Cov tshuaj Insulin Protafan: cov qauv (cov nqi), cov lus qhia, tshuaj xyuas

Protafan insulin yog hais txog qhov nruab nrab ntawm tib neeg lub cev insulin.

Qhov yuav tsum tau siv cov tshuaj Insulin Protafan NM mem hluav yuav tshwm sim nrog ntau yam kab mob thiab xwm txheej. Ua ntej tshaj plaws, nrog hom 1 thiab hom 2 mob ntshav qab zib. Tsis tas li ntawd, cov tshuaj tau qhia nyob rau theem ntawm kev tsis kam mus rau thawj zaug tshuaj hypoglycemic.

Cov tshuaj no tseem siv nrog kev sib txuas ua ke (ib feem ntawm kev tiv thaiv kab mob hauv lub qhov ncauj hypoglycemic) yog tias kuaj ntshav qab zib hauv cov poj niam cev xeeb tub thiab yog tias kev noj zaub mov tsis pab;

Cov kab mob sib kis thiab kev phais mob (kev sib xyaw ua ke lossis kho mob monotherapy) kuj tseem yog lub laj thawj ntawm kev teem caij.

Kuv tuaj yeem hloov pauv tshuaj, yeeb tshuaj licas

1. Insulin Bazal (tus nqi kwv yees 1435 rubles);
2. Humulin NPH (tus nqi kwv yees 245 rubles);
3. Protafan NM (tus nqi kwv yees 408 rubles);
4. Aktrafan NM (nqe hais txog
5. Protafan NM Penfill (nqe kwv yees li 865 rubles).

Cov yam ntxwv ntawm cov tshuaj

Cov tshuaj yog ncua kev qhia hauv qab daim tawv nqaij.

Pawg, cov khoom uas nquag:

Isulin insulin-tib neeg semisynthetis (tib neeg semisynthetic). Nws muaj lub sijhawm ua haujlwm nruab nrab. Protafan NM yog contraindicated nyob rau hauv: insulinoma, hypoglycemia thiab hypersensitivity rau yam tshuaj nquag.

Yuav noj li cas thiab haus li cas?

Cov tshuaj insulin raug txhaj ib zaug lossis ob zaug ib hnub, ib nrab teev ua ntej noj tshais. Ntawm qhov chaw no, qhov twg txhaj tshuaj yuav raug, nws yuav tsum tau hloov tas li.

Cov koob tshuaj yuav tsum tau xaiv rau txhua tus neeg mob ib tus zuj zus. Nws qhov ntim nyob ntawm seb cov piam thaj hauv cov zis thiab ntshav txaus, ntxiv rau qhov yam ntxwv ntawm chav kawm ntawm tus kab mob. Yeej, qhov tshuaj yog muab 1 lub sijhawm toj ib hnub thiab yog 8-24 IU.

Hauv cov menyuam yaus thiab cov neeg laus uas muaj qhov mob siab txog insulin, qhov koob tshuaj tau raug txo mus rau 8 IU ib hnub. Thiab rau cov neeg mob uas tsis tshua muaj siab zoo, tus kws kho mob koom nrog yuav muab tshuaj ntau dua 24 IU nyob rau ib hnub. Yog tias qhov koob tshuaj txhua hnub ntau dua li 0.6 IU rau ib kg, tom qab ntawd cov tshuaj raug muab los ntawm ob qhov kev txhaj tshuaj, uas tau ua nyob hauv ntau qhov chaw.

Cov neeg mob uas tau txais 100 IU lossis ntau dua toj ib hnub, thaum hloov cov tshuaj insulin, yuav tsum tau saib xyuas tas li los ntawm cov kws kho mob. Hloov cov tshuaj nrog rau lwm qhov yuav tsum tau ua nrog kev soj ntsuam tsis tu ncua ntawm cov piam thaj hauv ntshav.

Cov chaw muag tshuaj

Cov khoom ntawm Insulin Protafan:

• txo qis kom ntshav qabzib ntau ntxiv;
• txhim kho kev nqus ntawm cov piam thaj hauv cov ntaub so ntswg;
• pab txhawb kev txhim kho protein synthesis zoo dua;
• lowers tus nqi ntawm cov piam thaj tsim tawm los ntawm lub siab;
• txhim kho glycogenogenesis;
• txhim kho lipogenesis.

Microinteraction nrog receptors nyob rau sab nraud cell membrane txhawb txoj kev tsim ntawm insulin receptor complex. Los ntawm kev tsim kho hauv lub siab ua haujlwm thiab cov roj ntsha, ua haujlwm ua ke ntawm CAMP lossis nkag mus rau hauv cov leeg nqaij lossis cell, insulin receptor complex ua rau cov txheej txheem uas tshwm sim hauv cov hlwb.

Nws kuj tseem pib ua ke ntawm qee cov enzymes tseem ceeb (glycogen synthetase, hexokinase, pyruvate kinase, thiab lwm yam).

Qhov txo qis hauv cov piam thaj hauv ntshav tshwm sim los ntawm:

• cov piam thaj ntau ntxiv hauv cov hlwb;
• kev txhawb nqa glycogenogenesis thiab lipogenesis;
• nce kev nqus thiab nqus ntawm cov piam thaj los ntawm cov ntaub so ntswg;
• protein synthesis;
• txo qis rau hauv tus nqi ntawm cov piam thaj ntau lawm los ntawm daim siab, i.e. kev txo qis hauv kev puas tsuaj ntawm glycogen thiab li ntawd.

Thaum twg cov tshuaj ciali tuaj rau hauv thiab ntev li cas nws yuav kav?

Tam sim ntawd qhov kev nthuav tawm ntawm qhov kev ncua raug tshem tawm, cov nyhuv tsis tshwm sim. Nws pib ua nyob rau hauv 60 - 90 feeb.

Cov txiaj ntsig siab tshaj plaws tshwm sim thaum 4 txog 12 teev. Lub sijhawm ua ntawm 11 mus rau 24 teev - nws tag nrho nyob ntawm qhov koob tshuaj thiab kev sau ntawm insulin.

Sab sij huam

Kev mob ntshav siab (qhov muag tsis pom kev thiab hais lus, pallor ntawm daim tawv nqaij, tsis meej pem txav, nce hws, coj tus cwj pwm txawv, palpitations, voos, tshee, kev nyuaj siab, nce ntxiv, ntshai, ntxhov siab, insomnia, ntxhov siab, nkees nkees, hauv plab lub qhov ncauj, mob taub hau ;

Kev tsis haum tshuaj (kev ua kom tsis muaj ntshav txaus, tso zis, mob ua tsis taus pa, ua npaws, mob hlwb);

Ib qho kev nce ntxiv ntawm titer ntawm cov tshuaj tiv thaiv kev tiv thaiv insulin nrog kev nce ntxiv ntawm glycemia;

Mob ntshav qab zib acidosis thiab hyperglycemia (tawm tsam keeb kwm yav dhau los ntawm kev kis tus kab mob thiab kub taub hau, tsis muaj zaub mov noj, plhaw txhaj tshuaj, tsis tshua muaj kev txhaj tshuaj): lub ntsej muag yaug, tsaug zog, tsis qab los noj mov, nqhis dej tas li);

Qog ntshav txias hypoglycemic;

Nyob rau theem pib ntawm kev kho - kho tsis raug thiab edema (qhov tshwm sim ib ntus uas tshwm sim nrog kev kho ntxiv);

Kev tsis nco qab ntawm qhov tsis nco qab (qee lub sijhawm tsis xeev rov qab thiab lub xeev precomatose nthuav dav);

Ntawm qhov chaw txhaj tshuaj, khaus, hyperemia, lipodystrophy (hypertrophy lossis atrophy ntawm cov roj ntsha subcutaneous);

Thaum pib ntawm kev kho yog ib qho kev pom tsis paub dhau los;

Hla kev tiv thaiv kab mob nrog tib neeg cov tshuaj insulin.

Cov tsos mob ntawm kev overdose:

• cramps
• tawm hws;
• hypoglycemic coma;
• palpitations
• insomnia
• tsis pom kev thiab hais lus;
• tshee hnyo
• tangled tsiv;
• tsaug zog
• nce kev qab los noj mov;
• tus cwj pwm coj txawv txawv;
• Ntxhov siab vim
• txob taus
• paresthesia nyob rau hauv lub qhov ncauj kab noj hniav;
• Kev Nyuaj Siab
• pallor
• ntshai
• mob taub hau.

Yuav kho tus overdose li cas?

Yog hais tias tus neeg mob nyob hauv lub xeev tsis nco qab lawm, ces tus kws kho mob tau sau ntawv dextrose, uas tau muab tshuaj los ntawm ib tug neeg mob plab, intramuscularly lossis intravenously. Glucagon lossis hypertonic dextrose kev daws teeb meem tseem tau muab tshuaj ntxiv ib leeg.

Tus mob hypoglycemic coma, 20 txog 40 ml, i.e. 40% dextrose kev daws teeb meem kom txog rau thaum tus neeg mob tawm ntawm qhov tsis nco qab.

Cov lus qhia tseem ceeb:

1. Ua ntej koj siv tshuaj insulin los ntawm lub pob, koj yuav tsum xyuas tias cov tshuaj hauv lub raj mis muaj cov xim pob tshab. Yog tias clouding, nag lossis daus los yog lub cev txawv teb chaws pom, qhov kev daws teeb meem raug txwv.
2. Qhov kub ntawm cov tshuaj ua ntej kev tswj hwm yuav tsum yog chav kub.
3. Thaum muaj kev kis mob, ua haujlwm ntawm lub qog ua haujlwm tsis zoo, Addiosn tus kab mob, mob raum tsis ua haujlwm, mob hypopituitarism, nrog rau cov neeg mob ntshav qab zib thaum muaj hnub nyoog laus, cov koob tshuaj insulin yuav tsum tau kho tus kheej.

Cov laj thawj ntawm kev ua ntshav siab tuaj yeem yog:

• noj ntau dhau
• ntuav
• hloov yeeb tshuaj;
• cov kab mob uas txo qis qhov xav tau ntawm insulin (mob siab thiab mob raum, hypofunction ntawm cov thyroid caj pas, pituitary, adrenal cortex);
• tsis ua raws kev noj mov;
• sib cuam tshuam nrog lwm yam tshuaj;
• zawv plab
• lub cev overvoltage;
• hloov chaw txhaj tshuaj.

Thaum hloov ib tus neeg mob los ntawm tsiaj cov tshuaj insulin rau tib neeg cov insulin, qhov kev txo qis hauv cov ntshav qab zib yuav tshwm sim. Kev hloov mus rau tib neeg cov kua dej yuav tsum tau ua raws li kev kho mob, thiab nws yuav tsum tau ua raws li kev saib xyuas nruj ntawm kws kho mob.

Thaum lub sijhawm thiab tom qab yug menyuam, xav tau cov tshuaj insulin tuaj yeem txo qis. Thaum lub sijhawm lactation, koj yuav tsum saib xyuas koj niam ntau lub hlis, kom txog thaum xav tau cov tshuaj insulin.

Ib qho kev xav ua ntej rau kev nce qib ntawm cov ntshav qog tuaj yeem ua rau tsis zoo rau lub peev xwm ntawm tus neeg mob tsav tsheb thiab tswj kev txhim kho thiab cov tshuab thiab tshuab.

Los ntawm kev siv cov piam thaj lossis zaub mov ntau hauv cov carbohydrates, cov neeg mob ntshav qab zib tuaj yeem nres ib hom mob ntshav qab zib tsawg. Nws raug nquahu tias tus neeg mob ib txwm muaj tsawg kawg 20 g suab thaj nrog nws.

Yog tias txo lub qog ntshav qab zib tau raug ncua, nws yog qhov yuav tsum tau ceeb toom rau tus kws kho mob uas yuav kho qhov hloov kho.

Thaum cev xeeb tub, qhov yuav tsum tau txo qis (1 hlis) lossis nce ntxiv (2-3 trimesters) ntawm lub cev xav tau cov tshuaj insulin yuav tsum raug txiav txim siab.

Kev cuam tshuam nrog lwm yam tshuaj

Kev tiv thaiv tus mob ntshav qab zib tau nce los ntawm:

• MAO inhibitors (selegiline, furazolidone, procarbazine);
• sulfonamides (sulfonamides, hypoglycemic qhov ncauj tshuaj);
• NSAIDs, ACE inhibitors thiab salicylates;
• anabolic steroids thiab methandrostenolone, stanozolol, oxandrolone;
• carbonic anhydrase inhibitors;
• ethanol;
• androgens;
• chloroquine;
• bromocriptine;
• quinine;
• tetracyclines;
• quinidine;
• clofribate;
• pyridoxine;
• ketoconazole;
• Li + npaj;
• mebendazole;
• theophylline;
• fenfluramine;
• cyclophosphamide.

Kev mob ntshav siab ntshav qis yog los ntawm:

1. H1 blockers - vitamin receptors;
2. glucagon;
3. epinephrine;
4. somatropin;
5. phenytoin;
6. GCS;
7. nicotine;
8. qhov ncauj tiv thaiv;
9. tshuaj maj;
10. estrogens;
11. morphine;
12. voj thiab thiazide diuretics;
13. diazoxide;
14. BMKK;
15. calcium antagonists;
16. cov thyroid hormones;
17. clonidine;
18. heparin;
19. tricyclic cov tshuaj tiv thaiv kab mob;
20. sulfinpyrazone;
21. danazole;
22. sympathomimetics.

Tseem muaj cov tshuaj uas tuaj yeem ua rau ob qho ua kom tsis muaj zog thiab txhim kho cov nyhuv glycemic ntawm insulin. Cov no suav nrog:

• pentamidine;
• beta-blockers;
• octreotide;
• reserpine.