Cov tshuaj yog ib pab pawg ntawm cov tshuaj hypoglycemic. Nws yog noj ntawm ncauj. Lub luag haujlwm tseem ceeb yog cuam tshuam cov txheej txheem ntawm cov tshuaj insulin. Txawm li cas los xij, qhov no tsis txhais tau hais tias nws tuaj yeem siv rau insulin-dependant pathological mob. Cov thaj tsam ntawm cov tshuaj nthuav tawm vim muaj kev cuam tshuam rau ntawm cov txiav. Nws muaj ntau yam kev sib kis, kev txheeb ze ntawm kev siv. Txhawm rau tshem tawm cov tshuaj tiv thaiv tsis zoo thiab nce kev ua haujlwm, cov tshuaj yuav tsum tau nyob rau ib lub sijhawm.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Glimepiride.
Lub luag haujlwm tseem ceeb ntawm glimepiride yog qhov cuam tshuam rau kev tsim cov tshuaj insulin.
ATX
A10BB12.
Tso cov ntawv thiab cov nyob ua ke
Cov tshuaj muaj nyob rau hauv cov sib txawv, sib txawv hauv qhov ntau npaum ntawm cov tshuaj nquag: 2, 3 thiab 4 mg. Koj tuaj yeem yuav nws hauv cov ntawv zoo. Cov ntsiav tshuaj muaj cov khoom xyaw nquag ntawm tib lub npe. Cov nyob hauv kuj tseem muaj lwm yam:
- lactose;
- microcrystalline cellulose;
- pregelatinized hmoov txhuv nplej siab;
- sodium lauryl sulfate;
- magnesium stearate.
Tsis tas li ntawd, cov tshuaj yeeb yaj kiab tuaj yeem ntim cov dyes. Txawm li cas los xij, lawv tsis yog ib feem ntawm txhua yam ntawm glimepiride, tab sis muaj nyob hauv cov ntsiav tshuaj nrog qhov ntau npaum ntawm cov tshuaj loj ntawm 3 mg. Cov tshuaj tau muaj hauv pob ntawm 30 pcs.
Pharmacological kev txiav txim
Cov tshuaj sawv cev rau cov tshuaj hypoglycemic ntawm sulfonamides pawg. Nws yog vim tus yeeb tshuaj ntawm lub cim thib peb. Lub hauv paus ntsiab lus ntawm kev ua haujlwm yog raws li kev ua kom muaj txheej txheem ntawm cov kua dej tso tawm. Cov nyhuv no ua tiav los ntawm kev txhawb qee cov hlwb ntawm endocrine feem ntawm lub txiav. Lawv ua ntau lub zog: ua kom tso tawm ntawm insulin, tib lub sijhawm ua rau txo qis ntshav qabzib.
Cov tshuaj muaj cov koob tshuaj koob tshuaj. Yog li, nrog qhov txo qis ntawm glimepiride, qhov kev siv ntawm cov kua dej tso tawm tsawg dua. Txawm li cas los xij, nrog cov pib ntawm cov ntaub ntawv no, cov tshuaj muaj tib theem ntshav plasma txuas ntxiv qee qhov ntawm nws cov analogues nyob rau hauv cov koob tshuaj loj dua. Cov nyhuv no tiav vim muaj kev nkag siab ntau ntxiv rau insulin.
Cov tshuaj yog hluavtaws. Vim tias lub peev xwm los kho cov neeg mob lub cev thaum muaj cov tshuaj insulin tsis txaus, nws siv rau cov tsis muaj ntshav qab zib kom tsis txhob mob ntshav qab zib thiab hom II mob ntshav qab zib mellitus. Cov txheej txheem ntawm kev ua kom muaj zog ntawm cov tshuaj insulin yog cov ntau yam. Nws yog ua raws li kev xa cov piam thaj mus rau hauv beta hlwb ntawm cov txiav, uas ua rau kev nce siab hauv kev ua haujlwm ntawm kev ua haujlwm ntawm AFT. Enzyme lwg me thaiv cov tshooj calcium ATP-dependant.
Glimepiride yog siv rau qhov tsis yog-insulin-mob ntshav qab zib mellitus thiab hom II mob ntshav qab zib mellitus.
Qhov no ua rau muaj kev cuam tshuam ntawm cov txheej txheem ntawm kev tso cov poov tshuaj los ntawm lub cell. Tom qab ntawd lub depolarization ntawm lub cell membrane tsim. Nyob rau qib no, muaj cov calcium uas muaj peev xwm tso tau qhib, uas ua rau cov calcium ntau ntxiv hauv lub cytoplasm ntawm beta hlwb. Thaum kawg theem, kev txav ntawm cov kua dej mus rau lub cell cell ceev nrawm, yog li ntawd, cov kua dej insulin muaj sib xyaw nrog cov cell ua ke.
Qhov kom zoo ntawm cov tshuaj yog qhov tsawg kawg nkaus ntawm kev ua kom muaj zog ntawm cov kua dej tso tawm, yog li txo qhov kev pheej hmoo ntawm kev mob ntshav qab zib. Lwm lub zog: qhov txo qis hauv kev nqus ntawm cov nqus dej ntawm insulin los ntawm daim siab, ua rau qeeb ntawm kev tsim cov piam thaj hauv cov nqaij hauv lub cev no. Tsis tas li ntawd, kev txwv tsis pub muaj ntau ntawm cov txheej txheem biochemical uas ua rau kev tsim cov ntshav txhaws yog sau tseg. Qhov no muab cov txiaj ntsig antithrombotic.
Lwm cov cuab yeej yog lub peev xwm ntawm Glimepiride los ua kom pom cov tshuaj anti-atherogenic. Qhov no txhais tau tias ua tsaug rau nws txoj kev txhim kho ntawm cov kab mob ntawm cov hlab plawv txhawm rau tiv thaiv. Qhov no tshwm sim tau los ntawm normalizing lipid cov ntsiab lus. Tsis tas li ntawd, ib qho kev txo qis hauv theem ntawm cov aldehyde me yog tau sau tseg.
Vim tias qhov no, kev siv ntawm lipid oxidation tsawg dua. Cov tshuaj hauv cov lus nug tseem koom nrog lwm cov txheej txheem biochemical, tshwj xeeb, nws tshem tawm cov kev mob tshwm sim ntawm oxidative kev nyuaj siab nrog cov neeg mob ntshav qab zib mellitus.
Cov Tshuaj Pharmacokinetics
Cov tshuaj ua sai sai. Tom qab 120 feeb, qhov siab tshaj ntawm glimepiride kev ua ub no tau mus txog. Cov txiaj ntsig tshwm sim yog tswj tau 1 hnub. Tom qab qhov no, qhov kev kub siab ntawm cov tshuaj nquag pib txo. Kev ruaj khov ntawm cov txheej txheem biochemical uas raug cuam tshuam los ntawm cov nquag muaj tshwm sim hauv 2 lub lis piam.
Qhov zoo ntawm cov khoom yog ceev thiab tiav haum. Cov tshuaj hauv cov lus nug yog 100% bioavailable. Thaum nws nkag mus rau hauv lub siab, cov txheej txheem ntawm oxidation ntawm cov tshuaj tshwm sim. Hauv qhov no, ib qho ua kom tawm ntawm lub cev (metabolite) tso tawm, uas yog qhov sib zog me dua li glimepiride hais txog kev siv ntawm lub cev. Txheej txheem metabolic txuas ntxiv. Raws li qhov tshwm sim, ib qhov chaw tsis muaj tub rog tawm.
Qhov kev tshem tawm ib nrab-lub neej ua rau 5-8 teev. Nws lub sijhawm nyob ntawm lub xeev ntawm lub cev thiab lub xub ntiag ntawm lwm txoj kev pathologies. Cov nquag ua haujlwm tau tshwm sim hauv daim qauv hloov kho. Ntxiv mus, feem ntau cov tshuaj raug tshem tawm ntawm lub cev thaum tso zis, cov khoom seem thaum tso quav.
Ib nrab-lub neej ntawm glimepiride los ntawm lub cev yog 5-8 teev.
Kev ntsuas rau siv
Cov tshuaj muaj qhov chaw nqaim ntawm kev siv. Yog li, nws tau tsim tshuaj rau ntshav qab zib hom II. Yog tias cov nyhuv ua kom tsis zoo yog tsis muaj zog txaus, lawv hloov ntawm monotherapy mus rau txoj kev kho mob. Hauv qhov no, kev pom zoo yuav ntxiv tshuaj Insulin lossis Metformin (250 mg) tuaj yeem pom zoo.
Cov Yuav Tsum Muaj
Nws raug txwv tsis pub siv cov cuab yeej yog muaj lus nug:
- metabolic acidosis, nrog kev cuam tshuam ntawm cov metabolism metabolism tsis zoo;
- mob plab zom mov tsis xeev, precoma;
- yam 1 mob ntshav qab zib mellitus;
- pathologies nyob rau hauv cov zaub mov uas ceases mus rau nqus lossis cov txheej txheem no yog fraught nrog cov teeb meem;
- cov tshuaj tiv thaiv ib qho tsis zoo rau cov tshuaj hauv cov tshuaj no thiab lwm tus neeg sawv cev los ntawm pawg sulfonamides thiab sulfonylurea derivatives;
- kev pheej hmoo siab ntawm hypoglycemia;
- cov tshuaj tiv thaiv tsis zoo rau lactose, lactase deficiency, glucose-galactose malabsorption syndrome.
Nrog saib xyuas
Tus neeg mob yuav tsum tau saib xyuas lub sijhawm kho mob nrog rau cov tshuaj muaj mob thaum muaj kev kho mob sai rau cov tshuaj insulin:
- hlawv nrog kev puas tsuaj loj heev rau sab nraud kev sib xyaw ua ke;
- kev phais mob hnyav;
- ntau raug mob;
- cov kab mob hauv kev pheej hmoo ntawm malabsorption ntawm cov zaub mov nce, piv txwv li, mob hnyuv lossis ua paresis ntawm lub plab.
Yuav ua li cas coj glimepiride
Cov ntsiav tshuaj yog npaj rau cov thawj coj hauv qhov ncauj. Lawv tsis tuaj yeem zom, tab sis nws pom zoo kom nqos nrog dej. Cov tshuaj tau coj tawm ntawm lub plab khoob, ua ntej noj mov.
Nrog ntshav qab zib
Feem ntau, thaum pib thawj theem, 1 mg ntawm cov tshuaj raug xaj 1 zaug nyob rau ib hnub. Tom qab ntawd, nrog so ntawm 1-2 lub lis piam, cov nyiaj no nce thawj zaug txog 2 mg, tom qab ntawd txog 3 mg. Ntawm theem kawg, 4 mg yog tau txais kev kho mob. Qhov ntau npaum li cas txhua hnub ntawm qhov tshuaj yog 6 mg.
Cov ntsiav tshuaj tsis tuaj yeem zom, tab sis nws pom zoo kom nqos nrog dej.
Raws li tib lub ntsiab cai, nws yog ib qho tsim nyog ua yog tias nws tau npaj los siv cov tshuaj hauv cov lus nug ib txhij nrog Metformin. Koj tuaj yeem hloov cov neeg mob los ntawm Metformin rau insulin. Hauv qhov no, txuas ntxiv chav ntawm txoj kev kho nrog nrog koob tshuaj uas kho tau cuam tshuam. Tus nqi no yuav tsum tau tsau. Qhov koob tshuaj cov kua dej kuj tseem maj mam nce zuj zus. Pib lub chav kawm ntawm kev kho mob nrog qhov tsawg kawg nkaus.
Thaum nws yog qhov yuav tsum tau hloov tus neeg mob los ntawm ib qho tshuaj hypoglycemic mus rau cov tshuaj hauv nqe lus nug, qhov tshuaj tsawg kawg ntawm glimepiride kuj tau sau tseg ua ntej. Tus nqi pom zoo ntawm cov tshuaj nquag yog 1 mg. Tom qab ntawd nws tau nce mus rau qib uas xav tau.
Kev phiv ntawm gliperimide
Cov tshuaj tuaj yeem pab txhawb kev txhim kho ntawm ntau cov txheej txheem pathological, uas yuav tsum tau txiav txim siab thaum teem caij.
Ntawm ib feem ntawm cov khoom hauv nruab nrog kev pom
Pom kev tsis pom kev (rov ua dua tshiab).
Kev kho mob txoj hnyuv
Xeev siab, ntuav tawm tsam keeb kwm yav dhau los ntawm tus kab mob pathological no, tso quav tawm, mob epigastric, ua haujlwm tsis zoo hauv lub siab, uas tau tshwm sim los ntawm daj ntseg, kab mob siab, hloov pauv ntawm cov cim tseem ceeb ntawm daim siab ua haujlwm thaum kuaj sim.
Hematopoietic plab hnyuv siab raum
Tus nab npawb ntawm cov kab mob loj hlob raws li kev hloov pauv ntawm qhov muaj pes tsawg leeg cov ntshav, xws li leukopenia, thiab lwm yam
Los ntawm ib sab ntawm cov metabolism
Kev ua haujlwm kom ntshav qab zib. Feem ntau cov feem ntau, lawv txhim kho tom qab qhov kawg ntawm txoj kev kho vim muaj kev hloov pauv ntawm kev noj haus. Qee lub sij hawm vim li cas yog txhaum txoj kev txiav txim ntawm cov tshuaj thaum kho.
Kev ua xua
Feem ntau feem ntau, mob urticaria tsim, tab sis cov cim tsis pom zoo yuav tshwm sim: lub cev tsis muaj zog, dyspnea, anaphylactic shock.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Nws tsis raug pom zoo kom koom nrog kev ua si uas yuav tsum tau saib xyuas qib siab. Qhov no yog vim qhov tseeb tias thaum pib theem pib ntawm kev kho lossis thaum hloov los ntawm ib cov tshuaj hypoglycemic mus rau lwm qhov, cov tsos mob hauv qab no tuaj yeem tshwm sim: ploj ntawm kev saib xyuas, txo qis hauv cov hlwb kev tsis haum tshuaj.
Tom qab siv cov tshuaj, anaphylactic shock yuav tsim.
Cov lus qhia tshwj xeeb
Nws raug nquahu kom noj cov tshuaj thaum lub sijhawm. Vim qhov no, ua kom ruaj ntseg ntawm tus neeg mob lub sijhawm tiav sai dua. Yog tias koj tsis tuaj raws lub sijhawm teem tseg, nws raug txwv tsis pub tuaj ntawm koj qhov kev txiav txim siab txhawm rau muab tshuaj ntau ntxiv. Tham nrog kws kho mob.
Yog tias cov tsos mob ntawm hypoglycemia tshwm sim thaum siv cov ntsiav tshuaj nrog qhov tseem ceeb ntawm 1 mg ntawm glimepiride, tom qab ntawd cov ntshav qabzib tuaj yeem yog qhov qub tsuas yog los ntawm kev noj zaub mov tshwj xeeb.
Raws li koj tau txais cov tshuaj hauv cov lus nug, qhov xav tau rau nws tsawg dua. Qhov no yog vim maj mam nce ntawm insulin rhiab heev.
Nws yuav tsum tau yug los hauv lub siab tias hauv cov neeg mob uas kuaj pom cov kab mob ntawm cov kab mob endocrine, txoj kev pheej hmoo ntawm kev tsim adrenocortical insufficiency nce.
Muab hais tias muaj txiaj ntsig zoo ntawm glimepiride tswj tau ntau lub lis piam, so yuav tsum tau thaum hloov los ntawm ib qho tshuaj hypoglycemic mus rau lwm qhov.
Thaum noj Glimepiride, nws yog ib qho tsim nyog yuav tsum tau ua ntu zus los ntsuas kev ntsuas kom thiaj li soj ntsuam cov kua nplaum hauv cov ntshav, nrog rau glycated hemoglobin.
Thaum noj cov tshuaj hauv nqe lus nug, nws yog ib qho tsim nyog yuav tsum ua ntu zus rau kev ntsuam xyuas. Hauv qhov no, cov ntsiab lus ntawm cov piam thaj hauv cov ntshav, nrog rau glycated hemoglobin, yog kwv yees.
Siv rau lub sijhawm qub
Cov yam ntxwv ntawm cov tshuaj tsis hloov pauv ntawm cov neeg mob ntawm pab pawg no. Yog li, kev hloov kho tshuaj tsis tsim nyog.
Txiag tej menyuam
Tsis raug muab teev tseg.
Siv thaum cev xeeb tub thiab lactation
Cov yeeb tshuaj yog txwv rau kev siv. Nyob rau theem ntawm kev npaj cev xeeb tub lossis thaum pub mis niam, tus poj niam pauv mus rau insulin.
Daim ntawv thov rau lub raum khiav tsis zoo
Tsis raug muab teev tseg.
Siv rau lub siab ua haujlwm tsis zoo
Nws tsis raug nquahu kom siv cov tshuaj vim tias muaj kev koom tes ntawm lub cev no hauv cov txheej txheem ntawm kev tso tshuaj.
Glimepiride noj overdose
Yog tias cov tshuaj nce siab, cov ntshav qog ntshav yuav nce sai sai. Qhov no pathological mob yog khaws rau 12-72 teev. Cov tsos mob: lub plawv dhia ceev tsis zoo, ntxhov siab vim, kub siab, mob hauv siab, mob siab, ua kom tsis muaj zog, xeev siab, ua raws li ntuav, nce siab thiab mob taub hau. Adsorbents, laxatives pab tshem tawm cov cim qhia.
Yog tias cov tshuaj loj ntawm cov tshuaj tau raug coj, pais plab lav ua raws li dextrose pom zoo. Qhov kev siv dag siv zoo li ntawd tau coj tawm hauv tsev kho mob. Ntxiv mus, nws yog ib qho tseem ceeb los tswj cov qib ntawm cov piam thaj hauv cov ntshav.
Kev cuam tshuam nrog lwm yam tshuaj
Ua qhov kev siv ntawm glimepiride cai thaum ua ntawv thov insulinosoderzhaschih agents, hypoglycemic tshuaj, ACE inhibitors, anabolic steroids, coumarin derivatives, allopurinol, chloramphenicol, cyclophosphamide, disopyramide, Feniramidola, fenfluramine, fluoxetine, Dizopiramidona, tshuaj ntawm ifosfamide, guanethidine, Miconazole, Pentoxifylline, phenylbutazone, txhais tau tias pawg ntawm salicylates, quinolones, tetracyclines, sulfonamides.
Ib qho kev nce ntxiv ntawm qhov kev siv ntawm glimepiride tau sau tseg nrog kev siv tshuaj tua kab mob thaum muaj kev sib xyaw, cov tshuaj hypoglycemic, coumarin derivatives.
Lwm yam tshuaj, ntawm qhov tsis sib xws, txo qhov kev ua haujlwm ntawm glimepiride. Cov no suav nrog: Acetazolamide, barbiturates, corticosteroids, diuretics, Epinephrine, Diazoxide, nicotinic acid, sympathomimetics, laxatives, Glucagon, estrogen- thiab cov tshuaj progesterone uas muaj tshuaj, Rifampicin, Phenytoin, cov tshuaj hormones uas tau kho rau cov thyroid pathologies.
Cawv tau zoo
Nws tsis raug nquahu kom siv cov cawv uas muaj cawv nrog glimepiride, vim tias nws nyuaj rau twv seb cov nyhuv yuav ua li cas. Cov dej cawv tuaj yeem txhim kho thiab ua rau cov nyhuv ntawm tus neeg sawv cev nug.
Analogs
Hloov chaw ntawm glimepiride sau tseg:
- Glibenclamide;
- Glianov;
- Amaryl;
- Diabeton, lwm yam.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Cov tshuaj yog ib qho tshuaj xaj.
Kuv tuaj yeem yuav yam tsis tas yuav tshuaj
Tsis muaj lub sijhawm zoo li no.
Nqi
Tus nqi nws txawv nyob ntawm seb ntau npaum ntawm glimepiride thiab yog 190-350 rubles.
Cia rau cov neeg mob rau cov tshuaj
Cov menyuam yaus yuav tsum tsis muaj kev nkag tau rau cov tshuaj. Txais txais cua kub hauv tsev - mus txog + 25 ° ะก.
Hnub tas sij hawm
Cov tshuaj yeeb tshuaj no tuaj yeem siv tsis pub dhau 2 xyoos txij li hnub tso tawm.
Chaw tsim tshuaj paus
"Cov Khw Muag Khoom Noj - Leksredstva", Russia
Xyuas
Alice, 42 xyoo, Kirov
Tshuaj rau cov neeg mob ntshav qab zib yog qhov zoo dua li kev txhaj tshuaj, vim tias nws yooj yim dua, koj tsis tas yuav muaj kev txawj txhaj tshuaj. Thiab tsis yog txhua tus muaj peev xwm tiv taus hom ntshav. Yog li, Kuv tau nug tus kws kho mob kom nws khaws cov tshuaj hauv daim ntawv loj. Coj mus tshem tawm cov tsos mob. Sab sij huam tsis tshwm sim.
Elena, 46 xyoo lawm, St. Petersburg
Thaum lub cev ua haujlwm tsis zoo, tsis muaj tshuaj kho. Vim li no, Kuv yuav tsum hloov nws. Thaum muaj hnub nyoog 45 xyoos, kab mob siab hepatic tau kuaj pom. Tab sis kuv nyiam qhov kev txiav txim ntawm Glimepiride, nws sai sai muab cov txiaj ntsig kho kom zoo, qhov tshwm sim tau txais tau khaws cia ntev.
