Zokor yog cov tshuaj uas txo cov ntshav phom sij hauv lub cev, tiv thaiv lub cev los ntawm kev txhim kho cov kab mob phom sij ntawm lub siab thiab cov hlab ntshav. Cov tshuaj muaj cov txiaj ntsig tom qab 2-4 lub lis piam los ntawm qhov pib ntawm chav kawm ntawm txoj kev kho.
Hauv cov tshuaj no rau cov neeg mob, qhov tshwm sim ntawm kev mob plawv sai li sai tau 55%, tuag los ntawm 30%, tus naj npawb ntawm kev ua haujlwm thiab mob plawv nres los ntawm 37%.
Tsis yog txhua tus neeg mob tuaj yeem tuaj yeem them cov nqi statin; tus nqi nruab nrab ntawm ib pob hauv kev siv tshuaj ntawm 10 mg yog txog 500-700 rubles Lavxias. Rau Zokor hauv qhov ntau npaum ntawm 20 mg yuav tau them txog 700-900 rubles.
Yog tias, vim li cas los xij, Zokor ntsiav tshuaj tsis haum rau tus neeg mob ntshav qab zib, tus kws kho mob pom zoo tias nws tau kho nrog analogues ntawm cov tshuaj. Cov kev ua yeeb yaj kiab uas nrov thiab nrov tshaj plaws yuav tsum raug hu ua cov nyiaj: Aterostat, Vasilip, Levomir, Zovatin. Lwm cov qauv zoo:
- Atromidine;
- Lovastatin;
- Liprimar;
- Rosuvastatin.
Tag nrho cov tshuaj no muaj kwv yees feem ntau ntawm cov tshuaj tseem ceeb, lawv qhov tshuaj ntau npaum li cas. Hauv qhov no, qhov sib txawv ntawm cov ntsiav tshuaj nyob rau hauv cov chaw tsim khoom, cov nqi ntawm cov khoom siv pabcuam siv, kev lag luam npoo, lub npe nrov ntawm cov chaw muag tshuaj.
Cov lus qhia rau kev siv tshuaj
Kev siv cov tshuaj Zokor yog qhov tsim nyog los ntawm kev noj zaub mov kom yuag. Cov ntsiav tshuaj tau sau rau hauv ib daim li 5 txog 80 mg, noj thaum pw. Nws yog txwv tsis pub ntau tshaj qhov kev pom zoo noj, ntau npaum li cas ntawm kev siv tshuaj tau xaiv ib tus zuj zus.
Kev kho pauv yog nqa tawm tsis ntau tshaj ib zaug txhua 30 hnub. Lub chav kawm ntawm txoj kev kho yog ntev, yog tias cov tshuaj cais tawm arbitrarily, tus neeg mob tus mob rov qab mus rau nws lub xeev qub.
Tus txheej txheem muab tshuaj rau ntshav qab zib, mob plawv, mob hlab ntsha tawg yog 40 mg rau ib hnub, ntxiv rau cardio load thiab zaub mov noj. Nrog rau daim ntawv me me ntawm hypercholesterolemia, kev tswj hwm pib nrog 10-20 mg ntawm cov tshuaj txhua txhua thaum yav tsaus ntuj, yog tias tsim nyog, txo cov roj (cholesterol) qis dua los ntawm ntau dua 45%, cov tshuaj tau nce ntxiv rau 40 mg. Txoj kev kho yuav tsum tau saib xyuas los ntawm kws kho mob.
Qhov ntau kawg txhua hnub noj tshuaj yuav tsum tsis pub ntau tshaj 10 mg yog tias Zokor tau muab tshuaj nrog rau cov tshuaj:
- Cyclosporin;
- Danazole;
- Gemfibrozil.
Familial hypercholesterolemia (mob caj dab loj) yuav noj 40 mg txhua hmo ua ntej yuav mus pw. Qee lub sij hawm nws pom tias yuav tsum siv 80 mg ntawm cov tshuaj, faib cov koob thib peb zaug, tswj kev sib txuam sib luag.
Thaum siv tib txhij nrog Verapamil thiab Amiodarone, tus nqi no yog 20 mg. Cov qauv mob uas tsis zoo ntawm lub raum ua kom xav tau qhov tsawg ntawm cov tshuaj txhua hnub rau 10 mg.
Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm oval ntsiav tshuaj, txhua pob muaj 14-28 pieces. Hauv tsev muag tshuaj koj tuaj yeem yuav Zokor 10 lossis Zokor 20 mg. Ntxiv nrog rau lub ntsiab lus tseem ceeb ntawm simvastatin, ntsiav tshuaj muaj ascorbic acid (vitamin C), lactose monohydrate, hmoov txhuv nplej siab, citric acid thiab talc.
Ua ntej txoj kev kho mob, nws yog ib qho tseem ceeb yuav tsum ua rau kev sim tshuaj rau lub siab ua haujlwm, tom qab ntawd koj yuav tsum rov ua qhov kev tshawb fawb ib lub sijhawm.
Yog hais tias qhov kev txwv sab sauv ntawm qhov siab tshaj yog tshaj los ntawm peb lossis ntau zaus, cov tshuaj tau qhia tias tau tso tseg, hloov nrog kev sib piv.
Cov khoom tseem ceeb
Cov tshuaj yog pom zoo rau cov neeg mob ntshav qab zib nrog ib qho kev xav ua rau cov mob ntshav siab hauv lub plawv, nrog cov neeg mob ntshav siab ntau ntxiv. Nws kov yeej nrog cov tsos mob ntawm kev mob plawv, txo cov kev pheej hmoo ntawm kev tuag hauv cov kab mob plawv, thiab dhau los ua qhov kev ntsuas ntawm kev tiv thaiv kev mob plawv, xws li mob hlab ntsha tawg, mob plawv nres.
Tus mob ntshav qab zib tuaj yeem suav rau kev tiv thaiv kev txhim kho ntawm kev puas tsuaj phom sij rau cov hlab ntsha peripheral. Nrog ischemic tus kab mob nrog hypercholesterolemia, txoj kev txhim kho ntawm txoj hlab ntshav atherosclerosis tau qeeb.
Qhov siab tshaj plaws ntawm cov tshuaj yeeb dej caw tau mus txog tom qab 1.3-2.4 teev tom qab noj Zokor ntsiav tshuaj. Kwv yees li 85% ntawm cov tshuaj hauv qhov ncauj yog nqus tau tam sim ntawd. Piv nrog rau lwm cov tshuaj, qib siab ntawm simvastatin nyob rau hauv daim siab ua haujlwm raug pom.
Thov Zokor yuav tsum:
- yog tias tsim nyog, kev kho kom rov ua dua ntawm txoj hlab ntshav;
- kom tsis muaj zog tawm tsam ntawm angina pectoris;
- kom txo qis tag nrho thiab tsis tshua muaj roj cholesterol;
- kom nce cov roj (cholesterol) zoo;
- yog tias tsim nyog, tswj cov nyiaj triglycerides ntau.
Tom qab thawj cov tshuaj nkag rau hauv lub siab, nws yog metabolized, tom qab ntawd metabolites thiab cov tshuaj tau tshem tawm nrog bile. Kev siv tshuaj tsis yog nyob ntawm kev noj zaub mov, zaub mov tsis cuam tshuam rau lub khw muag tshuaj ntawm cov tshuaj.
Nrog rau siv ntev, kev txuam nrog hauv cov ntaub so ntswg ntawm lub cev tsis tshwm sim.
Kev phiv tshuaj tiv thaiv thiab tshuaj tiv thaiv
Raws li txoj cai, Zokor tau pom zoo los ntawm lub cev, dhau los ntawm txoj kev coj zoo. Dua li ntawm qhov no, zoo li lwm yam tshuaj, muaj cov kev phiv tshuaj. Li ntawm 0.1-10% ntawm cov neeg mob ntshav qab zib tau kuaj pom muaj ntshav tsis txaus, asthenic qaug dab peg, plaub hau ploj, kiv taub hau, daj ntseg, thiab mob ntshav qab zib.
Tsis tas li ntawd, dermatomyositis, myalgia, mob nqaij hlav hauv plab, mob leeg, dyspepsia tsis suav nrog. Ua tau rau cov tawv nqaij ua pob ua pob, khaus khaus, tsis hnov tsw qab, txha caj qaum, mob rhabdomyolysis.
Kev siv cov ntsiav tshuaj tuaj yeem ua rau pathologies ntawm kev tiv thaiv kab mob, kev ua xua: o, mob ntsws mob ntsws, mob tso zis, mob tsis zoo rau lub teeb, mob caj dab. Cov neeg mob uas ua rau lub cev zom zaub mov tsis txaus siab tau pom tias muaj kev nce ntxiv hauv ESR, tawv nqaij hyperemia thiab ua tsis taus pa.
Muaj cov ntaub ntawv xwm txheej:
- nce kev ua si ntawm creatine phosphokinase;
- nce rau hauv qhov nyiaj ntawm transaminase;
- nce nyob rau hauv alkaline phosphatase concentration.
Yog tias pom tias cov tsos mob tshwm sim, nws yuav tsum tau txo qhov ntau npaum li cas lossis tsum tsis noj, hloov cov tshuaj nrog analogues.
Muaj Zokor thiab contraindications, lawv suav nrog kev xeeb tub, lub sijhawm ntawm kev pub niam mis, ib tus neeg tsis haum rau cov tshuaj ntawm cov tshuaj. Koj tsis tuaj yeem haus cov ntsiav tshuaj rau cov nplooj siab ua haujlwm, nrog rau kev hloov siab ntau ntxiv ntawm ib qho etiology. Rau cov neeg mob ntshav qab zib nrog qhov pheej hloov siab hloov ntshav transaminase, cov tshuaj yog tshuaj nrog kev ceev faj.
Ib qho kev pom zoo zoo sib xws rau cov cawv quav cawv, rhabdomyolysis. Cov ntsiav tshuaj tsis yog kws kho thaum yau.
Kev cuam tshuam nrog lwm yam tshuaj
Nws yog ib qho tseem ceeb rau kev koom tes noj Zokor nrog lwm cov tshuaj, qhov no yuav zam kom tsis txhob poob qis hauv kev kho mob.
Fibrates, ntxiv rau fenofibrate, nicotinic acid, ua ke nrog Zokor, ua rau muaj qhov cuam tshuam hypocholesterolemic, ua rau muaj qhov tshwm sim ntawm kev tsim myopathy.
Cov tshuaj kuj tseem tuaj yeem cuam tshuam cov txiaj ntsig ntawm coumarin anticoagulants; thaum siv ua ke, kev saib xyuas los ntawm tus kws kho mob tau qhia. Nrog txoj kev ua no, kev tuaj yeem los ntshav tau tiv thaiv.
Concurrent siv nrog qee cov tshuaj ua rau muaj kev pheej hmoo ntawm myopathy, feem ntau peb tab tom tham txog tshuaj Erythromycin, Terithromycin, Ketoconazole. Nws tsis pom zoo kom noj cov tshuaj kom ntau:
- Verapamil;
- Amiodarone;
- Danazole;
- Cyclosporin.
Lwm qhov kev pom zoo yog kom tsis txhob haus ntau cov kua txiv qaub, tshwj xeeb tshaj yog txiv kab ntxwv qaub. Cov khoom lag luam nce qhov kev ua haujlwm ntawm cov tshuaj hauv cov ntshav ntshav.
Zokor ntsiav tshuaj muab muag tshwj xeeb los ntawm cov kws kho mob sau ntawv.
Lub txee lub neej ntawm yeeb tshuaj, raug rau qhov kub thiab txias, tsis pub tshaj ob xyoos txij li hnub ua khoom siv.
Cov lus qhia tshwj xeeb
Kev siv Zokor ntev ntev tuaj yeem ua rau myopathy nrog cov yam ntxwv ntawm tus mob: mob nqaij, qhov tsis muaj zog dav dav, nrog los ntawm kev nce kaum tawm zaug ntawm creatine phosphokinase.
Myopathy ua rau nws tus kheej xav tias ob lub raum tsis ua haujlwm, nws tuaj yeem ua rau lub txim ntsig kev tu siab. Qhov ntxim nyiam ntawm myopathy nce nrog nce mloog ntawm ib yam khoom hauv ntshav ntshav thaum noj cov tshuaj inhibitory.
Txhua tus ntshav qab zib rau leej twg Zokor yog kws kho yuav tsum paub txog qhov yuav tsum tau sab laj nrog kws kho mob sai li sai tau rau tej leeg nqaij thiab tshwj xeeb tshaj yog tsis hnov mob.
Thaum pib ntawm cov chav kawm ntawm kev kho mob, nrog txhua qhov nce ntawm cov tshuaj, nws yog ib qho yuav tsum tau soj ntsuam kev saib xyuas ntawm creatine phosphokinase. Yog tias muaj kev qhia rau txoj kev npaj phais mob, txwv tsis pub noj tshuaj ob peb hnub ua ntej txheej txheem. Yog li lawv ua nws nyob rau thawj hnub tom qab kev cuam tshuam.
Ua ntej kho cov tshuaj thiab thaum kho, nws yog ib qho yuav tsum tau soj ntsuam daim siab ua haujlwm, cov kev tshawb fawb ntxiv tau qhia rau cov neeg mob ntshav qab zib uas tau txais siab ntau ntawm cov tshuaj.
Cov lus qhia ntawm Zokora Rosuvastatin
Rau cov neeg mob ntshav qab zib uas muaj teeb meem roj cholesterol siab, Zokor hloov nrog rosuvastatin ntsiav tshuaj. Cov tshuaj ua ib txoj haujlwm zoo heev ntawm kev ua kom lub cev cov roj uas txhaws muaj zog ntau dua thiab txo qis cov khoom uas tsis muaj zog.
Cov tshuaj no tau ntaus nqi rau cov kabmob plaub-rau ntev, tau siv coj los ua kom tshem tawm ntawm hypercholesterolemia, thiab siv los ua cov tshuaj tiv thaiv kev tiv thaiv vascular atherosclerosis thiab nws lub txim.
Ua tsaug rau txoj kev huv huv ntawm cov hlab ntshav, qhov tsim ntawm atherosclerotic plaques, inhibition ntawm txoj kev loj hlob ntawm ischemic mob stroke, thiab lub plawv nres nrog kev tiv thaiv kab mob rau cov kab mob plawv.
Rosuvastatin ntsiav tshuaj yog qhov feem ntau tau kawm ntawm statins, qhov ua tau zoo tau pom hauv kev sim. Ib qhov tshwj xeeb ntawm analogues yog cov yeeb yam:
- sib ntaus tawm tsam cov cholesterol;
- nyem ntawm cov txheej txheem hloov qeeb qeeb;
- nce cov roj (cholesterol) zoo.
Cov ntsiab lus tseem ceeb tshaj plaws yog qhov inhibition ntawm tus mob mus ntev hauv lub cev ntawm cov ntshav qab zib, vim tias nws yog qhov tseeb uas ua rau atherosclerosis.
Cov tshuaj tawm hauv kev tsim cov tshuaj nitrogen, pab txhawb kev ua kom cov leeg ntshav so, tsim cov nyhuv ntxiv. Tom qab siv cov ntsiav tshuaj, cov tshuaj nquag tam sim ntawd nkag mus rau hauv qhov system, raug faib kom sib kis thoob plaws cov ntaub so ntswg thiab cov cell. Ntxiv mus, kev lees paub yog qeeb qeeb dua li ntawm cov qauv analogues, lub sijhawm ntawm qhov tsis pom los yog siab dua.
Peak plasma cov tshuaj muaj peev xwm tuaj yeem ncav cuag li 5 teev tom qab noj. Txawm hais tias qhov tseeb tias cov tshuaj tau sau tseg hauv kev txo qis, qhov no tsis cuam tshuam nrog kev cuam tshuam ib txwm nrog lwm cov tshuaj.
Cov Kev Txwv thiab contraindications
Zoo li lwm cov ntsiav tshuaj, rosuvastatin muaj qhov tseeb contraindications. Ua ntej tshaj plaws, peb tab tom tham txog kev tsis lees paub rau qee yam tshuaj (suav nrog cov ua dhau los). Nws yuav tsum nco ntsoov tias cov tshuaj tsis yog kws kho mob rau cov neeg mob ntshav qab zib thaum cev xeeb tub, rau cov menyuam yaus hnub nyoog qis dua 18 xyoo, tshwj tsis yog muaj mob los ntawm caj ces hypercholesterolemia.
Tshuaj tiv thaiv txwv tsis pub lub siab mob tsis ua haujlwm los ntawm kev ua haujlwm ntawm lub cev tsis zoo thaum lub caij cell puas, ua kom nce siab ntawm daim siab enzymes.
Txwv tsis pub siv tib lub sijhawm nrog cyclosporine. Tsis tas li ntawd ib tug contraindication yog myopathy - ib tug pathology ntawm striated pob txha nqaij, ib tug predisposition rau nws kev loj hlob.
Cov ntaub ntawv hais txog statins yog muab hauv video hauv tsab xov xwm no.
