Glimepiride siv tshuaj los txo cov piam thaj hauv ntshav qab zib

Glimepiride (hauv Latin qhia - Glimepiride) - Qhov no yog ib hom tshuaj tsis zoo li niaj hnub no. Ntawm tag nrho cov tshuaj tiv thaiv kab mob uas sawv cev rau chav kawm ntawm sulfonylurea tshuaj, qhov no yog qhov tshuaj yooj yim heev. Thaum cov tshuaj ua ntej pom nyob hauv cov khw muag tshuaj, lawv yog ib hom tshuaj uas nrov tshaj plaws. Tab sis tom qab nrhiav tau ntawm ib qho kev kawm tshiab ntawm cov tshuaj (incretins), lawv tau pib undeservedly tsis nco qab nws.

Cov tshuaj tseem muaj cov yeeb yaj kiab tshwj xeeb: ntxiv cov neeg mob ntawm cov nqaij mos ua rau cov insulin endogenous, txo kev tsim cov piam thaj hauv lub siab, tiv thaiv kev tsim cov ntshav txhaws, thiab txo qis ntawm cov dawb radicals.

Dosage daim ntawv

Cov chaw tsim tshuaj paus hauv tsev PHARMSTANDART ua Glimepiride ua 4 tshuaj ntsiav tshuaj:

• Lub teeb liab xim - 1 mg txhua;
• Lub teeb ntsuab Hawj txawm - 2 mg txhua;
• Lub teeb daj - 3 mg;
• Lub teeb xiav xim - 4 mg txhua.

Cov kaus poom ntim rau hauv cov ntawv ci txhuas ntawm 10 pcs., Cov phiaj tso rau hauv ntawv ntim. Khaws cov tshuaj rau hauv nws lub thawv qub ntawm chav sov tsis pub dhau 3 xyoos. Rau Glimepiride, tus nqi hauv khw muag tshuaj yog los ntawm 153 rubles. mus txog 355 RUB. nyob ntawm ntau npaum li cas. Hom kev faib tawm cov tshuaj yog tshuaj.

Glimepiride - analogues thiab cov lus ua

Cov tshuaj kho mob thaum xub thawj, thawj zaug, feem ntau kawm, yog Amaril los ntawm lub tuam txhab Sanofi Aventis. Tag nrho lwm yam tshuaj, suav nrog glimepiride, yog cov tshuaj analogues, cov tuam txhab kws tsim khoom tsim lawv raws li cov ntawv muaj tswv. Ntawm cov nto moo tshaj plaws:

• Glimepiride (Russia);
• Diamerid (Russia);
• Diapyrid (Ukraine);
• Glimepirid Teva (Croatia);
• Glemaz (Argentina);
• Glianov (Jordan);
• Glibetik (Poland);
• Amaril M (Kauslim Teb);
• Glairi (Is Nrias teb).

Kev Sib xyaw ntawm cov tshuaj Glimepiride

Glimepiride yog ib qho tshuaj tiv thaiv kab mob hauv lub qhov ncauj nrog hypoglycemic tej zaum. Cov tshuaj yog zwm rau pab pawg ntawm sulfonamides, derivatives ntawm urea.

Qhov pib ua haujlwm tseem ceeb ntawm cov tshuaj yog glimepiride. Hauv ib ntsiav tshuaj, nws qhov hnyav yog 1 txog 4 mg. Cov tshuaj ua kom muaj zog yog ntxiv nrog cov khoom siv pabcuam: sodium starch, povidone, polysorbate, microcrystalline cellulose, lactose, magnesium stearate, indigo txhuas kua roj vanish.

Kws Tshuaj

Glimepiride yog ib qho tshuaj tiv thaiv kab mob los ntawm sulfonylurea pawg uas nquag thaum noj ntawm qhov ncauj. Nws yog tsim los tswj hom mob ntshav qab zib hom 2. Cov txheej txheem ntawm kev ua ntawm cov tshuaj yog raws li kev ua kom muaj β-hlwb lub luag haujlwm rau kev tsim cov tshuaj insulin endogenous. Cov tshuaj khi rau cov membrane protein ntawm cov hlwb ua kom sai.

Zoo li txhua yam tshuaj nyob hauv pab pawg no, cov tshuaj tsub kom qhov rhiab ntawm cov nqaij mos ua rau cov kua nplaum tawm. Nws muaj tshuaj noj thiab ntxiv txaws-rov qab zoo. Kev tsim tawm cov tshuaj insulin nyob rau hauv kev cuam tshuam ntawm cov tshuaj tshwm sim vim kev txhim kho nkag mus rau cov calcium calcium: kev nce ntawm kev nkag mus ntawm calcium tuaj yeem txhawb kev tso tawm ntawm insulin.

Ntawm cov cuam tshuam ntxiv, qhov txo qis ntawm qhov tsis kam ntawm cov cell mus rau lub cev thiab qhov kev txo qis ntawm nws qhov kev siv hauv lub siab tuaj yeem sau tseg. Hauv cov leeg nqaij thiab lub cev rog, cov piam thaj tau hlawv nrog kev pab los ntawm thauj cov protein, cov haujlwm uas nce ntxiv tom qab noj cov tshuaj.

Cov Tshuaj Pharmacokinetics

Lub bioavailability ntawm glimepiride yog 100%. Qhov sib xyaw kom tsawg ntawm cov as-ham qeeb qeeb dua kev nqus me ntsis. Qhov ntshav siab tshaj plaws cov ntsiab lus tau pom 2.5 teev tom qab cov tshuaj tau txais nyob rau hauv cov hnyuv. Kev faib tawm ntawm cov tshuaj yog tsawg (8.8 L), nws khi rau cov kab mob protein ntau li ntau tau (99%), kev tshem tawm cov tshuaj yog 48 ml / min.

Nrog kev rov qab noj tshuaj dua, qhov nruab nrab ib nrab-lub neej yog 5-8 teev. Nrog rau qhov nce ntxiv hauv cov tshuaj kho mob, lub sijhawm no nce. Metabolites raug tshem tawm lawm: 58% ntawm ib koob tshuaj uas muaj lub npe hu ua radioot isotope nyob hauv cov zis thiab 35% hauv cov quav. Ib nrab-lub neej ntawm cov khoom lwj yog 3-6 teev.

Tsis muaj qhov sib txawv hauv cov pharmacokinetics ntawm glimepiride hauv cov ntshav qab zib ntawm cov tub ntxhais hluas lossis cov hnub nyoog tiav, poj niam lossis txiv neej. Hauv cov neeg mob ntshav qab zib nrog kev tshem tawm creatinine tsawg, tsis muaj kev phom sij ntawm kev txuam nrog tshuaj. Cov teeb meem pharmacokinetic nyob rau hauv 5 cov neeg mob tom qab cholecystectomy zoo ib yam li cov neeg muaj ntshav qab zib noj qab haus huv hauv qhov no.

Hauv 26 cov tub ntxhais hluas muaj hnub nyoog 12-17 xyoo, nrog rau 4 tus menyuam hnub nyoog 10-12 xyoo, cov neeg mob ntshav qab zib hom 2, ib koob tshuaj tsawg kawg (1 mg) ntawm cov tshuaj pom tias tshwm sim zoo ib yam li cov neeg laus.

Leej twg yog tus muab tshuaj

Ntsiav tshuaj yog tshuaj rau cov ntshav qab zib hom 2 yog glycemic tswj los ntawm kev hloov kho hauv lub neej tsis txaus. Nws yog qhov ua tau los ntawm kev muab tshuaj rau cov tshuaj ntxiv ib qho ntxiv, hauv txoj kev kho mob nrog lwm tus neeg mob hypoglycemic.

Leej twg tsis pom muaj glimepiride

Cov tshuaj tsis haum rau cov neeg mob ntshav qab zib nrog hom mob 1; lawv tsis siv rau cov ketoacidosis uas mob ntshav qab zib, tsis nco qab thiab precoma, zoo li yog rau mob raum thiab mob siab rau kev ua haujlwm siab.

Zoo li ib yam tshuaj twg, glimepiride tsis raug siv rau cov neeg mob ntshav qab zib nrog lub siab rhiab rau cov khoom xyaw ntawm cov mis, thiab zoo li lwm yam tshuaj sulfonylamide.

Glimepiride yog sib kis hauv kev xeeb tub thiab lactation.

Yuav siv li cas Glimepiride kom raug

Txhawm rau kom 100% glycemic tswj, kev siv tshuaj kho mob tsis txaus.

Cov qauv npaj qhia txog cov leeg mob hauv ntshav qab zib ntawm yam thib 2 ntawm lub teeb thiab nruab nrab daim ntawv yuav yog cov hauv qab no:

• Tawm dag zog - 2-3 p. / Lub limtiam;
• Kev taug kev muaj zog - 3 rubles / vas thiv.;
• Ua luam dej, caij tsheb kauj vab, ntaus pob tesniv lossis seev cev;
• Taug kev ntaiv, taug kev ntsiag to - txhua hnub.

Yog tias qhov kev cuam tshuam no tsis haum, koj tuaj yeem ua kev tawm dag zog txhua txhua hnub. Hauv qhov chaw zaum, mob ntshav qab zib tuaj yeem yog lub sijhawm so tsis pub ntev tshaj 30 feeb.

Cov tshuaj zoo tshaj plaws yog xaiv los ntawm tus kws kho mob, coj mus rau hauv tus account theem ntawm tus kab mob, concomitant pathologies, cov xwm txheej dav dav, hnub nyoog ntawm tus neeg mob, nws lub cev cov tshuaj tiv thaiv tshuaj.

Glimepiride cov lus qhia rau kev siv pom zoo siv 1 mg / hnub. (ntawm ib tug pib koob tshuaj)Cov. Nrog li ntawm 1-2 lub lis piam, thaum nws tseem muaj peev xwm los soj ntsuam qhov txiaj ntsig, nws tuaj yeem yog titrated yog tias kev kho yav dhau los tsis zoo txaus. Cov cai ntau dua li 4 mg / hnub. thov tshwj xeeb. Qhov ntau npaum li cas ntawm kev siv tshuaj yog txog li 6 mg / hnub.

Yog tias qhov siab tshaj plaws ntawm cov tshuaj metformin tsis muab 100% glycemic tswj, Glimepiride tuaj yeem coj los ua cov kev txhawb nqa nyob rau tib lub sijhawm, nws zoo kawg nkaus ua ke nrog cov tshuaj no, txawm tias ua ke ua tshuaj nrog ob lub zog ua ke no raug tso tawm. Cov kev kho mob zoo sib xws pib nrog qhov txhaj tshuaj tsawg kawg ntawm glimepiride (1 g), kev soj ntsuam txhua hnub ntawm cov ntsuas glucometer yuav pab kho cov kev cai. Txhua yam hloov pauv ntawm cov txheej txheem algorithm tsuas yog ua rau kev saib xyuas mob nkeeg.

Tej zaum muaj kev sib xyaw ua ke ntawm glimepiride thiab nrog kev npaj tshuaj insulinCov. Qhov ntau npaum ntawm cov ntsiav tshuaj, qhov no, yuav tsum yog thawj zaug tsawg. Raws li cov txiaj ntsig ntawm kev ntsuam xyuas, txhua ob lub lim tiam ib qho tshuaj ntawm cov tshuaj tuaj yeem hloov kho.

Feem ntau, siv ib zaug tshuaj kho mob. Ua ke nrog kev noj tshais lossis noj mov tom qab nws, yog tias noj tshais hauv qab zib yog qhov cim.

Nws yog qhov zoo tshaj plaws rau kev noj tshuaj rau ob peb feeb ua ntej noj mov, raws li nws yuav siv sij hawm los nqis tes ua. Yog tias koj tsis nco qab lub sijhawm noj Glimepiride, cov tshuaj yuav tsum noj thaum thawj zaug, tsis tas hloov cov tshuaj ntau dua.

Yog tias qhov tsawg kawg ntawm Glimepiride ua rau cov tsos mob ntawm kev mob ntshav qab zib, cov tshuaj tau raug muab tso tseg, vim tias nws txaus rau tus neeg mob los tswj nws cov piam thaj nrog kev noj zaub mov kom zoo, kev xav zoo, ua raws li kev pw tsaug zog thiab so kom txaus, ua si lub cev.

Thaum ua tiav kev tswj hwm ntshav qab zib tau tiav, cov tshuaj tiv thaiv hormone yuav poob qis, uas txhais tau tias dhau sijhawm, yuav tsum tau noj tshuaj tsawg dua. Nws tseem yuav tsum tau hloov kho qhov koob tshuaj nrog poob phaus sai sai, hloov pauv ntawm kev ua haujlwm ntawm lub cev, ntxiv kev nyuaj siab tom qab thiab lwm yam cuam tshuam rau glycemic crises.

Muaj peev xwm ntawm hloov ntawm lwm cov tshuaj tiv thaiv kab mob rau glimepiride

Thaum hloov los ntawm lwm cov kev xaiv kho mob ntshav qab zib hom 2 nrog rau cov neeg tiv thaiv qhov ncauj, ib nrab-lub neej ntawm cov tshuaj ua ntej tau raug coj los siv. Yog tias cov tshuaj muaj lub sijhawm no ntev dhau los (xws li chlorpropamide), ncua sijhawm ntau hnub yuav tsum tau tswj xyuas ua ntej hloov mus rau glimepiride. Qhov no yuav txo qhov pheej hmoo ntawm kev txhim kho hypoglycemia vim muaj txiaj ntsig ntxiv ntawm 2 tus neeg sawv cev. Thaum hloov cov tshuaj, cov tshuaj pib noj yog pom zoo ntawm tsawg kawg 1 mg / hnub. Txoj kev ua tiav rau cov nyiaj haujlwm zoo sib xws.

Glimepiride insulin hloov rau cov neeg mob ntshav qab zib nrog hom 2 yog ua rau muaj mob hnyav thiab nyob hauv kev saib xyuas tas mus li.

Sab sij huam

Rau glimepiride, nrog rau lwm cov tshuaj sulfa, ib qho khoom pov thawj lub hauv paus ntawm lawv cov hauj lwm zoo tau sau ntau ntxiv. Cov kev tshawb fawb soj ntsuam kuj tau tshuaj xyuas lawv kev nyab xeeb. Raws li cov lus pom zoo ntawm WHO, qhov kev pheej hmoo ntawm kev tsim tawm hauv kev xav tau raug txheeb xyuas los ntawm kev ntsuas hauv qab no:

• Ntau zaus ≥ 0.1;
• Feem ntau: txij li 0.1 txog 0.01;
• Caws yug: los ntawm 0.01 txog 0.001;
• Tsis tshua muaj: ntawm 0.001 txog 0.0001;
• Tsis tshua muaj neeg nyiam <0, 00001;
• Nws tseem tsis tau paub yog tias, raws li muaj cov txheeb cais, nws tsis muaj peev xwm ntsuam xyuas qhov kev pheej hmoo ntawm kev pheej hmoo.

Cov txiaj ntsig ntawm kev tawm tsam los ntawm lub cev los ntawm ntau cov plab hnyuv siab raum thiab cov kab ke raug nthuav tawm hauv lub rooj. Feem ntau ntawm lawv tsis ruaj khov thiab dhau rau lawv tus kheej tom qab hloov cov tshuaj.

Pab nrog overdose

Qhov phom sij tseem ceeb ntawm kev siv tshuaj ntau dhau ntawm Glimepiride yog hypoglycemia ntev txog 72 teev, tom qab ib txwm ua haujlwm, rov huam mob tuaj yeem ua tau. Thawj cov tsos mob ntawm kev haus ntau dhau yuav tshwm sim tsuas yog ib hnub tom qab kev nqus ntawm cov tshuaj. Nrog rau cov tsos mob no (mob plab tsis txaus, mob hauv siab), tus neeg raug tsim txom yuav tsum tau soj ntsuam hauv tsev kho mob. Nrog hypoglycemia, mob hlab ntsha hlwb kuj tseem muaj peev xwm: tsis pom kev tsis pom kev thiab kev sib koom tes, tes tshee tshee, ntxhov siab, isomnia, mob leeg, ua pa tsis nco qab.

Kev pabcuam thawj zaug thaum noj ntau dhau yog kev tiv thaiv kev nqus ntawm kev siv tshuaj ntau dhau los ntawm kev ntxuav lub plab. Koj yuav tsum ua rau lub gag reflex nyob rau hauv txhua txoj kev, tom qab ntawd haus cov tshuab hluav ncaig lossis lwm qhov adsorbent thiab qee qhov laxative (piv txwv li, sodium sulfate). Nyob rau tib lub sijhawm, lub tsheb thauj neeg mob yuav tsum raug hu kom mob sai sai.

Tus neeg raug tsim txom yuav tau txhaj tshuaj pleev xim rau qab zib: ua ntej, 50 ml ntawm 50% tov, tom qab ntawd - 10%. Raws li feem ntau tau, koj yuav tsum txheeb xyuas theem ntawm cov piam thaj hauv ntshav. Ntxiv nrog rau kev kho mob tshwj xeeb, tsos mob kuj tau siv.

Yog tias tus me nyuam yaus noj cov tshuaj glimepiride, cov tshuaj qabzib yog xaiv rau hauv qhov muaj feem yuav ua rau muaj ntshav qab zib tsawg. Cov theem ntawm kev pheej hmoo yog tsis nquag ntsuas nrog glucometer.

Glimepiride thaum cev xeeb tub

Kev hloov pauv los ntawm cov cai hauv cov ntshav sib xyaw thaum lub sijhawm cev xeeb tub tuaj yeem ua rau lub cev tsis xws luag lossis ua rau lub neej puas, thiab glycemic tsis suav nrog qhov no tsis muaj qhov tshwj xeeb. Txhawm rau txo teratogenic txaus ntshai, tus poj niam yuav tsum tau saib xyuas nws tus kheej glycemic profile tsis tu ncua.

Yog tias cev xeeb tub - mob ntshav qab zib uas muaj hom mob 2, nws yog pauv mus ib ntus rau insulin. Cov poj niam twb nyob rau theem kev npaj ntawm tus menyuam yuav tsum ceeb toom lawv tus kws tshuaj endocrinologist txog kev hloov pauv tom ntej kom kho txoj kev kho mob.

Tsis muaj cov ntaub ntawv hais txog cov kev cuam tshuam rau tib neeg lub plab ntawm glimepiride. Yog tias peb tsom mus rau cov kev tshwm sim los ntawm kev kawm txog cov tsiaj cev xeeb tub, cov tshuaj muaj tshuaj lom deev muaj feem cuam tshuam nrog cov nyhuv hypoglycemic ntawm glimepiride.

Nws tsis yog tsim cov tshuaj nkag mus rau leej niam cov kua mis, tab sis cov tshuaj tau nkag mus rau leej niam cov kua mis ntawm cov nas, yog li cov ntsiav tshuaj tseem raug muab tso tseg thaum lactation. Txij li lwm cov tshuaj ntawm sulfonylomide series kis mus rau hauv niam mis, qhov txaus ntshai ntawm cov ntshav qog ntshav hauv menyuam yaus yog qhov tseeb tiag.

Cov menyuam

Tsis muaj ntaub ntawv qhia txog kev siv cov tshuaj rau cov neeg mob ntshav qab zib uas muaj hnub nyoog 8 xyoo rov hauv. Rau cov neeg laus dua (txog 17 xyoo), muaj qee qhov kev pom zoo rau kev siv tshuaj raws li kev kho mob monotherapy. Cov ntaub ntawv tshaj tawm tsis txaus rau kev siv ntau dua ntawm cov tshuaj los ntawm pawg kab mob ntshav qab zib no, yog li ntawd

Cov yam ntxwv ntawm Kev Kho Mob Glimepiride

Lawv noj tshuaj li ob peb feeb ua ntej noj mov kom cov tshuaj nqus thiab pib ua haujlwm. Nrog cov nyiaj them tsis txaus rau lub peev xwm ntawm cov tshuaj nrog carbohydrates, nws tuaj yeem ua rau mob hypoglycemic. Kev tawm tsam tuaj yeem lees paub los ntawm kev sib koom ua ke ntawm cov tsos mob hauv qab no: mob taub hau, hma tsis qab los noj mov, dyspeptic cuam tshuam, isomnia, rov qab txawv, tshwm sim ntawm kev tawm tsam, tiv thaiv kev tawm tsam, nce kev ntxhov siab, cuam tshuam, tsis pom kev thiab tsis hais lus, tsis meej pem nco qab, ploj ntawm rhiab thiab tswj, ceas hlwb tawg, tsaus muag , precom thiab coma. Adrenergic counterregulation tshwm sim los ntawm kev tawm hws ntau ntau, ntub dej ntawm lub duav, kev ntxhov siab ntau ntxiv, lub plawv dhia ceev ceev, kev kub siab, mob plawv.

Kev paub txog kev kho cov neeg mob ntshav qab zib nrog cov tshuaj tiv thaiv ntawm sulfonylomide series qhia tau hais tias, txawm hais tias qhov ntsuas pom tseeb ntawm kev ntsuas los nres nres, muaj kev pheej hmoo ntawm nws tshwm sim rov tshwm sim. Cov mob ntshav qab zib ntshav ntau thiab lub caij nyoog ntev, uas ib txwm ua haujlwm tau qis los ntawm kev ua kom muaj suab thaj, suav nrog kev kho mob sai sai, suav nrog nyob hauv chaw nyob ruaj ruajCov. Cov xwm txheej hauv qab no ua rau muaj kev pheej hmoo hypoglycemic:

• Tsis mloog cov lus qhia kho mob, tsis tuaj yeem koom tes;
• Kev tshaib plab, pluas noj mov tsis noj, zaub mov tsis txaus noj vim kev ua neej tsis zoo;
• Tsis ua raws li cov ntsiab cai ntawm cov khoom noj muaj roj tsawg;
• Tsis muaj qhov sib npaug ntawm tus nqi ntawm cov leeg mob thiab cov nyiaj tau los los ua kom tau cov carbohydrates;
• Kev haus cawv tsis quav cawv, tshwj xeeb tshaj yog nrog kev noj zaub mov tsis zoo;
• Cov hlwv thiab hepatic tsis ua hauj lwm;
• Noj tshuaj ntawm glimepiride;
• Decompensated endocrine pathologies uas cuam tshuam rau cov txheej txheem metabolic (pituitary lossis adrenal tsis txaus, lub qog ua haujlwm tsis txaus);
• Concurrent siv lwm yam tshuaj.

Nrog txoj kev kho tshuaj, yuav tsum tau saib xyuas tas li ntawm glycemia. Txhawm rau zam kom tsis txhob muaj teeb meem, nws yog qhov yuav tsum tau ua ntu zus mus rau lwm qhov kev ntsuam xyuas:

• Tshawb xyuas qhov ua tau zoo ntawm glycated hemoglobin - 1 zaug / 3-4 hlis;
• Kev sab laj ntawm tus kws kho keeb, kws kho qhov muag, kws kho plawv, neurologist - yog tias tsim nyog;
• Microalbuminuria - 2 zaug / xyoo;
• Kev ntsuam xyuas ntawm lipid profile + BH - 1 lub sijhawm / xyoo;
• Kev kuaj ntawm ob txhais ceg - 1 lub sijhawm / 3 hlis;
• HELL - 1 zaug / hli;
• ECG - 1 zaug / xyoo;
• Kev tshuaj ntsuam dav dav - 1 zaug / xyoo.

Nws yog ib qho tseem ceeb rau kev saib xyuas lub sijhawm ua haujlwm ntawm lub siab thiab cov ntshav sib xyaw ua ke, tshwj xeeb yog cov feem ntshav thiab cov qe ntshav dawb.

Yog tias lub cev muaj kev ntxhov siab hnyav (raug mob, kub hnyiab, phais, mob hnyav), hloov cov ntsiav tshuaj ib ntus nrog insulin yog ua tau.

Tsis muaj kev paub dhau los ntawm kev siv cov tshuaj rau kev kho mob ntshav qab zib nrog mob hepatic loj pathologies, nrog rau cov neeg mob hemodialysis. Hauv lub raum lossis mob rau lub cev tsis muaj peev xwm, qhov ntshav qab zib tau pauv mus rau insulin.

Glimepiride muaj lactose. Yog hais tias tus mob ntshav qab zib tau kev tshuaj ntsuam genetic galactose intolerance, lactase deficiency, malabsorption ntawm galactose-qabzib, nws tau txais kev hloov kho.

Cov nyhuv ntawm glimepiride ntawm lub peev xwm tswj hwm cov txheej txheem nyuaj

Cov kev kawm tshwj xeeb ntawm glimepiride txog kev muaj peev xwm tsav tsheb lossis kev ua haujlwm hauv kev tsim khoom hauv thaj chaw muaj kev pheej hmoo siab tseem tsis tau ua. Tab sis, vim tias cov tshuaj muaj cov kev mob tshwm sim nyob rau hauv daim ntawv ntawm hypoglycemia, muaj kev pheej hmoo ntawm txo qis ntawm qhov ceev ntawm cov tshuaj tiv thaiv thiab kev mloog zoo vim qhov tsis pom kev thiab lwm cov tsos mob hypoglycemic.

Thaum muab tshuaj rau noj, cov ntshav qab zib yuav tsum tau ceeb toom ntawm kev phom sij ntawm kev muaj txim loj thaum tswj cov txheej txheem nyuajCov. Qhov no muaj tseeb tshwj xeeb tshaj yog rau cov neeg uas feem ntau muaj qhov teeb meem ntshav qab zib, nrog rau cov neeg uas tsis muaj peev xwm paub txog cov tsos mob ntawm qhov teeb meem tab tom yuav tuaj.

Cov txiaj ntsig ntawm kev sib txuam nrog lwm cov tshuaj

Kev siv cov tshuaj ib txhij tuaj yeem ua rau cov ntshav qab zib nce ntxiv rau qhov muaj peev xwm ntawm glimepiride thiab inhibit nws lub zog. Qee cov tshuaj tsis nyob nruab nrab thaum siv ua ke. Tsuas yog tus kws kho mob tshwj xeeb muaj peev xwm muab qhov kev ntsuas tseeb ntawm kev sib raug zoo, yog li ntawd, thaum kos duab kev kho mob, nws yog qhov yuav tsum ceeb toom rau tus kws kho mob endocrinologist txog txhua yam tshuaj uas tus kab mob ntshav qab zib tau noj los kho cov kab mob concomitant.

Ntxiv dag zog rau cov nyhuv hypoglycemic ntawm Glimepiride provokes kev siv tib lub sijhawm phenylbutazone, azapropazone thiab oxyphenbutazone, insulin thiab tshuaj tiv thaiv kab mob hypoglycemic, lub caij nyoog-ua hauj lwm sulfanilamides, metformin, tetracyclines, MAO inhibitors, salicylic aminocyclinolefonolonon , miconazole, fenfluramine, disopyramides, pentoxifylline, fibrates, tritocvalian, ACE inhibitors, fluconazole , Fluoxetine, allopurinol, simpatolitikov, cyclo, Trojan thiab phosphamide.

Kev txwv tsis pub rau hypoglycemic muaj peev xwm ntawm glimepiride yog ua tau nrog kev sib koom tes kho nrog estrogens, saluretics, diuretics, glucocorticoids, thyroid stimulants, phenothiazine derivatives, adrenaline, chlorpromazine, sympathomimetics; nicotinic acid (tshwj xeeb tshaj yog siv ntau npaum li cas), laxatives (nrog rau siv ntev), phenytoin, diazoxide, glucagon, barbiturates, rifampicin, acetosolamide.

Qhov tshwm sim tsis tau zoo yog muab los ntawm txoj kev kho kom ruaj khov nrog β-blockers, clonidine thiab reserpine, nrog rau kev haus dej cawv.

Glimepiride muaj peev xwm txo qis lossis ua kom muaj txiaj ntsig rau lub cev ntawm coumarin derivatives.

Glimepiride Xyuas

Glimepiride, raws li kws kho mob thiab cov neeg mob, yog cov tshuaj zoo heev. Nws txoj kev nyab xeeb yog muab rau hauv koob tshuaj me me, nws tseem muaj ntau qhov ntxiv uas tsis tuaj yeem tab sis zoo siab. Tab sis, zoo li txhua yam tshuaj tiv thaiv kab mob, Amaril analogue siv tau yog tias tus mob ntshav qab zib nws tus kheej pab nws.

• Olga Grigoryevna, Cheeb Tsam Moscow. Kuv haus ib ntsiav tshuaj ntawm Glimepiride (2 mg) ua ntej noj tshais, thiab tom qab noj mov - tseem yog Metforminum ntev thaum sawv ntxov thiab yav tsaus ntuj txog 1000 mg. Yog tias kuv tsis ua txhaum kev noj zaub mov, ces tshuaj muaj qab zib. Kuv tsis paub tias nws cov txiaj ntsig zoo dua li cas, tab sis, nyob rau hnub so, thaum nws nyuaj rau zam kev noj mov thiab noj mov dhau, kuv haus 3 mg ntawm Glimepiride. Kuv muab tshuaj rau ntawm polyclinic raws li kev txo qis tshuaj, yog vim li cas txhua yam zoo rau kuv.
• Andrey Vitalievich, Yekaterinburg. Txog li 3 xyoos Kuv tau sau ntawv yuav Amaril, haus 4 mg thaum sawv ntxov. Tom qab ntawd hauv qhov chaw kuaj mob tsis muaj kev pab dawb Amaril, lawv hloov nws nrog Glimepirid, nyiaj siv rau cov qauv siv. Kuv sim coj nws hauv tib cov tshuaj - qab zib dhia mus txog 12 mmol / l (nws siv los ua tsis siab tshaj 8). Tus kws kho mob nce qhov koob tshuaj rau 6 mg, txhua yam zoo li yuav tsis zoo, tab sis kuv tseem yuav Amaril. Thiab ntxiv, 4 mg ib hnub twg tau txaus rau kuv. Tab sis kuv yuav zaum rov qab mus rau ib qho pub dawb, vim tias kuv tseem yuav cov tshuaj noj plawv thiab cov ntsiav tshuaj roj. Nws yog qhov kev tu siab uas tau tso tseg dawb Amaril.
• Cov neeg kho mob ib txwm ntseeg hais tias hom ntshav qab zib hom 2 tsis yog tsuas yog ib tus kabmob los ntawm kev ua kom tsis zoo thiab ua rau lub neej tsis muaj zog xwb, tabsis kuj los ntawm qhov tsis muaj peev xwm txaus siab rau lub neej, los ntawm kev ntxhov siab. Yuav kom teb tau rau lawv, koj yuav tsum yog tus neeg muaj kev sib haum xeeb, xav tau kev hlub.