Glimepiride (Glimepiride) - qhov tseem niaj hnub ntawm kev npaj sulfonylurea. Nrog rau cov ntshav qab zib, nws nce kev tso tawm ntawm cov tshuaj insulin rau hauv cov ntshav, txo glycemia. Thawj thawj zaug, cov tshuaj txuam no tau siv los ntawm Sanofi hauv Amaryl ntsiav tshuaj. Tam sim no cov tshuaj nrog cov tshuaj tiv thaiv no yog tsim thoob plaws ntiaj teb.
Lavxias glimepiride kuj pom zoo zoo, txo cov ntshav qab zib, ua rau muaj kev cuam tshuam tsawg kawg, zoo li thawj cov ntsiav tshuaj. Kev txheeb xyuas tau qhia txog qhov ua tau zoo tshaj plaws thiab tus nqi qis ntawm cov tshuaj hauv tsev, yog li nws tsis yog qhov ceeb uas cov ntshav qab zib Glimepiride feem ntau nyiam tus thawj Amaril.
Leej twg tau qhia glimepiride
Cov tshuaj no raug pom zoo rau kev ua haujlwm ntawm glycemia tsuas yog hauv hom 2 mob ntshav qab zib. Cov lus qhia rau kev siv tsis tau hais meej thaum kho nrog Glimepiride tsuas yog muaj tseeb xwb, txij li kev xaiv ib hom tshuaj tshwj xeeb thiab nws qhov ntau npaum li cas lub peev xwm ntawm tus kws kho mob tuaj koom. Cia peb sim los xyuas seb leej twg tau qhia tawm yeeb tshuaj Glimepiride.
Mob ntshav qab zib nce ntxiv rau ob qho laj thawj: vim tias muaj kev tiv thaiv insulin thiab ib qho txo qis hauv kev tso tawm ntawm insulin los ntawm beta hlwb nyob hauv thaj chaw txiav txiav. Cov tshuaj Insulin txhim kho txawm tias ua ntej pib muaj ntshav qab zib, nws tuaj yeem pom nyob rau hauv cov neeg mob rog rog thiab ntshav qab zib. Qhov laj thawj yog cov khoom noj tsis zoo, tsis muaj kev tawm dag zog, rog dhau. Qhov xwm txheej no nrog cov tshuaj insulin ntau ntxiv, hauv txoj kev no lub cev sim kov yeej qhov tsis kam ntawm cov hlwb thiab ntxuav cov ntshav ntawm cov piam thaj ntau. Lub sijhawm no, kev kho qhov tseeb yog hloov mus rau lub neej noj qab haus huv thiab sau cov tshuaj metformin, uas yog cov tshuaj uas txo qis thaum muaj tshuaj insulin.
Lub siab dua tus neeg mob glycemia, qhov hnyav dua ntshav qab zib mellitus loj zuj zus. Kev pib mob cuam tshuam nrog txo qis ntawm insulin secretion, thiab hyperglycemia rov tshwm sim hauv tus neeg mob. Raws li kws kho mob, hauv kev kuaj mob ntshav qab zib, insulin tsis muaj peev xwm pom nyob rau yuav luag ib nrab ntawm cov neeg mob. Nyob rau theem no ntawm tus kabmob, ntxiv rau cov insulin, cov tshuaj uas txhawb kev ua haujlwm ntawm cov qe hlwb yuav tsum raug kho. Qhov ua tau zoo thiab pheej yig ntawm lawv yog sulfonylurea derivatives, cim npe PSM.
Mob ntshav qab zib thiab siab surges yuav yog ib yam dhau los
- Li qub ntawm qab zib -95%
- Kev tshem tawm ntawm cov hlab ntsha thrombosis - 70%
- Ntaus tau ntawm lub plawv dhia muaj zog -90%
- Kev tshem tawm ntshav siab - 92%
- Qhov nce hauv lub zog nruab hnub, txhim kho pw tsaug zog thaum hmo ntuj -97%
Raws li qhov dhau los, peb yuav hais cov cim qhia rau teem caij siv tshuaj yeeb tshuaj Glimepiride:
- Qhov tsis muaj txiaj ntsig ntawm kev noj zaub mov zoo, tawm dag zog thiab metformin.
- Muaj pov thawj los ntawm kev tsom xam ntawm kev tsis muaj lawv tus kheej insulin.
Cov kev qhia tso cai rau siv cov tshuaj Glimepiride nrog insulin thiab metformin. Raws li kev txheeb xyuas, cov tshuaj kuj mus tau zoo nrog glitazones, gliptins, incretin mimetics, acarbose.
Tus txheej txheem ntawm kev ua ntawm cov tshuaj
Qhov kev tso tawm ntawm cov tshuaj insulin los ntawm tus txiav mus rau hauv cov hlab ntshav yog ua tau vim muaj cov KATP tshwj xeeb tshooj. Lawv muaj nyob rau hauv txhua chav nyob thiab muab cov dej ntws los ntawm cov poov tshuaj los ntawm nws daim nyias nyias. Thaum cov concentration ntawm cov piam thaj hauv cov hlab hauv cov txwv tsis pub dhau, cov kab ke ntawm cov roj ntsha qhib. Nrog rau kev loj hlob ntawm glycemia, lawv kaw, uas ua rau muaj kev nkag mus ntawm calcium, thiab tom qab ntawd tso cov kua dej.
Cov tshuaj yeeb tshuaj Glimepiride thiab tag nrho lwm PSM kaw cov kab mob potassium, yog li ua cov tshuaj insulin ntau ntxiv thiab ua kom zais. Qhov ntau ntawm cov tshuaj hormones tso rau hauv cov ntshav tsuas yog nyob ntawm qhov ntau npaum ntawm glimepiride, thiab tsis nyob rau theem ntawm cov piam thaj.
Dhau ob peb lub xyoos dhau los, 3 tiam, lossis kev tsim dua tshiab, ntawm PSM tau raug tsim thiab sim. Cov kev ua ntawm 1 tiam tshuaj, chlorpropamide thiab tolbutamide, tau txais kev cuam tshuam zoo los ntawm lwm cov tshuaj kho ntshav qab zib, uas feem ntau ua rau cov neeg tsis muaj mob ntshav qab zib tsawg. Nrog kev tsim los ntawm PSM 2 tiam, glibenclamide, glyclazide thiab glipizide, cov teeb meem no tau daws tau. Lawv cuam tshuam nrog lwm yam cuam tshuam ntau zog dua li thawj PSM. Tab sis cov tshuaj no kuj muaj ntau qhov tsis txaus: hauv kev ua txhaum ntawm kev noj zaub mov thiab thauj khoom, lawv ua rau lub cev tsis muaj ntshav qab zib, ua rau lub cev yuag yuag zuj zus, thiab vim li no, nce ntxiv ntawm cov tshuaj insulin. Raws li qee cov kev tshawb fawb, PSM 2 tiam yuav cuam tshuam tsis zoo rau lub plawv kev ua haujlwm.
Thaum tsim cov tshuaj Glimepiride, cov kev mob tshwm sim saum toj no tau coj mus rau hauv tus account. Lawv tau tswj hwm los txo lawv hauv qhov kev npaj tshiab.
Qhov kom zoo dua ntawm Glimepiride hla PSM ntawm cov tiam dhau los:
- Kev pheej hmoo ntawm hypoglycemia thaum noj yog qis dua. Cov kev sib txuas ntawm cov tshuaj nrog cov receptors tsis tshua ruaj khov dua li ntawm nws cov pab pawg analogues, ntxiv rau, lub cev ib nrab khaws cov txheej txheem uas inhibit cov synthesis ntawm insulin nrog cov piam thaj tsawg. Thaum ua si kis las, tsis muaj carbohydrates nyob rau hauv cov zaub mov, glimepiride ua rau cov ntshav qog ntshav qab zib tsawg dua lwm PSM. Kev soj ntsuam pom tias cov piam thaj thaum noj cov tshuaj glimepiride ua rau qis dua li ib txwm muaj ntawm 0.3% ntawm cov neeg mob ntshav qab zib.
- Tsis cuam tshuam qhov hnyav. Kev noj tshuaj insulin ntau hauv cov ntshav txwv tsis pub cov rog rog ntau dhau, cov ntshav qab zib hauv lub cev ntau ntxiv ua rau muaj qhov nce ntxiv thiab ua kom muaj caloric ntau. Glimepiride muaj kev nyab xeeb hauv qhov no. Raws li cov neeg mob, nws tsis ua rau kom yuag, thiab nrog kev rog nws tseem muaj feem ua rau poob phaus.
- Tsis tshua muaj kev pheej hmoo ntawm cov kab mob plawv. PSM muaj peev xwm sib cuam tshuam nrog KATP cov chaw nyob tsis yog nyob rau hauv lub leeg, tab sis kuj nyob rau ntawm cov hlab ntsha, nce kev pheej hmoo ntawm lawv cov pathology. Cov tshuaj glimepiride ua haujlwm tsuas yog hauv cov txiav, yog li nws tau tso cai rau cov neeg mob ntshav qab zib nrog mob qog thiab mob plawv.
- Cov lus qhia cuam tshuam lub peev xwm ntawm Glimepiride los txo qis insulin, nce glycogen synthesis, thiab thaiv cov kua nplaum ntau lawm. Qhov kev txiav txim no muaj zog ntau dua li metformin, tab sis zoo dua li tus so ntawm PSM.
- Cov tshuaj sai dua li kev ntsuas analogues, xaiv cov koob tshuaj thiab kev ua tiav ntawm kev them nyiaj rau ntshav qab zib siv sijhawm tsawg dua.
- Glimepiride ntsiav tshuaj txhawb nqa ob theem ntawm insulin secretion, yog li ntawd, lawv txo glycemia sai dua tom qab noj mov. Cov tshuaj siv ua haujlwm laus feem ntau hauv theem 2.
Tsuas tshuaj
Feem ntau lees txais qhov tshuaj ntawm glimepiride, uas cov tuam ntxhab ua raws, yog 1, 2, 3, 4 mg ntawm cov tshuaj nquag hauv ib ntsiav tshuaj. Koj tuaj yeem xaiv cov tshuaj muaj cai nrog cov neeg qhov siab, yog tias tsim nyog, cov koob tshuaj tau hloov yooj yim. Raws li txoj cai, lub ntsiav tshuaj yog nruab nrog kev pheej hmoo, uas tso cai rau koj faib nws ib nrab.
Cov piam thaj txo qis ntawm cov tshuaj nce ntxiv ib txhij nrog kev nce hauv koob tshuaj los ntawm 1 txog 8 mg. Raws li cov mob ntshav qab zib, neeg feem coob xav tau tsuas yog 4 mg lossis tsawg dua ntawm glimepiride los them rau ntshav qab zib. Cov tshuaj loj yog ua tau rau cov neeg mob uas mob ntshav qab zib thiab cov kab mob insulin muaj zog. Lawv yuav tsum maj mam txo qis thaum lub xeev ruaj khov - txhim kho cov tshuaj insulin rhiab heev, poob phaus, thiab hloov lub neej.
Qhov kev cia siab poob hauv glycemia (nruab nrab cov nuj nqis raws li txoj kev tshawb no):
| Koob tshuaj mg | Kev kawm txo qis | ||
| Kev yoo mov qabzib, mmol / l | Cov piam thaj Postprandial, mmol / l | Glycated hemoglobin,% | |
| 1 | 2,4 | 3,5 | 1,2 |
| 4 | 3,8 | 5,1 | 1,8 |
| 8 | 4,1 | 5,0 | 1,9 |
Cov ntaub ntawv los ntawm cov lus qhia ntawm cov kab lus rau kev xaiv qhov koob txhaj tshuaj:
- Cov tshuaj pib rau yog 1 mg. Nws yog feem ntau txaus rau cov neeg mob ntshav qab zib nrog cov ntshav qabzib me ntsis, thiab rau cov neeg mob raum tsis ua haujlwm. Cov kab mob siab tsis muaj kev cuam tshuam qhov loj ntawm koob.
- Cov naj npawb ntawm cov ntsiav tshuaj tau nce ntxiv kom txog thaum cov khoom qab zib tau mus txog. Txhawm rau kom tsis txhob mob hypoglycemia, ntau npaum cov tshuaj tau nce qeeb, ntawm cov sijhawm ntawm 2 lub lis piam. Lub sijhawm no, kev ntsuas ntau zaus ntawm glycemia xav tau dua li ib txwm muaj.
- Kev loj hlob tus qauv: txog li 4 mg, ntxiv 1 mg, tom qab - 2 mg. Thaum cov piam thaj tau mus txog qhov qub, tso tseg cov ntsiav tshuaj ntau ntxiv.
- Qhov kev tso cai ntau kawg nkaus yog 8 mg, nws muab faib ua ob peb koob: 2 txog 4 mg lossis 3; 3 thiab 2 mg.
Cov lus qhia ntxaws ntxiv rau siv
Qhov siab tshaj plaws ntawm cov tshuaj tshwm sim tom qab txog 2 teev los ntawm nws txoj kev tswj hwm. Lub sijhawm no, glycemia tuaj yeem txo qis me ntsis. Raws li, yog tias koj haus cov tshuaj Glimepiride ib hnub ib zaug, lub sijhawm ntawm lub ncov yuav yog ib qho, yog tias koj faib cov koob tshuaj 2 zaug, lub ncov yuav yog ob, tab sis hnyav dua. Paub txog qhov tshwj xeeb ntawm cov tshuaj no, koj tuaj yeem xaiv lub sijhawm nkag. Nws raug nquahu tias lub ncov ntawm kev nqis tes ua poob ntawm lub sijhawm tom qab noj mov tag nrho uas muaj cov carbohydrates qeeb, thiab tsis sib thooj nrog lub hom phiaj kev tawm dag zog.
Txoj kev pheej hmoo ntawm kev mob ntshav qab zib yog nce los ntawm cov xwm txheej tsis txaus los yog noj zaub mov tsis zoo, kev ua haujlwm siab nrog kev noj zaub mov tsis txaus, muaj mob hnyav, mob endocrine, thiab qee yam tshuaj.
Kev sib txuam tshuaj raws li cov lus qhia:
| Kev taw qhia ntawm kev ua | Sau cov tshuaj |
| Ntxiv dag zog rau cov nyhuv ntawm cov ntsiav tshuaj, ua rau muaj kev pheej hmoo qog ntshav qab zib. | Cov tshuaj insulin, cov tshuaj tiv thaiv kab mob ua kom zoo. Cov tshuaj steroid, testosterone, qee yam tshuaj tua kab mob (chloramphenicol, tetracycline), streptocide, fluoxetine. Antitumor, antiarrhythmic, antihypertensive, antifungal agents, fibrates, anticoagulants. |
| Nqa cov suab thaj-txo cov nyhuv, qhov nce siab ib ntus hauv kev noj tshuaj ntawm cov tshuaj Glimepiride yog qhov tsim nyog. | Diuretics, glucocorticoids, adrenomimetics, estrogens, triiodothyronine, thyroxine. Cov koob tshuaj ntau ntawm cov vitamin B3, kho lub sij hawm ntev nrog cov tshuaj tso quav. |
| Ua rau cov tsos mob ntawm cov ntshav tsis txaus, uas ua rau nws tsis yooj yim kom paub thaum lub sijhawm. | Clonidine, sympatholytics (reserpine, octadine). |
Cov ntaub ntawv ua los ntawm cov dej cawv los ntawm cov lus qhia glimepiride: cov dej cawv haus cawv nce kev pheej hmoo ntawm kev phiv tshuaj, tsis paub meej cuam tshuam rau cov ntshav qab zib. Raws li kev txheeb xyuas, cov kua nplaum feem ntau sawv thaum lub tsiab peb caug, tab sis thaum tsaus ntuj nws poob qis, nce mus rau qhov muaj ntshav qab zib tsawg kawg. Kev haus dej haus cawv ib ce tsis zoo yuav txo cov nyiaj mob ntshav qab zib, tsis hais tshuaj dab tsi kho tau.
Cov yam ntxwv ntawm kev coj menyuam yaus thiab poj niam cev xeeb tub
Thaum siv thaum cev xeeb tub, cov tshuaj Glimepiride nkag mus rau hauv cov ntshav ntawm tus menyuam hauv plab thiab tuaj yeem ua rau ntshav muaj ntshav tsis txaus nyob hauv. Tsis tas li, cov tshuaj kis mus rau niam mis, thiab los ntawm qhov ntawd mus rau hauv cov hnyuv hauv cov menyuam. Thaum cev xeeb tub thiab HB, noj Glimepiride yog txwv tsis pub. FDA (Asmeskas Cov Tshuaj Noj Txhaum Cai) cais tawm Glimepiride ua chav kawm C. Qhov no txhais tau tias cov kev tshawb fawb tsiaj tau qhia tias cov tshuaj no muaj qhov tsis zoo rau cov menyuam hauv plab.
Glimepiride tsis zoo rau cov menyuam yaus, txawm tias lawv tau tshawb pom tus mob ntshav qab zib hom 2. Cov tshuaj tsis dhau qhov kev ntsuam xyuas tsim nyog, nws cov nyhuv ntawm kev hloov zuj zus tsis tau kawm txog.
Sau cov kev mob tshwm sim
Qhov tshwm sim cuam tshuam loj tshaj plaws ntawm Glimepiride yog hypoglycemia. Raws li kev ntsuam xyuas, nws qhov kev pheej hmoo yog tsawg dua li ntawm qhov muaj zog tshaj plaws PSM - glibenclamide. Cov piam thaj hauv ntshav, uas ua rau mus pw hauv tsev kho mob thiab xav tau cov hnoos qeev uas muaj kua nplaum qab zib, hauv cov neeg mob ntawm Glimepiride - 0.86 units rau 1000 tus neeg-xyoo. Piv nrog glibenclamide, qhov ntsuas no yog 6.5 npaug qis dua. Qhov tsis muaj txiaj ntsig qhov zoo ntawm cov tshuaj yog qhov qis dua ntawm kev kub siab ntawm lub cev thaum ua haujlwm nquag lossis qoj ib ce muaj zog.
Lwm cov kev phiv tseem ceeb ntawm glimepiride los ntawm cov lus qhia rau kev siv:
| Thaj tsam ntawm kev ua txhaum | Kev piav qhia | Zaus |
| Kev tiv thaiv kab mob | Kev ua xua tsis haum. Tej zaum yuav tshwm sim tsis tsuas yog ntawm glimepiride, tab sis kuj rau lwm yam tshuaj ntawm cov tshuaj. Hauv qhov no, hloov cov tshuaj nrog kev sib piv ntawm lwm qhov chaw tsim tshuaj paus tuaj yeem pab tau. Cov kev txhaum fab hnyav uas yuav tsum tau tshem tawm txoj kev kho sai sai yog muaj tsawg heev. | < 0,1% |
| Kev kho mob txoj hnyuv | Kho mob, zoo nkaus li lub siab puv nkaus, mob plab. Raws plab, xeev siab. | < 0,1% |
| Ntshav | Tsawg cov platelet suav. Muaj cov pov thawj ntawm ib qho teeb meem raug rho tawm ntawm mob hnyav ntawm thrombocytopenia. | < 0,1% |
| Txo cov qe ntshav dawb, cov qe ntshav liab. Kev Hyponatremia. | tus neeg mob | |
| Lub siab | Ntau cov neeg mob hepatic enzymes hauv ntshav, kab mob siab. Pathologies tuaj yeem txhim kho mus txog lub siab tsis ua haujlwm, yog li lawv qhov kev tshwm sim yuav tsum tsis ua ntxiv ntawm cov tshuaj Tom qab tshem tawm, cov kev ua txhaum cai ploj mus. | tus neeg mob |
| Tawv | Photosensitivity - kev nce hauv rhiab heev rau tshav ntuj. | tus neeg mob |
| Organs ntawm tsis pom kev | Thaum pib ntawm kev kho mob lossis nrog kev nce ntxiv, qhov tsis pom kev zoo tuaj yeem ua haujlwm. Lawv tshwm sim los ntawm cov piam thaj txo thiab yuav kis tau rau lawv tus kheej thaum lub qhov muag yoog raws li cov xwm txheej tshiab. | tsis tau txhais |
Kuj tseem muaj lus hais txog qhov ua tau ntawm kev tsis haum xeeb ntawm antidiuretic hormone. Qhov kev mob tshwm sim no tseem raug sim, yog li nws tsis tau suav nrog cov lus qhia.
Muaj peev xwm yuav muaj ib tug overdose
Tsis muaj teeb meem li cas niaj hnub thiab maj mam siv tshuaj Glimepiride, nws tseem nyob ntawm sulfonylurea derivative, uas txhais tau hais tias nws noj ntau dhau ua rau cov ntshav qab zib tsawg. Qhov kev mob tshwm sim no yog txais tau ntawm cov tshuaj ntawm cov tshuaj, nws tsuas tuaj yeem zam tau los ntawm kev saib zoo ntawm kev siv ntau npaum.
Txoj cai ntawm kev tiv thaiv kev tiv thaiv hypoglycemia los ntawm cov lus qhia rau kev siv: yog tias Glimepiride ntsiav tshuaj ploj, los yog tsis muaj tseeb tias cov tshuaj tau qaug cawv, cov koob tshuaj yuav tsum tsis txhob nce ntxiv ntawm koob tshuaj ntxiv, txawm hais tias cov ntshav qab zib nce siab.
Kev siv ntshav qab zib tuaj yeem nres nrog cov piam thaj - kua txiv qab zib, tshuaj yej lossis qab zib. Nws tsis tas yuav tos tus cwj pwm tshwm sim, cov ntaub ntawv glycemic txaus. Txij li thaum cov tshuaj ua haujlwm yuav luag ib hnub, qab zib rov qab zoo li qub tseem tuaj yeem rov qab ua rau cov lej txaus ntshai. Txhua lub sijhawm no koj yuav tsum tau saib xyuas glycemia, tsis txhob tawm ntawm cov ntshav qab zib ib leeg.
Lub zog muaj zog tshaj ib zaug, ntev ntev kev siv ntau ntawm cov tshuaj glimepiride yog lub neej puas tsuaj. Hauv cov neeg mob ntshav qab zib, poob ntawm kev nco qab, mob hlwb, mob ntshav qab zib tsis nco qab tuaj yeem ua tau. Thaum muaj mob hnyav, pheej rov qab ua ntxiv rau hauv qab zib tuaj yeem nyob ntev ntau hnub.
Kev siv tshuaj ntau dhau - mob plab zom zaub mov, nqus tau, rov qab los ntawm normoglycemia los ntawm kev qhia cov kua nplaum rau hauv txoj hlab ntshav.
Cov Yuav Tsum Muaj
Muaj qee kis, kev noj cov tshuaj Glimepiride tuaj yeem tsim kev phom sij rau kev noj qab haus huv:
- HS, cov me nyuam muaj hnub nyoog;
- kev xeeb tub, mob ntshav qab zib hauv lub cev;
- nyob rau hauv cov qauv mob hnyav ntawm hepatic lossis lub raum tsis ua haujlwm. Kev siv cov tshuaj glimepiride hauv cov neeg lim ntshav tsis tau kawm;
- paub tseeb hom ntshav qab zib 1. Yog tias cov kab mob ntshav qab zib mob pauv sai no tau txheeb xyuas (Modi, mob latent), kev teem caij rau cov tshuaj glimepiride yog ua tau;
- mob hnyav ntshav qab zib. Kev siv ntshav qab zib kom tsawg yuav tsum tau muab tshem tawm ua ntej noj cov ntsiav tshuaj tom ntej. Rau txhua hom diabetic com thiab precom, txhua yam kev npaj ntsiav tshuaj tso tseg;
- yog tias qhov mob ntshav qab zib ua xua rau ib qho twg ntawm cov khoom siv ntawm cov ntsiav tshuaj, kev ntsuas tshuaj tiv thaiv kab mob yog tau nrog siv txuas ntxiv;
- vim qhov tseeb tias qhov muaj pes tsawg leeg ntawm cov ntsiav tshuaj suav nrog lactose, lawv tsis tuaj yeem nqa los ntawm cov neeg mob uas muaj keeb ntawm kev tsis sib haum ntawm nws txoj kev cia siab.
Cov kev qhia tau hais txog kev saib xyuas tshwj xeeb thaum pib ntawm kev kho mob nrog glimepiride, nyob rau theem ntawm kev xaiv koob tshuaj, thaum hloov pauv kev noj haus lossis kev ua neej. Hyperglycemia tuaj yeem ua rau muaj kev raug mob, kis thiab mob tshwj xeeb, tshwj xeeb tshaj yog cov neeg nrog los ntawm kub taub hau. Hauv lub sijhawm rov qab, ntawm qhov tsis tooj, hypoglycemia yog ua tau.
Cov kab mob zom tau tuaj yeem hloov kho cov nyhuv ntawm cov ntsiav tshuaj yog tias nqus tau cuam tshuam. Cov kab mob tsis muaj zog ntawm cov piam thaj-6-phosphate dehydrogenase thaum noj tshuaj Glimepiride tej zaum yuav ua rau hnyav dua.
Glimepiride analogues
Muaj cov analogues nyob hauv Russia sau npe hauv cov ntawv sau npe ntawm cov tshuaj:
| Cov pab pawg | Npe | Chaw tsim tshuaj paus | Lub teb chaws ntau lawm |
| Ua tiav analogues, cov tshuaj nquag muaj tsuas yog glimepiride. | Amaril | Sanofi | Lub teb chaws Yelemees |
| Glimepiride | Rafarma, Atoll, Pharmproekt, Verteks, Pharmstandard. | Lavxias | |
| Instolit | Pharmasynthesis | ||
| Glimepiride Canon | Canonpharma | ||
| Diamerid | Akrikhin | ||
| Ntshe | Pab pawgavavavis | Iceland | |
| Glimepiride-teva | Pliva | Croatia | |
| Glemaz | Kimika Montpellier | Argentina | |
| Glemauno | Wokhard | Is Nrias teb | |
| Meglimide | Krka | Slovenia | |
| Glumedex | Hlaub Pung Pharma | Kauslim | |
| Ib nrab analogues, kev npaj ua ke uas muaj glimepiride. | Avandaglim (nrog rosiglitazone) | GlaxoSmithKlein | Lavxias |
| Amaryl M (nrog metformin) | Sanofi | Fab Kis teb |
Raws li kev ntsuam xyuas ntawm cov ntshav qab zib, cov kab mob zoo ntawm Amaril yog Glimepiride-Teva thiab Glimepiride tsim tawm hauv tsev. Qhov seem ntawm cov generics hauv chaw muag tshuaj yog qhov tsis tshua muaj.
Glimepiride lossis Diabeton - uas zoo dua
Cov tshuaj ua si hauv Diabeton yog gliclazide, PSM 2 tiam. Cov ntsiav tshuaj muaj tus qauv tshwj xeeb, uas muab cov tshuaj maj mam ntws tawm hauv cov ntshav. Vim qhov no, Diabeton MV tsis tshua muaj peev xwm ua rau cov ntshav qab zib tsawg dua li cov gliclazide. Ntawm tag nrho cov muaj PSM, nws yog hloov kho glyclazide thiab glimepiride uas endocrinologist pom zoo li kev nyab xeeb tshaj plaws. Lawv muaj cov txiaj ntsig zoo li qab zib hauv kev txo qis hauv qhov sib piv (1-6 mg rau glimepiride, 30-120 mg rau gliclazide). Qhov zaus ntawm cov ntshav qog ntshav qis hauv cov tshuaj no kuj tseem nyob ze.
Diabeton thiab Glimepiride muaj qhov sib txawv. Qhov tseem ceeb tshaj plaws ntawm lawv yog:
- Glimepiride yog tus cwj pwm los ntawm kev txo qis ntawm insulin txoj kev loj hlob / txo qis hauv cov piam thaj - 0.03. Hauv Diabeton, qhov ntsuas no yog 0.07. Vim yog qhov tseeb tias thaum noj cov ntsiav tshuaj glimepiride, cov tshuaj insulin yog ua tsawg dua, cov ntshav qab zib poob phaus, cov tshuaj tiv thaiv insulin tsawg dua, thiab cov hlwb ua haujlwm ntev dua.
- Muaj cov ntaub ntawv los ntawm kev tshawb fawb uas ua pov thawj txoj kev txhim kho hauv cov neeg mob ntawm pathologies ntawm cov hlab plawv tom qab hloov los ntawm Diabeton rau Glimepiride.
- Hauv cov neeg mob noj cov tshuaj metformin nrog glimepiride, kev tuag yog me dua qis dua nyob rau hauv cov ntshav qab zib uas tau muab tshuaj kho nrog gliclazide + metformin.
Glimepiride lossis Amaryl - uas zoo dua
Amaril yog thawj cov tshuaj tsim los ntawm ib tus thawj coj hauv kev ua lag luam ntawm cov tshuaj tiv thaiv kab mob, kev txhawj xeeb ntawm Sanofi. Tag nrho cov kev tshawb fawb tau hais los saum toj no tau ua nrog kev koom tes ntawm cov tshuaj no.
Tsis tas li, glimepiride npaj tau tsim nyob hauv tib lub npe lag luam los ntawm tsib lub tuam txhab Lavxias. Lawv yog cov generics, los yog analogues, muaj qhov sib npaug los yog zoo sib xws. Tag nrho lawv puav leej pheej yig dua li Amaril. Qhov sib txawv ntawm tus nqi yog vim qhov tseeb tias cov tshuaj no tsis dhau txhua qhov kev kuaj mob uas yuav tsum tau sau npe tshuaj tshiab. Cov txheej txheem rau cov generics tau yooj yim dua, nws txaus rau lub chaw tsim khoom kom paub meej cov roj ntsha sib luag ntawm nws cov ntsiav tshuaj mus rau tus thawj Amaril. Cov neeg kawm ntawv ntawm kev ua kom huv, excipients, ntsiav tshuaj daim ntawv yuav txawv.
Dua li ntawm qhov tseeb hais tias kev tshuaj xyuas ntawm Amaril thiab Lavxias Glimepirides yog qhov siv tib yam, muaj cov neeg mob ntshav qab zib uas tsuas yog xav siv cov tshuaj qub. Yog tias muaj lub siab xav tias qhov tsis tseem ceeb tuaj yeem ua haujlwm zuj zus, nws zoo dua los yuav Amaril, txij li kev ntseeg siab hauv qhov kev kho mob kws kho mob yog ib qho tseem ceeb heev. Cov nyhuv placebo cuam tshuam rau peb txhua tus thiab muaj qhov cuam tshuam ncaj qha rau peb lub neej.
Nqi thiab cia
Glimepiride pob nqi, 4 mg muab tshuaj:
| Lub Khw | Chaw tsim tshuaj paus | Tus nqi nruab nrab, rub. |
| Amaril | Sanofi | 1284 (3050 rubles rau pob ntawm 90 pcs.) |
| Glimepiride | Vertex | 276 |
| Ozoov | 187 | |
| Cov Kws Muag Tshuaj | 316 | |
| Xaws Pob Kws | 184 | |
| Glimepiride Canon | Canonpharma | 250 |
| Diamerid | Akrikhin | 366 |
Cov pheej yig tshaj tawm cov khoom siv yog tsim los ntawm Samara Ozone thiab Pharmproject los ntawm St. Petersburg. Ob lub tuam txhab yuav yuav cov tshuaj los ntawm cov tuam txhab Indian.
Lub txee lub neej ntawm cov tuam ntxhab sib txawv thiab yog 2 lossis 3 xyoos. Cov tseev kom muaj rau kev cia kub yog qhov qub - tsis siab tshaj 25 degrees.
