Hauv daim ntawv teev npe ntawm cov tshuaj hypoglycemic zoo, Janumet muaj nqis qhia. Nws qhov tshwj xeeb yog qhov sib xyaw ua ke, uas tso cai kom ua tiav qhov txiaj ntsig ntawm tus nqi pheej yig.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Tshuaj hauv INN - Metformin + Sitagliptin.
Hauv daim ntawv teev npe ntawm cov tshuaj hypoglycemic zoo, Janumet muaj nqis qhia.
ATX
Qhov ATX code yog A10BD07.
Tso cov ntawv thiab cov nyob ua ke
Daim ntawv tsuas tshuaj ntawm Janumet 50 yog cov ntsiav tshuaj, txawm li cas los xij, lawv yuav muaj qhov sib txawv.
Cov tshuaj muaj pes tsawg leeg hauv cov tshuaj muaj cov tshuaj ua haujlwm hauv qab no:
- sitagliptin phosphate monohydrate - hauv ib qhov nyiaj ntawm 64.25 mg (cov ntsiab lus no sib npaug nrog 50 mg ntawm sitagliptin);
- metformin hydrochloride - tus nqi ntawm cov khoom siv no tuaj yeem ncav cuag 500, 850 lossis 1000 mg (nyob ntawm seb qhov qhia tau ntau npaum li cas ntawm cov tshuaj).
Ntu cov ntsiab lus yog:
- sodium fumarate;
- povidone;
- dej lim dej;
- sodium lauryl sulfate.
Biconvex ntsiav tshuaj, zaj duab xis-coated, du ntawm ib sab thiab ntxhib ntawm lwm yam. Xim txawv raws qhov tsuas tshuaj: lub teeb liab liab (50/500 mg), paj yeeb (50/850 mg) thiab liab (50/1000 mg).
Cov ntsiav tshuaj muab tso rau hauv blisters ntawm 14 pcs. Lub thawv ntawv thawv ntawv tuaj yeem ntim ntawm 1 txog 7 daim hlau.
Pharmacological kev txiav txim
Cov tshuaj ntsiav Yanumet - ib qho tshuaj sib xyaw. Nws muaj 2 hypoglycemic tshuaj uas zoo sib txuam rau txhua lwm qhov kev ua. Kev noj tshuaj pab ua kom cov ntshav qab zib tsis tuaj yeem tswj hwm hauv cov neeg mob ntshav qab zib hom II.
Kev noj tshuaj pab ua kom cov ntshav qab zib tsis tuaj yeem tswj hwm hauv cov neeg mob ntshav qab zib hom II.
Sitagliptin
Qhov kev tivthaiv no muaj cov khoom ntawm tus yam ntxwv muaj peev xwm xaiv tau (DPP-4). Nws feem ntau siv rau hauv txoj kev kho mob hnyav ntawm hom II mob ntshav qab zib mellitus.
DPP-4 inhibitors ua los ntawm kev ua kom muaj zog. Thaum tiv thaiv cov kev ua ntawm DPP-4, sitagliptin tsub kom muaj kev nce siab ntau ntawm cov piam thaj insulinotropic polypeptide (HIP) thiab glucagon-zoo li peptide 1 (GLP-1). Cov ntsiab lus no yog cov tshuaj hormones los ntawm tsev neeg incretin. Lawv txoj haujlwm yog koom nrog kev tswj hwm cov piam thaj hauv tsev.
Nrog cov ntshav qabzib ib txwm los yog ntshav qabzib, HIP thiab GLP-1 leeb lub zog ntawm cov tshuaj insulin los ntawm cov kab mob ntawm cov txiav. GLP-1 kuj tseem tuaj yeem tiv thaiv kev zom khoom ntawm glucagon hauv lub cev txiav, uas txo cov synthesis ntawm cov piam thaj hauv lub siab.
Qhov peculiarity ntawm sitagliptin yog tias ntawm kev siv tshuaj pom zoo, cov khoom no tsis cuam tshuam kev ua haujlwm ntawm cov enzymes ntsig txog, suav nrog DPP-8 thiab DPP-9.
Metformin
Qhov kev tivthaiv no tseem muaj cov yam ntxwv hypoglycemic. Nyob rau hauv nws cov cawv, cov neeg raug kev txom nyem los ntawm hom II mob ntshav qab zib mellitus nce ntxiv nyob hauv qab. Qhov no tau piav qhia los ntawm kev txo qis hauv cov ntshav postprandial thiab basal plasma glucose qib.
Pharmacological mechanism ntawm kev ua ntawm metformin yog lub hauv paus txawv ntawm kev txiav txim ntawm qhov ncauj hypoglycemic, uas zwm rau lwm pab pawg pharmacological. Kev siv cov tshuaj yuav pab ua tiav cov ntsuas hauv qab no:
- piam thaj ntau lawm hauv lub siab yog txo qis;
- qhov feem pua ntawm cov piam thaj hauv kev nqus txo hauv plab;
- ua kom nrawm nrawm ntes thiab tshem tawm cov piam thaj hauv cov ntshav yuav ua rau muaj qhov tsis haum siab ntau ntxiv rau kev txhaj tshuaj insulin.
Qhov zoo ntawm cov khoom tivthaiv no (piv nrog sulfonylurea) yog qhov tsis muaj kev txhim kho ntawm hypoglycemia thiab hyperinsulinemia.
Cov Tshuaj Pharmacokinetics
Qhov ntau npaum ntawm cov tshuaj Yanumet sib raug rau cov txheej txheem ntawm metformin thiab sitagliptin cais. Qhov ua tau kom zoo ntawm metformin muaj qhov ntsuas ntawm 87%, sitagliptin - 60%.
Cov khoom ua kom nquag plias ntawm muaj pes tsawg leeg yog dhau los ntawm lub raum.
Kev ua siab tshaj plaws ntawm sitagliptin tau tiav li 1-4 teev tom qab kev tswj hwm qhov ncauj. Qhov kev nqus khoom noj tsis muaj kev cuam tshuam rau tus nqi thiab ntim ntawm qhov nqus. Metformin kev ua haujlwm pib tshwm tom qab 2 teev. Nrog cov khoom noj muaj txiaj ntsig ntau, tus nqi nqus tau txo.
Cov khoom ua kom nquag plias ntawm muaj pes tsawg leeg yog dhau los ntawm lub raum.
Kev ntsuas rau siv
Yanumet yog tsim los tsim cov kev tswj ntshav qab zib hauv cov neeg mob ntshav qab zib hom 2. Cov kws kho mob tau sau tshuaj rau hauv qee kis:
- Thaum tsis muaj qhov xav tau tshwm sim los ntawm kev kho mob nrog Metformin. Hauv qhov no, kev npaj ua ke txhim kho glycemic profile thiab lub neej zoo ntawm cov ntshav qab zib.
- Ua ke nrog gamma receptor antagonists.
- Nrog rau cov piam thaj tsis tiav los ntawm kev txhaj tshuaj insulin.
Cov Yuav Tsum Muaj
Nws raug nquahu kom tsis txhob noj cov tshuaj no nrog:
- tus kheej rhiab rau cov khoom hauv cov tshuaj muaj pes tsawg leeg;
- ntshav qab zib hom I;
- mob dias taub;
- ntau yam kabmob kis;
- xeev poob siab;
- mob raum tsis zoo;
- kev tso tshuaj rau tshuaj uas muaj iodine;
- mob siab rau daim siab hnyav;
- cov kab mob nrog cov pa oxygen tsis txaus;
- tshuaj lom, dej cawv;
- cev xeeb tub thiab pub niam mis;
- tsis tau muaj hnub nyoog 18 xyoo.
Nrog saib xyuas
Raws li cov lus qhia, cov tshuaj yog raug hais rau cov neeg laus laus uas muaj kev ceev faj heev.
Yuav ua li cas noj Janumet 50?
Cov ntsiav tshuaj tau noj thaum sawv ntxov ntawm lub plab khoob nrog zaub mov noj. Nrog rau kev siv ob zaug, cov tshuaj yog coj thaum sawv ntxov thiab yav tsaus ntuj. Tus kws kho mob sau cov tshuaj ntau npaum li cas, thaum coj mus rau hauv tus neeg mob tus mob, nws lub hnub nyoog thiab kev kho mob tam sim no:
- Yog tias tsis muaj tshuaj glycemic tswj nrog metformin hauv qhov siab tshaj plaws zam koob tshuaj. Cov neeg mob zoo li no tau sau Janumet 2 zaug hauv ib hnub. Tus nqi ntawm sitagliptin yuav tsum tsis pub tshaj 100 mg rau ib hnub, kev noj cov tshuaj metformin yog xaiv tam sim no.
- Yog tias muaj kev hloov pauv los ntawm kev kho mob nrog metformin + sitagliptin complex. Thawj zaug koob tshuaj ntawm Yanumet hauv qhov no yog xaiv sib npaug ua ntej.
- Thaum tsis muaj cov nyhuv tsim nyog ntawm kev noj ua ke ntawm metformin thiab sulfonylurea. Kev noj tshuaj ntawm Yanumet yuav tsum suav nrog qhov siab tshaj plaws txhua hnub ntawm sitagliptin (100 mg) thiab qhov tshuaj tiv thaiv tam sim no ntawm metformin. Qee qhov xwm txheej, kev siv tshuaj sib xyaw ua ke raug pom zoo kom ua ke nrog sulfonylurea, tom qab ntawd qhov ntau npaum ntawm qhov kawg yuav tsum raug txo kom tsawg. Txwv tsis pub, nws muaj qhov pheej hmoo ntawm lub qog ntshav qab zib.
- Thaum tsis muaj qhov xav tau tshwm sim los ntawm kev noj cov tshuaj metformin thiab PPAR-y agonist. Cov kws kho mob sau ntawv rau Yanumet ntsiav tshuaj uas muaj cov tshuaj tam sim no txhua hnub ntawm metformin thiab 100 mg ntawm sitagliptin.
- Hloov qhov tsis ua hauj lwm zoo ntawm metmorphine thiab insulin nrog tshuaj txhua hnub ntawm cov ntsiav tshuaj uas muaj 100 mg ntawm sitagliptin thiab ib koob tshuaj metformin. Qhov ntim ntawm cov tshuaj insulin yuav tsum tau ua kom tsawg.
Nrog ntshav qab zib
Cov ntsiav tshuaj yog tsim tshwj xeeb rau cov neeg mob uas muaj ntshav qab zib hom 2. Cov tib neeg uas muaj mob ntshav qab zib hom 1 tau sib kis.
Phiv Rov tuaj ntawm Yanumet 50
Tus neeg sawv cev hypoglycemic no muaj ntau cov kev mob tshwm sim. Tus kws kho mob yuav tsum paub cov neeg mob kom zoo rau lawv, vim tias yog pom ib lossis ntau cov tsos mob tshwm sim, koj yuav tsum tsis kam noj tshuaj. Tam sim ntawd tom qab qhov no, koj yuav tsum sab laj nrog kws kho mob, qhov uas lawv yuav kuaj cov ntshav thiab suav cov lactate ntau npaum li cas.
Kev kho mob txoj hnyuv
Los ntawm kev kuaj mob hauv plab, ib qho xim hlau hauv lub qhov ncauj yog ib txwm pom. Tsawg dua qhov pom yog xeev siab thiab ntuav. Flatulence thiab kev loj hlob ntawm raws plab yog tau thaum pib ntawm kev kho mob. Qee cov neeg mob qhia txog kev mob plab.
Ntuav yog ib qho tshwm sim ntawm cov tshuaj.
Los ntawm ib sab ntawm cov metabolism
Coob tus neeg mob muaj lub cev tsis txaus siab hauv lub cev. Qhov no yog nrog nrog hypoglycemia. Muaj qee zaus, mob hypothermia, kev txhim kho ntawm kev ua pa ntawm lub ntsws, qhov zoo li qaug zog, mob plab, thiab hypotension raug kuaj.
Ntawm ib sab ntawm daim tawv nqaij
Cov tshuaj tiv thaiv tawv nqaij feem ntau qhia tau tsis txaus ntseeg rau cov khoom siv ua cov ntsiav tshuaj. Hauv qhov no, dermatitis, tawm pob thiab khaus yuav tshwm sim. Tsawg dua qhov tsis tshua pom muaj yog Stevens-Johnson syndrome thiab hlaus nqaij vasculitis.
Los ntawm cov hlab plawv system
Muaj qee zaus, megaloblastic anemia yuav tshwm sim vim malabsorption ntawm cov vitamin B12 thiab folic acid.
Kev ua xua
Kev ua xua tshwm sim los ntawm daim tawv nqaij khaus thiab tawm pob.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Cov tshuaj tsis muaj qhov cuam tshuam ncaj qha rau qhov ceev ceev ntawm lub cev psychomotor cov tshuaj tiv thaiv thiab kev kub siab. Lub sijhawm no, noj cov tshuaj sitagliptin tuaj yeem ua rau nkees nkees thiab qaug zog. Vim li no, tsav lub tsheb thiab lwm cov txheej txheem nyuaj yuav tsum ua nrog ceev faj.
Cov lus qhia tshwj xeeb
Txoj kev noj tshuaj ntev yuav tsum tau saib xyuas lub raum tsis tu ncua.
Yog tias tus neeg mob tau kuaj mob lossis txheej txheem txheej txheem siv tshuaj muaj tshuaj iodine, Janumet yuav tsum tsis txhob siv 48 teev ua ntej thiab tom qab.
Hauv cov neeg mob uas muaj tus kab mob pancreatitis thiab mob raum, cov tshuaj muaj peev xwm ntxiv cov tsos mob ntawm tus kabmob. Txhawm rau tiv thaiv qhov no, tus kws kho mob yuav tsum kho cov ntau npaum li cas thiab ua tib zoo saib xyuas tus neeg mob lub sijhawm.
Hauv cov neeg mob pancreatitis, cov ntsiav tshuaj yuav ua rau muaj kev mob tshwm sim ntau dua.
Siv thaum cev xeeb tub thiab lactation
Cov poj niam thaum cev xeeb tub thiab lactation tsis pom zoo kom noj cov tshuaj hypoglycemic no. Hauv cov xwm txheej zoo li no, kev kho yog ua raws li kev siv tshuaj insulin.
Teem Tau ntawm Yanumea rau 50 tus menyuam
Tsis muaj cov ntaub ntawv tshawb fawb txog ntawm cov nyhuv ntawm cov tshuaj sib txuam rau hauv lub cev ntawm cov menyuam yaus. Vim li no, Janumet tsis raug samfwm rau cov neeg mob hnub nyoog qis dua 18 xyoo.
Siv rau lub sijhawm qub
Cov neeg hauv lub hnub nyoog laus tau xaj cov tshuaj no, tab sis ua ntej no, kev kuaj mob ntawm lub raum yuav tsum ua.
Daim ntawv thov rau lub raum khiav tsis zoo
Cov tshuaj tsis raug pom zoo rau cov neeg muaj mob raum (suav nrog cov neeg tsis mob raum).
Siv rau lub siab ua haujlwm tsis zoo
Yog tias qhov ua rau lub siab ua haujlwm tsis zoo, noj Janumet tsis pom zoo. Qhov no yog vim qhov pheej hmoo ntawm cov kab mob lactic acidosis.
Noj ntau tshaj ntawm Yanumet 50
Yog tias tus neeg mob tshaj li kev siv tshuaj kho kom haum, qhov no yuav tsim kev loj hlob ntawm cov kab mob lactic acidosis. Yuav kom tswj tau qhov xwm txheej, pais plab lav tau ua tiav thiab hemodialysis yog kev kho mob.
Lwm qhov cim ntawm kev noj tshuaj ntau dhau yog hypoglycemia. Nrog kev sib qhia me me, tus neeg mob tau pom zoo kom noj cov khoom noj uas muaj cov khoom noj carbohydrates ntau. Mob ntshav qab zib ntshav siab lossis ntshav qis yuav tsum tau taug qab los ntawm kev txhaj tshuaj Glucagon lossis Dextrose tov. Tom qab tus neeg mob rov qab nco qab, lawv tau muab cov khoom noj uas yog carbohydrate-nplua nuj.
Yuav kom tswj tau qhov xwm txheej nyob rau kis dhau los ntawm kev siv tshuaj ntau dhau hoos, kev kho mob hemodialysis yog kev kho mob.
Kev cuam tshuam nrog lwm yam tshuaj
Nrog rau txoj kev kho mob ntau ntxiv ntawm tus neeg mob, tus kws kho mob yuav tsum coj mus rau hauv tus lej ntawm kev sib xyaw ntawm cov ntsiav tshuaj nrog lwm cov tshuaj.
Qhov kev txiav txim ntawm Yanumet tsis muaj zog nyob rau hauv qhov muaj ntawm cov tshuaj hauv qab no:
- Phenothiazine;
- Glucagon;
- thiazide diuretics;
- nicotinic acid;
- corticosteroids;
- cov thyroid hormones;
- Isoniazid;
- estrogens;
- sympathomimetics;
- calcium antagonists;
- Phenytoin.
Kev tiv thaiv hypoglycemic yog kho kom zoo thaum siv ua ke nrog cov tshuaj hauv qab no:
- cov tshuaj uas tsis yog tshuaj steroidal;
- Cov tshuaj insulin
- beta-blockers;
- sulfonylurea derivatives;
- Oxytetracycline;
- Acarbose;
- Cyclophosphamide;
- ACE thiab MAO inhibitors;
- derivatives ntawm clofibrate.
Nrog cimetidine, muaj kev pheej hmoo ntawm acidosis.
Nrog sulfonylurea derivatives lossis insulin. Feem ntau nws muaj ntshav qab zib hauv qhov tsis muaj kev hloov kho tshuaj.
Cawv tau zoo
Nrog rau kev haus cawv, kev pheej hmoo ntawm cov kev mob tshwm sim ntxiv.
Analogs
Ntawm cov analogues hu ua:
- Amaryl M;
- Yanumet Ntev;
- Douglimax;
- Velmetia;
- Avandamet;
- Glucovans;
- Glibomet;
- Galvus Met;
- Gluconorm;
- Choj.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Hauv cov khw muag tshuaj, nws yog daim ntawv qhia tshuaj nruj me ntsis.
Kuv puas yuav tau yam tsis muaj daim ntawv yuav tshuaj?
Cov tshuaj uas zwm rau hauv pab pawg no yuav tsis yuav nws yam tsis muaj kws kho mob sau ntawv.
Nqe rau Yanumet 50
Tus nqi ntawm cov tshuaj hauv Ukraine, Russia thiab lwm lub tebchaws yog nyob ntawm seb tsuas pub tshuaj npaum li cas yog muab hauv cov ntsiav tshuaj thiab muaj pes tsawg daim uas muaj nyob hauv pob. Hauv cov khw muag tshuaj hauv Moscow, tus nqi rau Yanumet yog li nram qab no:
- 500 mg + 50 mg (56 pcs.) - 2780-2820 rubles;
- 850 mg + 50 mg (56 pcs.) - 2780-2820 rubles;
- 1000 mg + 50 mg (28 pcs.) - 1750-1810 rubles;
- 1000 mg + 50 mg (56 pcs.) - 2780-2830 rubles.
Cia rau cov neeg mob rau cov tshuaj
Cov tshuaj yuav tsum tau muab cia rau hauv qhov chaw tiv thaiv los ntawm tshav ntuj ncaj qha thiab ya raws. Yuav tsum muaj qhov kub thiab txias ntau txog + 25 ° C.
Hnub tas sij hawm
Cov tshuaj no tuaj yeem siv rau 2 xyoos.
Chaw tsim tshuaj paus
Cov ntsiav tshuaj yog tsim los ntawm lub tuam txhab tshuaj Patheon Puerto Rico Inc. hauv Puerto Rico. Ntim ntawm cov tshuaj yog nqa los ntawm cov tuam txhab sib txawv:
- Merck Sharp & Dohme B.V, nyob hauv Netherlands;
- OJSC "Tshuaj-Tshuaj nroj tsuag" AKRIKHIN "hauv Russia;
- Frosst Iberica hauv Spain.
Cov tshuaj yog raug faib tawm los ntawm cov khw muag tshuaj nruj me ntsis raws li cov ntawv sau tshuaj.
Kev txheeb xyuas txog Yanumet 50
Alexandra, tus kws kho keeb (endocrinologist), tau paub txog kev kho mob 9 xyoo, Yaroslavl.
Cov tshuaj muaj tshuaj tswj tau ua pov thawj nws cov hauj lwm zoo hauv kev kuaj mob hauv tsev kho mob thiab hauv kev coj ua. Kuv feem ntau sau cov tshuaj no rau kuv cov neeg mob insulin dependence. Cov kev mob tshwm sim muaj tsawg. Qhov xav tau qhov tseem ceeb yog muab tshuaj rau.
Valery, endocrinologist, muaj kev paub txog kev kho mob rau 16 xyoo, Moscow.
Yanumet tso cai rau koj kom ua tiav cov txiaj ntsig xav tau nyob rau hauv ntau yam thaum cov piam thaj tsis tuaj yeem tswj nrog Metformin. Qee tus neeg mob tau ntshai hloov mus rau hom kev kho mob no vim tias muaj feem tshwm sim thiab qhov phom sij ntawm hypoglycemia. Lub caij no, hauv kev coj ua, cov xwm txheej no tuaj yeem hu ua tsis tshua muaj neeg, tshwj xeeb tshaj yog tias kev noj tshuaj kom raug thiab lwm tus kws kho mob cov lus pom zoo.
