Yuav kom kho cov ntshav ntshav qabzib ntau, cov ntshav qab zib tau tsim cov tshuaj insulin. Ib qho ntawm ntau yam ntawm cov tshuaj txhaj tiv thaiv hypoglycemic yog insulin aspart.
Cov tshuaj yog cov bioengineered analogue ntawm tib neeg cov tshuaj insulin, nrog lub sijhawm luv luv ntawm kev ua. Nws yog siv ua ib feem ntawm txoj kev kho mob tseem ceeb rau cov ntshav qab zib mellitus thiab replenishes qhov xav tau rau insulin, nyob rau hauv kev ua txhaum ntawm endogenous ntau lawm ntawm lub cev.
Qhia txog ntawm cov tshuaj
Cov tshuaj muaj nyob rau hauv daim ntawv ntawm kev daws rau subcutaneous thiab tso ntshav txhaj tshuaj. Aspart insulin belongs rau cov chav kawm ntawm cov tshuaj uas tau tsim tawm siv cov khoom siv bioengineering. Nws tau los ntawm kev rov ua kom zoo DNA ntawm kev ua haujlwm ntawm Saccharomyces cerevisiae, nrog kev hloov ntawm ib qho ntawm cov amino acids.
Pharmacological kev ua ntawm cov tshuaj nquag yog tswj los ntawm kev nqus ntawm cov piam thaj, thiaj li yuav txo cov ntshav qab zib hauv cov neeg mob ntshav qab zib mellitus.
Insulin aspart tsim cov txheej txheem insulin receptor uas muab cov txheej txheem hauv qab no:
- Thauj thiab qabzib uptake;
- Enzyme synthesis;
- Glycogenogenesis;
- Lipid metabolism hauv cov txheej txheem muaj qabzib txhaws;
- Kev Txuag ntawm glycogen hauv hepatocytes.
Muaj ob daim ntawv nyob rau hauv uas aspart tsim:
- Ib theem. Txoj kev daws teeb meem meej, muaj kev tshwm sim luv luv (3-5 teev), tom qab kev tswj hwm subcutaneous. Tso rau nws kom tswj glycemia thaum noj zaub mov carbohydrate.
- Biphasic. Kev npaj ua ke ua ke hauv daim ntawv ntawm kev ncua yog hais rau kev kho mob ntshav qab zib hom 2 nkaus xwb. nws yog raws li kev sib xyaw ntawm cov tshuaj insulin luv luv nrog tshuaj yeeb-tshuaj nruab nrab. Qhov kev ua haujlwm txo qhov hnyav nyob ntev txog li 6 teev.
Txij li cov txheej txheem ib-qib muaj lub sijhawm luv luv ntawm kev nqus thiab cov metabolism, nws yog siv raws li kev kho kom zoo nrog cov insulin ntev ntev. Cov tshuaj Biphasic yog siv los ua lwm yam tshuaj rau qhov ncauj qab zib kom qis, los yog siv nrog lawv.
Pauv npe thiab daim foos tso tawm
Aspart yog tsim ob qho tib si hauv cov ntawv ntshiab thiab raws li ib feem ntawm kev npaj ua ntej. Muaj ob peb daim ntawv qhia tshuaj nyob rau hauv uas insulin aspart ua cov yam khoom tseem ceeb. Lub npe kev lag luam yog nyob ntawm qhov muaj pes tsawg leeg thiab daim ntawv ntawm cov tshuaj.
| Hom | Lub Khw | Daim ntawv tso tawm |
| Ib theem | NovoRapid® Penfill® | Lub pob txha laum uas hloov tau |
| NovoRapid® Flexpen® | Cov xaum xaum xaum | |
| Biphasic | NovoMix® 30 Penfill® | Lub pob txha laum uas hloov tau |
| NovoMix® 30 FlexPen® | Cov xaum xaum xaum | |
| Rysodeg® Penfill® | Lub pob txha laum uas hloov tau | |
| Risedeg® FlexTouch® | Cov xaum xaum xaum |
Lub cim lag luam yog tus tswv ntawm lub tuam txhab Danish Novo Nordisk.
Cov lus qhia rau kev siv
Txoj kev ntawm kev siv thiab ntau npaum li cas ntawm cov tshuaj yog nyob ntawm daim ntawv ntau npaum li cas, hom kab mob, muaj cov kab mob sib xyaw ua ke thiab lub hnub nyoog ntawm tus neeg mob.
Cov lus qhia dav dav, rau ob hom aspart, muaj raws li hauv qab no:
- Kev hno yog muab tso rau hauv subcutaneously (nyob rau hauv cov roj txheej), txij li cov tshuaj insulin luv luv qee qhov poob nws cov khoom thiab tawm sai sai los ntawm lub cev, nrog txhaj tshuaj intramuscular;
- Qhov chaw txhaj tshuaj yuav tsum tau hloov ua ntu zus, vim tias cov rog tuaj yeem ua rau hauv cov txheej rog.
- Lipodystrophic cov chaw;
- Koob tsis pom zoo kom siv tshuaj tiv thaiv ua ntej kis mob.
Yuav siv cov tshuaj insulin li cas? Cov lus qhia rau kev siv muaj cov lus qhia sib txawv rau ib-theem thiab ob-theem tshuaj.
Kev siv ntawm ib-leeg-theem aspart
Tus neeg sawv cev ntawm pawg no ntawm cov tshuaj hypoglycemic yog NovoRapid. Nws yog cov yeeb tshuaj ntaus nrig nrawm nrog lub sijhawm luv luv ntawm kev txiav txim. Cov nyhuv glycemic tshwm sim tom qab 10-20 feeb, tom qab txhaj tshuaj subcutaneous lossis infusion. Qhov siab tshaj plaws tau pom tshwm sim tom qab 40 feeb thiab maj mam txo, kom txog qhov tsawg kawg nkaus tom qab 5 teev.
Txhawm rau tswj cov glycemia ib txwm, tsis muaj ntu kev nce lossis txo cov piam thaj (sab nraum thaj chaw ib txwm muaj), yuav tsum ua tib zoo saib xyuas ntshav qabzib ntau ntau yog tsim nyog.
Nws yog nqa tawm siv cov txhais tau tias hauv qab no:
- Ntshav qab zib cov ntshav;
- CGMS cov kab ke rau kev kho lub twj tso kua mis (kev ntsuas hauv qab zib hauv tshuab hluav taws xob).
Kev ntsuas yuav tsum ntsuas ua ntej thiab tom qab noj mov. Txhawm rau ntsuas qhov tseeb ntawm ib qho tshuaj ntawm cov tshuaj, cov piam thaj qib ua ntej noj mov tau raug coj mus rau hauv tus lej, thiab cov nqi postprandial raug siv los ntsuas qhov ntsuas.
NovoRapid yog muab tshuaj subcutaneously siv U 100 cov tshuaj insulin, tus cwj mem xaum hluav taws xob los yog lub tshuab nqus insulin. Kev tswj hwm ntawm qhov tso tawm tsuas yog tso cai los ntawm cov neeg kho mob tsim nyog, nyob rau hauv cov xwm txheej ntawm kev kho mob xwm txheej ceev. Qhov ntim ntawm qhov ntsuas rau kev txhaj tshuaj ib zaug yog txiav txim los ntawm tus kws kho mob tuaj koom.
Kev yuav tsum tau txhua hnub yog xam ntawm tus kheej, nyob ntawm kev nkag siab ntawm tus neeg mob thiab lub cev qhov hnyav. Cov kev xav tau txhua hnub nyob hauv qhov ntau ntawm 0.5-1 U / kg lub cev hnyav. Koj tsis tuaj yeem nkag rau tag nrho cov tshuaj txhua hnub ntawm aspart tam sim ntawd, vim tias qhov no yuav ua rau cov ntshav qog ntshav qis thiab tsis nco qab. Koob tshuaj ib zaug tau muab cais rau ib qho ntawm cov khoom noj carbohydrate.
Cov tib neeg xav tau cov tshuaj insulin luv luv nyob ntawm cov tshuaj hormones thiab lub cev, nrog rau lub sijhawm nruab hnub. Thaum sawv ntxov ntxov, qhov kev xav tau yuav nce ntxiv, thiab tom qab ua haujlwm hnyav rau lub cev lossis thaum yav tsaus ntuj - yuav tsawg zuj zus.
Kev siv cov tshuaj biphasic aspart
NovoMix (tus sawv cev ntawm biphasic aspart) yog siv rau cov neeg mob uas muaj hom 2. Cov koob tshuaj pom zoo, thaum pib ntawm kev kho, yog 12 units, uas tau muab noj rau yav tsaus ntuj, ua ntej noj mov. Txhawm rau kom tau txais txiaj ntsig zoo tswj tau, nws tau hais kom faib ib koob tshuaj ua ob zaug. Nrog cov lus qhia no, lawv muab 6 chav NovoMix ua ntej noj tshais thiab yav tsaus ntuj, tseem ua ntej noj mov.
Tsuas yog kev tso cai nkaus xwb ntawm biphasic aspart tso cai. Txhawm rau tswj cov ntshav qab zib thiab kev hloov kho tshuaj, nws yog qhov tsim nyog los ntsuas ntshav qib. Kev hloov koob tshuaj yog nqa tawm tom qab teeb tsa daim ntawv qhia lub sijhawm, txiav txim siab ceev cov ntshav qab zib (thaum sawv ntxov, ntawm lub plab khoob), rau 3 hnub.
Cov kev thaiv tsis zoo thiab cov tshwm sim
Muaj ntau ntau yam qhia txog kev siv tshuaj insulin aspart nrog kev ceev faj. Cov ncauj lus sib khi thiab txwv tsis pub siv rau ob qho-ib-theem thiab kev koom ua ke ntawm cov tshuaj. Lub ntsiab contraindication yog ib tug neeg intolerance mus rau lub ntsiab tshuaj thiab ntxiv Cheebtsam uas ua rau cov tshuaj.
Tus lej ntawm kev txwv yog paub rau kev siv cov tshuaj aspart, nrog rau lwm cov tshuaj:
- Sulfites thiab tshuaj ntawm thiol pawg rhuav tshem aspart;
- Hypoglycemic ntsiav tshuaj, thioctic acid, beta-blockers, zoo li qee yam tshuaj tua kab mob txhim kho cov nyhuv hypoglycemic;
- Cov pab pawg thiazolidinedione ntau ntxiv qhov kev pheej hmoo ntawm lub plawv nres.
Tsis tshua muaj mob, cov tshuaj tiv thaiv tau tsim nyob rau hauv cov ntshav uas txo cov nyhuv glycemic ntawm aspart. Kev siv tshuaj tsis txaus los yog ntau dhau ntawm cov tshuaj, nrog kev xam tsis raug ntawm ib koob tshuaj, tuaj yeem ua rau hyperglycemia lossis hypoglycemia.
CEEV FAJ Kev siv ntau dhau ntawm cov tshuaj ua rau yus mob plab thiab tuag.
Cov kev mob tshwm sim hauv zos yog qhov nyob ntawm qhov chaw, ua rau pom ntawm qhov chaw txhaj tshuaj. Tom qab txhaj tshuaj, me me liab lossis o, khaus, hematomas tsis tuaj yeem pom. Nrog kev tshem tawm ntawm tus neeg mob siab ntev los ntawm lub xeev qhov qog ntshav ntau lub sijhawm ntev, mob neuropathy thiab mob ntshav qab zib sai tuaj yeem pib txhim kho.
Nqi thiab analogues
Tus nqi ntawm cov tshuaj yog nyob ntawm daim ntawv uas insulin aspart yog tsim. Tus nqi ntawm cov tshuaj thiab cov analogues yog pom nyob rau hauv lub rooj.
| Npe | Daim ntawv tso tawm | Tus nqi nruab nrab, rub. |
| NovoRapid® Penfill® | 3 ml / 5 pcs | 1950 |
| NovoRapid® Flexpen® | 1700 | |
| NovoMix® 30 FlexPen® | 1800 | |
| Apidra SoloStar | 2100 | |
| Biosulin | 1100 |
Cov qauv ntawm aspart muaj cov txiaj ntsig zoo sib xws, tab sis tau ua raws ntawm lwm cov tshuaj nquag. Cov tshuaj yog npaj rau siv tshuaj.
Cov tshuaj Insulin aspart yog ib tus neeg sawv cev hypoglycemic zoo. Nws tsis muaj ntau ntawm contraindications thiab siv ua ib feem ntawm txoj kev kho mob ntshav qab zib mellitus, ob hom. Cov tshuaj yog qhov haum rau cov menyuam yaus thiab cov laus, zoo rau cov laus.
