Trazhenta yog yeeb tshuaj tshiab rau kev txo cov ntshav qab zib hauv ntshav qab zib, hauv Lavxias nws tau sau npe hauv xyoo 2012. Cov khoom xyaw nquag ua haujlwm ntawm Trazhenta, linagliptin, belongs rau ib chav kawm kev nyab xeeb tshaj plaws ntawm cov kab mob hypoglycemic - DPP-4 inhibitors. Lawv zoo siab ntev, muaj yuav luag tsis muaj kev phiv, thiab kev xyaum tsis ua rau kev mob ntshav qab zib.
Lub cev mob hauv ib pawg tshuaj nrog kev ua ze ze sawv sib nrug. Linagliptin muaj qhov ua tau zoo tshaj plaws, yog li hauv ib ntsiav tshuaj tsuas yog 5 mg ntawm cov tshuaj no. Tsis tas li ntawd, lub raum thiab lub siab tsis koom nrog nws txoj kev nthuav dav, uas txhais tau hais tias cov neeg mob ntshav qab zib nrog kev tsis txaus ntawm cov kabmob no tuaj yeem siv Trazhentu.
Kev ntsuas rau siv
Cov kev qhia ntawv tso cai Trazent tshuaj kho tshwj xeeb rau cov neeg mob ntshav qab zib hom 2. Raws li txoj cai, nws yog cov kab noj tshuaj 2, uas yog, nws tau qhia rau hauv kev kho mob thaum kho kev noj haus, kev tawm dag zog, metformin hauv kev pom zoo lossis ntau tshaj plaws tau tseg los muab cov nyiaj them txaus rau ntshav qab zib.
Kev ntsuas rau kev nkag mus:
- Trazhent tuaj yeem raug kho raws li tsuas yog hypoglycemic thaum metformin tsis muaj qhov ua tsis zoo lossis nws qhov kev siv yog contraindicated.
- Nws tuaj yeem raug siv los ua ib feem ntawm kev kho mob nrog sulfonylurea derivatives, metformin, glitazones, insulin.
- Txoj kev pheej hmoo ntawm cov ntshav qog ntshav qab zib thaum siv Trazhenta yog tsawg heev, yog li, cov tshuaj no yog rau cov neeg mob ua rau muaj kev phom sij poob qab zib.
- Ib qho ntawm feem ntau thiab ua rau kev mob ntshav qab zib ntau dhau los ua rau lub raum tsis ua haujlwm - mob hlwb nrog kev txhim kho lub raum tsis ua haujlwm. Rau qee qhov, qhov tshwm sim no tshwm sim hauv 40% ntawm cov neeg mob ntshav qab zib, feem ntau nws pib asymptomatic. Kev tsim txom ntawm kev nyuaj uas yuav tsum tau kho ntawm kev kho mob, vim tias feem ntau cov tshuaj tawm tas los ntawm lub raum. Cov neeg mob yuav tsum tso tseg metformin thiab vildagliptin, txo qhov ntau ntxiv ntawm acarbose, sulfonylurea, saxagliptin, sitagliptin. Ntawm kev pov tseg ntawm kws kho mob, tsuas yog glitazones, glinids thiab Trazhent nyob twj ywm.
- Nquag ntawm cov neeg mob ntshav qab zib thiab ua rau lub siab ua haujlwm tsis zoo, tshwj xeeb tshaj yog cov roj ua haujlwm hepatosis. Hauv qhov no, Trazhenta tsuas yog cov tshuaj los ntawm DPP4 inhibitors, uas qhov kev qhia tso cai rau siv tau yam tsis muaj kev txwv. Qhov no muaj tseeb tshwj xeeb rau cov neeg laus laus uas muaj kev pheej hmoo siab ntshav qis.
Pib nrog Trazhenta, koj tuaj yeem cia siab tias glycated hemoglobin yuav nqis los txog li 0.7%. Hauv kev sib xyaw nrog metformin, cov txiaj ntsig tau zoo dua - txog 0.95%. Cov kws kho mob cov lus pov thawj qhia tias cov tshuaj muaj txiaj ntsig zoo ib yam rau cov neeg mob tsuas yog kuaj mob ntshav qab zib mellitus thiab nrog kev paub txog tus kab mob ntau dua 5 xyoos. Kev tshawb nrhiav ntau dua 2 xyoos tau ua pov thawj pom tias cov txiaj ntsig ntawm Trazent tshuaj tsis tsawg zuj zus mus.
Mob ntshav qab zib thiab siab surges yuav yog ib yam dhau los
- Li qub ntawm qab zib -95%
- Kev tshem tawm ntawm cov hlab ntsha thrombosis - 70%
- Ntaus tau ntawm lub plawv dhia muaj zog -90%
- Kev tshem tawm ntshav siab - 92%
- Qhov nce hauv lub zog nruab hnub, txhim kho pw tsaug zog thaum hmo ntuj -97%
Cov tshuaj ua haujlwm li cas?
Cov tshuaj hormones ntawm incretin yog ncaj qha cuam tshuam txo cov piam thaj kom txog qib siab ntawm lub cev. Lawv qhov kev nce siab ntxiv hauv kev teb rau kev nkag mus ntawm cov piam thaj rau hauv cov hlab. Qhov tshwm sim ntawm kev ua haujlwm ntawm incretins yog ib qho kev nce ntxiv hauv cov hluavtaws ntawm cov kua dej, qhov kev txo qis hauv glucagon, uas ua rau glycemia poob.
Tus incretins tau nrawm dua puas tsuaj los ntawm cov enzymes tshwj xeeb DPP-4. Cov tshuaj Trazhenta tuaj yeem khi rau cov enzymes no, ua haujlwm qeeb, thiab vim li ntawd, ua kom lub neej ntev ntawm incretins thiab nce kev tso tawm ntawm cov tshuaj insulin rau hauv cov ntshav hauv ntshav qab zib.
Qhov ua tau zoo dua ntawm Trazhenta yog qhov kev tshem tawm ntawm cov tshuaj nquag nrog cov kua tsib hauv cov hnyuv. Raws li cov lus qhia, tsis pub ntau dua 5% ntawm linagliptin nkag mus rau hauv cov zis, yog tias lub cev nyob hauv lub siab tsawg dua.
Raws li cov mob ntshav qab zib, qhov zoo ntawm Trazhenty yog:
- noj cov tshuaj ib hnub ib zaug;
- tag nrho cov neeg mob tau sau tsuas noj ib zaug xwb;
- tsis tas yuav hloov kho koob tshuaj rau cov kab mob ntawm daim siab thiab lub raum;
- tsis tas yuav tsum muaj kev kuaj mob ntxiv los txhawm rau xaiv Trazenti;
- cov tshuaj tsis muaj tshuaj lom rau daim siab;
- qhov ntau npaum tsis hloov pauv thaum noj Trazhenty nrog lwm cov tshuaj;
- kev sib cuam tshuam yeeb tshuaj ntawm linagliptin yuav luag tsis txo nws cov hauj lwm zoo. Rau cov ntshav qab zib, qhov no yog qhov tseeb, vim tias lawv yuav tsum tau siv tshuaj ntau yam nyob rau tib lub sijhawm.
Tsuas tshuaj thiab muab ntau npaum
Cov tshuaj Trazhenta muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj hauv qhov xim liab tob. Txhawm rau tiv thaiv kev ua cuav, ntawm ib sab ntawm cov khoom lag luam ntawm cov khw muag khoom lag luam, Beringer Ingelheim pawg ntawm cov tuam txhab, raug nias tawm, nyob rau lwm qhov - cim D5.
Cov ntsiav tshuaj yog nyob rau hauv zaj duab xis plhaub, nws qhov kev faib ua feem tsis muaj. Hauv pob ntawv muag hauv teb chaws Russia, 30 ntsiav tshuaj (3 lub hlwv ntawm 10 pcs.). Txhua ntsiav tshuaj ntawm Trazhenta muaj 5 mg linagliptin, hmoov txhuv nplej siab, mannitol, magnesium stearate, dyes. Cov lus qhia rau kev siv muab cov npe ua tiav ntawm cov khoom ntu pabcuam.
Cov lus qhia rau kev siv
Thaum muaj ntshav qab zib mellitus, qhov kev pom zoo noj txhua hnub yog 1 ntsiav tshuaj. Koj tuaj yeem haus nws thaum lub sijhawm yooj yim, tsis muaj kev sib txuas nrog pluas noj. Yog tias Trezhent cov tshuaj tau raug muab tshuaj ntxiv rau metformin, nws cov koob tshuaj yog tsis pauv.
Yog tias koj plam cov ntsiav tshuaj, koj tuaj yeem noj nws thaum tib hnub. Haus dej haus Trazhent nyob rau hauv ob txoj kev txwv yog txwv, txawm tias kev txais tos tsis tuaj lawm hnub ua ntej.
Thaum siv concomitantly nrog glimepiride, glibenclamide, gliclazide thiab analogues, hypoglycemia yog ua tau. Txhawm rau zam lawv, Trazhenta yog qaug cawv ib yam li ua ntej, thiab cov koob tshuaj ntawm lwm cov tshuaj raug txo kom txog thaum normoglycemia tiav. Tsis pub dhau tsawg kawg peb hnub txij li pib Trazhenta qhov kev noj haus, kev tswj ntshav qabzib yog xav tau, txij li thaum cov nyhuv ntawm cov tshuaj yuav maj mam tshwm sim. Raws li kev txheeb xyuas, tom qab xaiv cov koob tshuaj tshiab, qhov ntau zaus thiab mob hnyav ntawm hypoglycemia tau tsawg dua ua ntej pib kho nrog Trazhenta.
Muaj cov tshuaj sib cuam tshuam tau raws li cov lus qhia:
| Cov tshuaj noj nrog Trazhenta | Kev tshawb fawb tshwm sim |
| Metformin, Glitazone | Cov nyhuv ntawm cov tshuaj tsis hloov pauv. |
| Sulfonylurea npaj | Qhov kev xav ntawm glibenclamide hauv cov ntshav txo qis li ntawm 14%. Qhov kev hloov no tsis muaj kev cuam tshuam tseem ceeb rau cov ntshav ntshav. Nws tau kwv yees tias Trazhenta tseem ua nrog kev hwm rau pawg analogues ntawm glibenclamide. |
| Ritonavir (siv los kho HIV thiab mob siab C) | Nce qib linagliptin los ntawm 2-3 zaug. Xws li kev siv ntau dhau tsis cuam tshuam rau glycemia thiab tsis ua rau lub cev tsis muaj tshuaj lom. |
| Rifampicin (tshuaj tiv thaiv mob ntsws TB) | Txo kev txwv ntawm DPP-4 los ntawm 30%. Kev txo qis muaj peev xwm ntawm Trazenti tuaj yeem txo qis me ntsis. |
| Simvastatin (statin, normalizes lipid muaj pes tsawg leeg ntawm cov ntshav) | Qhov siab ntawm simvastatin yog nce ntxiv los ntawm 10%, kev kho qhov tshuaj tsis tas yuav tsum. |
Hauv lwm cov tshuaj, cuam tshuam nrog Trazhenta tsis pom.
Dab tsi yuav ua mob
Cov tshuaj phiv tuaj yeem tshwm sim Trazenti raug tshuaj xyuas thaum kuaj mob thiab tom qab muag cov tshuaj no. Raws li lawv cov txiaj ntsig, Trazhenta yog ib qho muaj kev tiv thaiv kab mob ntshav qab zib tsawg tshaj plaws. Txoj kev pheej hmoo ntawm cov kev tsis zoo uas cuam tshuam nrog kev noj tshuaj yog qhov tsawg heev.
Qhov ntxim siab, hauv pawg neeg mob ntshav qab zib uas tau txais cov placebo (ntsiav tshuaj yam tsis muaj tshuaj lom neeg), 4.3% tsis kam kho, vim li cas pom tseeb kev phiv. Hauv pawg uas coj Trazhent, cov neeg mob no tau tsawg dua, 3.4%.
Hauv cov lus qhia rau kev siv, txhua yam teeb meem kev noj qab haus huv ntsib los ntawm cov neeg mob ntshav qab zib thaum lub sijhawm kawm tshawb fawb nyob rau hauv lub rooj loj. Ntawm no, thiab kis, thiab kis, thiab kab mob cab. Nrog qhov siab qhov tseeb yuav yog Trazenta tsis yog tus ua rau cov kev ua txhaum no. Kev nyab xeeb thiab kev kho mob ntawm Trazhenta, thiab nws cov kev sib xyaw nrog cov tshuaj tiv thaiv kab mob ntshav ntxiv tau sim. Hauv txhua qhov xwm txheej, tsis pom muaj cov kev mob tshwm sim tshwj xeeb.
Kev kho mob nrog Trazhenta muaj kev nyab xeeb thiab hais txog kev ua kom lub qog ntshav qab zib. Cov lus taw qhia hais tias txawm tias nyob hauv cov neeg mob ntshav qab zib nrog qhov tsis txaus siab rau cov ntshav qab zib (cov neeg laus uas mob raum, mob rog), qhov ntau zaus ntawm cov ntshav qog ntshav qab zib tsis ntau dua 1%. Trazhenta tsis cuam tshuam loj heev rau kev ua haujlwm ntawm lub plawv thiab cov hlab ntsha, tsis ua rau nce qhov hnyav nce ntxiv, zoo li sulfonylureas.
Noj ntau dhau
Ib koob tshuaj 600 mg ntawm linagliptin (120 ntsiav tshuaj ntawm Trazhenta) tau pom zoo zoo thiab tsis ua rau muaj mob. Qhov cuam tshuam ntawm kev txhaj tshuaj ntau dua ntawm lub cev tsis tau kawm. Raws li cov yam ntxwv ntawm kev quav yeeb tshuaj, kev ntsuas zoo ntawm kev siv ntau tshaj yog kev tshem tawm cov ntsiav tshuaj tsis muaj tshuaj tiv thaiv los ntawm kev mob plab (lub plab zom mov). Cov tsos mob kho mob thiab saib xyuas cov cim tseem ceeb tseem ua. Kev lim ntshav hauv kev siv tshuaj ntau dhau ntawm Trazhenta yog qhov tsis muaj txiaj ntsig.
Cov Yuav Tsum Muaj
Tshuaj tsis zoo tsis siv rau:
- Yog tias tus mob ntshav qab zib tsis muaj cov qe beta muaj peev xwm ua cov tshuaj insulin. Qhov ua rau yuav muaj hom 1 mob ntshav qab zib lossis pancreatic resection.
- Yog tias koj fab rau txhua qhov ntawm cov ntsiav tshuaj.
- Hauv cov mob hyperglycemic mob ntshav qab zib. Cov kev kho mob uas tau pom zoo rau ketoacidosis yog cov tshuaj insulin rau txo qis glycemia thiab dej ntsev kom kho qhov lub cev qhuav dej. Tej ntsiav tshuaj npaj tau lawm kom txog thaum tus mob tso.
- Nrog niam mis. Linagliptin muaj peev xwm nkag mus rau hauv cov mis, cov plab zom mov ntawm tus menyuam yaus, ua rau nws muaj txiaj ntsig ntawm nws cov metabolism hauv cov metabolism.
- Thaum cev xeeb tub. Tsis muaj pov thawj dabtsi txog qhov ua tau ntawm linagliptin nkag mus rau hauv cov hniav.
- Hauv cov neeg mob ntshav qab zib qis dua 18 xyoo. Qhov ua rau cov me nyuam lub cev tsis tau kawm.
Raug rau kom mob siab rau kev noj qab haus huv, Trazhent raug tso cai xaiv cov neeg mob hnub nyoog laus dua 80 xyoo, mob leeg mob thiab mob txhaws nqaij leeg. Siv ua ke nrog cov tshuaj insulin thiab sulfonylurea yuav tsum muaj cov kev tswj xyuas ntshav qabzib, vim tias nws tuaj yeem ua rau mob ntshav qab zib.
Dab tsi analogues yuav hloov
Trazhenta yog cov tshuaj tshiab, kev tiv thaiv patent tseem tseem muaj zog tiv thaiv nws, yog li ntawd nws yog txwv tsis pub tsim cov tshuaj analogues nyob hauv Russia nrog tib yam tshuaj. Hauv kev hais txog kev ua haujlwm, kev nyab xeeb thiab kev ua haujlwm ntawm kev nqis tes, cov pawg analogues yog qhov ze tshaj rau Trazent - DPP4 inhibitors, lossis gliptins. Txhua yam tshuaj los ntawm pawg no feem ntau hu ua xaus nrog -gliptin, yog li lawv tuaj yeem sib txawv los ntawm ntau lwm cov tshuaj tiv thaiv kab mob ntshav qab zib.
Sib piv cov yam ntxwv ntawm gliptins:
| Cov ntsiab lus | Linagliptin | Vildagliptin | Saxagliptin | Sitagliptin |
| Lub Khw | Trazenta | Galvus | Onglisa | Januvia |
| Chaw tsim tshuaj paus | Beringer Ingelheim | Novartis Pharma | Astra Zeneka | Merk |
| Kev ntsuas tshuaj, tshuaj mob nrog tib yam tshuaj muaj zog | Glycambi (+ empagliflozin) | - | - | Xelevia (tag nrho cov analogue) |
| Metformin Ua Ke | Gentadueto | Galvus Met | Combogliz Prolong | Yanumet, Velmetia |
| Nqe rau lub hlis ntawm kev txais neeg kawm, tshiav | 1600 | 1500 | 1900 | 1500 |
| Txais hom, ib hnub ib zaug | 1 | 2 | 1 | 1 |
| Pom zoo siv ib koob tshuaj, mg | 5 | 50 | 5 | 100 |
| Chaw Sau Ntawv | 5% - zis, 80% - quav | 85% - zis, 15% - quav | 75% - zis, 22% - quav | 79% - zis, 13% - quav |
| Koob tshuaj hloov kho rau lub raum tsis ua haujlwm | - (tsis tas yuav) | + (tsim nyog) | + | + |
| Tshuaj xyuas raum ntxiv | - | - | + | + |
| Koob hloov hauv daim siab tsis ua hauj lwm | - | + | - | + |
| Kev txheeb xyuas cov tshuaj sib cuam tshuam | - | + | + | + |
Kev npaj Sulfonylurea (PSM) yog cov pheej yig analogues ntawm Trazhenta. Lawv kuj txhim kho cov tshuaj insulin, tab sis cov tshuab ntawm lawv cov nyhuv ntawm cov hlwb hlwb sib txawv. Trazenta tsuas ua haujlwm tom qab noj mov. PSM txhawb kev tso tawm ntawm cov tshuaj insulin, txawm tias cov ntshav qab zib yog qhov qub, yog li lawv feem ntau ua rau lub plawv tsis muaj ntshav qab zib. Muaj cov pov thawj uas PSM cuam tshuam tsis zoo rau lub xeev ntawm cov qe hlwb. Cov tshuaj Trazhenta hauv qhov no yog nyab xeeb.
Cov niaj hnub thiab tsis muaj mob ntawm PSM yog glimepiride (Amaryl, Diameride) thiab ntev glycazide (Diabeton, Glidiab thiab lwm yam analogues). Qhov zoo ntawm cov tshuaj no yog tus nqi qis, ib lub hlis ntawm kev tswj hwm yuav raug nqi 150-350 rubles.
Kev cai cia thiab nqe
Ntim Trazhenty nqi 1600-1950 rubles. Koj tuaj yeem yuav nws tsuas yog sau daim ntawv yuav tshuaj. Linagliptin muaj nyob hauv cov npe tshuaj tseem ceeb (Tshuaj tseem ceeb thiab Cov Tshuaj Tseem Ceeb), yog li yog tias muaj kev qhia, ntshav qab zib sau npe nrog tus kws kho mob endocrinologist tuaj yeem nrhiav tshuaj pub dawb.
Lub sijhawm tas sijhawm ntawm Trazenti yog 3 xyoos, qhov kub hauv qhov chaw khaws cia yuav tsum tsis pub tshaj 25 degrees.
