Atorvastatin-Teva yog qhov tshuaj hypolipidemic. Tus txheej txheem ntawm kev ua ntawm cov lipid-txo cov tshuaj yog kom txo qib ntawm cov "phem" cov roj cholesterol, nrog rau cov nyiaj triglycerides thiab lipoproteins uas muaj tsawg thiab tsawg ceev. Nyeg, lawv nce qhov siab ntawm cov lipoproteins ntau ntom thiab cov roj "zoo".
Atorvastatin-Teva muaj nyob rau hauv daim ntawv ntawm cov yeeb yaj kiab dawb-npog ntsiav tshuaj. Ob daim ntawv sau tau muab sau rau ntawm lawv saum npoo, ib qho yog "93", thiab qhov thib ob yog nyob ntawm qhov ntau npaum li cas ntawm cov tshuaj. Yog tias qhov koob tshuaj yog 10 mg, tom qab ntawd cov ntawv sau "7310" tau sau ntxiv, yog tias 20 mg, tom qab ntawd "7311", yog tias 30 mg, tom qab ntawd "7312", thiab yog tias 40 mg, ces "7313".
Lub hauv paus ua haujlwm tseem ceeb ntawm Atorvastatin-Teva yog atorvastatin calcium. Tsis tas li, cov tshuaj muaj pes tsawg leeg suav nrog ntau yam ntxiv, cov txuam nrog cev. Cov no suav nrog, piv txwv, lactose monohydrate, titanium dioxide, polysorbate, povidone, alpha-tocopherol.
Tus txheej txheem ntawm kev txiav txim ntawm Atorvastatin-Teva
Atorvastatin-Teva, raws li twb tau hais thaum pib, yog tus sawv cev lipid-txo qis. Tag nrho nws lub zog yog tswj kev tiv thaiv, uas yog, inhibiting qhov kev txiav txim ntawm enzyme nyob rau hauv lub npe HMG-CoA reductase.
Lub luag haujlwm tseem ceeb ntawm cov enzyme no yog tswj hwm kev tsim cov roj cholesterol, txij li qhov tsim ntawm nws cov ua ntej, mevalonate, los ntawm 3-hydroxy-3-methyl-glutaryl-coenzyme A. tshwm sim thawj zaug Cov roj ntsha synthesized, ua ke nrog triglycerides, xa mus rau lub siab, qhov uas nws ua ke nrog lipoproteins tsawg heev. Cov. Cov tshuaj sib txuas tau dhau mus rau hauv cov ntshav ntshav, thiab tom qab ntawd nrog nws tam sim no xa mus rau lwm yam kabmob thiab cov ntaub so ntswg.
Tsawg lipoproteins tsawg kawg yog hloov pauv mus rau qhov tsawg kawg ntawm lipoproteins los ntawm kev hu rau lawv cov receptors tshwj xeeb. Raws li qhov tshwm sim ntawm qhov kev sib txuam no, lawv lub catabolism tshwm sim, uas yog, lwj.
Cov tshuaj txo cov roj cholesterol thiab lipoproteins ntau hauv cov ntshav ntawm cov neeg mob, inhibiting cov nyhuv ntawm qhov enzyme thiab nce tus naj npawb ntawm receptors hauv lub siab rau lipoproteins tsawg ntom. Qhov no ua rau lawv ntes ntau dua thiab pov tseg. Cov txheej txheem ntawm kev coj ua ntawm atherogenic lipoproteins kuj tseem poob qis. Ntxiv rau, cov concentration ntawm cov roj lipoprotein ntau dua cov roj cholesterol nce thiab triglycerides txo nrog rau apolipoprotein B (cov protein nqa khoom).
Kev siv Atorvstatin-Teva qhia cov txiaj ntsig zoo hauv kev kho mob tsis yog atherosclerosis, tab sis kuj tseem muaj lwm yam kab mob cuam tshuam nrog lipid metabolism, uas lwm txoj kev kho lipid tsis ua hauj lwm zoo.
Nws tau tshawb pom tias qhov kev pheej hmoo ntawm kev tsim kab mob cuam tshuam nrog kev mob plawv thiab cov hlab ntsha, xws li mob plawv thiab mob hlab ntsha tawg, yog qhov tsawg.
Pharmacokinetics ntawm Atorvastatin-Teva
Cov tshuaj no yog nqus sai heev. Txog li ob teev, qhov siab tshaj plaws ntawm cov tshuaj tau muab teev cia hauv tus neeg mob cov ntshav. Kev nqus, uas yog, kev nqus, tuaj yeem hloov nws txoj kev nrawm.
Piv txwv li, nws tuaj yeem ua rau qeeb dua thaum noj ntsiav tshuaj nrog zaub mov. Tab sis yog tias kev nqus li no poob qis, ces nws tsis cuam tshuam rau cov nyhuv ntawm Atorvastatin nyob rau hauv txhua txoj kev - cov roj cholesterol tseem poob qis raws li kev noj tshuaj. Thaum nkag mus rau hauv lub cev, cov yeeb tshuaj yauv yauv hloov presystemic hloov pauv hauv kev mob plab. Nws yog nruj heev khi rau cov protein ntau - 98%.
Lub ntsiab ntawm cov metabolic pauv nrog Atorvastatin-Teva tshwm sim hauv lub siab vim raug isoenzymes. Raws li cov txiaj ntsig ntawm cov txiaj ntsig no, cov tshuaj ua kom lub cev yog tsim, uas yog lub luag haujlwm rau kev txwv tsis pub HMG-CoA reductase. 70% ntawm tag nrho cov cuam tshuam ntawm cov tshuaj tshwm sim vim cov metabolites no.
Atorvastatin raug tawm hauv lub cev nrog cov kab mob hepatic bile. Lub sijhawm thaum lub ntsiab ntawm cov tshuaj nyob rau hauv cov ntshav yuav sib npaug li ib nrab ntawm qhov qub (lub npe hu ua ib nrab neej) yog 14 teev. Qhov ua rau ntawm qhov enzyme yuav kav ntev li ib hnub. Tsis pub ntau tshaj ob feem pua ntawm cov nyiaj uas tau lees txais yuav txiav txim los ntawm kev kuaj xyuas tus neeg mob lub tso zis. Rau cov neeg mob uas tsis muaj lub raum tsis txaus, nws yuav tsum nco ntsoov tias thaum lub sijhawm hemodialysis Atorvastatin tsis tawm ntawm lub cev mus.
Qhov siab tshaj plaws ntawm kev siv yeeb tshuaj tshaj li qhov kev tswj hwm los ntawm 20% hauv cov poj niam, thiab tus nqi ntawm nws cov kev tshem tawm yog txo 10%.
Hauv cov neeg mob uas muaj mob rau daim siab puas vim yog kev haus cawv tsis txaus, qhov ntau tshaj plaws tau nce txog 16 zaug, thiab cov neeg tso tawm tau nce li 11 zaug, hauv qhov tsis sib thooj.
Kev taw qhia thiab contraindications rau siv
Atorvastatin-Teva yog cov tshuaj siv dav hauv kev kho mob niaj hnub.
Kev kho mob ntawm ib yam ntawm cov kab mob saum toj no thiab cov kab mob pathologies yog ua tiav thaum tswj hwm kev noj zaub mov kom pab txo cov ntshav muaj roj (muaj cov zaub thiab txiv hmab txiv ntoo, legumes, tshuaj ntsuab, txiv ntseej, nqaij ntses, nqaij qaib, qe), nrog rau thaum tsis muaj txiaj ntsig los ntawm ua ntej thov kev kho mob.
Muaj ntau tus taw qhia uas nws ua pov thawj kom ua tau zoo heev:
- atherosclerosis;
- thawj hypercholesterolemia;
- heterozygous tsev neeg thiab tsis-tsev neeg hypercholesterolemia;
- hom xyaw hypercholesterolemia (hom thib ob raws li Fredrickson);
- siab triglycerides (plaub yam raws li Fredrickson);
- tsis txaus ntawm lipoproteins (yam thib peb raws li Fredrickson);
- homozygous tsev neeg hypercholesterolemia.
Kuj tseem muaj ob peb qhov kev ua txhaum sib txuas rau kev siv Atorvastatin-Teva:
- Cov kab mob mob siab nyob hauv cov theem nquag lossis hauv theem ntawm exacerbation.
- Kev nce qib hauv qhov kev kuaj mob hepatic (ALT - alanine aminotransferase, AST - aspartate aminotransferase) ntau dua peb zaug, tsis muaj laj thawj tseeb;
- Daim siab ua haujlwm.
- Cev xeeb tub thiab lactation.
- Cov menyuam yaus hnub nyoog qis dua.
- Kev ua xua tshwm sim thaum noj qee yam ntawm cov tshuaj.
Muaj qee kis, cov tshuaj no yuav tsum tau muab nrog cov kev ceev faj heev. Cov no muaj xws li:
- kev haus dej haus cawv ntau dhau;
- mob siab txog kab mob siab;
- hormonal tsis txaus;
- tsis txaus ntawm electrolytes;
- metabolic ntshawv siab;
- tsis tshua muaj ntshav siab;
- cov mob sib kis tau yooj yim;
- Yog tsis kho tus mob epilepsy;
- cov haujlwm ua haujlwm dav thiab raug mob;
Tsis tas li ntawd, ceev faj thaum noj cov tshuaj yuav tsum ua kom lub cev muaj nyob rau hauv pathologies ntawm cov leeg ua ke.
Cov lus qhia rau kev siv tshuaj
Qhov ntau npaum ntawm cov tshuaj yog txiav txim siab los ntawm thawj tus kab mob uas xav tau kev kho mob, theem ntawm cov cholesterol, lipoproteins thiab triglycerides. Tsis tas li, cov tshuaj tiv thaiv ntawm cov neeg mob rau kev kho mob tsis tu ncua yog ib txwm coj mus rau hauv tus account. Lub sijhawm ntawm kev noj cov tshuaj tsis nyob ntawm kev noj zaub mov ntau dua. Koj yuav tsum noj ib ntsiav tshuaj lossis ntau dua (nyob ntawm tus kws kho mob lub hwj tshuaj) ib hnub ib zaug.
Feem ntau feem ntau, kev siv Atorvastatin-Teva pib nrog koob tshuaj 10 mg. Txawm li cas los xij, cov koob tshuaj no tsis yog ib txwm ua tau zoo, thiab yog li ntawd cov koob tshuaj yuav nce ntxiv. Kev tso cai ntau tshaj yog 80 mg rau ib hnub. Yog tias muaj qhov nce ntxiv ntawm cov tshuaj tseem yuav tsum tau ua, tom qab ntawd nrog cov txheej txheem no, kev saib xyuas cov lipid profile yuav tsum tau ua thiab kev kho yuav tsum tau xaiv raws li lawv. Hloov cov chav kawm ntawm txoj kev kho yog tsim nyog tsis ntau tshaj ib hlis ib zaug.
Lub hom phiaj tseem ceeb ntawm kev kho mob yog kom roj qis dua qub. Cov cai ntawm cov roj (cholesterol) hauv cov ntshav yog 2.8 - 5.2 mmol / L. Nws yuav tsum nco ntsoov tias rau cov neeg mob uas muaj lub siab tsis ua haujlwm, tej zaum nws yuav tsum tau txo qhov koob tshuaj lossis txiav kiag li kev noj tshuaj.
Sab sij huam tshuaj
Thaum lub sij hawm siv Atorvastatin-Teva, ntau cov kev phiv los ntawm ntau yam plab hnyuv siab raum thiab lub nruab nrog cev kuj yuav tshwm sim. Qee qhov kev mob tshwm sim yog qhov tshwj xeeb tshaj plaws.
Kev ua haujlwm hauv nruab nrab thiab ntu: pw tsaug zog ib ce, mob taub hau, tsis nco qab, tsis muaj zog, ploj lossis cuam tshuam rhiab, neuropathy.
Lub plab zom mov: kev mob plab, ntuav, raws plab, kev ua kom muaj roj ntau dhau, cem quav, kem plab, cov txheej txheem ua rau lub siab thiab lub plab, lub ntsej muag daj ntsig nrog stagnation ntawm bile, ua rau sab dhau.
Musculoskeletal system: mob hauv cov leeg, tshwj xeeb tshaj yog cov leeg nraub qaum, mob nqaij pob txha, mob sib koom tes, rhabdomyolysis.
Kev ua xua tawm: los ntawm hom tawv nqaij ua pob ua pob ua pob, khaus khaus, ua xua sai ua rau daim tawv nqaij anaphylactic poob siab, o.
Hematopoietic system: txo qis ntawm cov lej ntawm platelets.
Cov kab mob ua haujlwm: qhov ua kom tsawg lossis nce ntxiv hauv cov ntshav qabzib, qhov kev nce siab hauv kev ua haujlwm ntawm cov enzyme hu ua creatine phosphokinase, edema ntawm sab sauv thiab qis dua, qhov hnyav nce.
Lwm tus: lub zog qis dua, qhov mob ntawm lub hauv siab, lub raum tsis txaus, lub cev faus hws, nce zog.
Txog qee cov kab kev thiab cov xwm txheej, Atorvastatin-Teva yuav tsum tau txiav txim siab nrog kev ceev faj, piv txwv:
- Siv dej cawv;
- Pathology ntawm lub siab;
- Kev kuaj ua rau daim siab ua haujlwm ntau dua vim tsis muaj qhov pom tseeb;
Yuav tsum tau ceev faj thaum siv tshuaj tiv thaiv lwm yam tshuaj tua kab mob, tshuaj tua kab mob, tshuaj tiv thaiv kab mob, thiab cov vitamins.
Kev cuam tshuam nrog lwm yam tshuaj
Atorvastatin-Teva yog fraught nrog txoj kev txhim kho myopathy - cov leeg tsis muaj zog, zoo li txhua yam tshuaj rau pawg ntawm HMG-CoA reductase inhibitors. Nrog rau kev siv ntau yam tshuaj, ntau qhov kev pheej hmoo ntawm kev txhim kho cov kab mob no tuaj yeem nce ntxiv. Cov no yog cov tshuaj xws li tshuaj tiv thaiv kab mob (ib qho ntawm cov chaw muag tshuaj ntawm cov tshuaj tiv thaiv kab mob), tshuaj tua kab mob (erythromycin thiab macrolides), tshuaj tua kab mob, vitamins (PP, lossis nicotinic acid).
Cov pab pawg no ua rau ib qho enzyme tshwj xeeb hu ua CYP3A4, uas yog lub luag haujlwm tseem ceeb hauv Atorvastatin-Teva metabolism. Nrog hom kev sib txuam no, qib ntawm atorvastatin nyob rau hauv cov ntshav tuaj yeem nce vim yog inhibition ntawm cov azymentioned enzyme, vim tias cov tshuaj tsis tau metabolized zoo. Kev npaj rau cov pab pawg ntawm cov fibrates, piv txwv li, Fenofibrate, inhibit cov txheej txheem ntawm kev hloov pauv ntawm Atorvastatin-Tev, vim qhov txiaj ntsig ntawm nws cov nyiaj hauv cov ntshav kuj nce ntxiv.
Atorvastatin-Teva tseem tuaj yeem ua rau txoj kev txhim kho rhabdomyolysis - qhov no yog ib qho kab mob hnyav uas tshwm sim raws li lub txiaj ntsig ntawm kev ua haujlwm ntev ntawm myopathy. Hauv cov txheej txheem no, cov leeg nqaij ua rau cov kev puas tsuaj loj heev, lawv cov kev faib hauv cov zis yog pom, uas tuaj yeem ua rau mob raum tsis zoo. Rhabdomyolysis feem ntau txhim kho nrog kev siv Atorvastatin-Teva thiab cov pab pawg tshuaj saum toj no.
Yog tias koj sau tshuaj rau hauv qhov siab tshaj plaws tau tso cai rau ib hnub (80 mg ib hnub) ua ke nrog mob glycoside Digoxin, tom qab ntawd muaj qhov nce ntxiv ntawm cov tshuaj Digoxin los ntawm kwv yees li ib feem tsib ntawm cov tshuaj noj.
Nws yog qhov tseem ceeb heev rau kev sib xyaw ua ke ntawm kev siv ntawm Atorvastatin-Teva nrog rau cov tshuaj tiv thaiv kev xeeb tub uas muaj cov tshuaj estrogen thiab nws cov keeb kwm, vim tias muaj kev nce qib hauv cov poj niam cov tshuaj hormones. Nws tseem ceeb rau cov poj niam ntawm kev muaj me nyuam hnub nyoog.
Ntawm cov zaub mov, nws raug nquahu kom txo qis kev siv cov kua txiv kab ntxwv qaub, vim nws muaj ntau dua ib yam tshuaj uas txwv tsis pub muaj cov enzyme, nyob rau hauv kev cuam tshuam ntawm cov txheej txheem loj ntawm Atorvastatin-Teva tshwm sim thiab nws qib hauv cov ntshav nce ntxiv. Cov tshuaj no tuaj yeem yuav hauv txhua lub tsev muag tshuaj nrog cov tshuaj noj.
Cov ntaub ntawv hais txog cov tshuaj Atorvastatin tau muab nyob hauv video hauv tsab xov xwm no.
