Glimecomb belongs rau cov pab pawg ntawm cov tshuaj tiv thaiv kab mob sib xyaw ua ke. Nws yog qhov txawv txav ntawm qhov tsis xws luag, tsis muaj kev sib txuam hauv Lavxias kev sib xyaw ntawm cov khoom siv nquag. Cov tshuaj muaj metformin thiab gliclazide. Tag nrho cov txiaj ntsig ntawm cov tshuaj no tso cai rau txo qis nrawm thiab postprandial glycemia los ntawm 3 mmol / l, tsis cuam tshuam rau qhov hnyav ntawm cov ntshav qab zib
Qhov tseem ceeb tau zoo ntawm Glimecomb dhau ntawm kev npaj ua ke nrov tshaj plaws uas muaj cov tshuaj metformin thiab glibenclamide yog txo kev pheej hmoo ntawm hypoglycemia. Glimecomb yog tsim los ntawm Akrikhin enterprise nyob ze Moscow.
Cov lus qhia rau kev teem caij
Sulfonylurea derivatives (PSM) yog cov tshuaj ntau tshaj 2 rau cov neeg mob ntshav qab zib tom qab metformin. Kev sib xyaw ntawm PSM thiab metformin yog qhov yuav tsum tau ua rau cov neeg mob uas tsis tshua muaj cov zaub mov tsis zoo, kev ua kis las, thiab metformin tsis muab qhov xav txo qis hauv qab zib. Cov tshuaj no ua rau cov kab mob tseem ceeb ntawm kev sib txuas ntawm cov ntshav qab zib hom 2 tsim: tiv thaiv insulin siab thiab insulin tsis txaus, yog li lawv muab cov txiaj ntsig zoo tshaj plaws rau kev sib xyaw. Glyclazide, ib qho tshuaj ntawm Glimecomb, yog PSM ntawm 2 tiam thiab suav hais tias yog ib qho kev nyab xeeb tshaj plaws hauv nws pawg.
Glimecomb ntsiav tshuaj tuaj yeem muab tshuaj:
- Thaum cov kev kho mob tas los tsis tseg muab cov nyiaj zoo rau cov ntshav qab zib.
- Tam sim ntawd tom qab kuaj mob ntshav qab zib, yog tias qib ntawm glycemia yog siab heev.
- Yog hais tias tus mob ntshav qab zib tsis zam metformin ntau hauv qhov ntau.
- Txhawm rau txo cov ntsiav tshuaj ntau hauv cov neeg mob noj gliclazide thiab metformin.
- Tus mob ntshav qab zib nyob rau hauv leej twg glibenclamide (Maninil thiab analogues) lossis nws cov tshuaj ua ke nrog metformin (Glibomet et al.) Ua rau muaj ntshav nce qis qis los yog tsis paub txog tias yuav muaj ntshav qab zib tsawg.
- Cov neeg mob uas lub raum tsis ua haujlwm rau leej twg glibenclamide raug txwv.
- Ntshav qab zib uas nyuaj los ntawm kab mob plawv. Nws tau raug pov thawj tias gliclazide tsis cuam tshuam tsis zoo rau myocardium.
Raws li kev tshawb fawb, twb tau ib hlis ntawm kev kho mob nrog Glimecomb, yoo cov piam thaj txo qis los ntawm qhov nruab nrab ntawm 1.8 mmol / L. Nrog txuas ntxiv ntawm kev siv tshuaj, nws cov nyhuv ua rau muaj zog, tom qab 3 lub hlis txo yog twb 2.9. Peb lub hlis kho cov dej qab zib ib txwm nyob hauv ib nrab ntawm cov neeg mob uas mob ntshav qab zib mellitus, thaum koob tsis ntau tshaj 4 ntsiav tshuaj ib hnub. Qhov hnyav nce thiab mob ntshav qab zib heev, uas yuav tsum tau mus pw hauv tsev kho mob, tsis tau sau nrog cov tshuaj no.
Mob ntshav qab zib thiab siab surges yuav yog ib yam dhau los
- Li qub ntawm qab zib -95%
- Kev tshem tawm ntawm cov hlab ntsha thrombosis - 70%
- Ntaus tau ntawm lub plawv dhia muaj zog -90%
- Kev tshem tawm ntshav siab - 92%
- Qhov nce hauv lub zog nruab hnub, txhim kho pw tsaug zog thaum hmo ntuj -97%
Cov Tshuaj Kho Mob Glimecomb
Kev sib xyaw ntawm PSM thiab metformin yog suav tias yog tshuaj lom neeg. Txawm hais tias muaj qhov tshwm sim ntawm cov kab mob hypoglycemic tshiab, lub koom haum koom tes mob ntshav qab zib thoob ntiaj teb thiab Ministry of Health ntawm Lavxias tseem txuas ntxiv pom zoo rau kev sib xyaw ua ke no yog qhov kev xav tau tshaj plaws. Glimecomb yog qhov yooj yim rau kev siv thiab pheej yig. Nws cov khoom siv ob qho tib si nkaus thiab muaj kev nyab xeeb.
Glyclazide nrog cov ntshav qab zib hom 2 txhawb kev tsim tawm ntawm nws tus kheej insulin, thiab pib ua haujlwm hauv thawj theem ntawm nws qhov kev tso tawm, thaum suab thaj nyuam qhuav nkag mus rau hauv cov hlab ntshav. Qhov kev ua no tso cai rau koj kom sai glycemia tom qab noj mov, xa cov piam thaj rau cov ntaub so ntswg. Glyclazide tiv thaiv kev txhim kho angiopathy: tiv thaiv thrombosis, txhim kho microcirculation thiab lub xeev ntawm cov phab ntsa ntawm cov hlab ntsha. Qhov ua tau zoo ntawm gliclazide ntawm chav kawm ntawm retinopathy thiab nephropathy tau ua pov thawj. Glimecomb ntsiav tshuaj xyaum tsis ua rau muaj qhov txawv txav ntawm cov kua dej hauv cov ntshav, yog li lawv tsis ua kom lub cev hnyav. Cov lus qhia kuj tau sau tseg lub peev xwm ntawm gliclazide los txhim kho cov tshuaj insulin, tab sis qhov no nws tseem nyob deb ntawm metformin, ib tus thawj coj lees paub hauv kev tawm tsam insulin tsis kam.
Metformin yog ib yam tshuaj nkaus xwb pom zoo rau txhua tus mob ntshav qab zib hom 2 yam tsis suav daws. Nws stimulates kev hloov ntawm cov piam thaj los ntawm cov hlab ntshav mus rau cov hlwb, inhibits kev tsim cov piam thaj los ntawm lub siab, ncua nws qhov kev nqus ntawm cov hnyuv. Cov tshuaj ua tiav rau cov lipid metabolism tsis zoo, uas yog tus yam ntxwv rau hom 2 ntawm tus kabmob. Vim muaj ntau cov kev soj ntsuam zoo ntawm cov ntshav qab zib, metformin yog siv rau cov neeg poob phaus. Nws tsis ua rau kev mob ntshav qab zib, thaum siv raws li cov lus qhia ua haujlwm tag. Qhov tsis zoo ntawm qhov kev tivthaiv ntawm Glimecomb no yog qhov muaj ntau ntawm qhov tsis xav tau ntawm lub plab zom mov.
Pharmacokinetics ntawm cov tshuaj tiv thaiv:
| Cov tsis | gliclazide | metformin | |
| Bioavailability,% | mus txog 97 | 40-60 | |
| Cov sijhawm ua haujlwm siab tshaj plaws tom qab tswjhwm | 2-3 teev | 2 teev thaum thov rau ntawm lub plab khoob; 2.5 teev yog tias koj noj tshuaj tib lub sijhawm nrog zaub mov, raws li cov lus qhia. | |
| Ib nrab-lub neej, teev | 8-20 | 6,2 | |
| Thim ntawm txoj kev,% | ob lub raum | 70 | 70 |
| txoj hnyuv | 12 | siab txog 30 | |
Tsuas tshuaj
Cov tshuaj Glimecomb muaj tib qho kev xaiv tshuaj - 40 + 500, hauv ib ntsiav tshuaj 40 mg ntawm glyclazide, 500 mg ntawm metformin. Txhawm rau kom tau txais ib nrab koob, cov ntsiav tshuaj tuaj yeem faib, muaj kev pheej hmoo ntawm nws.
Yog tias cov ntshav qab zib tsis tau noj cov tshuaj metformin ua ntej, 1 ntsiav tshuaj yog suav tias yog pib siv tshuaj. Tom ntej 2 lub lis piam nws tsis xav ua kom tau nws, yog li koj tuaj yeem txo qhov kev pheej hmoo ntawm qhov tsis xis nyob hauv cov hnyuv. Cov neeg mob uas tau paub txog cov tshuaj metformin thiab tiv thaiv nws zoo yuav tuaj yeem kho tam sim ntawd txog 3 Glimecomb ntsiav tshuaj. Cov koob tshuaj ntau yam tau txiav txim siab los ntawm tus kws kho mob, coj mus rau hauv tus neeg mob qib glycemia thiab lwm yam tshuaj uas nws noj.
Yog tias qhov pib pib tsis muab cov nyhuv yam xav tau, nws yog maj mam nce ntxiv. Txhawm rau tiv thaiv hypoglycemia, lub caij nyoog nruab nrab ntawm kev kho tshuaj yuav tsum yog tsawg kawg ib lub lim tiam. Qhov tso cai ntau tshaj yog 5 ntsiav tshuaj. Yog tias nyob ntawm qhov tshuaj no, Glimecomb tsis them nyiaj rau cov ntshav qab zib mellitus, lwm qhov txo cov tshuaj qab zib yog cov tshuaj rau tus neeg mob.
Yog tias tus neeg mob tau txais tshuaj tiv thaiv kab mob siab tshaj plaws, Glimecomb hauv ntshav qab zib tuaj yeem yuav haus cawv nrog metformin. Tus naj npawb ntawm cov ntsiav tshuaj nyob rau hauv cov ntaub ntawv no tau suav kom meej tag nrho cov koob tshuaj metformin tsis pub dhau 3000 mg.
Cov kev cai rau noj cov tshuaj Glimecomb
Txhawm rau txhim kho kev zam ntawm metformin thiab tiv thaiv kom tsis txhob muaj cov piam thaj hauv qab zib, Glimecomb ntsiav tshuaj tau qaug cawv ib txhij nrog zaub mov lossis tam sim ntawd. Cov zaub mov yuav tsum ua kom zoo thiab yuav tsum muaj cov carbohydrates, dua li nyuaj rau kev zom. Kev txiav txim los ntawm kev txheeb xyuas, nce txog 15% ntawm cov neeg mob ntshav qab zib ntseeg tau hais tias kev noj Glimecomb thiab lwm yam tshuaj txaws txo qis qhov lawv xav tau ua raws li kev noj zaub mov noj. Raws li qhov tshwm sim, lawv noj tshuaj rau qhov siab nce cov tshuaj, uas ua rau lawv cov kev mob tshwm sim ntau dua thiab cov nqi kho mob, yws cov piam thaj ntawm cov piam thaj, thiab ua rau lub ntsej muag ntshav qab zib ua ntej.
Tam sim no tsis yog ib hom tshuaj kho mob ntshav qab zib rau ntshav qab zib tuaj yeem hloov cov zaub mov noj. Nrog rau hom kab mob 2, khoom noj khoom haus yog pom tias tsis muaj cov carbohydrates ceev, nrog kev txwv ntawm cov carbohydrates qeeb, thiab feem ntau nrog cov zaub mov tsis muaj calorie ntau - hom ntshav qab zib 2. Cov kev kho mob suav nrog kev ua kom hnyav ntawm lub cev nyhav thiab cov haujlwm ntau ntxiv.
Txhawm rau kom muaj txiaj ntsig zoo ntawm Glimecomb thaum nruab hnub, noj ntau npaum li cas tau muab faib ua 2 koob tshuaj - sawv ntxov thiab yav tsaus ntuj. Raws li kev tshuaj xyuas, cov txiaj ntsig kho tau zoo tshaj plaws raug pom nyob hauv cov neeg mob uas noj tshuaj peb zaug (tom qab noj mov tas), txawm hais tias cov lus qhia rau kev siv tsis muaj rau qhov kev xaiv ntawd.
Sab sij huam
Feem ntau ntawm cov kev mob tshwm sim tuaj yeem ua kom tsis muaj zog yog tias koj ua raws li txoj cai rau kev noj thiab nce qhov koob tshuaj los ntawm cov lus qhia. Kev tshem tawm ntawm Glimecomb vim qhov tsis zwm rau yog tsis tshua muaj.
| Undesirable zoo ntawm cov tshuaj | Cov ua rau tshwm sim, tshwm sim thaum lawv tshwm sim |
| Kev ntshav siab | Muaj tshwm sim nrog kev xaiv tshuaj tsis yog los yog kev noj zaub mov tsis txaus. Txhawm rau tiv thaiv nws, zaub mov tau faib tusyees thoob plaws hauv lub hnub, carbohydrates yuav tsum muaj nyob hauv lawv txhua tus. Yog tias hypoglycemia tshwm sim tau paub meej nyob rau tib lub sijhawm, cov khoom noj txom ncauj me me yuav pab kom tsis txhob muaj mob. Nquag tas li nyob hauv qab zib - ib lub ntees los txo cov tshuaj ntawm Glimecomb. |
| Lactic acidosis | Ib qho kev tsis txaus ntseeg uas tsis tshua muaj tshwm sim, qhov ua rau yog kev txhaj tshuaj ntau tshaj ntawm metformin lossis noj Glimecomb hauv cov neeg mob uas nws yog contraindicated. Hauv cov kab mob hauv lub raum, yuav tsum tau tshuaj xyuas lawv lub luag haujlwm tsis tu ncua. Qhov no yog qhov tsim nyog thiaj li yuav tshem tawm cov tshuaj hauv lub sijhawm yog tias qhov kev soj ntsuam loj ntawm kev tsis txaus ntseeg tau pom. |
| Cov lus tsis zoo ua rau lub plab zom mov, ntuav, zawv plab, saj ntawm cov hlau. | Cov kev mob tshwm sim no feem ntau nrog rau pib ntawm metformin. Hauv feem ntau cov neeg mob, lawv ploj ntawm lawv tus kheej hauv 1-2 lub lis piam. Txhawm rau txhawm rau txhim kho kev ua siab ntev ntawm Glimecomb, koj yuav tsum maj mam nce nws cov koob tshuaj ntau ntau, pib txij li pib los. |
| Daim siab ua kom puas, hloov hauv cov ntshav muaj pes tsawg leeg | Yuav tsum tso tseg cov tshuaj, tom qab qhov kev ua txhaum no ploj mus ntawm lawv tus kheej, txoj kev kho yog tsis tshua muaj. |
| Pom kev tsis pom kev | Lawv yog ib ntus, pom nyob rau hauv cov neeg mob ntshav qab zib nrog rau lub siab pib. Txhawm rau zam lawv, cov koob tshuaj ntawm Glimecomb yuav tsum tau nce ntxiv maj mam txhawm rau kom tsis txhob muaj qhov ntse me me hauv glycemia. |
| Kev ua xua tsis haum | Muaj tsawg heev. Thaum lawv tshwm sim, nws raug nquahu kom hloov Glimecomb nrog kev sib piv. Cov neeg mob ntshav qab zib uas muaj kev fab tshuaj rau gliclazide yog qhov muaj kev pheej hmoo ntawm tib cov kev cuam tshuam rau lwm tus PSM, yog li lawv tau qhia ua ke ntawm metformin nrog gliptins, piv txwv li, Yanumet lossis Galvus Met. |
Cov Yuav Tsum Muaj
Thaum koj tsis tuaj yeem haus dej Glimecomb:
- ntshav qab zib hom 1;
- ntshav qog. Cov tshuaj tsis tuaj yeem quav kom txog thaum cov ntshav qab zib nce siab mus rau qhov qub;
- mob ntshav qab zib tsis txaus, mob hnyav thiab raug mob uas yuav tsum tau kho tshuaj insulin. Ib kis ntawm cov kab mob lactic acidosis yav dhau los;
- cev xeeb tub, pub niam mis;
- Xoo hluav taws xob nrog iodine-muaj cov tshuaj tiv thaiv kev sib xyaw;
- intolerance rau ib qho ntawm cov tshuaj ntawm cov tshuaj;
- lub raum, lub siab ua haujlwm, hypoxia, thiab cov kab mob uas yuav ua rau cov kev tsis zoo no;
- kev quav dej cawv, ib qib siab haus cawv ntau.
Hauv cov neeg mob uas muaj cov kabmob hormonal, cov laus ntshav qab zib nrog lub zog ntev dhau los, qhov kev pheej hmoo ntawm kev phiv yog nce, yog li thaum noj Glimecomb, lawv yuav tsum tau tshwj xeeb tshaj yog txog lawv cov kev noj qab haus huv.
Sib xyaw nrog lwm yam tshuaj
Cov nyhuv ntawm Glimecomb tuaj yeem ua kom muaj zog lossis txhawb zog thaum noj nrog lwm cov tshuaj. Cov npe ntawm kev sib txuam nrog tshuaj muaj ntau heev, tab sis feem ntau qhov kev hloov pauv ntawm qhov tsis muaj txiaj ntsig tsis yog qhov tseem ceeb thiab tuaj yeem hloov kho yooj yim los ntawm kev hloov ntau npaum
| Qhov cuam tshuam ntawm cov nyhuv ntawm glimecomb | Kev Npaj |
| Txo cov kev ua tau zoo, muaj peev xwm ua tau hyperglycemia. | Glucocorticoids, feem ntau cov tshuaj hormones, nrog rau cov tshuaj tiv thaiv; adrenostimulants, tshuaj qaug dab peg, diuretics, nicotinic acid. |
| Lawv muaj cov nyhuv hypoglycemic, yuav txo tau qhov koob tshuaj Glimecomb ntxiv. | ACE inhibitors, sympatholytics, antifungal, tshuaj tiv thaiv tuberculosis, NSAIDs, fibrates, sulfonamides, salicylates, steroids, microcirculation stimulants, vitamin B6. |
| Nce kev ntxim nyiam ntawm lactic acidosis. | Ib qho cawv. Ib qho dhau heev ntawm metformin hauv cov ntshav tau tsim thaum noj furosemide, nifedipine, mob glycosides. |
Dab tsi analogues los hloov
Glimecomb tsis muaj tag nrho cov analogues tso npe ntawm Lavxias Federation. Yog tias cov tshuaj tsis nyob hauv tsev muag tshuaj, ob lub tshuaj nrog tib lub tshuaj muaj peev xwm hloov nws:
- Metformin muaj nyob hauv thawj Glucofage tsim nyob rau hauv Fabkis, German Siofor, Lavxias Metformin, Merifatin, Gliformin. Txhua tus muaj tshuaj ntau npaum 500 mg. Rau cov neeg mob ntshav qab zib nrog kev tsis txaus siab ntawm metformin, kev hloov pauv ntawm cov tshuaj yog qhov zoo dua, uas ua kom ntseeg tau tias kev sib koom ua ke ntawm cov tshuaj mus rau hauv cov ntshav thiab txo qhov kev pheej hmoo ntawm phiv. Cov no yog cov tshuaj Metformin Ntev Canon, Metformin MV, Formin Ntev thiab lwm yam.
- Gliclazide kuj tseem yog cov hypoglycemic heev. Cov tshuaj yog ib feem ntawm Lavxias Glidiab thiab Diabefarm. Modic Gliclazide tam sim no tau txiav txim siab daim ntawv nyiam. Nws siv tau tuaj yeem txo cov zaus thiab mob hnyav ntawm cov qog ntshav qab zib. Modic gliclazide muaj nyob hauv kev npaj Diabefarm MV, Diabeton MV, Gliclazide MV, Diabetalong, etc. Thaum muas, koj yuav tsum them sai sai rau qhov tshuaj, koj yuav tsum faib cov ntsiav tshuaj ib nrab.
Muaj ntau ntau pab pawg analogues ntawm Glimecomb ntawm kev ua lag luam Lavxias. Feem ntau ntawm lawv yog kev sib txuas ntawm metformin nrog glibenclamide. Cov tshuaj no tsis muaj kev nyab xeeb dua li glimecomb, vim lawv feem ntau ua rau lub ntsej muag ntshav tsis zoo. Ib qho kev hloov zoo rau Glimecomb yog Amaril (metformin + glimepiride). Tam sim no, qhov no yog qib siab tshaj plaws ob tshuaj tiv thaiv kab mob nrog PSM.
Nqi
Tus nqi ntawm ib pob ntawm 60 ntsiav tshuaj ntawm Glimecomb yog los ntawm 459 txog 543 rubles. Gliclazide thiab metformin los ntawm tib lub tuam txhab tsim tawm yuav raug nqi 187 rubles. rau tib lub koob tshuaj (60 ntsiav tshuaj ntawm Glidiab 80 mg nqi 130 rubles, 60 ntsiav tshuaj. Gliformin 500 mg - 122 rubles). Tus nqi ntawm kev sib koom ua ke ntawm qhov kev npaj qub ntawm gliclazide thiab metformin (Glucofage + Diabeton) yog kwv yees li 750 rubles, ob qho tib si nyob rau hauv daim ntawv hloov kho.
