Bagomet yog cov tshuaj noj nrog hypoglycemic lub peev xwm, uas yog siv los them rau cov ntshav qab zib tsis muaj tshuaj tua kab mob ntshav qab zib mellitus (DM), yog tias sulfonylurea txoj kev kho tsis zoo txaus.
Pharmacological cov yam ntxwv ntawm Bagomet
Bagomet yog ib qho tshuaj hypoglycemic uas ua rau ob qho tib si sai ntawm cov piam thaj thiab qhov ua tau zoo tom qab noj mov. Cov tshuaj tsis cuam tshuam rau kev tsim ntawm cov tshuaj insulin. Ntawm cov kev mob tshwm sim ntawm cov neeg mob ntshav qab zib tsis yog kho. Kev muaj peev xwm kho tau tshwm sim tom qab inhibition ntawm glycogenolysis thiab gluconeogenesis, provoking inhibition of glycogen hauv daim siab.
Bagomet txhim kho kev ua tau zoo ntawm cov enzyme uas ua rau nrawm glycogen synthes, nce kev thauj khoom muaj peev xwm ntawm daim nyias nyias transporter. Cov tshuaj kho cov lipid metabolism - nrog hom 2 ntshav qab zib muaj txoj hmoo ua kom poob phaus.
Bagomet muab piv nrog lub peev xwm sib xyaw kom zoo thiab qhov kev zom sai.
Thaum noj, cov tshuaj tam sim ntawd nqus los ntawm lub plab zom mov, qhov siab tshaj plaws tau mus txog hauv ob thiab ib nrab teev. Ua rau kom qis li qhov ua tau ntawm cov tshuaj txuam thaum tau txais zaub mov. Bagomet cov kev ntsuas kev nyab xeeb yog mus txog 60% ntawm tag nrho cov tshuaj ntawm cov tshuaj xa mus rau cov kabmob.
Raws li cov txiaj ntsig ntawm kev tshawb fawb pharmacokinetic, peb tuaj yeem xaus tias cov tshuaj sai sai rau ntawm cov ntaub so ntswg, ua kom muaj hauv plasma. Cheebtsam ntawm cov tshuaj tsis khi rau cov protein, nws tuaj yeem nkag mus rau hauv cov ntshav liab, tab sis hauv cov ntshav lawv muaj tsawg dua piv rau ntshav.
Cov kev sim tau paub meej tias cov tshuaj hauv lub cev tsis suav daws - lub raum nws zoo nws nyob hauv nws lub xeev qub. Hauv qhov no, ib nrab-lub neej yog rau thiab ib nrab xuaj moos. Bagomet tawm tawm yog qhov kev xav los ntawm kev ua haujlwm siab glomerular pom thiab lub raum plab tsis pom kev, yog li ntawd, txhua tus neeg mob nrog lub raum pathologies yog qhov muaj kev pheej hmoo.
Ib nrab-lub neej tau nce, uas txhais tau tias muaj kev pheej hmoo ntawm kev txuam nrog tshuaj.
Kev ntsuas qhov tseeb thiab txoj kev siv
Bagomet yog npaj rau kev kho mob rau cov neeg mob ntshav qab zib nrog hom insulin-ywj pheej ntawm cov kab mob thiab kev rog (hauv qhov tsis muaj ketoacidosis thiab kev tsis txaus teb rau kev kho mob nrog sulfonylureas).
Cov tshuaj yog npaj rau kev siv sab hauv. Nqos cov ntsiav tshuaj kom tag nrho nrog dej. Qhov no feem ntau tshwm sim nrog cov zaub mov lossis tam sim ntawd tom qab nws. Kev muab tshuaj thawj zaug yog 500-100 mg / hnub, nyob ntawm qib glycemia. Koj tuaj yeem hloov kho tsuas yog tom qab ob lub lim tiam ntawm kev nquag thiab kev saib xyuas ntawm glycemic ntsuas.
Yog tias tus kws kho mob tsis tau txiav txim siab txog tus neeg mob txog tus neeg mob, tom qab ntawd tus qauv muab tshuaj kho tau yog li ntawm 1500 txog 2000 mg. Nws yog tsis yooj yim sua kom dhau qhov siab tshaj plaws kev coj ua. Yog tias cov tshuaj provokes kev quav ntawm cov quav, koj tuaj yeem tsoo qhov kev cai niaj hnub los ntawm 2-3 zaug.
Nrog cov kev kho mob nyuaj "Bagomet ntxiv rau cov tshuaj insulin npaj", cov qauv tshuaj yog 1500 mg / hnub. Rau cov ntsiav tshuaj nrog lub peev xwm ncua ntev, qhov qib siab zoo rau txhua hnub yog 850 mg -1000 mg. Nrog kev muaj peev xwm tiv taus ib txwm, lawv nres ntawm tus nqi saib xyuas ntawm 1700 mg / hnub, thiab qhov txwv - 2550 mg / hnub. Hauv kev kho ua txoj siv nrog lwm cov tshuaj txo suab thaj, ib ntsiav tshuaj (850 mg lossis 100 mg) yog tshuaj.
Hauv kev laus, Bagomet noj tsis ntau tshaj 1000 mg / hnub. Koj tuaj yeem muab tshuaj rau cov menyuam yaus hnub nyoog 10 xyoo. Cov menyuam yaus, nrog rau cov laus, yuav tsum pib ib chav kho mob nrog 500-850 mg / hnub. Hauv cov menyuam yaus, qhov tshuaj ntau tshaj txhua hnub yog 2000 mg.
Sab sij huam
Feem ntau, cov tshuaj tau txais txiaj ntsig zoo los ntawm cov neeg mob feem ntau, tab sis, zoo li nrog ib qho tshuaj twg, nws muaj kev mob tshwm sim.
| Tso cai los ntawm qhov uas tej zaum yuav muaj kev ua txhaum | Hom mob tshwm sim |
| Lub plab zom mov |
|
| Ntshav ncig | Megaloblastic anemia |
| Lub hauv nruab nrog cev | Renal tsis ua haujlwm vim yog qhov tsis txaus thauj ntawm kev tawm ntawm Bagomet. |
| Endocrine system | Mob Hypoglycemia (tsuas yog tias cov koob tshuaj siab tshaj). |
| Kev fab tshuaj tiv thaiv | Khaus thiab ua pob rau ntawm daim tawv nqaij. |
| Kev zom zaub mov |
|
Cov kev soj ntsuam ua ntej pom tau hais tias Bagomet tsis cuam tshuam rau mutagenicity, carcinogenicity thiab teratogenicity. Nws tsis cuam tshuam ntawm kev ua me nyuam muaj qhov ua pov thawj.
Cov Yuav Tsum Muaj
Nws tsis pom zoo kom nqa Bagomet nrog cov kab mob hauv qab no:
- Cov ketoacidosis uas mob ntshav qab zib, mob ntshav qab zib tsis xeev thiab cov keeb kwm caj ces;
- Cov teeb meem ua pa;
- Mob pathologies, tshwj xeeb tshaj yog nyob rau hauv kev mob plawv;
- Cerebral ntshav khiav tsis zoo;
Cov kab mob lactic acidosis;
- Kev haus dej cawv, lub cev qhuav dej;
- Mob raum;
- Muaj feem raug ntxim rau cov khoom xyaw ntawm Bagomet mis;
- Cov kev ua haujlwm xav tau hloov cov ntsiav tshuaj nrog kev txhaj tshuaj insulin;
- Daim siab ua haujlwm;
- Cev xeeb tub thiab pub mis;
- Xoo hluav taws xob siv iodine ua kev sib piv (txwv - txwv rau 2 hnub ua ntej thiab tom qab kuaj);
- Kev noj haus hypogalogy;
- Kev paub tab (tom qab 60 xyoo) hnub nyoog, tshwj xeeb tshaj yog nrog cov leeg mob hnyav ua rau cov kab mob lactic acidosis;
- Menyuam yaus (muaj txog li 10 xyoo) hnub nyoog.
Cov ntsiab lus ntawm cev xeeb tub
Cov kev sim tshuaj tsis tau lees tias cov mutagenic thiab teratogenic cov yam ntxwv ntawm Bagomet, tab sis lawv tsis tau sau tseg rau cov poj niam cev xeeb tub. Cov tshuaj tuaj yeem nkag rau hauv niam mis, yog tias tsis muaj lwm txoj hauv Bagomet, tus menyuam yuav tsum pauv mus rau kev pub mis.
Qhia Txog Kev Sib Koom Tes Nrog Tshuaj
Bagomet's hypoglycemic muaj peev xwm txhim kho los ntawm sulfonamides, insulin, acarbose, tshuaj tsis-steroidal anti-inflammatory tshuaj, ACE thiab MAO inhibitors, oxytetracycline, β-blockers.
Glucocorticosteroids, GOK, epinephrine, glucagon, cov tshuaj tiv thaiv qog tshuaj, cov tshuaj sympathomimetics, thiazide thiab "voj" diuretics, derivatives ntawm phenothiazine thiab nicotinic acid inhibit nws txoj haujlwm.
Qhov kev tshem tawm ntawm Bagomet los ntawm cov plab hnyuv siab raum yog tiv thaiv los ntawm cimetidine. Anticoagulant muaj peev xwm ntawm Coumarin derivatives inhibits Bagomet.
Siv dej cawv txuam lactic acidosis. Nws cov kev pom yog kev poob ntawm lub cev kub, myalgia, tsis xis nyob hauv plab plab, mob plab tsis ua hauj lwm, ua tsis taus pa, ua tsis taus pa, tsaus muag. Ntawm thawj kev ntseeg ntawm tus neeg raug mob, lawv mus pw hauv tsev kho mob thiab kev kuaj mob meej meej los ntawm kev kuaj xyuas qhov concentration ntawm lactate hauv cov plab hnyuv siab raum thiab cov ntaub so ntswg.
Tshuav cov tsos mob
Yog hais tias cov koob tshuaj ntawm Bagomet yog saum toj no ntau tshaj qhov tau tso cai, lactic acidosis nrog rau qhov tshwm sim loj tshaj plaws hauv daim ntawv ntawm kev tsis nco qab thiab txawm tuag taus yog ua tau. Cov txiaj ntsig zoo sib xws yog tshwm sim los ntawm kev nce siab ntawm cov tshuaj hauv lub cev muaj teeb meem nrog nws cov zis tawm los ntawm lub raum. Qhov teeb meem loj tuaj hauv ob peb teev thiab xa nrog cov yam ntxwv ntawm tus yam ntxwv:
- Dyspeptic cuam tshuam;
- Kev Ntshav Siab;
- Kev ua txhaum ntawm lub suab sib dhos ntawm txoj hnyuv;
- Mob plab hauv plab;
- Nkauj Hnub Qub;
- Poob kev sib koom tes;
- Tsaus muag thiab mob plab tso dag.
Yog tias tsawg kawg ntawm qee cov tsos mob tau tshwm sim, Bagomet yuav tsum tau kho kom sai, thiab tus neeg raug mob yuav tsum tau mus pw hauv tsev kho mob.
Tso tawm daim ntawv, muaj pes tsawg leeg, chaw cia khoom
Cov ntsiav tshuaj tuaj yeem muaj cov duab thiab xim sib txawv, nyob ntawm qhov ntau npaum li cas: dawb, puag ncig thiab convex - 500 mg txhua qhov, nyob rau hauv daim ntawv ntawm tsiav tshuaj - 850 mg bluish hauv xim thiab 1000 mg hauv dawb. Cov yav tas muaj lub zog ntev. Qhov tshwj xeeb ntawm daim ntawv tso tawm yog cov kab sib faib thiab cov chaw tsim khoom lub logo, embossed ntawm txhua cov ntsiav tshuaj.
Ib ntsiav tshuaj muaj los ntawm 500 txog 100 mg ntawm cov tshuaj ua kom nquag plias metformin hydrochloride ntxiv rau cov neeg tsis muaj zog nyob hauv daim ntawv ntawm croscarmellose sodium, povidone, stearic acid, pob kws hmoov txhuv, lactose monohydrate.
Cov khoom siv xub ntiag nrog cov tshuaj yuav tsum tau muab tso rau hauv qhov chaw uas cov menyuam yaus nkag tsis tau, txog rau qhov kub txog 25 ° C. Khaws Bagomet tsis pub dhau ob xyoos.
Cov lus ua piv txwv thiab analogues tshuaj
Bagomet synonyms suav nrog cov tshuaj uas ob pawg (tshuaj tiv thaiv kab mob hauv qhov ncauj) thiab cov nquag ua ke (metformin) coincide.
- Methamine;
- NovoFormin;
- Formmetin;
- Rau menyuam yaus.
Bagomet's analogs yog cov tshuaj nyob rau hauv uas tsawg kawg ib tus kab mob lossis kev mob sib txig sib luag hauv cov lus pov thawj, hauv qhov xwm txheej ntshav qab zib hom 2 no.
- Av ‡ Q
- Apidra
- Baeta;
- Glemaz;
- Glidiab;
- Glucobay;
- Khoom Plig Ntsuas;
- Lymphomyozot;
- Levemir Penfill;
- Levemir Flekspen;
- Multisorb;
- Methamine;
- NovoFormin;
- Piroglar;
- Formmetin;
- Rau menyuam yaus.
Nrog cov kev kho mob nyuaj nrog lwm cov tshuaj ntawm cov txiaj ntsig zoo sib xws, nws yog ib qho tseem ceeb uas yuav tsum xav txog qhov muaj peev xwm txo tus mob ntshav qab zib tsawg. Cov tshuaj muaj peev xwm ua kom muaj kev cuam tshuam kev sib txuam thiab txo qis kev cuam tshuam psychomotor, yog li thaum ua haujlwm nrog cov txheej txheem lossis thaum tsav tsheb, nws zoo dua rau qhov tsis kam noj cov tshuaj. Kev siv Bagomet yuav tsum tau ua raws li qhov kev noj haus cov zaub mov uas tsis muaj cov carb uas yuav tswj hwm kev noj cov carbohydrates hauv cov ntshav.
Kev txheeb xyuas txog Bagomet
Txog ntawm cov tshuaj Bagomet, kev tshuaj xyuas ntawm kws kho mob feem ntau yog qhov zoo. Raws li cov kws tshaj lij, kev noj tshuaj xws li cov tshuaj yeeb tshuaj no muaj peev xwm tswj cov ntshav qab zib nyob ntev li 12 teev. Cov cib fim no lav nws qee yam zoo: koj tuaj yeem txo qhov zaus ntawm kev noj tshuaj, txhim kho kev soj ntsuam ntawm cov txheej txheem hauv metabolic. Tib lub sijhawm, kev nqus ntawm cov khoom nquag los ntawm kev ua haujlwm ntawm txoj hnyuv zoo tuaj thiab muaj kev pheej hmoo ntawm kev tsim cov kev mob tshwm sim tsawg dua.
Cov lus piav qhia txog cov tshuaj tsis tuaj yeem ua tus qauv qhia rau kev siv. Ua ntej yuav khoom, koj yuav tsum sab laj nrog endocrinologist, thiab ua ntej noj tshuaj Bagomet, nyeem cov lus qhia rau kev siv los ntawm lub khw tsim khoom. Cov ntaub ntawv hais txog Bagomet yog muab rau kev paub dav dav nrog nws lub peev xwm thiab tsis yog kev qhia rau kev kho tus kheej. Kev noj tshuaj zoo rau tus mob ntshav qab zib, mob ntshav qab zib thiab cov kab mob ntawm cov mob ntshav qab zib tsuas yog tsim los ntawm ib tus kws kho mob tshwj xeeb.
