Hauv lub ntiaj teb uas tau nce nqi kho mob, cov tshuaj tsis raug cai yog qhov pheej hmoo loj los txo tus nqi thiab muab kev nkag mus rau cov tshuaj tseem ceeb rau cov tib neeg uas tsis muaj peev xwm them taus rau lawv.
Kev npaj rau cov tsis tseem ceeb yuav tsum muaj cov khoom siv sib xyaw ua ke thiab yuav tsum zoo ib yam lossis tsis pub dhau qhov ntau ntawm cov tshuaj muaj ntau yam nrog cov tshuaj muaj txiaj ntsig nrog cov tshuaj pharmacokinetic thiab pharmacodynamic. Ntau lub chaw tsim khoom tsim cov qib sib npaug rau cov tshuaj uas twb muaj lawm tsis muaj pov thawj kev nyab xeeb thiab ua tau zoo los ntawm kev kuaj mob hauv tsev kho mob. Kev npaj dav dav yog txiav txim siab sib npaug nrog cov tshuaj yog tias tus nqi thiab qhov nqus ntawm tsis nqus tsis qhia qhov sib txawv ntawm qhov npaj tau teev tseg.
Txawm li cas los xij, qee tus neeg mob thiab kws kho mob muaj kev xav tias generics tsis tshua zoo tshuaj. Cov neeg mob tau kho lawv cov tshuaj muaj npe, thiab feem ntau tsis xav hloov lawv. Tshwj xeeb tshaj yog nyob rau hauv lub ntsej muag ntawm kev tsim tawm kev txhawb nqa los ntawm cov tuam txhab uas tsis lees paub cov txiaj ntsig ntawm cov tshuaj tsis tseem ceeb. Cov kws kho mob feem ntau muaj qhov kev xav tsis zoo ntawm cov generics. Cov kev sib raug zoo no yog cov khoom lag luam thiab cov ntaub ntawv kev cai ntawm cov tuam txhab tsim khoom lag luam.
Cov yam ntxwv tseem ceeb ntawm kev siv tshuaj
Atorvastatin, tus neeg sawv cev lipid txo qis muag hauv qab hom npe Lipitor los ntawm PfizerInc., Nkag mus rau lub lag luam hauv xyoo 1996 thiab tau dhau los ua tshuaj zoo tshaj plaws hauv ntiaj teb uas qhov kev txiav txim siab tswj kev tswj hwm lipid metabolism.
Pfizer txoj cai rau Atorvastatin tag sijhawm thaum lub Kaum Ib Hlis 2011. Lwm cov tuam ntxhab pib xa cov tshuaj feem ntau ntawm cov tshuaj thaum Lub Tsib Hlis 2012. Thawj lub tuam txhab uas tsim cov tshuaj analogue ntawm cov tshuaj thiab qhia nws rau kev ua lag luam yog RanbaxyLaboratories los ntawm Is Nrias teb, nws yog lub tuam txhab tshuaj ntau tshaj plaws.
Kev saib xyuas tus neeg mob thiab tus kws kho mob ntawm cov generic atorvastatin Ranbaxy tau dhau los ntawm ntau yam kev tswjhwm zoo. Kev xav tsis zoo, vim qhov teeb meem tswj tau qhov zoo, zam dhau qhov ua rau muaj kev tsis zoo ntawm tus neeg siv khoom rau cov tshuaj.
Nws yog qhov nyuaj rau tshem tawm cov kev xav tsis zoo rau cov tshuaj vim tias muaj qee cov kev tshawb fawb tau tau ua uas tau soj ntsuam qhov ua tau zoo ntawm cov tshuaj feem ntau Atorvastatin.
Kev txhais lus ntawm cov kev tshawb fawb no tsuas yog muaj ntau yam:
- tsawg cov kev tshawb fawb kawm;
- tsis muaj pab pawg siv.
Txawm hais tias muaj cov txiaj ntsig zoo ntawm cov tshuaj no rau cov roj (cholesterol) phem, nws tseem tau ua pov thawj. Tias yog vim li cas, niaj hnub no cov twj tau siv dav.
Atorvastatin siv rau dab tsi?
Atorvastatin yog tshuaj muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj nrog ntau npaum ntawm 10 mg, 20, 30, 40, 60 lossis 80 milligrams. Tsis tas li, cov tshuaj no muaj nyob hauv hom lub npe Lipitor. Tab sis nws yuav tsum raug sau tseg tias hauv rooj plaub thib ob, nws tus nqi yuav nce siab dua me ntsis.
Atorvastatin yog siv los ua kom qis siab:
- tag nrho cov roj;
- LDL
- lwm cov rog hu ua triglycerides thiab apolipoprotein BB cov ntshav.
Nws raug pom zoo rau kev siv los ntawm cov neeg laus thiab cov menyuam yaus hnub nyoog dhau 10 xyoo nrog lub hauv paus, tsev neeg, lossis kev sib xyaw hypercholesterolemia. Nws yog siv thaum noj zaub mov muaj roj tsawg thiab kev hloov pauv hauv lub neej, xws li nce lub cev, tsis txhob txo cov roj cholesterol txaus.
Kev qhia rau kev noj tshuaj suav nrog feem ntau tiv thaiv kev ntsuas txhawm rau tiv thaiv kab mob plawv, xws li:
- Angina pectoris.
- Plawv nres
- Mob stroke.
Cov tshuaj no kuj tseem siv thaum muaj kev xav tau kev phais mob plawv lub plawv rau cov neeg muaj kev pheej hmoo siab mob plawv. Cov no suav nrog cov haus luam yeeb, rog dhau los lossis cov neeg rog, thiab cov neeg muaj ntshav qab zib thiab ntshav siab lossis keeb kwm mob plawv.
Hauv qhov no, atorvastatin tuaj yeem siv tau txawm tias theem roj hauv siab tsis pub dhau.
Atorvastatin ua haujlwm li cas?
Nws muaj ob hom roj (cholesterol) - "tsis zoo", hu ua lipoprotein tsawg (LDL), thiab "zoo", hu ua lipoprotein ntau ntau (HDL). LDL txiav txim siab ntawm cov hlab ntsha thiab nce kev pheej hmoo mob plawv los ntawm kev nqaim cov hlab ntsha (atherosclerosis), thaum HDL yeej tiv thaiv cov hlab ntsha ntawm qhov no.
Atorvastatin ua haujlwm los ntawm kev txo qis roj LDL hauv lub siab. Vim li ntawd, cov kab mob siab yuav nqus cov ntshav LDL los ntawm cov ntshav. Cov tshuaj ua rau txo qis me ntsis hauv kev coj ua ke ntawm lwm qhov "rog" phem hauv cov ntshav, hu ua triglycerides, thiab nce me ntsis hauv HDL synthesis. Cov txiaj ntsig zuag qhia tag nrho yog qhov txo qis ntawm cov "rog phem" hauv cov ntshav thiab nce ntxiv ntawm cov "zoo".
Statins, xws li atorvastatin, ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv cov kab mob plawv thiab mob stroke, vim lawv txo cov kev pheej hmoo ntawm cov roj (cholesterol) nyob rau hauv cov hlab ntsha tseem ceeb ntawm lub plawv thiab lub hlwb. Ib yam kev thaiv ntawm cov hlab ntsha txwv cov ntshav ncig thiab yog li txwv txoj kev xa oxygen tawm los ntawm lub plawv lossis hlwb hlwb. Hauv plawv, qhov no tuaj yeem ua rau lub hauv siab mob (angina pectoris) thiab mob hnyav tuaj yeem ua rau lub plawv nres (myocardial infarction), thaum nyob hauv lub hlwb nws tuaj yeem ua rau mob stroke.
Cov tshuaj no ua rau qeeb ntawm cov txheej txheem ntawm poob ntawm elasticity los ntawm phab ntsa ntawm cov hlab ntsha, tsis hais txog qib pib ntawm cov roj (cholesterol). Qhov no txo txoj kev pheej hmoo ntawm kev ua cov txheej txheem txhawm rau txhim kho cov ntshav ntxiv rau lub plawv, xws li nthuav tawm lub lumen ntawm cov leeg ntshav lossis txhim kho lub plawv hla ntawm cov pob txha.
Nws kuj tseem txo cov kev pheej hmoo ntawm lub plawv nres, mob hlab ntsha tawg, thiab tuag los ntawm kab mob plawv.
Yuav ua li cas thiaj kho tau cov tshuaj?
Raws li tau hais dhau los, cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj.
Koj tuaj yeem yuav cov tshuaj txhuam hniav, nws yog qhov haum rau cov neeg mob uas tawg zom zaub mov. Feem ntau, cov tshuaj yuav tsum noj ib hnub ib zaug. Kev noj tshuaj ntau npaum li cas yog tus kws kho mob tau mus kawm.
Nws yog ib qho tseem ceeb kom nco ntsoov tias yog tsis muaj kev sib tham ua ntej, yuav cov khoom no tsis pom zoo. Yog li, ua ntej koj yuav tsum sab laj nrog koj tus kws kho mob, cais tawm qhov tsim txom raug mob los ntawm kev siv, thiab nrhiav kom paub cov kev noj tshuaj ntau npaum li cas. Thiab tseem yuav tau txais daim ntawv qhia ua yuav khoom.
Cov kev mob tshwm sim heev tshaj yog:
- mob taub hau
- zawv plab
- cov tsos mob khaub thuas-zoo li.
Koj tsis tuaj yeem noj tshuaj thaum cev xeeb tub. Txwv tsis pub, cov tshuaj tseem ceeb tuaj yeem tsim kev puas tsuaj rau tus menyuam hauv plab.
Atorvastatin tuaj yeem coj los ntawm cov neeg laus thiab menyuam yaus hnub nyoog 10 xyoo. Tab sis tib lub sijhawm, nws tsis haum rau qee pab pawg ntawm cov tib neeg.
Nws yog ib qho tseem ceeb uas yuav tau qhia rau tus kws kho mob txog cov nuances hauv qab no:
- Kev twv tshuaj tiv thaiv atorvastatin lossis lwm yam tshuaj yav dhau los.
- Mob siab raum lossis mob raum.
- Txoj kev npaj xeeb tub.
- Cev xeeb tub
- pub niam mis rau menyuam noj.
- Mob ntsws heev.
- Mob stroke vim ntshav tawm hauv lub hlwb;
- Txais tos kom haus dej cawv kom ntau thiab haus cawv kom tsawg.
- Txo cov thyroid kev ua si.
Yog lawm, qhov no tsuas yog cov npe ntawm kev ceeb toom. Xav paub ntau ntxiv tuaj yeem tau txais thaum mus ntsib koj tus kws kho mob.
Cov lus qhia rau kev siv tshuaj
Zoo li lwm tus neeg sawv cev, Atorvastatin muaj cov lus qhia rau kev siv, uas tau piav qhia kom meej cov txheej txheem ntawm daim ntawv thov ntawm tus neeg sawv cev, nrog rau cov ntaub ntawv tseem ceeb.
Nws yuav tsum raug sau tseg tias kev tshuaj xyuas sab laug los ntawm ntau dua ib tus kws kho plawv los ntawm thoob plaws lub ntiaj teb tau xav tias cov tshuaj no muaj cov txiaj ntsig zoo.
Ntxiv nrog rau cov tshuaj no, lub tuam txhab Ratiopharm tso tawm Liptor, uas tsis tshua nrov hom hnub no. Ob lub cuab yeej no tau xyaum tsis muaj qhov sib txawv. Ob qho ntawd thiab lwm, cov kws kho mob koom yuav tsum sau tshwj tseg. Peb yuav tsum tsis txhob hnov qab tias lawv qhov kev siv tsis tuaj yeem tsis yog ib qho muaj txiaj ntsig xwb, tab sis kuj pom cov txiaj ntsig tsis zoo yog tias cov tshuaj siv rau lwm lub hom phiaj.
Cov lus qhia rau kev siv muaj cov ntaub ntawv uas cov ntsiav tshuaj chewable muaj cov tshuaj hu ua aspartame, yog li koj yuav tsum xub tham nrog koj tus kws kho mob ua ntej noj cov tshuaj.
Qhov no yog qhov tseeb tshwj xeeb tshaj yog rau cov neeg muaj phenylketonuria (ib qho tsis sib haum xeeb ntawm cov protein metabolism).
Atorvastatin yuav tsum noj ib hnub ib zaug. Tib lub sijhawm, koj tuaj yeem nqa nws thaum twg los tau, tab sis koj yuav tsum ua raws tib lub sijhawm nyob rau txhua hnub.
Cov tshuaj tsis ua txhaum txoj kev zom, yog li nws tuaj yeem nqa nrog lossis tsis muaj zaub mov noj. Kev txhaj tshuaj rau cov neeg laus ib txwm yog 10 mg rau 80 mg rau ib hnub. Hauv cov menyuam yaus, cov tshuaj ib txwm dhau los ntawm 10 mg rau 20 mg ib hnub ib zaug. Kev txhaj tshuaj ntau dua qee zaum siv. Tus kws kho mob ib leeg zuj zus txiav txim qhov nyiaj Atorvastatin uas haum rau tus menyuam lossis tus neeg laus.
Cov koob tshuaj pom zoo yog nyob ntawm theem ntawm cov roj (cholesterol) thiab cov tshuaj ntxiv los ntawm tus neeg mob.
Muaj kev phiv ntau
Ib qhov tsawg tab sis muaj kev phiv loj heev yog qhov qhia ua mob rau lub cev lossis ua kom tsis muaj zog hauv lub cev.
Tom qab cov pauv zoo li no hauv kev noj qab haus huv, koj tuaj yeem txuas ntxiv noj tshuaj, tab sis koj yuav tsum sab laj nrog koj tus kws kho mob. Tshwj xeeb yog hais tias qhov tsis xis nyob tsis ploj mus ntev.
Atorvastatin yuav tsum tsis ua mus ntxiv yog tias:
- mob leeg
- tsis muaj zog lossis mob plab - cov no yuav yog qhov qhia ntawm cov nqaij ntshiv thiab lub raum puas tsuaj;
- yellowness ntawm daim tawv nqaij los yog sclera ntawm lub qhov muag - qhov no tej zaum yuav pom ntawm daim siab mob;
- daim tawv nqaij ua pob nrog liab-liab pob, tshwj xeeb tshaj yog ntawm xib teg ntawm txhais tes lossis lub qab xib taws;
- mob plab plab - qhov no tuaj yeem yog cov tsos mob ntawm tus mob pancreatitis thiab lwm yam teeb meem nrog tus txiav;
- kev hnoos
- txoj kev xav txog siav siav;
- poob phaus.
Tsawg tsawg zaus, muaj kev fab loj rau nws muaj peev xwm ua tau. Nws yog ib qho xwm txheej kub ceev, qhov ntawd koj yuav tsum tau mus ntsib kws kho mob sai. Cov cim ceeb toom ntawm kev tsis haum tshuaj yog:
- Cov tawv nqaij ua pob khaus xws li khaus.
- Rubella
- Npuas tev tawv nqaij.
- Teeb meem ua pa lossis hais lus.
- Kev pauv ntawm lub qhov ncauj, lub ntsej muag, daim di ncauj, tus nplaig lossis lub caj pas.
Txhawm rau zam qhov tshwm sim, nws yog ib qho tseem ceeb kom ua raws li cov lus qhia thiab kev noj tshuaj.
Kuv yuav tsum nco ntsoov dab tsi thaum siv cov khoom lag luam?
Yog lawm, nws tsis tuaj yeem sib cav tias cov tshuaj no muaj kev nyab xeeb rau tib neeg kev noj qab haus huv.
Tab sis yog tias ua kom raug, nws yuav pab tau zoo heev yog tias tsim nyog los tswj cov lipid metabolism.
Qee cov tshuaj cuam tshuam rau qhov ua tau zoo ntawm atorvastatin thiab tuaj yeem ua rau muaj kev pheej hmoo ntawm phiv loj heev.
Cov tshuaj uas tsis sib xyaw nrog atorvastatin yog:
- qee cov tshuaj tua kab mob thiab tshuaj tua kab mob;
- ib cov tshuaj rau HIV;
- qee cov tshuaj kho kabmob siab;
- Svarfarin (tiv thaiv kom txhob coagulation ntshav);
- Cyclosporin (kho cov mob psoriasis thiab mob caj dab);
- Colchicine (ib qho tshuaj kho rau gout);
- tshuaj noj tswj kev xeeb tub;
- Verapamil;
- Diltiazem
- Amlodipine (siv rau cov ntshav siab thiab mob plawv);
- Amiodarone (ua rau koj lub siab nyob ruaj khov).
Yog tias tus neeg mob tau noj cov tshuaj saum toj no, nws yuav tsum ceeb toom nws tus kws kho mob. Hauv qhov xwm txheej no, nws raug samfwm kom txo qis tshuaj Atorvastatin lossis kev pom zoo kom siv cov tshuaj analogue. Tab sis ib qho tshuaj zoo sib xws yuav tsum tau muaj nyob hauv pab pawg statins.
Cov ntaub ntawv hais txog cov tshuaj Atorvastatin tau muab nyob hauv video hauv tsab xov xwm no.
