Tresiba yog qhov ntev tshaj plaws basal insulin uas sau npe mus rau hnub tim. Thaum pib, nws tau tsim rau cov neeg mob uas tseem muaj lawv tus kheej kev sib txuas ntawm cov tshuaj insulin, uas yog, rau hom ntshav qab zib hom 2. Tam sim no qhov kev ua tau zoo ntawm cov tshuaj tau paub tseeb rau cov neeg mob ntshav qab zib nrog hom 1 mob.
Tresibu yog tsim los ntawm cov lus nrov hauv Danish kev txhawj xeeb NovoNordisk. Tsis tas li, nws cov khoom lag luam yog cov ib txwm ua Actrapid thiab Protafan, cov qauv tshiab tshiab ntawm cov tshuaj insulin Levemir thiab NovoRapid. Cov neeg mob ntshav qab zib uas tau paub dhau los hais tias Treshiba tsis yog qhov ua tsis tau zoo rau nws cov neeg ua ntej - Protafan ntawm lub sijhawm nruab nrab ntawm kev ua thiab ntev Levemir, thiab nyob rau hauv cov nqe lus ntawm kev ruaj khov thiab kev coj ua haujlwm tseem ceeb tshaj lawv.
Treshiba lub hauv paus ntsiab lus ntawm kev ua haujlwm
Txog hom mob ntshav qab zib hom 1, yuav tsum tau rov qab los ntawm cov insulin uas ploj lawm los ntawm kev txhaj tshuaj ntawm cov khoom neeg tsim cov tshuaj lom neeg yog qhov yuav tsum tau ua. Nrog rau tus mob ntshav qab zib hom 2 ntev ntev, kho cov tshuaj insulin yog qhov ua tau zoo, yooj yim zam thiab kho tus nqi. Cov teeb meem tsis tseem ceeb ntawm cov tshuaj insulin yog qhov muaj kev pheej hmoo ntawm hypoglycemia.
Kev poob qab zib yog qhov tshwj xeeb tshaj yog thaum tsaus ntuj, vim nws tuaj yeem pom qhov dhau sijhawm, yog li qhov yuav tsum tau muaj kev nyab xeeb rau cov insulins ntev yog qhov kev loj hlob. Hauv cov ntshav qab zib mellitus, lub sijhawm ntev dua thiab ruaj khov, tsis tshua muaj txiaj ntsig cov tshuaj, txo qis kev pheej hmoo ntawm hypoglycemia tom qab nws cov thawj coj.
Insulin Tresiba ua tau raws li lub hom phiaj:
Mob ntshav qab zib thiab siab surges yuav yog ib yam dhau los
- Li qub ntawm qab zib -95%
- Kev tshem tawm ntawm cov hlab ntsha thrombosis - 70%
- Ntaus tau ntawm lub plawv dhia muaj zog -90%
- Kev tshem tawm ntshav siab - 92%
- Qhov nce hauv lub zog nruab hnub, txhim kho pw tsaug zog thaum hmo ntuj -97%
- Cov tshuaj yog zwm rau ib pawg tshiab ntawm ntxiv-ntev insulins, txij li nws ua haujlwm ntev dua li cov so, 42 teev lossis ntau dua. Qhov no yog vim qhov tseeb tau hloov cov tshuaj hormones molecules "lo ua ke" hauv qab daim tawv nqaij thiab tawm hauv cov ntshav qeeb qeeb.
- Thawj 24 teev, cov tshuaj nkag mus rau hauv cov ntshav tusyees, tom qab ntawd cov nyhuv hloov zoo heev. Lub ncov ntawm qhov kev ua yog tsis tuaj kiag li, qhov profile yuav luag tiaj.
- Txhua qhov kev txhaj tshuaj zoo ib yam. Koj tuaj yeem paub meej tias cov tshuaj yuav ua haujlwm zoo li nag hmo. Cov nyhuv ntawm kev sib luag ntawm cov tshuaj muaj sib npaug zoo sib xws hauv cov neeg mob ntawm cov hnub nyoog sib txawv. Qhov hloov tau ntawm kev nqis tes ua hauv Tresiba yog 4 npaug tsawg dua li ntawm Lantus.
- Tresiba ua rau 36% tsis muaj ntshav qab zib tsawg dua li cov tshuaj insulin ntev hauv lub sijhawm txij xyoo 0:00 txog 6:00 teev nrog cov ntshav qab zib hom 2. Nrog rau hom kab mob 1, qhov kom zoo dua tsis pom tseeb, cov tshuaj txo cov kev mob qog nqaij hlav ntshav qaug qis txog 17%, tab sis nce kev pheej hmoo thaum nruab hnub mob ntshav qab zib tsawg los ntawm 10%.
Cov tshuaj nquag ua haujlwm ntawm Tresiba yog degludec (hauv qee qhov chaw - degludec, lus Askiv degludec). Qhov no yog tib neeg cov tshuaj insulin, nyob rau hauv uas tus qauv ntawm lwg me me raug hloov pauv. Zoo li lub cev ntuj tsim, nws muaj peev xwm khi rau cell receptors, txhawb txoj kev hla ntawm cov piam thaj hauv cov ntshav mus rau cov ntaub so ntswg, thiab maj mam tsim cov piam thaj hauv cov siab.
Vim nws cov qauv hloov kho me ntsis, qhov tshuaj insulin no nquag tsim cov hexamers nyob rau hauv daim cartridge. Tom qab qhia txog ntawm daim tawv nqaij, nws tsim ib hom ntawm cov khoom, uas yog nqus maj mam thiab ntawm qhov ceev, uas ua kom muaj kev sib luag ntawm cov tshuaj hormones hauv cov ntshav.
Daim ntawv tso tawm
Cov tshuaj muaj nyob rau hauv 3 daim ntawv:
- Treciba Penfill - cov roj cartridges nrog ib qho kev daws teeb meem, kev cia siab ntawm qhov hormone nyob rau hauv lawv yog tus qauv - U Insulin tuaj yeem raug ntaus nrog cov koob txhaj tshuaj lossis ntxig cov roj cartridge rau hauv NovoPen cwjmem thiab cov zoo sib xws.
- Tresiba FlexTouch nrog concentration U100 - syringe cwjmem nyob rau hauv uas 3 ml cartridge yog mounted. Tus cwj mem tuaj yeem siv tau kom txog thaum muaj cov tshuaj insulin hauv nws. Cartridge hloov tsis muab. Kauj ruam theem - 1 chav tsev, qhov koob tshuaj loj tshaj plaws rau 1 kev qhia - 80 units.
- Tresiba FlexTouch U200 - tsim los ua kom tau raws li kev xav tau ntau ntxiv rau cov tshuaj hormones, feem ntau cov no yog cov neeg mob ntshav qab zib mellitus uas muaj insulin tsis kam loj. Qhov kev nqus ntawm cov tshuaj insulin yog ob npaug, yog li qhov ntim ntawm cov tshuaj tov rau hauv qab daim tawv yog qhov tsawg dua. Nrog tus cwj mem syringe, koj tuaj yeem nkag mus ib zaug txog 160 chav nyob. hormone hauv kev tsub ntxiv ntawm 2 units. Cartridges nrog lub siab zoo ntawm degludec Nyob rau hauv tsis muaj qhov tsis tuaj yeem koj tuaj yeem ua txhaum tawm ntawm lub phwj qub qub thiab ntxig rau lwm yam, vim tias qhov no yuav ua rau kom muaj kev txwv ntau tshaj ob zaug thiab muaj ntshav siab ntau.
Daim ntawv tso tawm
| Kev nqus ntawm insulin hauv kev daws teeb meem, kev ua haujlwm hauv ml | Cov tshuaj insulin hauv 1 daim cartridge, chav tsev | |
| ml | chav nyob | ||
| Penfill | 100 | 3 | 300 |
| FlexTouch | 100 | 3 | 300 |
| 200 | 3 | 600 | |
Hauv tebchaws Russia, txhua 3 daim ntawv sau npe ntawm cov tshuaj muaj npe, tab sis hauv cov chaw muag tshuaj lawv muab feem ntau Tresib FlexTouch ntawm cov tshuaj ib txwm muaj. Tus nqi rau Treshiba yog siab dua rau lwm cov insulins ntev. Ib lub pob ntim nrog 5 xaum xaum (15 ml, 4500 units) tus nqi yog 7300 txog 8400 rubles.
Ntxiv rau degludec, Tresiba muaj glycerol, metacresol, phenol, zinc acetate. Lub acidity ntawm kev daws teeb meem nyob ze rau nruab nrab vim qhov sib ntxiv ntawm hydrochloric acid los yog sodium hydroxide.
Cov lus qhia rau kev teem caij Tresiba
Cov tshuaj yog siv ua ke nrog cov insulins ceev rau kev hloov pauv hormone rau kev kho mob ntshav qab zib ob hom. Nrog hom 2 mob, tsuas ntev insulin tuaj yeem kho nyob hauv thawj theem. Thaum pib, cov lus qhia hauv Lavxias rau kev siv tau tso cai siv Treshiba tshwj xeeb rau cov neeg mob laus. Tom qab kev tshawb fawb paub tseeb txog nws txoj kev nyab xeeb rau kev muaj kab mob loj hlob, kev hloov pauv tau ua raws li cov lus qhia, thiab tam sim no nws tso cai siv cov tshuaj no rau menyuam yaus txij thaum 1 xyoos.
Cawv ntawm degludec rau kev xeeb tub thiab kev loj hlob ntawm cov menyuam yaus mus txog ib xyoos tseem tsis tau kawm, yog li ntawd, cov tshuaj Tresib insulin tsis tau sau tseg rau cov pawg no ntawm cov neeg mob. Yog tias tus mob ntshav qab zib tau sau tseg yav dhau los ua rau muaj kev tsis haum tshuaj ntau dua rau ntawm degludec lossis lwm yam ntawm kev daws, nws kuj tau pom zoo kom tsis txhob kho nrog Tresiba.
Cov lus qhia rau kev siv
Yog tias tsis muaj kev paub txog cov cai tswj kev siv tshuaj insulin, kev them nyiaj zoo rau ntshav qab zib yog tsis tau. Ua tsis tiav cov lus qhia tuaj yeem ua rau mob hnyav: ketoacidosis thiab mob ntshav qab zib siab heev.
Yuav ua li cas yuav ua rau kev kho mob nyab xeeb:
- muaj ntshav qab zib hom 1, qhov yuav tsum tau xaiv yuav tsum raug xaiv hauv lub tsev kho mob. Yog tias tus neeg mob tau txais insulin ntev ntev, thaum pauv mus rau Tresiba, qhov koob tshuaj yog thawj zaug tsis hloov, tom qab ntawd kho rau cov ntaub ntawv glycemic. Cov tshuaj puv tawm nws cov nyhuv tsis pub dhau 3 hnub, yog li thawj zaug tshuaj kho tsuas yog tso cai nkaus xwb tom qab lub sijhawm no tau dhau mus;
- nrog hom 2 tus kab mob, qhov pib kis yog 10 units, nrog qhov nyhav nyhav - txog 0.2 ib pawg. ib kg Tom qab ntawd nws tau maj mam hloov mus txog thaum glycemia normalizes. Raws li txoj cai, cov neeg mob rog rog, txo qis kev ua haujlwm, muaj zog tiv thaiv insulin, thiab ntev mus ntev ua kom cov ntshav qab zib mellitus yuav tsum tau txhaj ntau dua ntawm Treshiba. Thaum kev kho mob zuj zus, lawv maj mam poob;
- Txawm hais tias qhov tseeb ntawm cov tshuaj insulin Tresiba ua haujlwm rau ntau dua 24 teev, lawv txhaj nws ib hnub ib zaug thaum sijhawm sijhawm. Kev nqis tes ntawm cov koob tshuaj txuas ntxiv yuav tsum yog qee qhov sib tshooj nrog lub koob dhau los;
- cov tshuaj tuaj yeem tau muab tsuas yog subcutaneously. Kev txhaj tshuaj Intramuscular yog qhov tsis txaus siab, vim tias nws tuaj yeem ua rau poob qab zib, mob ntshav qab zib yog lub neej tsis zoo;
- qhov chaw txhaj tshuaj tsis yog qhov tseem ceeb, tab sis feem ntau ib qho ncej puab yog siv rau cov insulins ntev, txij li lub cev luv luv tau txhaj rau hauv lub plab - yuav ua li cas thiab qhov twg txhaj tshuaj insulin;
- rab koob xaum hluav taws xob yog qhov khoom siv yooj yim, tab sis nws zoo dua yog tias tus kws kho mob paub koj txog cov cai rau kev coj ua. Tsuas yog nyob rau hauv rooj plaub, cov cai no tau theej tawm hauv cov lus qhia uas txuas nrog rau txhua ntim;
- Ua ntej txhua qhov kev qhia, koj yuav tsum xyuas kom meej tias cov tsos ntawm qhov kev daws tsis tau hloov pauv, daim cartridge yuav tsis txav, thiab lub koob tau dhau los. Txhawm rau tshuaj xyuas txoj kev noj qab haus huv ntawm cov kab ke, ib koob tshuaj ntawm 2 pawg tau teeb tsa rau ntawm xaum xaum npuav. thiab thawb lub piston. Lub pob tshab yuav tsum tshwm ntawm lub qhov koob. Rau Treshiba FlexTouch yuavtsum siv rab koob NovoTvist, NovoFayn thiab lawv cov analogues los ntawm lwm cov tuam ntxhab tsim nyog;
- tom qab qhia txog kev tov, rab koob tsis tshem tawm ntawm daim tawv nqaij rau ob peb feeb kom insulin tsis pib xau. Qhov chaw txhaj tshuaj yuav tsum tsis txhob muab rhaub lossis zaws.
Treshiba tuaj yeem siv nrog txhua yam tshuaj ua kom ntshav qab zib, suav nrog tib neeg thiab tshuaj insulin, nrog rau cov ntsiav tshuaj noj rau ntshav qab zib hom 2.
Sab sij huam
Muaj peev xwm tshwm sim tsis zoo ntawm kev kho mob ntshav qab zib los ntawm Treciba thiab kev soj ntsuam ntawm lawv qhov kev pheej hmoo:
| Sab sij huam | Qhov tshwm sim ntawm qhov tshwm sim,% | Cov yam ntxwv ntawm tus yam ntxwv |
| Kev ntshav siab | > 10 | Kev kub ntxhov, pallor ntawm daim tawv nqaij, nce tawm hws, poob siab, nkees, tsis tuaj yeem muaj peev xwm mloog, nqhis dej heev. |
| Cov tshuaj tiv thaiv hauv kev tswj hwm | < 10 | Cov ntshav liab me, mob, ua xua ntawm thaj chaw txhaj tshuaj. Raws li kev txheeb xyuas, lawv feem ntau tshwm sim thaum pib ntawm kev kho tshuaj insulin, thaum kawg nws ploj lossis qaug zog. Edema tshwm sim tsawg dua 1% ntawm cov neeg mob ntshav qab zib. |
| Lipodystrophy | < 1 | Ib qho pauv ntawm tuab ntawm daim ntaub uas subcutaneous yog nrog los ntawm o. Txo qhov kev pheej hmoo ntawm lipodystrophy, qhov yuav tsum tau hloov tas mus li hauv thaj chaw txhaj tshuaj. |
| Kev ua xua tsis haum | < 0,1 | Ntau zaus, kev ua xua tshwm sim los ntawm qhov khaus khaus, khaus khaus, raws plab, tab sis kev phom sij phiv los ntawm lub cev kuj tseem muaj peev xwm ua tau. |
Kev ntshav siab
Kev mob ntshav qab zib yog qhov tshwm sim ntawm kev noj ntau dhau ntawm Tresib insulin. Nws tuaj yeem tshwm sim los ntawm lub koob tshuaj tsis dhau, lub yuam kev thaum tswj hwm, tsis muaj cov piam thaj vim kev noj haus yuam kev lossis tsis ua rau lub cev ua si.
Feem ntau, cov tsos mob pib mloog zoo li twb nyob rau theem ntawm kev mob ntshav qab zib tsawg. Nyob rau lub sijhawm no, qab zib tuaj yeem nce tau ceev nrooj nrog tshuaj yej qab zib lossis kua txiv, kua qabzib. Yog hais tias muaj ntshav qab zib mellitus hais lus lossis kev paub tsis meej nyob rau hauv qhov chaw, ncua luv ntawm lub siab nco qab pib, qhov no qhia kev hloov pauv ntawm hypoglycemia mus rau theem hnyav. Lub sijhawm no, tus neeg mob tsis tuaj yeem tiv thaiv kev poob qab zib ntawm nws tus kheej, nws xav tau kev pab ntawm lwm tus.
Cov cai cia
Txhua txhua insulins yog cov npaj tsis yooj yim; hauv qab kev cia tsis zoo lawv poob lawv cov hauj lwm zoo. Cov cim ntawm kev lwj yog flakes, lumps, sediment, muaju nyob rau hauv daim cartridge, kua huab. Lawv yuav tsis tshwm sim tas li, feem ntau cov tshuaj insulin tsis tuaj yeem paub qhov txawv ntawm cov paib sab nraud.
Cov lus qhia rau kev siv pom zoo khaws cia lub pob txhav kaw qhov kub thiab txias ntawm qis dua 8 ° C. Txee lub neej tsuas yog siv txog 30 lub lis piam, muab cia raws li cov cai khaws cia. Tsis pub khov ntawm cov tshuaj yuav tsum tsis txhob tso cai, vim tias insulin yog protein nyob hauv qhov thiab pov tseg thaum kub qis dua xoom.
Ua ntej siv thawj zaug, Trecibu tawm ntawm lub tub yees kom ntev li 2 teev. Cov xaum xaum nrog lub thawv pib yuav khaws cia ntawm chav sov li 8 lub lis piam. Raws li cov mob ntshav qab zib, cov tshuaj yuav ua tsis tau sai sai tom qab lub sijhawm no, thiab qee zaum ua haujlwm ntxov dua. Tresiba insulin yuav tsum muaj kev tiv thaiv los ntawm kev tiv thaiv ultraviolet thiab microwave, ntsuas kub (> 30 ° C). Tom qab txhaj tshuaj, tshem tawm cov koob los ntawm rab koob txhaj tshuaj thiab kaw lub taub hau nrog lub hau.
