Cov tshuaj hauv tebchaws Glimepiride (INN) los ntawm cov tuam txhab pharmacological Pharmstandard zoo txo cov ntshav glycemia hauv cov neeg mob uas muaj tus mob 2 hom mob ntshav qab zib mellitus.
Tshwj xeeb, tus neeg sawv cev rau kev tiv thaiv kab mob pab nrog kev ua kom tsis txaus ntawm kev noj zaub mov noj, qoj ib ce thiab poob phaus. Zoo li txhua yam tshuaj, glimepiride muaj qee yam kev qhia ntawm kws tshuaj uas tus kws kho mob thiab tus neeg mob yuav tsum paub txog.
Lub npe Latin ntawm cov cuab yeej no yog Glimepiride. Lub ntsiab tseem ceeb ntawm cov tshuaj yog cov pab pawg ntawm sulfonylureas. Cov chaw tsim khoom tseem ntxiv cov khoom ntxiv me me rau cov khoom lag luam: cov piam thaj mis (lactose), microcrystalline cellulose, sodium lauryl sulfate, pregelatinized hmoov txhuv nplej siab, magnesium stearate thiab qee qhov doog.
Tus kws tsim tshuaj tsim cov tshuaj tiv thaiv kab mob rau hauv cov qauv tshuaj (1 ntsiav tshuaj muaj 1, 2, 3 lossis 4 mg ntawm glimepiride).
Cov tshuaj tau noj ntawm qhov ncauj, ntxuav nrog ib qhov me me ntawm cov dej. Tom qab nkag mus rau tib neeg lub cev, cov ntsiab lus siab tshaj plaws ntawm cov tshuaj nquag tau mus txog hauv thaj tsam li 2.5 teev. Noj xyaum tsis cuam tshuam rau qhov nqus ntawm glimepiride.
Cov khoom tseem ceeb ntawm cov khoom siv sib txuam tau pom raws li hauv qab no:
- Txhawb kev tsim cov piam thaj txo qis cov tshuaj hormones los ntawm beta hlwb ntawm islets ntawm Langerhans.
- Cov lus teb zoo dua ntawm cov qe hlwb rau lub zog kev ua kom zoo ntawm cov piam thaj. Nws yuav tsum raug sau tseg tias tus nqi ntawm cov tshuaj insulin ua yog qhov tseem ceeb tshaj li nyob hauv qab ntawm cov tshuaj ib txwm muaj - sulfonylurea derivatives.
- Kev txwv tsis pub cov piam thaj tso tawm los ntawm lub siab thiab txo qis kev nqus ntawm cov piam thaj txo cov tshuaj hormones los ntawm lub siab.
- Ua rau muaj kev cuam tshuam ntau ntxiv ntawm cov phiaj hlwb ntawm adipose thiab cov leeg nqaij mus rau qhov cuam tshuam ntawm insulin.
- Glimeperid nce cov ntsiab lus ntawm endogenous alpha-tocopherol, qhov kev ua ntawm glutathione peroxidase, catalase, thiab superoxide dismutase. Qhov no ua rau txo qis hauv kev txhim kho oxidative kev nyuaj siab, uas ib txwm muaj nrog tus mob ntshav qab zib hom 2.
- Xaiv inhibition ntawm cyclooxygenase, nrog rau kev txo qis ntawm kev hloov pauv ntawm thromboxane A2 los ntawm arachidonic acid. Txoj kev no muaj cov nyhuv antithrombotic.
- Kev kho cov lipid ntau ntau thiab ua rau lub ntsej muag txo qis ntawm malondialdehyde hauv cov ntshav ntshav. Cov txheej txheem ob no ua rau lub zog tiv thaiv atherogenic ntawm cov tshuaj.
Ib feem peb ntawm cov metabolites ntawm glimepiride yog ua tawm los ntawm txoj hnyuv, thiab ob feem peb yog tawm los ntawm lub raum.
Hauv cov neeg mob uas muaj mob raum, tshem tawm ntawm glimepiride nce thiab qhov kev xav ntawm nws qhov nruab nrab hauv cov ntshav cov ntshav tsawg zuj zus.
Cov lus qhia rau kev siv ntsiav tshuaj
Daim ntawv yuav tshuaj los ntawm tus kws kho mob tshwj xeeb yog qhov mob tseem ceeb uas koj tuaj yeem yuav cov tshuaj Glimepiride. Thaum mus yuav tshuaj, nws yog kev coj mus mloog kom zoo rau cov lus piav qhia hauv daim ntawv qhia nrog daim ntawv qhia.
Qhov ntau npaum ntawm cov tshuaj thiab lub sijhawm kho yog txiav txim los ntawm tus kws kho keeb, raws li qib glycemia ntawm tus neeg mob thiab nws lub xeev kev noj qab haus huv. Thaum noj Glimepiride, cov lus qhia rau kev siv muaj cov ntaub ntawv uas nws xub pib haus 1 mg ib hnub ib zaug. Ua kom tau qhov zoo tshaj plaws ntawm kev nqis tes ua tshuaj, qhov ntau npaum no yuav raug coj los tswj cov suab thaj kom zoo.
Yog tias koob tshuaj qis kawg nkaus (1 mg) tsis muaj txiaj ntsig, cov kws kho mob maj mam muab 2 mg, 3 mg lossis 4 mg ntawm cov tshuaj ib hnub. Tsawg tsawg zaus, kev noj ntau dua tuaj yeem raug nce ntxiv rau 3 mg ob zaug ib hnub nyob rau hauv kev saib xyuas nruj ntawm kws kho mob.
Cov ntsiav tshuaj yuav tsum tau ua kom tiav, tsis yog zom thiab ntxuav nrog kua. Yog tias koj hla kev noj tshuaj, koj tsis tuaj yeem siv tshuaj ntau dua ob zaug.
Ua ke nrog glimepiride nrog insulin, qhov koob tshuaj ntawm cov tshuaj hauv nqe lus nug tsis tas yuav hloov pauv. Kev kho tshuaj Insulin yog kho nrog qhov tsawg kawg nkaus, maj mam nce ntxiv. Kev siv sib xyaw ua ke ntawm ob qho tshuaj yuav tsum muaj kev tshwj xeeb los ntawm kws kho mob.
Thaum hloov cov kev kho mob, piv txwv li, qhov hloov pauv los ntawm lwm tus neeg sawv cev tiv thaiv kab mob rau glimepiride, lawv pib nrog cov koob tshuaj tsawg kawg nkaus (1 mg).
Cov kev hloov pauv ntawm kev siv tshuaj insulin mus rau kev noj tshuaj Glimepiride yog ua tau, thaum tus neeg mob khaws cov lus zais ntawm cov kabmob pancreatic beta hlwb hauv cov ntshav qab zib hom 2. Raws li kev saib xyuas ntawm tus kws kho mob, cov neeg mob noj 1 mg ntawm cov tshuaj ib hnub ib zaug.
Thaum muas lub tshuaj tiv thaiv kab mob, koj yuav tsum them sai sai rau nws hnub tas sij hawm. Rau glimepiride, nws yog 2 xyoos.
Cov tshuaj tiv thaiv thiab kev tsis haum
Zoo li lwm yam tshuaj, Cov tshuaj Glimepiride contraindications thiab cov txiaj ntsig tsis zoo yuav yog qhov laj thawj vim li cas nws txoj kev siv raug txwv rau qee pawg neeg mob.
Txij li cov tshuaj muaj pes tsawg leeg ntawm cov ntsiav tshuaj suav nrog cov tshuaj uas ua rau muaj kev tsis haum tshuaj, ib qho tseem ceeb contraindications ntawm cov tshuaj no hypoglycemic yog hypersensitivity rau cov Cheebtsam.
Ib qho ntxiv, qhov tau txais ntawm cov nyiaj yog txwv thaum:
- mob ketoacidosis;
- insulin tiv ntshav qab zib;
- mob plab zom mov tsis xeev, precoma;
- raum lossis nplooj siab ua haujlwm tsis zoo;
- coj menyuam;
- pub niam mis.
Cov neeg tsim tawm ntawm cov tshuaj no tau ua ntau yam kev kho mob thiab cov kev kawm tom qab muag lag luam. Raws li qhov tshwm sim, lawv tau tswj hwm los ua cov npe ntawm cov kev mob tshwm sim, uas suav nrog:
- Cov tshuaj tiv thaiv ntawm daim tawv nqaij (khaus, tawm pob, urticaria).
- Lub plab zom mov tsis zoo (raws plab, ntuav, xeev siab, mob plab).
- Kev ua haujlwm ntawm daim siab ua haujlwm tsis zoo (kab mob siab, nce siab enzymes, daj ntseg, mob siab thiab cholestasis).
- Kev poob hauv cov ntshav qab zib sai heev (cov ntshav qog ntshav qab zib).
- Cov tshuaj tiv thaiv kev tsis haum ntshav (ntshav siab, ua tsis taus pa, poob siab).
- Txo cov ntsiab lus sodium hauv cov ntshav.
- Txo tsis pom kev pom (feem ntau tshwm sim hauv thawj lub lis piam ntawm kev kho).
- Kev cuam tshuam ntawm hematopoietic system (kev txhim kho ntawm agranulocytosis, leukopenia, hemolytic anemia nyob rau hauv cov ntshav qab zib mellitus, thrombocytopenia, pancytopenia).
Nyob rau hauv cov ntaub ntawv ntawm overdose, hypoglycemia tshwm sim, kav los ntawm 12 mus rau 72 teev. Raws li qhov txiaj ntsig ntawm kev noj ntau, tus neeg mob muaj cov tsos mob li nram no:
- mob sab xis;
- bouts ntawm xeev siab thiab ntuav;
- kev zoo siab;
- kev tuaj yeem ua mob leeg rau lub cev (tshee);
- nce toj zog;
- convulsions thiab tsis muaj kev sib koom tes;
- coma kev loj hlob.
Cov tsos mob saum toj no feem ntau tshwm sim los ntawm kev nqus ntawm cov tshuaj hauv cov hnyuv. Raws li kev kho mob, mob plab zom mov lossis ntuav yog qhov tsim nyog. Txhawm rau ua qhov no, siv cov pa roj carbon activated lossis lwm yam adsorbents, nrog rau cov neeg ua kom zoo nkauj. Tej zaum yuav muaj qee zaum mob pw hauv tsev kho mob ntawm tus neeg mob thiab tso ntshav qabzib rau lub cev.
Kev cuam tshuam nrog lwm yam tshuaj
Rau ntau tus mob ntshav qab zib, lo lus nug tshwm sim seb Glimepiride tuaj yeem noj nrog lwm yam tshuaj ntxiv rau kev txhaj tshuaj insulin. Nws tsis yog yooj yim heev los muab lus teb. Muaj cov npe ntau heev ntawm cov tshuaj uas tuaj yeem muaj qhov sib txawv ntawm cov txiaj ntsig ntawm glimepiride. Yog li, qee qhov nce nws cov nyhuv hypoglycemic, thaum lwm tus, ntawm qhov tsis sib xws, txo nws.
Hauv qhov no, cov kws kho mob pom zoo kom lawv cov neeg mob qhia txhua qhov kev hloov pauv hauv lawv lub xeev kev noj qab haus huv, nrog rau ib qho kab mob sib kis nrog cov ntshav qab zib.
Lub rooj qhia cov tshuaj tseem ceeb thiab tshuaj uas cuam tshuam rau glimepiride. Lawv siv ua ke yog qhov tsis muaj kev cia siab, tab sis qee kis nws tuaj yeem raug kho nyob rau hauv kev saib xyuas nruj ntawm tus kws kho mob tshwj xeeb.
Cov tshuaj uas tuaj yeem txhim kho qhov kev tiv thaiv hypoglycemic yog:
- cov tshuaj insulin;
- Fenfluramine;
- Cov kab plaub hau;
- coumarin derivatives;
- Disopyramids;
- Allopurinol;
- Chloramphenicol;
- Cyclophosphamide;
- Feniramidol;
- Fluoxetine;
- Guanethidine;
- MAO inhibitors, PASK;
- Phenylbutazone;
- Sulfonamides;
- ACE inhibitors;
- anabolics;
- Chaw Pov Thaiv;
- Isophosphamides;
- Miconazole;
- Pentoxifylline;
- Azapropazone;
- Tetracycline;
- quinolones.
Cov tshuaj noj uas ua kom cov suab thaj txo qis thaum siv ua ke nrog glimepiride:
- Tshuaj Acetazolamide.
- Corticosteroids.
- Diazoxide.
- Kev tshuaj ntsuab.
- Sympathomimetics.
- Tshuaj qaug cawv
- Progestogens.
- Phenytoin.
- Cov thyroid hormones.
- Estrogens.
- Phenothiazine.
- Glucagon.
- Rifampicin.
- Barbiturates
- Nicotinic acid
- Adrenaline.
- Coumarin derivatives.
Nws tseem yuav tsum tau ceev faj txog cov tshuaj xws li cawv thiab histamine H2 receptor blockers (Clonidine thiab Reserpine).
Cov lus qhia hauv Coumarin tuaj yeem ua rau ob leeg nce thiab txo qis glycemia hauv cov neeg mob.
Tus nqi, tshuaj xyuas thiab analogues tshuaj
Koj tuaj yeem yuav cov tshuaj no ob qho tib si hauv cov chaw muag tshuaj tsis tu ncua thiab ntawm cov khw tsim khoom lub vev xaib, tom qab pom daim duab ntawm pob tshwj xeeb ua ntej.
Nws tseem muaj peev xwm kom tau txais glimepiride ntawm cov ntsiab lus nyiam.
Rau Glimepiride, tus nqi nws txawv nyob ntawm daim ntawv ntau npaum li cas thiab cov naj npawb ntawm cov ntsiav tshuaj hauv pob.
Hauv qab no yog cov lus qhia txog tus nqi ntawm cov tshuaj (Pharmstandard, Russia):
- Glimepiride 1 mg - los ntawm 100 txog 145 rubles;
- Glimepiride 2 mg - los ntawm 115 txog 240 rubles;
- Glimepiride 3 mg - los ntawm 160 txog 275 rubles;
- Glimepepiride 4 mg - los ntawm 210 txog 330 rubles.
Raws li koj tuaj yeem pom, tus nqi tau zoo rau txhua tus neeg mob, tsis hais txog qib lawv cov nyiaj tau los. Hauv Is Taws Nem koj tuaj yeem pom ntau cov kev txheeb xyuas txog cov tshuaj. Raws li txoj cai, cov ntshav qab zib tau txaus siab rau qhov kev ua ntawm cov tshuaj no, thiab dhau li ntawd, koj yuav tsum tau haus nws tsuas yog ib hnub ib zaug.
Vim tias muaj kev phiv los sis contraindications, tus kws kho mob tuaj yeem sau ntau lub hauv paus hloov chaw. Ntawm lawv, cov tshuaj zoo ib yam (muaj tib lub tshuaj zoo sib xws) thiab cov tshuaj muaj yees (muaj cov tshuaj sib txawv, tab sis muaj cov nyhuv zoo sib xws) muaj qhov sib txawv.
Cov khoom nrov tshaj plaws uas muaj cov khoom sib xyaw ua ke yog:
- Ntsiav tshuaj Glimepiride Teva - yog ib yam tshuaj zoo uas txo cov ntshav qabzib. Cov tseem ceeb tuam txhab tsim yog neeg Ixayees thiab Hungary. Hauv Glimepiride Teva, cov lus qhia muaj yuav luag tib cov lus qhia ntsig txog nws siv. Txawm li cas los xij, cov tshuaj noj txawv ntawm cov tshuaj hauv tsev. Tus nqi nruab nrab ntawm 1 pob ntawm Glimepiride Teva 3 mg No. 30 yog 250 rubles.
- Glimepiride Canon yog lwm cov tshuaj txhim khu kev qha nyob rau hauv kev sib ntaus tawm tsam muaj ntshav siab glycemia thiab mob ntshav qab zib. Kev tsim khoom ntawm Glimepiride Canon tseem tau coj mus rau hauv tebchaws Russia los ntawm Canonfarm Production kws lub tuam txhab. Glimepiride Canon tsis muaj qhov sib txawv tshwj xeeb, cov lus qhia qhia tib yam contraindications thiab muaj kev phom sij. Tus nqi nruab nrab ntawm Glimepiride Canon (4 mg No. 30) yog 260 rubles. Cov tshuaj Glimepirid Canon muaj cov tshuaj ntau ntau thiab tuaj yeem siv tau thaum cov tshuaj tsis haum rau tus neeg mob.
- Thaj neeb yog tshuaj uas nrov ntawm cov neeg mob. Glimepiride, uas yog ib feem ntawm cov tshuaj Altar, txhawb kev nthuav tawm cov tshuaj insulin los ntawm beta hlwb. Thaj neeb muaj tib daim ntawv thov. Lub chaw tsim khoom ntawm cov khoom ntawm Altar yog Berlin-Chemie. Tus nqi rau 1 ntim ntawm Thaj Thaj yog nyob rau nruab nrab 250 rudders.
Muaj ntau cov tshuaj uas muaj cov kev kho zoo sib xws, piv txwv:
- Metformin yog ib tus neeg sawv cev hypoglycemic nrov. Qhov tseem ceeb ntawm tib lub npe (metformin), maj mam txo cov ntshav qabzib thiab yuav luag tsis ua rau muaj ntshav qab zib. Txawm li cas los xij, Metformin muaj cov npe ntev ntev ntawm contraindications thiab phiv. Tus nqi nruab nrab ntawm cov tshuaj Metformin (500 mg No. 60) yog 130 rubles. Txij li cov tshuaj tivthaiv no yog ib feem ntawm cov tshuaj loj, koj tuaj yeem nrhiav ntau hom npe - Metformin Richter, Canon, Teva, BMS.
- Lwm cov tshuaj rau ntshav hypoglycemic - Siofor 1000, Vertex, Diabeton MV, Amaril, thiab lwm yam.
Yog li, yog tias rau qee qhov laj thawj glimepiride tsis haum, analogues tuaj yeem hloov nws. Txawm li cas los xij, cov cuab yeej no muaj txiaj ntsig zoo hauv kev txhim kho hyperglycemia.
Cov ntaub ntawv hais txog kev ua haujlwm zoo tshaj plaws ntawm cov piam thaj yog muaj nyob hauv cov yeeb yaj kiab hauv tsab xov xwm no.
