Kev siv hluavtaws hypoglycemic ua rau muaj kev ncaj ncees hauv kev daws teebmeem cov ntshav qab zib. Lawv pab tswj kev saib xyuas cov ntshav qab zib kom qis thiab txo qis ntawm cov kab mob.
Ib ntawm cov tshuaj no yog Repaglinide.
Daim ntawv tso tawm
Repaglinide suav nrog 
nyob rau hauv kev sib xyaw ntawm ntau cov tshuaj nrog cov lag luam npe:
- NovoNorm;
- Diaglinide;
- Eglinides thiab lwm tus.
Cov nyhuv ntawm cov tshuaj no yog ua raws li thaj chaw pharmacological ntawm cov tshuaj repaglinide (repaglinide), uas yog lawv lub ntsiab lus tseem ceeb, thiab tuaj yeem txhim kho lossis hloov kho nrog kev pabcuam ntawm cov koom tes pabcuam.
Feem ntau, cov tshuaj muaj nyob hauv daim ntawv foos nrog kev saib xyuas ntawm cov tshuaj nquag muaj nyob hauv 0.5, 1 lossis 2 milligrams.
Pharmacological cov yam ntxwv ntawm cov quav
Cov txiaj ntsig tseem ceeb ntawm cov tshuaj yog txo cov ntshav qab zib, nws yog raws li cov txheej txheem ntawm kev ua kom tsis txhob ua haujlwm ntawm ATP-tubules nyob hauv cov plhaub ntawm lub pancreatic cells-hlwb.
Repaglinide ua rau ntawm cov poov tshuaj channel, pab txhawb kom tso tawm K ions+ los ntawm cov xov tooj ntawm tes, uas yuav pab txo cov polarization ntawm nws cov phab ntsa thiab tso tawm cov calcium calcium. Tag nrho cov no pab txhawb kev nce hauv cov tshuaj insulin thiab nws tso rau hauv cov ntshav.
Kev nqus ntawm cov khoom tshwm sim sai li sai tau, tom qab ib teev muaj qhov siab nyob rau hauv cov ntshav, maj mam txo thiab ploj tom qab 4 teev.
Hauv qhov no, cov khoom txuas zoo nrog cov plasma protein, los ntawm ntau dua 90 feem pua, thiab tom qab ntawd ua tiav nrog kev tso tawm:
- oxidized dicarboxylic acid;
- tshuaj tsw qab amines;
- acyl glucuronide.
Cov tshuaj no tsis muaj qhov ua kom tsis zoo thiab raug ntuav vim yog lub plab zom mov thiab qee qhov los ntawm lub raum.
Kev taw qhia thiab contraindications
Cov tshuaj raws li cov tshuaj repaglinide tau pom zoo rau kev txhim kho hom 2 mob ntshav qab zib mellitus, ob qho tib si li tshuaj ywj siab thiab hauv kev sib xyaw nrog metformin lossis thiazolidinediones, ntxiv thaum noj ib hom tshuaj tsis qhia muaj cov nyhuv txaus.
Cov tshuaj tiv thaiv kev siv tshuaj yog:
- muaj mob ntshav qab zib
thawj hom; - pathology loj ntawm daim siab;
- ua txhaum ntawm cov lactose metabolism;
- lub sijhawm cev xeeb tub thiab lactation;
- kev siv cov tshuaj gemfibrozil-based;
- ntshav qab zib ketoacidosis, coma lossis precoma;
- muaj kev kis kab mob, xav tau kev phais mob lossis lwm yam kev cuam tshuam uas kev kho mob insulin;
- hnub nyoog me;
- tob tob tob rau lub ntsiab thiab ib feem ntawm cov tshuaj.
thawj hom;Txij li cov tshuaj yeeb tshuaj yog qee tawm los ntawm ob lub raum, cov neeg mob uas muaj cov kab mob pathologies hauv cheeb tsam no yuav tsum noj cov tshuaj nrog ceev faj. Tib yam siv rau cov neeg mob uas tsis zoo thiab kev txom nyem los ntawm lub xeev febrile.
Thaum lub caij tswj hwm ntawm cov tshuaj repaglinide, nws yog ib qho tsim nyog yuav tsum tau ua tib zoo saib xyuas ntsuas cov ntshav qab zib kom tsis txhob txhawm rau tiv thaiv lub xeev ntawm cov ntshav qog ntshav thiab tsis nco qab. Nrog lub ntsej muag poob hauv cov piam thaj, qhov ntau ntawm cov tshuaj txo qis.
Cov lus qhia rau kev siv
Txais tos ntawm cov tshuaj yog nqa tawm raws li cov lus qhia ntawm cov tshuaj, uas suav nrog cov tshuaj. Feem ntau cov tshuaj muaj nyob hauv daim ntawv foos, lawv tau noj ntawm qhov ncauj 15-20 feeb ua ntej noj mov. Qhov ntau npaum no yog xaiv hauv txhua kis.
Nws yog qhov zoo dua los pib noj cov tshuaj repaglinide nrog qhov tsawg kawg nkaus: 0.5 mg. Tom qab ib lub lim tiam, koj tuaj yeem hloov kho los ntawm kev nce qhov ntxiv ntawm cov tshuaj los ntawm 0.5 mg. Qhov siab tshaj plaws uas tau tso cai yuav tsum yog 4 mg ib zaug lossis 16 mg rau ib hnub.
Yog tias tus neeg mob yav dhau los siv tshuaj sib txawv hypoglycemic thiab tau pauv mus rau repaglinide, kev muab tshuaj rau nws thawj zaug yuav tsum yog li 1 mg.
Yog tias koj tsis tau noj cov ntsiav tshuaj, tsis txhob nce ntau ntxiv rau kev noj tshuaj ua ntej tom ntej, qhov no tuaj yeem ua rau txo qis cov piam thaj hauv cov ntshav thiab pib ntawm lub qog ntshav qab zib. Ib qho kev hloov pauv ntawm cov tshuaj lossis hloov pauv ntawm cov tshuaj yuav tsum muaj nyob rau hauv kev saib xyuas ntawm tus kws kho mob thiab nyob rau hauv kev saib xyuas ntawm qab zib qhia nyob rau hauv cov zis thiab ntshav ntawm tus mob ntshav qab zib.
Sab sij huam
Feem ntau, thaum siv cov tshuaj raws li cov tshuaj repaglinide, kev mob ntshav qab zib muaj tshwm sim, uas tuaj yeem tshwm sim ob qho tib si vim tias tsis ua raws li cov cai rau kev siv tshuaj, thiab vim muaj qee tus neeg: nce kev tawm dag zog, tsis ua raws kev noj haus, thiab lwm yam.
Txuas ntxiv, qhov tshwm sim tsis zoo yuav tshwm sim rau hauv daim ntawv ntawm:
- pom kev tsis zoo;
- vasculitis;
- kev txhim kho ntawm cov hlab plawv;
- cov tshuaj tiv thaiv kab mob ua rau tawv nqaij thiab khaus;
- hypoglycemic coma thiab poob ntawm nco qab;
- ua txhaum ntawm daim siab;
- mob hauv plab, xeev siab, raws plab, lossis cem quav.
Thaum cov tshuaj kom zoo li qub lossis cov tshuaj hloov mus rau lwm cov tshuaj, cov tsos mob ploj.
Video los ntawm Dr. Malysheva txog cov cim qhia txog ntshav qab zib:
Yeeb tshuaj sib cuam tshuam
Kev siv tshuaj repaglinide, nws yog ib qho tsim nyog yuav tsum coj mus rau hauv nws txoj kev cuam tshuam nrog lwm cov tshuaj.
Los txhim kho cov nyhuv ntawm cov tshuaj muaj peev xwm:
- Gemfibrozil;
- anabolic tshuaj steroids;
- Rifampicin;
- Trimethoprim;
- Clarithromycin;
- Itraconazole;
- Ketoconazole thiab lwm yam kab mob hypoglycemic;
- oppressors ntawm monoamine oxidase thiab angiotensin-hloov enzyme;
- cov tshuaj uas tsis yog tshuaj steroidal;
- tsis xaiv khoom beta-blockers;
- salicylates.
Kev tswj hwm ib txhij ntawm cov tshuaj nrog repaglinide thiab gemfibrozil yog contraindicated, txij li nws coj mus rau ntau qhov nce hauv kev nqis tes ua ntawm cov tshuaj thiab qhov zoo li ua rau rov qab.
Ntawm kev ua haujlwm ntawm repaglinide, xws li cov neeg sawv cev xws li:
- Cimetidine;
- Simvastatin;
- Tshuaj Estrogen;
- Nifedipine.
Yog li ntawd, lawv tuaj yeem siv ua ke.
Kev cuam tshuam me ntsis ntawm qee qhov ntawm repaglinide tau pom nyob hauv kev sib piv rau cov tshuaj: Warfarin, Digoxin thiab Theophylline.
Cov hauj lwm zoo ntawm cov tshuaj txo:
- qhov ncauj tiv thaiv;
- glucocorticosteroids;
- Rifampicin;
- cov thyroid hormones;
- barbiturates;
- Danazole;
- sympathomimetics;
- Carbamazepine;
- thiazide derivatives.
Lawv siv yog pom zoo kom ua ke nrog nrog ntau cov kev kho me me ntawm cov khoom.
Kev pom zoo rau kev siv
Repaglinide yog qhov tsim nyog rau kev siv thaum kho kev noj zaub mov zoo thiab kev ua kom lub cev ib txwm tsis pub koj tswj ntshav qab zib.
Sij hawm dhau mus, kev ua haujlwm ntawm cov tshuaj txo qis, uas cuam tshuam nrog kev txhim kho ntawm tus kabmob thiab txo lub cev lub cev hloov mus rau qhov kev txiav txim ntawm cov tshuaj. Tom qab ntawv tus kws kho mob sau ib qho tshuaj ntxiv lossis nqa tshuaj kho kom haum.
Cov txiaj ntsig ntawm cov tshuaj yog tshuaj xyuas tas li los ntawm kev soj ntsuam ntawm kev saib xyuas ntawm cov piam thaj hauv ntshav thiab zis. Tus neeg mob tuaj yeem soj ntsuam ntawm nws tus kheej siv cov tshuaj hauv tsev, tab sis qee zaus yuav tsum muaj kev soj ntsuam los ntawm tus kws kho mob uas tuaj koom. Rau nws, nws yog qhov yuav tsum tau xeem hauv chav kuaj mob.
Nws kuj kuaj xyuas qib ntawm glycosylated hemoglobin, uas tso cai rau koj kom tau txais daim duab tiav ntawm cov txheej txheem kev kho. Thaum cov ntsuas pib pauv, qhov ntau npaum cov tshuaj yog hloov kho.
Lub cuab yeej siv nws tus kheej yog siv los ua ke nrog kev noj zaub mov noj thiab kev tawm dag zog ib txwm, uas yuav tsum tau tsim los ntawm kws kho mob. Tib lub sijhawm, kev hloov pauv ntawm cov zaub mov noj lossis cov kis las ncaws pob ua rau muaj kev hloov pauv hauv cov piam thaj hauv cov ntshav, uas yuav tsum muaj kev kho kom haum rau cov tshuaj noj. Txij li thaum tus neeg mob tsis tuaj yeem ua qhov no sai, nws raug nquahu kom zam kev hloov sai rau kev noj haus thiab kev ntxhov siab.
Repaglinide tsis tuaj yeem siv ib txhij nrog cov cawv cov neeg sawv cev, vim lawv txhim kho nws cov nyhuv. Cov tshuaj nws tus kheej tsis cuam tshuam rau lub peev xwm ntawm kev tsav tsheb, tab sis thaum muaj kev mob ntshav qab zib tsawg, lub peev xwm no raug txo ntau. Yog li no, thaum noj tshuaj, koj yuav tsum tswj hwm qhov qib ntawm cov piam thaj thiab tiv thaiv nws txoj kev poob qis.
Raws li tau qhia, cov neeg mob uas muaj pathologies ntawm lub luag haujlwm ntawm lub raum thiab mob siab, nrog rau kev txom nyem los ntawm cov kab mob ntawm lub plawv thiab cov hlab ntsha, yuav tsum siv cov tshuaj tshwj xeeb.
Muaj tsis muaj kev cuam tshuam ntawm cov ntxim rau cov poj niam cev xeeb tub thiab lactating. Yog li, kev nyab xeeb ntawm cov tshuaj rau tus menyuam tsis tau lees paus thiab cov tshuaj tsis tau teev tseg nyob rau lub sijhawm no. Tus pojniam uas xav tau tshuaj yuav tsum tsis kam pub mis rau menyuam noj.
Tib yam siv rau cov hnub nyoog lub yam ntxwv. Qhov meej tiag ntawm cov tshuaj rau cov neeg mob hnub nyoog qis dua 18 xyoo thiab tom qab 75 tsis paub. Hauv cov xwm txheej zoo li no, Repaglinide hloov pauv los ntawm cov tshuaj ntxiv los yog tseem tuaj yeem siv los ntawm tus neeg mob hauv lub hnub nyoog laus, yog tias nws nyob hauv kev saib xyuas ntawm tus kws kho mob endocrinologist.
Repaglinide-raws li kev npaj
Cov lus sau rau cov tshuaj yog Repaglinide-Teva, qhov kev nqis tes ua raws li cov tshuaj hauv nqe lus nug.
Cov lus piv txwv yog:
- Diagninid tus nqi los ntawm 200
rubles rau 30 ntsiav tshuaj; - Jardins los ntawm 200 rubles rau 30 ntsiav tshuaj;
- NovoNorm los ntawm 170 rubles rau 30 ntsiav tshuaj;
- Invokana los ntawm 2000 rubles rau 30 ntsiav tshuaj nrog qhov ntau npaum ntawm 100 mg .;
- Forsiga thaum 2000 rubles rau 30 ntsiav tshuaj nrog qhov ntau npaum ntawm 10 mg .;
rubles rau 30 ntsiav tshuaj;Tus nqi ntawm repaglinide thiab analogues nyob ntawm ntau yam:
- tsuas tshuaj
- chaw tsim tshuaj paus;
- muaj cov tshuaj concomitant;
- nqi kev cai ntawm lub tsev muag tshuaj saw thiab lwm yam.
Kev noj tshuaj hypoglycemic yog qhov tseem ceeb rau ntau cov neeg mob uas muaj ntshav qab zib hom 2. Nws tso cai rau lawv los txhim kho lub neej zoo thiab txo qis kev puas tsuaj ntawm tus kabmob. Txawm li cas los xij, tag nrho cov no ua tau tsuas yog tias qhov yuav tsum tau ua ntawm cov lus qhia rau kev siv tshuaj thiab kev tswj ntawm qhov ntsuas ntawm lub xeev ntawm lub cev raug pom.
