dua ntawm cov piam thaj.
Ntau tshaj 50% ntawm cov neeg mob uas muaj tshuaj tiv thaiv insulin thiab tsis txaus insulin ntau lawm tau txais cov nyhuv hypoglycemic.
Cov lus qhia rau kev teem caij
Cov tshuaj Metformin yog ib qho tseem ceeb hauv kev kho mob rau cov ntshav qab zib tsis yog-insulin (hom pathology 2).
Tshuaj Metformin hydrochloride-kuj tseem siv rau hom 1 ntawm endocrine los tswj cov ntshav qabzib, ntxiv rau cov tshuaj insulin.
Lwm qhov ntsuas:
- txoj kev kho cov rog ntawm cov keeb kwm ntawm insulin tsis kam;
- polycystic zes qe menyuam mob;
- nrog ntshav qab zib cov ntshav ntawm lub plab khoob;
- hauv kev ua kis las tshuaj;
- nrog qhov txo qis hauv cov kua dej siab ntev.
Tsuas tshuaj
Cov chaw lag luam kws tshuaj muaj ob hom tshuaj Metformin:
- lub caij nyoog;
- zoo tib yam.
Cov ntsiav tshuaj muaj qhov sib txawv ntau npaum - los ntawm 500 txog 1000 mg. Ntau cov tshuaj tiv thaiv kab mob ua ke kuj muaj cov tshuaj ua kom nquag plias, tab sis ua kom tsawg dua.
Tus kws kuaj mob endocrinologist tau xaiv qhov zoo tshaj plaws hauv kev txiav txim siab txog qib ntshav qabzib hauv cov ntshav thiab hom ntshav qab zib. Qhov yuav tsum tau ua kom tau txiaj ntsig zoo tshaj plaws rau kev txo qis qab zib yog 500 mg. Nrog rau qhov kev pheej hmoo siab ntawm hyperglycemia, raws li kws kho mob tau hais tseg, koj tuaj yeem nce cov txiaj ntsig ntawm metformin hydrochloride rau 2 g.
Mob ntshav qab zib Hom 2
Metformin yog qhov tseem ceeb hypoglycemic. Qhov nruab nrab ntau npaum li cas txhua hnub yog 0.5 lossis 0.85 g, qhov ntau npaum li cas yog 1 ntsiav tshuaj.
Nrog rau kev txhim kho mob plab zom mov lossis xeev siab, siv cov tshuaj nrog zaub mov, zoo tom qab noj mov, haus dej nrog dej.
Nrog txoj kev ua kom tsis muaj zog, hauv kev pom zoo nrog tus kws kho mob, koj tuaj yeem nce cov tshuaj rau niaj hnub rau 2 g.
Cov khoom noj carbohydrate metabolism rov zoo li qub tom qab ob rau peb lub lis piam. Nrog rau qhov txo qis hauv theem ntawm hyperglycemia, ntau npaum li cas yog txo qis. Kev kho ntawm cov naj npawb ntawm cov ntsiav tshuaj thiab kev tso cai txhua hnub yog tso cai raws li tus kws kho mob hauv endocrinologist.
Tseem ceeb nuances:
- nrog metabolic syndrome tawm tsam cov ntshav qab zib, koj tuaj yeem tau txais cov ntsiav tshuaj raws li metformin hydrochloride ua rau cov metabolism hauv qhov qub, txo qis triglycerides, txo qis ncov hyperglycemia tom qab noj mov;
- ua ke nrog sulfonylurea kev npaj kho txhim kho cov metabolism hauv 60% ntawm cov neeg mob. Cov theem ntawm glycemia txo qis - qab zib qhov tseem ceeb poob los ntawm 20-40%. Sij hawm dhau mus, lub cev tau siv rau qhov kev txiav txim ntawm cov tshuaj nrog sulfonylurea. Metformin ua kom tsawg kom muaj lipid metabolism hauv ruaj ntseg thiab pom cov ntshav qab zib kom zoo.
Yam 1 ntshav qab zib
Cov tshuaj feem ntau tau sau tseg rau hom 2 pathology, tab sis ntau tus kws kho mob ntxiv kev txhaj tshuaj ntawm insulin nrog Metformin.
Cov nyhuv cuam tshuam ua kom tus neeg mob tus mob.
Kev nce ntawm insulin ntau ntxiv tom qab txhaj tshuaj, ua ke nrog kev txo qis hauv cov piam thaj, txo qhov kev pheej hmoo ntawm cov teeb meem hauv insulin-hom mob.
Kev siv tshuaj tiv thaiv kev ua kom zoo (kev txhaj tshuaj ntawm insulin thiab metformin hydrochloride) txo qhov xav tau cia cov tshuaj hormones los ntawm 20% lossis ntau dua. Cov kev ntsuam xyuas feem ntau pom tias muaj kev txhim kho hauv cov metabolism hauv cov metabolism.
Yuav siv Metformin los tiv thaiv ntshav qab zib?
Cov kws kho mob Asmeskas thaum xaus ntawm lub xyoo pua 20 tau ua qhov kev tshawb fawb loj los kawm txog qhov tshwm sim ntawm tus neeg sawv cev hypoglycemic nrog cov teebmeem ntawm lub cev tsis zoo.
Cov neeg mob uas pheej hmoo raug caw tuaj koom: nrog kev tiv thaiv tsis muaj qabzib thiab paub tseeb tias mob ntshav qab zib.
Ntau tus neeg raug kev txom nyem los ntawm kev rog, yws ntawm cov ntshav siab, lub plawv muaj teeb meem, kev sim pom tau hais tias muaj feem cuam tshuam ntawm cov triglycerides thiab cov "cholesterol" phem.
Kev ntsuas tshwj xeeb thiab kev ntsuas tau ua ntawm 27 chaw. Cov neeg mob tau txais Metformin ib hnub ob zaug ntawm 850 g rau peb lub xyoos. Cov kev tshawb fawb pom tau tias: kev siv tshuaj kho mob, nrog rau kev txhim kho txoj kev ua neej thiab kev noj zaub mov zoo, txo kev tuag ntawm kev mob plawv.
Cov tshuaj tiv thaiv kev tiv thaiv yeeb tshuaj pom tau tias qhov ua tau zoo tshaj plaws thiab kev tshaj tawm cov ntshav qab zib muaj txiaj ntsig nrog lub siab cov ntshav qab zib hauv cov neeg muaj rog rog. Txawm hais tias kev ua neej zoo li niaj hnub no, kev muaj peev xwm txhim kho cov hom kabmob ntshav qab zib-hom mob ntshav qab zib tsawg dua 30%. Cov txiaj ntsig ntawm txoj kev kho mob thaum noj zaub mov, qhov nce ntawm lub cev muaj zog, thiab qhov txo qis hauv kev tsis txaus siab tseem muaj ntau dua: hauv 58% ntawm cov neeg muaj kev pheej hmoo, cov piam thaj nyob ruaj khov.
Cov Yuav Tsum Muaj
Tsis zoo li lwm hom tshuaj tiv thaiv kab mob, Metformin thiab nws cov lus txhais muaj tsawg dua kev txwv:
- tus me nyuam muaj hnub nyoog txog 10 xyoo;
- tau raug mob hnyav thiab khiav haujlwm hnyav;
- keeb kwm ntawm cov kab mob lactic acidosis;
- lactation lub sijhawm;
- cov calorie kom tsawg hauv qab 1000 kcal ib hnub: muaj kev pheej hmoo ntawm metabolic acidosis;
- lub raum tsis ua haujlwm;
- daim siab mob siab;
- cov kab mob plawv;
- cev xeeb tub
- cov mob uas tiv thaiv tus kab mob lactic acidosis tau.
Cov lus qhia tshwj xeeb
Thaum kho nrog Metformin, nws yog ib qho tseem ceeb kom paub: lub siab siab ntawm cov tshuaj tiv thaiv nquag tsis ua rau cov ntshav qog ntshav qab zib, tab sis nrog kev siv tshuaj ntau dhau, nws muaj peev xwm tsim kom muaj kev phom sij - lactic acidosis. Tus mob ntshav qab zib thiab cov neeg txheeb ze ntawm tus neeg mob yuav tsum paub cov cim ntawm tus kab mob hloov pauv kom sai hu rau lub tsheb thauj neeg mob ceev kom nws tau mus pw hauv tsev kho mob sai.
Cov duab kab mob nrog kev txhim kho ntawm cov kab mob lactic acidosis:- pa ceev heev;
- zawv plab
- kev mob siab qis;
- xeev siab
- mob plab heev;
- ntuav
- mob leeg nqaij;
- tsis nco qab.
Analogs
Metformin hydrochloride yog ib feem ntawm ntau yam tshuaj. Cov chaw lag luam kws tshuaj muab tshuaj nrog cov tshuaj sib xyaw hauv cov npe sib txawv rau cov chaw muag tshuaj. Qhov sib txawv ntawm cov pabcuam ntu tsis muaj feem cuam tshuam rau cov txheej txheem hauv lub cev.
Cov npe siv tau zoo raws li metformin hydrochloride:
- Rau menyuam yaus.
- Ntsia hauv qab.
- Metospanin.
- Glycomet.
- Siofor.
- Glyminfor.
- Novoformin.
- Vero-Metformin.
- Bagomet.
- Dianormet thiab lwm tus.
Kev tshuaj xyuas ntawm Metformin thiab nws cov analogues paub meej tias lub qog ntshav hypoglycemic nyob hauv hom 2 mob ntshav qab zib.
Cov txiaj ntsig zoo ntawm kev kho nrog ib hom tshuaj insulin-tiv thaiv kab mob ntawm pathology kuj tau ua pov thawj. Raws li kev niaj hnub, kev tsis zoo tshwm sim muaj tsawg feem pua ntawm cov neeg mob. Kev yuav siv tau tus nqi (ntawm 110 txog 190 rubles, ntim No. 30 thiab No. 60) yog qhov muaj txiaj ntsig zoo tshaj nrog qhov kev kho mob ntev.
