Atoris yog hypolipidemic tus neeg sawv cev ntsig txog statins. Cov tshuaj muaj nqis yog atorvastatin. Nws cov tshuab ntawm kev txiav txim yog lub peev xwm ntawm ib qho enzyme tshwj xeeb koom nrog cov tshuaj tiv thaiv cov roj (cholesterol) ua kom sib haum xeeb.
Los ntawm kev ua kom cov zus tau los ntawm cov roj (cholesterol), qhov rhiab heev ntawm receptors rau atherogenic lipids hauv hepatocytes thiab lwm cov hlwb nce. Cov qauv receptor no tuaj yeem khi LDL lwg me me thiab siv lawv los ntawm ntshav, uas, thaum kawg, ua rau kev txo qis hauv cov concentration ntawm atherogenic feem ntawm lipoproteins hauv cov ntshav. Kev ua haujlwm siab hypolipidemic ntawm cov tshuaj yeeb vim nws cov nyhuv ntawm endothelium ntawm cov hlab ntsha thiab cov khoom ua duab zoo nkauj.
Hauv qab ntawm cawv ntawm atorvastatin, vasodilation tshwm sim. Atorvastatin lwg me me qis dua qib ntawm cov roj (cholesterol) tag nrho, atherogenic feem ntawm lipoproteins, TG thiab lwm yam tshuaj atherogenic. Nws kuj tseem pab nce qib ntawm antiatherogenic lipoproteins. Kev ua rau txoj kev kho tau zoo tom qab 2-3 lub lis piam los ntawm qhov pib ntawm Atoris siv. Tom qab ib hlis, qhov siab tshaj plaws pom.
Atoris ncaj qha suav nrog atorvastatin thiab lwm yam ntu pabcuam.
Tus txheej txheem ntawm kev txiav txim ntawm cov tshuaj thiab cim rau kev siv
Feem ntau ntawm cov tshuaj no nqus los ntawm cov hnyuv. Vim tias lub siab ua rau cov metabolism hauv lub sijhawm ua kom lub siab, kev txiav txim siab txoj kev noj qab haus huv tsis pub dhau 12%.
Atorvastatin tsis hla cov neurovascular barrier. Cov sib xyaw ua ke siv feem ntau hauv cov tshuaj tiv thaiv bile). Yuav luag ib nrab ntawm cov tshuaj pov tseg nrog cov quav, li ob feem pua ​​- nrog zis.
Kev taw qhia rau kev teem caij Atoris yog hyperlipidemic mob. Txhawm rau kom txo qis cov roj cholesterol tag nrho, atherogenic lipoproteins thiab triglycerides.
Cov xwm txheej hauv qab no yog kev qhia txog kev teem caij Atoris:
- Thawj hyperlipidemia: nrog rau polygenic hypercholesterolemia, tsev neeg hypercholesterolemia thiab hom sib xyaw. Atoris kom tsawg zog muab cov lipoproteins ntau ntxiv ntawm anti-atherogenic feem hauv cov ntshav thiab qis dua qhov theem ntawm qhov piv ntawm atherogenic rau antiatherogenic. Nws siv thaum nws tsis tuaj yeem kho cov qib lipid los ntawm kev noj zaub mov noj thiab lwm txoj kev siv tshuaj tsis raug ntawm kev kho.
- Txog kev tiv thaiv cov kab mob plawv.
- Kev pheej hmoo ntawm mob plawv mob hnyav hauv cov neeg mob uas muaj subclinical kev mob plawv mob plawv, tab sis leej twg muaj qhov pheej hmoo. Cov pab pawg muaj kev phom sij suav nrog cov neeg uas lawv muaj hnub nyoog tshaj 55 xyoos, cov neeg haus luam yeeb raug mob ntshav siab, ntshav qab zib mellitus, nrog cov lipoproteins ntau ntom, nrog rau cov caj ces tsis zoo.
- Qhov pheej hmoo txaus ntshai ntawm kev mob plawv txaus hauv cov neeg mob uas muaj mob plawv los txhawm rau txo kev pheej hmoo tuag taus, mob hlab ntsha hlwb, mob hlab ntsha hlwb tsis txaus, kev mus pw hauv tsev kho mob thib ob hauv tsev kho mob vim tsis khov kho lub hlwb tsis zoo thiab hloov kho lub plawv.
Atoris tso tawm daim ntawv - ntsiav tshuaj. Cov tshuaj hauv qab no muaj nyob rau - cov ntsiav tshuaj nrog 10 koob, 20 mg, 30 mg thiab 40 mg.
Cov lus qhia rau kev siv tshuaj
Ua ntej pib txoj kev kho mob nrog Atoris, tus neeg mob yuav tsum pib ua kom cov lipid-txo cov zaub mov kom txo qis cov roj lipid ntau.Qhov kev noj haus yuav tsum tau ua raws lub sijhawm kho.
Cov tshuaj yog npaj rau cov thawj coj hauv qhov ncauj, tsis hais zaub mov dab tsi. Nws yog qhov zoo dua rau noj cov tshuaj rau yav tsaus ntuj. Tus kws kho mob teeb tsa qhov ntau npaum ntawm cov tshuaj thiab nws tuaj yeem sib txawv ntawm 10 txog 80 milligrams hauv ib koob rau 24 teev. Kev xaiv koob tshuaj yog kwv yees rau hauv thawj theem pib ntawm cov roj cholesterol, lub hom phiaj ntawm kev kho thiab cov yam ntxwv ntawm cov tshuaj cuam tshuam rau ntawm tus neeg.
Nws yog ua tau los siv atorvastatin hauv lwm daim ntawv tso tawm. Qhov peculiarity ntawm kev siv Atoris yog qhov yuav tsum tau saib lub sijhawm ntawm kev tswj hwm txhua hnub. Kev kho mob tshwm sim twb tau tom qab 2 lub lis piam los ntawm kev pib kho, thiab qhov siab tshaj plaws tau ua tiav ib hlis tom qab pib kho. Hauv qhov no, qhov ntau npaum li cas ntawm cov tshuaj tsis hloov pauv ntxov dua ib hlis tom qab pib kev noj tshuaj.
Thaum pib kho thiab raws li qhov koob ntawm cov tshuaj pauv, theem ntawm lipid feem nyob hauv cov ntshav yuav tsum tau saib xyuas. Raws li cov kev hloov hauv cov lipid profile, yuav tsum tau txhaj tshuaj kom haum.
Nyob rau hauv thawj hypercholesterolemia thiab sib xyaw hyperlipidemia, txoj kev kho yog pib nrog qhov kev kho mob tsawg kawg nkaus, uas tuaj yeem tau nce ntxiv tom qab ib hlis ntawm txoj kev kho, suav txog tus neeg mob cov lus teb rau kev kho mob.
Nrog cov muaj keeb hypercholesterolemia, koob txhaj tshuaj tau raug rau yav dhau los nosology. Thawj koob tshuaj yog xaiv coj mus rau hauv tus account tus yam ntxwv ntawm tus neeg mob, nrog rau kev coj mus rau hauv tus account qhov mob hnyav ntawm tus kab mob. Rau feem ntau cov neeg mob, qhov siab tshaj plaws kho tau zoo.
Nws yog qhov ua tau los siv Atoris hauv kev sib xyaw nrog lwm txoj hauv kev ntawm kev kho (xws li nrog plasmapheresis) lossis raws li kev kho mob monotherapy.
Kev phiv los ntawm kev noj tshuaj Atoris
Qhov tshwm sim tsis zoo tshuaj thiab qhov tshwm sim tsis zoo hauv qee kis muaj kev ywj pheej ntawm koob tshuaj thiab lub sijhawm kho.
Dua li ntawm qhov no, ib qho kev cuam tshuam ntxiv yog tshaj tawm nyob rau hauv cov neeg mob nrog kev kho lub sij hawm ntev tom qab qhov ntau kawg ntawm cov tshuaj.
Cov kev phiv loj muaj xws li:
- Ib txwm mob taub hau, kiv taub hau, nce mus txog mob taub hau. Ntau cov teeb meem pw tsaug zog, mus txog rau kev tsim kho npau suav phem. Kev nkees, kev ua kom tsis muaj zog, kev ua kom tsis zoo.
- Asthenia, nco tsis meej. Paresthesia, peripheral neuropathy, olfaction thiab saj cuam tshuam.
- Lub siab tsis xis nyob thiab lub siab ua haujlwm. Kho kev tsis txaus siab.
- Qhov muag qhuav. Tus mob txha caj qaum nyob hauv qab pob txha nqaj qaum, mob caj pas txha nqaj.
- Tachycardia, arterial hypertension (ntshav siab), atherosclerosis disturbances, mob qab sternum.
- Phlebitis, vasculitis. Lymphadenopathy, txo qis hauv cov ntshav txhaws.
- Aseptic mob ntsws, rhinitis; siv tshuaj yaj yeeb ua mob ntsws, mob ntshav ntswg.
- Cov mob uas ua rau lub plab zom mov: xeev siab, ntuav, kub ib ce tom qab lub pob tw, quav, tsam plab, poob ntawm lub cev nyhav, nce los yog poob qab los noj mov, poob phaus, lub qhov ncauj qhuav heev, nrhuab tawm, hloov pauv hauv qhov ncauj tawm; txoj hlab pas; cov leeg ntawm cov nplaig, lub plab, plab hnyuv me. Tej zaum qhov ntxiv ntawm duodenal mob rwj, mob ntshav tawm hauv lub qhov ncauj, tso quav tso quav thiab tenesmus. Cov pos hniav los ntshav ntau. Kev pom zoo ntawm cov leeg ceg, mob siab hloov ntawm lub hnab ua ke, leeg tsis muaj zog, mob nqaij thiab sab nraub qaum.
- Kev tiv thaiv kab mob rau cov mob genitourinary. Kev ua txhaum ntawm txoj hlab zis, nrog rau poob ntawm cov ntshav liab hauv cov zis.
- Vaginal los ntshav, uterine los ntshav. ICD.
- Kev mob hlwb ntawm phaum mob, kev sib daj sib deev hauv txiv neej. Muaj hws ntau. Eczematous ua pob, seborrhea, khaus ntawm daim tawv nqaij. Kev ua xua uas tsis haum: hu rau dermatitis; urticaria; Quincke's edema, anaphylactic kev poob siab yog qhov ua tau.
- Mauj vic mob o. Kev tsis haum rau UV sab, Stevens-Johnson syndrome, Lyell
- Cov ntshav qab zib qis (hypoglycemia).
- O o.
Cov teeb meem tsis txaus ntseeg suav nrog gynecomastia; exacerbation ntawm kev tsis hnov ​​tsw purine metabolism; kub taub hau, paub tsis meej genesis thiab do hau.
Cov kev txwv thiab qhov tshwm sim
Hauv kev xyaum geriatric, nws tsis pom zoo kom hloov pauv thawj zaug ntawm tshuaj. Hauv cov neeg muaj lub siab ua rau lub siab tsis ua haujlwm, nws yog ib qho tsim nyog yuav tsum tau siv cov tshuaj nrog kev ceev faj (txij li tus nqi ntawm cov metabolism thiab kev siv tshuaj atorvastatin txo qis).
Hauv qhov no, nws raug nquahu kom kuaj xyuas cov ntaub ntawv kuaj ntshav ntawm lub cev lipid thiab daim siab ua haujlwm. Nrog lub suab nce nyob rau hauv daim siab enzymes, ntau npaum li cas ntawm cov tshuaj yog pom zoo kom txo los yog tsis kam kho.
Hauv cov neeg mob uas muaj mob plawv, thiab rau lwm cov neeg sawv cev ntawm pab pawg muaj kev pheej hmoo siab mob plawv, lub hom phiaj ntawm txoj kev kho yog txo LDL tsawg dua 3 mmol / L thiab tag nrho cov roj cholesterol tsawg dua 5 mmol / L.
Cov contraindications rau kev teem caij Atoris suav nrog cov xwm txheej hauv qab no:
- mob siab mob siab, suav nrog tus kab mob siab ntev;
- hepatic cell tsis ua haujlwm;
- kev hloov pauv ntawm daim siab;
- nce kev ua si ntawm daim siab enzymes ntawm tsis paub etiology;
- striated leeg mob;
- cev xeeb tub thiab lactation;
- galactose intolerance;
- kev pheej hmoo siab ntawm cev xeeb tub;
- mob caj dab;
- cov menyuam hnub nyoog;
- ib tug neeg intolerance.
Nws tsis pom zoo kom sau ntawv tshuaj rau lub sijhawm cev xeeb tub thiab lactation. Cov twj yog tso cai rau siv los ntawm cov poj niam yug menyuam lub hnub nyoog tsuas yog thaum muaj qhov tsis tshua muaj siab ntawm kev cev xeeb tub thiab tus poj niam paub tag nrho txog qhov muaj txiaj ntsig teratogenic ntawm cov tshuaj.
Cov poj niam ntawm lub hnub nyoog yug menyuam thaum lub sijhawm noj Atoris raug pom zoo kom tiv thaiv lawv tus kheej los ntawm kev xeeb tub. Xws li kev npaj cev xeeb tub, tsum tsis txhob noj cov tshuaj 4 lub lis piam ua ntej hnub xeeb.
Nws yog contraindicated yuav siv cov tshuaj nyob rau hauv kev xyaum tsiaj txhu.
Cov lus qhia tshwj xeeb rau kev siv Atoris
Ua ntej pib Atoris, tus neeg mob yuav tsum pib ua raws li cov zaub mov hypolipidemic classical. Kev noj haus zoo li no yuav ua rau muaj kev cuam tshuam zoo dua ntawm cov tshuaj. Thaum noj tshuaj Atoris, kev nce siab hauv cov kev ua haujlwm ntawm daim siab enzymes tuaj yeem ua tau. Xws li nce ntawm transaminases yog hloov, tab sis yuav tsum tau soj ntsuam txhua zaus ntawm hepatocyte cov cim kev ua haujlwm.
Kev kho tsis nres thaum muaj ntau dua peb-npaug nce hauv theem ntawm daim siab enzymes. Atorvastatin tuaj yeem ua rau ib qho kev nce ntxiv hauv cov kev ua ntawm creatine phosphokinase thiab aminotransferase. Thaum mob lossis mob leeg tsis xis nyob, koj yuav tsum hu koj tus kws kho mob sai.
Thaum noj tshuaj Atoris, ntau yam tshuaj myopathies tuaj yeem txhim kho, nce mus rau rhabdomyolysis, tom qab ntawd mob mob raum tsis zoo.
Kev pheej hmoo siab ntawm rhabdomyolysis nyob rau hauv cov neeg mob uas siv cov tshuaj sib txuas hauv qab no nrog statins:
- Fibrates.
- Nicotinic acid thiab nws cov derivatives.
- Antimetabolites.
- Cov tshuaj tua kab mob, ib pawg ntawm macrolides.
- Antimycotic tus neeg sawv cev (azoles).
- Qee cov tshuaj muaj nyob hauv tshuaj tua kab mob.
Nyob rau thawj thawj qhov tsos mob ntawm kev txhim kho myopathy, qib ntawm creatine phosphokinase yuav tsum txiav txim siab tam sim ntawd.
Nrog ntau dua kaum-npaug ntau ntxiv hauv kev ua enzyme, kev kho yog tam sim ntawd tsum.
Tshuaj hauv kev xyaum
Atoris, nws cov lus qhia rau kev siv, tus nqi siab, nquag tshuaj xyuas tsis zoo ua rau tib neeg saib cov yeeb yaj kiab ntawm yeeb tshuaj.
Cov lus qhia rau kev siv yog qhov nyuaj heev thiab tsis loj heev rau txhua pawg ntawm lipid-txo tshuaj. Qhov no vim yog lub siab toxicity ntawm cov nyiaj no. Tab sis phau ntawv qhia no muaj cov lus piav qhia tag nrho ntawm cov chaw muag tshuaj thiab cov tshuaj ntawm cov tshuaj, muaj teeb meem tshwm sim thiab contraindications. Qhov kev rau txim ntawm kev tsis quav ntsej nyeem cov lus qhia tuaj yeem ua rau neeg tuag taus.
Kev kho mob Atoris yuav tsum yog kws kho mob sau tseg. Nyob rau hauv tsis muaj cov ntaub ntawv yuav tsum koj tus kheej-tshuaj. Qhov no yog qhov tseem ceeb vim qhov tseeb tias cov cuab yeej tsis haum nrog ntau yam tshuaj yeeb dej caw. Tsis muaj kev sib raug zoo nrog cov tshuaj xws li cyclosporine, fluconazole, spirolactone, thiab lwm yam.
Kev txiav txim siab los hloov cov tshuaj no nrog cov kws ua hauj lwm hauv tsev tsawg dua yuav tsum pom zoo nrog tus kws kho mob uas koom nrog thiab. Qhov sib txawv, hmoov tsis, tuaj yeem yog qhov tseem ceeb.
Txij li cov tshuaj cuam tshuam rau cov roj (cholesterol), nws yuav tsum tau saib xyuas tsis tu ncua kom ua raws li qhov noj tshuaj tsawg kawg nkaus.
Kuj, raws li tus xeeb ceem, haus cawv tsis sib xws nrog cov tshuaj nquag - atorvastatin. Xws li kev sib xyaw ua ke tsis nyab xeeb rau lub cev.
Cov tshuaj tiv thaiv nrov ntawm Atoris hauv pawg pharmacological yog Rosuvastatin thiab Simvastatin.
Tus nqi ntawm Atoris sib txawv raws li hnub xa tawm thiab qhov chaw muag khoom. Koj tuaj yeem yuav cov khoom lag luam ntawm txhua lub tsev muag tshuaj hauv Lavxias. Tus nqi ntawm cov tshuaj hauv Russia txawv ntawm 357 txog 1026 rubles. Hauv kev xyaum, qhov cuab yeej muaj ob qho tib si zoo thiab tsis zoo tshuaj xyuas ntawm kws kho mob.
Cov ntaub ntawv hais txog statins yog muab hauv video hauv tsab xov xwm no.
