NovoRapid Penfill yog qhov ua kom muaj cov kabmob hypoglycemic ua pa raws cov tshuaj insulin aspart. Qhov tom kawg txawv ntawm ntuj tsim los ntawm tib neeg cov kua dej los ntawm qhov muaj cov aspartic acid los ntawm tus neeg ua mov ci cov poov xab uas hloov pauv proline. Qhov hloov ntshav ntawm lub cev no tau txo lub sijhawm kom ua tiav cov txiaj ntsig kho kom zoo thiab lub sijhawm siv tshuaj, uas yog vim li cas nws pom zoo kom noj cov tshuaj ua ntej noj mov.
Lub Npe Tsis Yog Neeg Tsis Muaj Npe
Cov tshuaj insulin.
ATX
A10AB05.
Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm kev daws rau kev tswj hwm subcutaneously thiab intravenously, cartridges yog muab tso rau hauv blister ntim ntawm 5 pcs.
Tso cov ntawv thiab cov nyob ua ke
Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm kev daws rau kev tswj hwm subcutaneously thiab leeg. Kev pom, nws yog cov kua ntshiab, tsis muaj ntxhiab thiab tsis muaj kob. 1 ml ntawm cov tshuaj muaj 100 IU ntawm cov tshuaj nquag, uas sib haum rau 3500 μg. Raws li cov khoom siv ntxiv tau siv:
- glycerol;
- hydrochloric acid;
- sodium hydroxide;
- dej tsis huv rau kev txhaj tshuaj;
- phenol;
- zinc thiab sodium chloride;
- sodium hydrogen phosphate dihydrate;
- metacresol.
Cov tshuaj muaj nyob hauv 3 ml iav daim cartridges. Lub thawv ntim tau muab tso rau hauv blister pob ntawm 5 pcs.
Pharmacological kev txiav txim
Cov tshuaj insulin aspart yog cov hluavtaws sib xyaw ua ke ntawm tib neeg cov tshuaj hormones zais cia los ntawm beta hlwb ntawm cov txiav. Hauv cov txheej txheem ntau lawm hauv cov qauv molecular ntawm insulin, proline hloov los ntawm aspartic acid, yog li txo lub sijhawm kom ua tiav cov txiaj ntsig kho.
NovoRapid Penfill yog qhov ua kom muaj cov kabmob hypoglycemic ua pa raws cov tshuaj insulin aspart.
Cov tshuaj synthesized cuam tshuam nrog cov receptors nyob rau sab nraud ntawm lub cell membrane. Nrog rau txoj kev cuam tshuam no, insulin-receptor complex yog tsim los uas tsim cov tshuaj hexokinase, ib qho enzyme lub luag haujlwm rau cov synthesis ntawm glycogen, thiab pyruvate kinase.
Qhov ua rau lub ntsej muag yog vim muaj kev ua kom sai ntawm kev siv lub cev metabolism hauv lub cev thiab qhov nqus ntawm cov piam thaj los ntawm cov ntaub so ntswg, nce lipogenesis thiab glycogen tsim, thiab qeeb hauv gluconeogenesis hauv daim siab hepatocytes. Cov chaw muag tshuaj ntawm cov tshuaj nquag yog zoo ib yam li cov tshuaj lom neeg nyob hauv tib neeg. Tab sis tib lub sijhawm, tus nqi ntawm kev ua tiav ntawm kev kho mob hauv NovoRapid Penfill yog qhov ntau dua.
Insulin aspart yog nqus los ntawm subcutaneous rog txheej ntawm lub dermis thaum muab tshuaj subcutaneously sai thiab ua tiav cov teebmeem ntawm hypoglycemic nyob rau lub sijhawm luv dua li cov neeg ua kom tsis haum ntshav.
Cov Tshuaj Pharmacokinetics
Nrog kev qhia txog NovoRapid subcutaneously, lub sijhawm mus cuag cov ntshav siab tshaj plaws nyob rau hauv cov ntshav txo qis 2 zaug piv rau cov qauv kev tswj hwm ntawm cov tshuaj insulin. Cov txiaj ntsig siab tshaj plaws tau sau tseg tsis dhau 40 feeb tom qab kev txhaj tshuaj. Qhov kev nkag siab ntawm cov tshuaj insulin hauv cov ntshav rov qab rau nws cov txiaj ntsig qub tom qab 4-6 teev tom qab kev coj ntawm cov tshuaj. Hauv cov neeg mob uas tsis muaj cov kab mob ntshav qab zib tsis txaus insulin, qhov nqus ntshav qis dua, uas yog vim li cas lub sijhawm mus cuag lub siab tshaj plaws ntshav ntawm aspart insulin ncav cuag 60 feeb.
Kev ntsuas rau siv
Cov tshuaj no yog siv los ua kom muaj glycemic tswj thiab ua kom cov ntshav qab zib ib txwm nyob ntawm qhov muaj mob 1 thiab ntshav qab zib hom 2. Nyob rau hauv rooj plaub tom kawg, cov tshuaj tawm hauv kev txhim kho ntawm kev ua tiav ntawm kev tiv thaiv hypoglycemic qhov ncauj noj tshuaj. Ib nrab tawm tsam yuav tsum tau suav nrog NovoRapid hauv kev kho mob sib xyaw.
Cov tshuaj NovoRapid yog txwv tsis pub siv rau cov menyuam yaus hnub nyoog qis dua 2 xyoos.
Cov tshuaj yog siv thaum nws tsis tuaj yeem sau tshuaj rau lwm yam kab mob hypoglycemic tawm tsam keeb kwm yav dhau los ntawm kev txhim kho ntawm tus kab mob sib kis - cov txheej txheem kab mob nyuaj los ntawm kev tshwm sim ntawm cov kab mob theem ob.
Cov Yuav Tsum Muaj
Cov tshuaj yog nruj me ntsis txwv nyob rau hauv muaj cov qog ntshav qab zib thiab muaj kev cuam tshuam ntau ntxiv rau cov nquag muaj txiaj ntsig, cov menyuam yaus hnub nyoog qis dua 2 xyoos.
Nrog saib xyuas
Nws raug nquahu kom ceev faj rau cov neeg muaj lub siab tsis ua haujlwm, nyob hauv qhov muaj cov kab mob siab ntsws, thiab rau cov neeg laus dua 65 xyoos.
Yuav ua li cas noj NovoRapid Penfill?
Cov tshuaj yog muab tshuaj subcutaneously lossis txhaj tshuaj leeg. Kev noj tshuaj txhua hnub ntawm NovoRapid yog txiav txim siab los ntawm tus kws kho mob koom nrog tus kheej ib tus zuj zus raws li cov suab thaj thiab txhua hnub cov kev xav tau rau insulin. Nws raug nquahu kom suav nrog cov tshuaj hauv kev sib xyaw nrog kev kho mob nrog hypoglycemic tshuaj ntawm mob nrab lossis ntev ntev, uas noj ib zaug ib hnub.
Yuav kom ua tiav qhov kev tswj xyuas glycemic tsim nyog, nws yog ib qho tsim nyog yuav tsum tau ntsuas cov ntsuas ntshav qab zib ntev, nyob ntawm seb qhov tshuaj ntau npaum li cas yuav raug kho.
Kev txhaj tshuaj yuav ua li cas?
Koj tsis tuaj yeem nkag mus rau cov tshuaj intramuscularly. Nws raug nquahu kom hloov thaj chaw txhaj tshuaj nrog txhua qhov kev txhaj tshuaj txhawm rau txhawm rau txo qhov ntxim nyiam ntawm cov ntsaws ruaj ruaj thiab mob rau hauv qhov chaw no.
Nrog kev kho tus kheej, cov kua dej yog muab tshuaj subcutaneously. IV Txoj kev lis ntshav yog nqa tawm los ntawm kev saib xyuas ntawm tus kws kho mob. Txhawm rau nqa tawm sc txhaj tshuaj, nws yog ib qho tsim nyog kom ua raws li cov txheej txheem tsim:
- Nws yog qhov tsim nyog los tuav lub koob tso rau hauv qab ntawm daim tawv nqaij tsawg kawg 6 vib nas this los ntawm nias lub khawm pib (nws tawm tom qab tshem rab koob). Cov txheej txheem no yuav muab 100% kev tswj hwm kev noj cov tshuaj insulin thiab yuav tiv thaiv kom ntshav txhob nkag mus rau hauv daim cartridge.
- Koob yog rau kev siv nkaus xwb. Nrog kev rov ua dua ntawm cov tshuaj insulin nrog ib rab koob, qhov kev daws teeb meem yuav tuaj yeem los ntawm daim cartridge, vim tias lub cev yuav tau txais kev noj tshuaj tsis yog lawm ntawm lub cev.
- Tsis txhob rov qab ntim lub taub ntawv.
Nws raug nquahu kom koj ib txwm nqa lub tshuab nqus dej nrog koj thaum lub laub poob lossis cov khoom puas.
Kho ntshav qab zib
Qhov xav tau rau cov tshuaj insulin ib hnub rau cov neeg laus thiab cov menyuam yaus sib txawv li ntawm 0.5 txog 1 koog ntawm kev muab tshuaj rau 1 kg ntawm qhov hnyav. Nrog kev qhia ntawm cov tshuaj ua ntej noj mov, lub cev tau txais 50-70% ntawm qhov yuav tsum tau txhaj ntawm pancreatic hormone. Tus so yog rov qab hloov lub cev lossis lwm yam tshuaj qeeb qeeb. Nrog rau kev ua kom lub cev nce ntxiv, hloov mus rau kev noj zaub mov noj, muaj cov kab mob thib ob, hloov kho ntxiv yog tsim nyog.
Insulin aspart, tsis zoo li soluble tib neeg cov tshuaj insulin, muaj kev kub ceev thiab kev ua haujlwm luv luv, yog li ntawd cov tshuaj raug pom zoo kom ua ntej noj mov. Vim yog lub sijhawm ua haujlwm tsawg, qhov muaj feem ntau ntawm kev tsaus ntuj hypoglycemia yuav txo qis.
Rau kev tswj hwm cov dej num hauv chaw nyob ruaj ruaj, nws yog qhov tsim nyog los npaj dej ntws.
Rau kev tswj hwm cov dej num hauv chaw nyob ruaj ruaj, nws yog qhov tsim nyog los npaj dej ntws. Kev npaj ntawm Txoj kev lis ntshav muaj nyob rau hauv diluting 100 UNITS ntawm NovoRapid hauv 0.9% isotonic daws ntawm Sodium chloride yog li cov tshuaj ntawm insulin aspart sib txawv ntawm 0.05 txog 1 UNITS / ml.
Sab Sij Huam NovoRapida Penfill
Cov kev mob tshwm sim feem ntau tshwm sim feem ntau vim kev noj tshuaj tsis tsim nyog. Yuav kom txo tau qhov kev pheej hmoo ntawm hypoglycemia, nws yog ib qho tsim nyog yuav tsum xaiv cov koob txhaj tshuaj ntawm NovoRapid.
Los ntawm lub cev tiv thaiv kab mob
Tej zaum qhov tsos ntawm urticaria, tawm pob rau ntawm daim tawv nqaij, anaphylactic kev tsis haum.
Ntawm ib feem ntawm cov metabolism thiab khoom noj khoom haus
Txoj kev pheej hmoo siab ntshav qab zib nrog kev siv tshuaj tsis haum.
Nruab nrab hauv lub paj hlwb
Muaj qee zaus, mob hlab ntsha hlwb peripheral.
Ntawm ib feem ntawm cov khoom hauv nruab nrog kev pom
Pom kev tsis meej ua rau nws tus kheej muaj kev nyuaj siab tsis zoo lossis txhim kho tus mob ntshav qab zib.
Los ntawm lub tshuab ua pa
Muaj qee kis, kev ua pa luv tshwm sim.
Ntawm ib sab ntawm daim tawv nqaij
Tej zaum muaj kev txhim kho ntawm lipodystrophy.
Kev ua xua
Muaj qee qhov tshwj xeeb, muaj cov kev mob tshwm sim ntawm kev tsis haum tshuaj, nrog tawm pob thiab khaus khaus, tsis mob plab, nce hws, Quincke's edema, tachycardia, hypotension. Kev phiv tshuaj yog qhov phom sij rau lub neej tus neeg mob.
Cuam tshuam rau lub peev xwm los tswj cov tshuab
Nrog cov kev tswj ntawm glycemic poob, nrog hypoglycemia lossis hyperglycemia, lub peev xwm tseem ceeb yog qhov tsis pom thiab lub nrawm ntawm reflexes tsawg dua. Qhov no yog qhov txaus ntshai thaum tsav tsheb los yog siv lub tshuab ua tau yooj yim.
Noj NovoRapid Penfill yog qhov muaj kev phom sij thaum tsav tsheb.
Cov lus qhia tshwj xeeb
Nrog cov tshuaj ntshav qis los yog tawm ntawm txoj kev kho mob, kev loj hlob ntawm hypoglycemia thiab ketoacidosis muaj peev xwm tiv thaiv keeb kwm ntawm kev nce ntxiv ntawm qhov kev coj ua ntawm ketone lub cev thiab qab zib hauv ntshav plasma, tshwj xeeb tshaj yog nyob rau cov neeg mob uas muaj ntshav qab zib hom 1 mob ntshav qab zib. Hyperglycemia tej zaum yuav tshwm sim maj mam ntev zuj zus hauv lub lis piam. Cov tsos mob thawj zaug ntawm kev txhim kho hauv cov txheej txheem pathological yuav:
- qhov ncauj qhuav
- tsaug zog
- daim tawv liab;
- polyuria;
- kev tshaib plab heev;
- xeev siab, ntuav, thiab nqhis dej;
- hnov tsw ntawm acetone los ntawm lub qhov ncauj.
Ib qho yeeb yam ntawm cov pharmacokinetics ntawm kev ua yeeb yam luv luv yog kev txhim kho sai sai ntawm hypoglycemia, hauv kev sib piv rau soluble tib neeg cov kua dej.
Hauv cov neeg mob uas muaj lub siab thiab lub raum tsis ua haujlwm, tus nqi ntawm kev nqus ntawm insulin aspart yog txo.
Siv thaum cev xeeb tub thiab lactation
Hauv kev tshawb fawb txog cov tsiaj, insulin aspart pom tsis muaj embryotoxicity thiab teratogenicity. Thaum sau ntawv yuav NovoRapid, cov poj niam cev xeeb tub xav tau kev soj ntsuam tas li ntawm cov ntshav plasma cov piam thaj. Tus kws kho mob yuav tsum saib xyuas cov neeg mob.
Hauv thawj peb lub hlis ntawm kev txhim kho embryonic thiab lub sijhawm ua haujlwm, qhov kev xav tau rau cov kua dej tsawg dua, thaum nyob hauv lub sijhawm thib ob thiab thib peb lub zog feem ntau nce ntxiv.
Thaum lub sij hawm pub mis niam, nws yog ib qho tsim nyog yuav tau kho cov tshuaj ntawm cov kua dej.
Cawv tau zoo
Ethanol txhim kho qhov kev tiv thaiv hypoglycemic ntawm insulin aspart; yog li, haus dej haus cawv thaum lub sijhawm kho cov tshuaj yog nruj me ntsis txwv. Kev haus dej cawv ethyl tuaj yeem ua rau muaj kev txhim kho hypoglycemia thiab coma hypoglycemic.
Noj ntau tshaj NovoRapida Penfill
Kev mob ntshav qab zib tsawg tuaj yeem tsim tawm maj mam tiv thaiv keeb kwm ntawm kev tswj hwm ntev ntawm kev siv tshuaj ntawm NovoRapid. Txawm li cas los xij, ib qho koob tshuaj tseem tsis tau tsim kom muaj peev xwm ua rau lub chaw saib mob ntawm kev noj ntau dhau, vim tias lub xeev hypoglycemic nws qhov nws ua tau nws tus kheej nyob ntawm tus neeg mob ntawm tus neeg.
Cov ntshav qab zib tsawg, tus neeg mob muaj peev xwm tshem tawm ntawm nws tus kheej los ntawm kev noj khoom nrog cov piam thaj hauv qab zib lossis cov piam thaj hauv.
Kev mob ntshav siab ntau yog nrog los ntawm txoj kev tsis nco qab. Hauv qhov no, kev mus pw hauv tsev kho mob, kev qhia ntawm intramuscularly lossis subcutaneously 0.5-1 mg ntawm glucagon. Kev teem sijhawm ntawm Txoj kev lis ntshav ntawm cov dej qabzib yog tso cai. Yog tias tom qab 10-15 feeb tom qab kev tswj hwm ntawm Glucagon, nco qab tsis rov qab, koj yuav tsum nkag mus rau kev daws 5% ntawm Dextrose. Thaum kho kom rov qab tus mob thiab paub tus neeg mob, nws yog qhov yuav tsum tau muab cov zaub mov rau tus neeg mob nrog cov khoom noj kom ntau. Qhov no yog qhov tsim nyog los tiv thaiv txoj kev txhim kho ntawm rov qab.
Kev mob ntshav siab ntau yog nrog los ntawm txoj kev tsis nco qab.
Kev cuam tshuam nrog lwm yam tshuaj
Qee cov tshuaj tuaj yeem txhim kho cov nyhuv hypoglycemic ntawm NovoRapid:
- monoamine oxidase, ACE inhibitors, carbonic anhydrase inhibitors;
- cov tshuaj lithium;
- tsis xaiv khoom beta-blockers;
- sulfonamides;
- Fenfluramine;
- ethanol-muaj thiab hypoglycemic cov neeg sawv cev;
- Bromocriptine;
- tetracycline tshuaj tua kab mob;
- Octreotide;
- Pyridoxine.
Qhov kev ua kom tsis muaj zog ntawm kev kho kom zoo yog pom nrog kev tswj hwm tib lub sijhawm ntawm NovoRapid nrog calcium channel blockers, diuretics, Heparin, antidepressants, glucocorticosteroids, Morphine, thiab cov neeg sawv cev uas muaj cov thyroid hormones.
Reserpine thiab salicylates tuaj yeem ua rau tswj kev glycemic poob.
Kev haus luam yeeb vim muaj cov ntsiab lus nicotine tuaj yeem txo cov nyhuv ntshav qab zib tsawg.
Thiol-muaj cov tshuaj thiab sulfite-muaj cov tshuaj thaum sib tham nrog insulin ua rau kev puas tsuaj ntawm yav dhau los.
Analogs
Cov qauv tshuaj tiv thaiv kab mob thiab cov tshuaj sib xws nrog cov khoom muaj zog zoo xws li:
- Actrapid;
- NovoRapid syringe cwj mem;
- Apidra
- Biosulin;
- Gensulin;
- Cov tshuaj insulin.
Cov ntsiab lus ntawm lub tsev muag tshuaj tawm
Cov tshuaj yuav muag rau kev kho mob ncaj qha.
Kuv puas yuav tau yam tsis muaj daim ntawv yuav tshuaj?
Tus neeg sawv cev glycemic, yog siv tsis raug, tuaj yeem ua rau cov ntshav qog ntshav qab zib, uas tuaj yeem tsim mus rau hauv lub ntsej muag hypoglycemic. Tus mob no yog txaus ntshai, yog li kev siv tshuaj yeeb tshuaj tsis muaj tshuaj kho mob raug txwv.
Nqe rau NovoRapid Penfill
Tus nqi nruab nrab ntawm lub pob cartridges yog 1850 rubles.
Cia rau cov neeg mob rau cov tshuaj
Nws yog qhov tsim nyog yuav tsum khaws cov tshuaj ntawm qhov kub ntawm + 2 ... + 8 ° C. Nws pom zoo kom khaws hauv lub tub yees, tab sis tsis tuaj yeem khov. Daim cartridges yuav tsum cia rau hauv cov thawv ntawv los tiv thaiv los tiv thaiv tshav ntuj. Cov pob qhib uas tau qhib cia tau khaws cia ntawm qhov kub ntawm + 15 ... + 30 ° C thiab siv rau ib hlis.
Ib qho tshuaj tiv thaiv ntawm cov tshuaj tuaj yeem yog Apidra noj tshuaj.
Hnub tas sij hawm
30 hli
Chaw tsim tshuaj paus
Novo Nordisk A / S, Denmark.
Kev txheeb xyuas rau NovoRapida Penfill
Hauv lub sijhawm tshaj tawm kev lag luam, insulin aspart pom zoo nws cov nyhuv hauv khw pharmacological, vim tias muaj cov lus pom zoo los ntawm cov neeg mob thiab cov kws kho mob nyob hauv Is Taws Nem.
Cov kws kho mob
Zinaida Siyuhova, endocrinologist, Moscow.
Cov tshuaj muaj ultra-luv kev txiav txim siab, tso cai rau koj nkag mus rau hauv insulin tsis tsuas yog 10-15 feeb ua ntej noj mov, tab sis kuj thaum lub sijhawm noj mov. Kev ua tiav sai ntawm cov tshuaj kho tau yog ib qho tseem ceeb hauv kev kub ntxhov. Ua tsaug rau insulin aspart, ib tus neeg muaj mob ntshav qab zib hom 2 lossis ntshav qab zib insulin-cov ntshav qab zib tsis tuaj yeem hloov kho mus rau kab mob, kho kev noj haus raws li nws xav tau.
Ignatov Konstantin, endocrinologist, Ryazan.
Zoo li kev ua ntawm cov tshuaj insulin. Hauv cov xwm txheej tseem ceeb, nws yuav pab txo qis ntshav qab zib kom sai.Nyob rau tib lub sijhawm, tus neeg mob yuav tsum tau ua raws li cov tshuaj ntau dua raws li cov lus qhia, txwv tsis pub muaj kev pheej hmoo ntawm kev muaj ntshav qab zib ntau zuj zus. Tus neeg mob tuaj yeem tswj hwm tus kheej ntawm subcutaneous insulin infusion.
Cov neeg mob
Artemy Nikolaev, 37 xyoo, Krasnodar.
Kuv muaj ntshav qab zib hom 1 txij li kuv muaj 18 xyoo. Nqe Actrapid, uas tsis pab ua tiav glycemic tswj - qab zib tseem siab. Tus kws kho mob hloov Actrapid nrog kev sib xyaw ua ke nrog NovoRapid Penfill ua yeeb yam luv luv thiab Levemir ntev. NovoRapid nplua kuv lub cev. Txaus siab rau qhov chaw tsim tshuaj paus kom muaj cov insulin zoo.
Sofia Krasilnikova, 24 xyoos, Tomsk.
Kuv tau siv cov roj cartridges tau ntau xyoo. Qab zib qib tas li nyob hauv qhov ib txwm muaj. Thaum nws sawv, Kuv txawb kiag tam sim ntawd. Rau 10-15 feeb, rov qab los ua qub. Kuv tsis pom tias muaj kev phiv tshuaj dab tsi.
